Lozartan - instructions for use and reviews about the drug

Losartan is a time-tested antihypertensive agent used forlowering blood pressure. Instructions for use Losartan recommends it as a therapeutic and prophylactic agent for people suffering from hypertension and cardiovascular pathologies.

Clinical studies of the drug have shown that it significantly reduces the risk of developing and exacerbating heart disease, reducing the incidence of strokes and heart attacks. In addition to the main focus, Losartan slows the progression of renal failure, helps restore the function of kidneys after transplantation, reducing the mortality rates of patients.

Losartan: the principle of action of

The drug Losartan is an effective blocker of angiotensin II receptors. The active substance of the drug is potassium losartan. It eliminates the effect of angiotensin II, which causes vasoconstriction and supports the work of the heart muscle. The mechanism of action of the drug is to reduce blood pressure and pressure in the passing through the lungs circle( the so-called small circle of the circulatory system).

In addition, the action of Losartan is noted as a diuretic effect, due to which the body gets rid of sodium salts and uric acid. At the same time, potassium salts remain intact, useful for the normal functioning of the heart muscle. The therapeutic effect of Losartan is more than 24 hours, which allows taking 1 tablet of the drug per day. After ingestion, the active substance is rapidly absorbed from the digestive tract, its bioavailability reaches 33%.The drug is metabolized in the liver, with the formation of carboxyl metabolites.

Dosage form and composition

The main active ingredient in the drug is losartan potassium. It is its content is reflected in the dosage of the drug. The excipients include:

• lactose monohydrate;
• primollosa;
• microcrystalline cellulose;
• silica;
• Povidone;
• magnesium stearate.

Losartan is available in a single dosage form: in the form of round tablets coated with a shell, convex on both sides with an allowable surface roughness. The dosage of tablets is different: 12.5, 25.50, and 100 mg.

Depending on the dosage of the drug, Losartan tablets are different in color: a minimum dose of 12.5 mg and 25 mg of white with a light shade of gray;Losartan 50 mg - pink;100 mg have a yellowish tinge. Thus, even when the tablets are stored unpacked, their dosage is easily identifiable in appearance.

Often found packaging of this medicine - blisters, placed in a cardboard box with the appropriate name. In one blister is 10 or 15 tablets. The number of blisters varies from 2 to 6 pcs. Also, the preparation is packaged in contourcell packagings from 10 to 30 pcs.each. In the box there are from 1 to 6 such packages with tablets. The third form of packaging is a jar with a content of 10 to 100 tablets in each.

Indications for use

Direct indications for prescribing the drug are the following conditions:

• arterial hypertension, especially at the initial stage of manifestation;
• ischemia of the heart, which is chronic;
• chronic heart failure, provided there is no effect of therapy with other drugs;
• reduced risk of cardiovascular pathology and the number of deaths in patients with a diagnosis of hypertension and left ventricular hypertrophy;
• decreased circulating blood volume;
• rehabilitation after kidney transplant;
• protection of the kidneys and normalization of their activity in diabetes mellitus type II.

Often patients ask the question: " At what pressure do they take Losartan? . "Unambiguous instructions on this account does not exist. Everyone has his own "working" pressure and, with his rise, one patient can feel normal, and the other - completely loses efficiency.

Therefore, determine when to prescribe the drug, in what dosages and for how long it should be taken, should be decided by the attending physician. The boundary condition is usually considered the pressure 135/85 mm. Art. Anything higher than these values ​​is already a direct indication for the use of antihypertensive drugs.

Contraindications

Most drugs used to reduce blood pressure have a number of contraindications. Therefore, they should be appointed after a comprehensive survey and possible limitations. Absolute contraindications to the administration of Losartan are:

• hypersensitivity to the constituent ingredients of the drug;
• severe renal failure;
• intolerance to hereditary galactose;
• state of pregnancy;
• lactation;
• for children and adolescents up to the age of 18( due to lack of data on safety and efficacy of treatment).

Losartan refers to drugs that have a direct effect on the renin-angiotesin-aldosterone system. Its reception in the second and third trimesters of pregnancy is fraught with defects in the development of the fetus, which can lead to irreversible consequences, up to its intrauterine death. If the pregnancy is diagnosed with the medication, discontinue the course of treatment immediately.

To date, there is no data whether the active substance of the drug is excreted in breast milk. Therefore, it is not recommended to start treatment with lactation. If this is not possible due to the mother's condition, breastfeeding is suspended for the entire period of therapy with the drug.

Instruction for use

For the average patient, the daily dose of the drug is 50 mg, take it at one time at a convenient time. A certain group of patients may be doubled, but under the strict supervision of a specialist. If a patient is given a daily dose of 100 mg, it is usually divided into 2 divided doses. Conversely, a reduced dosage is prescribed for patients suffering from hepatic pathologies, with caution being prescribed for impaired renal function. How to take Losartan - the doctor decides after the examination of the patient and the diagnostic examination, the independence of the patient in this matter is inappropriate. During the intake of an antihypertensive drug, regular monitoring of blood pressure is necessary.

The active substance reaches its maximum concentration in the human body for one hour. The duration of the action is 24 hours. Visible effect of therapy is achieved after 4-6 weeks of regular use.

Food intake does not affect the activity of Losartan in the body, so it is very convenient to take it - you can do it at any time, regardless of food.

The main condition of drug treatment is the regularity of application and compliance with dosages. The discontinuation of taking the drug on the patient's initiative should be ruled out, even if there is a pronounced therapeutic effect. If, for some reason, I had to miss the appointment once, you should drink the pill right away, as soon as you remember it. If it's time to drink the next dose, then the previous one is missed and returned to the previous therapy.

