Dantrolene( Dantrolene) is a drug that belongs to the muscle relaxant group. It is used to treat and prevent the development of malignant hyperthermia, which develops after surgery.
In addition, drugs are widely used in neurology to combat muscle contractions of a spastic type, with spinal cord injuries, with multiple sclerosis and inflammation of muscle tissues.
Dantrolene acts as an active substance, in 1 ml of the solution contains 0.30 mg.
The drug should not be dissolved in a solution of sodium chloride isotonic type and in a glucose solution of 5% concentration.
Contents
- Pharmacological profile
- Indications and contraindications for use
- Features of application depending on the purpose
- Overdose and possible "pobochki"
- Combination and interaction with other drugs
- Special patients and situations
- View
- Purchase and storage
Pharmacological profile
Currentlytime pharmacological action of the drug is not fully understood. Doctors and scientists suggest that the drug is able to slow the release of calcium ions from the sarcoplasm.
In this case, the transmission of impulses of nerve cells to tissues of muscle type is inhibited. With the help of this, inhibition of muscle contractions of the reflex type occurs, and afterwards suppression of contractions of the spastic type.
Derivative from the disintegration of imidazoline does not show epileptic activity as other derivatives like Phenytoin.
Bioavailability is 75%.Metabolism occurs in the liver and is excreted from the body with urine and bile.
Dantrolene affects the calcium channels of the sarcoplasmic reticulum. The drug reduces the release of calcium from the reticulum and reduces the concentration of calcium of a free type in the sarcoplasm. Thus, there is a disconnection of the electromechanical coupling. The effect of the agent on the patient's body depends on the daily dosage.
Indications and contraindications for use
The drug is used in the following diseases:
- malignant hyperthermia;
- neuroleptic malignant syndrome;
- cerebral palsy;
- muscular hypertonicity;Multiple sclerosis
- ;
- stroke;
- paraplegia;
- overdose of ecstasy;
- serotonin syndrome;
- poisoning with dinitrophenol 2, 4 stages.
The drug can be used only with the permission of a doctor with all recommendations and dosages.
The drug can not be used in certain diseases and conditions. These include:
- intolerance components;
- malfunction in the liver;
- inadequate work of the heart and vascular system;
- children under 6 years;
- gestation period.
Stroke can be cured without medication:
Features of application depending on the purpose of
To prevent the consequences of anesthesia, the drug is injected into the vein an hour before the procedure begins. The amount of the drug is calculated based on the calculation of 2.4 mg per kilogram of adult weight.
For therapeutic action, the administration of the drug is started from 1 mg per kilogram. The dose is gradually increased until the syndrome is completely removed. The total dosage is 10 mg per kilogram.
The capsules are administered at a dose of 3 to 8 mg per kilogram for 24 hours and divided into 3 to 4 doses. Usually the drug is prescribed a few days before the operation. It is canceled after surgery for 2 - 3 days.
For the removal of spasticity, the medication begins with 25 mg within 24 hours, possibly a gradual increase in dosage if necessary. It is carried out, gradually adding on days 6 to 7 for 25 mg. The maximum daily dosage should not exceed 400 mg.
If the administered dose brings an effect, the metabolism will be normalized after 20 - 30 minutes.
Overdose and possible "pobochki"
Data on the drug overdose Dantrolen is not currently registered, but the application of the drug can trigger the development of side effects. These include:
- speech impairment;
- vision impairment;
- depressed, depressed;
- hallucinations;
- nausea;
- vomiting;
- headaches;
- dilution of stool;
- hepatitis( with long-term use);
- is a specific taste in the oral cavity.
If the above described symptoms occur, stop taking the medication and seek help immediately.
Less commonly, when using Dantrolen, the following symptoms may occur:
- weakness in the legs;
- a constant desire to sleep;
- dizziness;
- shortness of breath;
- dysphagia;
- decrease in air when inhaled.
Patients should be supervised, moving only with accompanying patients until the end of these manifestations.
When applying the drug, you must strictly follow the introduction of the drug and prevent its penetration into the soft tissues that surround the area of administration. This must be done to prevent the development of necrosis.
Combination and interaction with other drugs
During the application of the drug Dantrolene concurrently with other drugs, the following negative conditions may develop:
- calcium channel blockers with simultaneous administration with a drug are able to provoke arrhythmia, hyperkalemia and reduce the number of heartbeats;
- Vecuronium bromide in rare cases can provoke muscular-neural blockade;
- estrogen may cause an increase in drug toxicity in female patients over 36 years of age.
Special patients and situations
For children, the drug is prescribed by the doctor individually, with the calculation of the dosage for each small patient. The amount of the drug depends on the disease, its severity, and the condition and age of the child.
At present, there is no reliable data on the effect of Dantrolene on the body of a pregnant woman. However, doctors advise not to take the remedy, since it can cause hypotension in the fetus.
When breastfeeding is not recommended to use the drug, as it penetrates with milk and fetus.
During therapy with this drug, it is necessary to refrain from drinking alcoholic beverages, as this can aggravate the patient's health and exacerbate side effects.
In the treatment of this drug, driving is strictly forbidden due to dizziness.
Viewpoint
The effectiveness and safety of Dantrolene can be judged from the reviews of doctors and doctors.
There is a dangerous syndrome that is not known to many people. Its name is a malignant type of hyperthermia. It can develop with the introduction of anesthesia. The only drug that can fight this syndrome is Dantrolen. However, the problem is that it is banned on the territory of our country.
Anaesthesiologist Marina A.
I was recommended for a drug after a stroke. Its use became a discovery for me, because I did not meet such means. I was given injections, and after completing the therapy I felt much better. The only drawback for me was the price of the medicine.
Olga
The drug advised to buy a doctor for mom. She had muscular hypertonia, which did not respond to treatment. Get the remedy was difficult, because in Russia we did not find it( bought in Germany).After several courses of treatment, my mother felt better. She began to move quietly without help.
Evgenia
Comment The effectiveness of the application is confirmed by the successful therapy of malignant type hyperthermia and spastic syndrome. This remedy is used in many premedication regimens that are used before surgical interventions.
Purchase and storage of
Dantrolene is available in capsules of 50 or 25 mg and powder for injection of 20 mg. Ampoules with a powder solvent are sold as a set.
The cost of the drug depends on the number of packages in the box. The price of one package is on average from 140 to 145 euros. The cost in rubles depends on the euro rate at the time of purchase.
When storing and transporting the drug, it is necessary to strictly observe the temperature regime, which should not exceed a mark of 30 degrees Celsius. Do not allow direct sunlight, so the drug is stored and transported in special containers.
In Russia, the drug is not sold in pharmacies because of the narrow course of action. Dantrolene can be bought at pharmacies in Germany. The drug is dispensed only by the prescription of a practitioner's doctor according to the EU protocol.
The preparation has only one similar Dantrium agent. It is similar in composition and effect on the patient's body.
