Nitricium is a drug whose active substance is capable of blocking alpha-adrenoceptors, resulting in a vasodilating effect.
Belongs to the group of ergot alkaloids and peripheral vasodilators.
Effective in disorders of cerebral circulation, in particular with ischemia, ischemic stroke and hypoxia.
Contents
- Composition and preparation
- Pharmacological profile
- Scope and limitations for prescribing
- Instruction for use
- Overdose and additional indications
- Interaction with other medicines
- From the practice of using
- Acquisition of medication and analogs
Composition and formulation
Preparations Nitriciumand Nitciumium OOE differ in composition and form of output. The first is in the form of tablets( 10 mg in
Structural formula of nicergoline
one tablet), which contains the active ingredient nicergoline( 10 mg) and impurity elements in the form of magnesium stearate, corn starch, povidone, lactose monohydrate and anhydrous colloidal crystalline substance.
Nitricium The DNA has the form of capsules. One capsule( 30 mg) contains 30 mg of active ingredient nicergoline and auxiliary compounds: macrogol 4000, talc, spherical sugar and polyacrylate dispersion.
Pharmacological profile
The drug promotes vasodilation and lowering blood pressure. In addition, the drug helps reduce blood viscosity and prevents the adhesion of platelets. With the systematic administration of this drug in patients, psychomotor functions are stabilized and memory is improved. People with a diagnosis of dementia have cognitive improvements already three months after starting the medication.
When the drug is taken, the process of migration of impulses along the nervous processes is normalized. Also, the active components of the Nitserium promote better metabolism of norepinephrine and dopamine, improve the bioelectric activity of the brain.
The medication is able to have antihypoxic and anti-ischemic effects. Affects the intercellular metabolism( regulation and processing of glucose and oxygen), takes part in the unification of proteins and nucleic acids.
The active substance nicergoline affects the cholinergic neuronal transmission by blocking the alpha-adrenergic receptors. Also, the components of the drug prevent the appearance of adrenaline-induced platelet adhesion.
After using the drug, its constituent components undergo rapid and complete absorption. Maximum serum radioactivity in blood plasma is noted three hours after admission( with the administration of therapeutic doses).The half-life in this case is an average of fifteen hours. When taking low doses of the drug, the highest level of radioactivity is observed in an hour and a half after its use.
The drug has a large volume of distribution in tissues( more than 105 liters).Its bioavailability after taking is only 5%.Low bioavailability is due to persistent metabolism and hepatic clearance. About 80% of the drug is excreted in the urine and 10-20% - with feces.
Scope and limitations for prescribing
Indications for the use of tablets and capsules Nitcium:
- acute and chronic circulatory scarcity in the brain;
- therapy for stroke, ischemia and their consequences;
- is a migraine;
- Mixed and vascular dementia;
- Alzheimer's and Parkinson's;
- hypoxia;
- sleep disturbance;
- of cerebral circulation;
- atherosclerosis;
- presence of arterial hypertension( medication is used as part of complex therapy).
Contraindications to prescription:
- susceptibility to the active ingredient of the drug;
- previously suffered myocardial infarction;
- children's age;
- period of pregnancy and lactation;
- manifestation of acute hemorrhage;
- sharp drop in blood pressure;
- reception of sympathomimetics.
Instructions for Use
Capsules and tablets are given for oral use. The daily dose of Nitricium is taken at one time. The total daily intake for adults is 20-30 mg( two to three tablets).In the absence of the desired clinical effect, the dosage of the drug should be increased to six tablets per day.
Nitricium OOH( 30 mg) should be consumed before meals. The medication should be started with a dose of 30 mg( one capsule per day).
To improve the clinical effect, you can increase the dosage to two capsules per day. The average duration of the therapeutic course is six months.
The manifestation of the clinical effect occurs three months after the start of the drug use. If the kidneys work improperly, the doctor must adjust the necessary dose for each patient individually.
Overdose and additional indications
Signs of overdose are: general body fatigue, lower blood pressure and shortness of breath. When these symptoms manifest themselves, symptomatic therapy is used.
Side effects include redness of the skin( in rare cases), gastric disorders, insomnia and fatigue.
In the process of treatment with the drug Nitzerium, alcohol intake is contraindicated. Also, this drug is not recommended to be given to nursing mothers and pregnant women.
In case of disruption of the liver and kidney function, a complete examination and adjustment of the dose of the drug should be made. Not assigned to patients under the age of eighteen.
As one of the objectives of the appointment of the Nitserium is to improve the ability to focus attention, during the reception of this tool it is allowed to control the transport and other automated systems.
Interaction with other drugs
When combined with agents that act on blood coagulability, their effectiveness may vary. The drug is able to enhance the therapeutic effect of antihypertensive drugs. Reduces the effect of beta and alpha-adrenomimetics.
Nitserium is combined with Thioridazine, Risperidone and Haloperidol.
Parallel administration with Holstiramin and antacid agents results in incomplete absorption of nicergoline.
From the practice of using
The point of view of doctors and the feedback of patients who took the Nitricum.
Most often I prescribe Nitzerium for dementia and Parkinson's disease. For me, this drug showed a positive side. Outside effects are not so pronounced that it allows to undergo a full course of treatment, which is six months.
Kirill Andreevich, neurologist
I also think that this drug is effective and I assign it not only as a separate remedy, but as an additional( for example, with hypertension).
With regard to the manifestation of side effects, the degree of their severity mainly depends on the individual characteristics of the body, so dosage should be established only on an individual basis and after a complete examination.
Elena Vasilyevna, neurologist
I used this remedy for dementia. The doctor prescribed one dose a day for me. Improvements I felt only at the end of the therapeutic course. Side effects were observed at the beginning, then was drawn. In general, the medicine is not bad.
Rostislav Viktorovich, 49
Practice shows that the drug has the desired therapeutic effect and does not often cause side effects.
Acquisition of medication and analogs
The medication has two forms of release: capsules of Nitricium DNA( 30 mg) and tablets of Nitzerium( 10 mg), average price per pack of tablets is 290 rubles, capsules - 1000 rubles;
The medicine should be stored in a dark place where there is no direct sunlight. The shelf life of the drug in the form of tablets is two years, and in the form of capsules - three.
Deprecated by prescription.