The course of treatment with the drug has no age restrictions for people over 18 years old, it can be taken, including in the elderly and senile. At the same time, standard dosages of the drug are observed, adjustments are made only on an individual basis. The only "but": age patients with Lozartan should periodically monitor the kidneys, especially with the simultaneous treatment of non-steroidal anti-inflammatory drugs and diuretics.

To date, there is no data on the impact of Losartan on the ability to drive vehicles and dangerous mechanisms. For safety reasons, it is recommended that in the first days of taking the drug, avoid potentially dangerous actions that require rapid reaction and increased concentration.

Side effect of

Losartan is a strong drug, with an incorrectly selected dosage and weakness of the body that can cause a number of side effects in patients. It can be:

• severe dizziness;
• accelerated or delayed heartbeat;
• headaches;
• is an intestinal disorder;
• nausea and vomiting;
• dry mouth;
• pain in the peritoneal region;
• insomnia, a state of paranoia;
• short-term dips in memory;
• violation of taste sensations;
• change in visual acuity;
• nasal congestion, dry cough;
• increased sweating;
• sharp drop in blood pressure;
• edema of the face, mouth, tongue and larynx;
• muscle pains and spasms;
• impaired renal function;
• skin allergic reactions in the form of hives and other types of rash, itching.

Adverse effects are enhanced by alcoholic beverages, hot climates, prolonged dehydration, subfebrile body temperature and excessive physical exertion. Therefore, when undergoing treatment, if possible, it is necessary to observe a calm, measured rhythm of life, not to use prohibited products, etc.

In general, this list of side effects is given only as a probable effect. Under the conditions of therapy, in most cases, the drug is easily tolerated by the body without causing side effects. If such symptoms appear, they are mild and short-term, with withdrawal of the medicine. In any case, if there are undesirable reactions, you should consult a doctor, you may need to adjust the treatment regimen.

Interaction with other

drugs During clinical trials, there was no significant effect of Losartan on the intake of other medications. However, it should be noted that when combined with pressure-lowering agents, a mutual enhancement of the effect is found.

Also, while using Losartan and diuretics, there is a risk of hyperkalemia, and a sudden increase in pressure, which can adversely affect the patient's health.

Analogues of Losartan

Many Russian and foreign brands are among the structural analogues of the drug. Among them are the most famous ones:

• Vero Lozartan,
• Losartan Richter,
• Lozap, Lorista,
• Losartan Teva,
• Renikard,
• Boktran,
• Losartan Kanon

All analogues of the preparation have the same active ingredient in their composition, differences are observed only in the form of release,dosage, manufacturer and composition of auxiliary components. Decide which tool will better help to cope with the patient's problem in each specific case is the doctor's task.

Read more about the most effective high-pressure tablets here.

Price

This drug is officially included in the list of vital and essential medicines, therefore the price of Losartan largely depends on the decisions of the Federal Service for Supervision in Health Care and the Federal Tariff Service.

To date, a package of 30 tablets of the minimum dosage will cost, on average, 70 rubles. A similar package of 25 mg is 120 rubles, 50 mg is 130 rubles.

The maximum dosage of 100 mg will cost approximately 190 rubles, depending on the subject of the Russian Federation on whose territory it is sold. The opportunity to save and make a profitable purchase is. To do this, you should buy a package with a large number of tablets.

Comments on the application of Losartan can be found at specialized forums on the Internet. Basically, they are positive and confirm the effectiveness of the drug. Patients noted persistent lowering of blood pressure, improvement in general condition and good tolerability of the drug.

There are also negative opinions associated with the side effects of taking medication. But usually, such manifestations take place after the dose adjustment and the exact observance of all the doctor's recommendations.

Feedback on the application of

Review No.1

I have been taking Losartan for almost a year now. I am 60 years old and in recent years I suffered from hypertension, the pressure was kept at 160/100 and higher, several times there were severe seizures, when the pressure jumped abruptly, I had to call an ambulance.

The optimal remedy for a doctor's pressure is quite long. Several times I prescribed drugs that caused strong adverse reactions. As a result, I stopped at Losartan. Now I take a pill once a day, and this is enough to keep the pressure in the norm. Yes, and this drug does not cause unwanted reactions.

Zinaida Ivanovna, Samara

Response №2

Losartan is a strong preparation, it helps well at increased pressure. For me, this is the best option, I like that you only need to take the pill once a day. And, I can drink medicine at any convenient time and regardless of food intake.

Losartan can be taken for a long time, it is not addictive. Many complain of side effects, but they are almost all hypotensive drugs. At me in the beginning of reception there were giddinesses and headaches, but then all has passed or has taken place.

Constantine, Moscow

Review No. 3

Every second patient suffers from high blood pressure, especially in old age. I myself am a medical professional in the past, so I know what I'm talking about. The intake of antihypertensive drugs is vitally important and necessary, and they will have to be taken until the end of life.

When I started to jump pressure, immediately went to the doctor and together we picked up the optimal drug that allowed to keep blood pressure in the norm. I take Losartan. This is a reliable and time-tested tool, which is also inexpensive, which is especially important for us, pensioners. While I'm happy with everything, I do not see any need to replace the drug.

Anastasia Yakovlevna, Yekaterinburg

Review No.4

The doctor appointed Lozartan from high pressure. After he started taking the pill, there were headaches, tinnitus, dizziness. Plus, there was nausea, I completely lost my appetite. He tried to continue treatment for some time, but then refused this drug, because the pressure did not decrease.

I heard that Losartan helps a lot, but I did not fit. Now I accept Normalife, which does not cause such unpleasant symptoms.

Anatoly, Miass