The drug Mazeptil belongs to the group of neuroleptics. This antipsychotic agent with thioproperazine as the main active substance.
Has a pronounced antipsychotic effect, moderate sedative properties and to a small extent enhances the effect of taking painkillers and hypnotics.
Contents
- Composition and preparation
- Pharmacological properties and mechanism of action
- Indications and list of contraindications
- Other restrictions for prescribing
- Special patients
- Instructions for use: doses and scheme
- Interaction with other medicines
- Overdose and adverse reactions
- Opinionpatients and physicians: pros and cons of medicine
- Purchase and similar effects
Composition and form of release
Basic actionDosage substance of the drug is dimezilate thioproperazine. As auxiliary components are:
- wheat starch;
The formula of diozylate of thioprolidine
- lactose;
- magnesium stearate;
- sodium gentisate;
- ascorbic acid;
- colloidal silicon dioxide.
The drug is available in round pills of light yellow color. On one side of the medicine there is an engraving "RPR 04".The composition of the shell includes butyl acetoricinoleate and zein.
Also Mazeptil is available as a solution for injection, in ampoules of 1 ml.
Pharmacological properties and mechanism of action
The medicament has a powerful antipsychotic effect, has the ability to inhibit pathological processes in the central nervous system and provides a weak soothing effect.
The drug is rapidly absorbed and has a good dissolution ability, easily bypassing the histohematological barriers. The level of bioavailability is relatively low, from 25 to 35%.
The process of biotransformation occurs in the kidneys, and an insignificant part of the substance is excreted with bile.
Indications and list of contraindications
The drug is indicated for use in the presence of the following diseases: 
- schizophrenia in catatonic and hebephrenic form;
- manic syndrome;
- bipolar disorder;
- chronic hallucinatory psychoses;
- reactive psychosis;
- at attacks of polymorphic delirium.
Contraindications to the use of Mazeptil are such conditions:
- craniocerebral trauma;
- diseases characterized by circulatory disorders in the brain and spinal cord;
- presence of severe diseases of the cardiovascular system;
- comatose conditions and disorders in the central nervous system.
In addition, there are a number of restrictions on taking medication depending on the sex and age of the patient.
Other restrictions for the prescribing of
A precaution should be taken during medication when: •
- is prone to clots;
- disorder in the circulatory system;
- presence of an angle-closure glaucoma;
- clinical manifestations of prostatic hyperplasia( in men);
- malignant lesions in the mammary gland( in women);
- alcoholism;
- exacerbation of gastric ulcer diseases;
- disturbances in the respiratory system;
- predisposition to epilepsy;
- Parkinson's disease;
- is the advanced age of the patient.
Also, you should take extra care and take the medicine only under the supervision of a doctor in cases of renal and hepatic insufficiency.
Thioproperazine can provoke drowsiness, for this reason it is better for the time of treatment to give up driving and restrict any activity that requires a quick reaction and high concentration of attention.
To consume alcohol during treatment is contraindicated, since alcoholic beverages can enhance the action of the medicine, which can lead to undesirable consequences.
Special patients
A medical product for pregnancy and lactation is prescribed only in case of acute necessity. During the period of gestation, the drug should not be used for a long period of time, and in the third trimester it is advisable to reduce the dose.
After the birth of a child, careful medical monitoring of the state of his nervous system and the work of the organs of the gastrointestinal tract is required.
In childhood, the drug is not used, taking the drug is indicated for persons who have reached the age of 18 years.
Instructions for use: doses and the
regimen Ingestion should be started at a dose of 5 mg per day, increasing the volume by 5 mg every 2 or 3 days.
The average daily dose is 30 to 40 mg, but, if necessary, can be increased to 90 mg per day.
When the symptoms of the disease are stopped, the dosage is reduced, and the drug is taken as a supporting agent.
When administered intramuscularly, depending on the patient's condition and severity of the disease, the daily dose is 2.5-70 mg.
Interaction with other drugs
Thioproperazine is able to enhance the nephro- and hepatotoxicity of certain substances. 
It is not recommended to take this medication together with such types of drugs:
- barbiturates;
- with tranquilizers;
- with antihistamines;
- with antihypertensive medications;
- Levodopa;
- with morphine;
- with anticholinergic substances.
Overdose and Adverse Reactions
In case the dose of the drug is significantly exceeded, there are signs of extrapyramidal disorders, lowering blood pressure and breathing. In particularly severe cases, shock and coma are possible.
In case of an overdose, symptomatic treatment is performed depending on the clinical manifestations.
During the treatment, negative reactions to the active substances of the drug in different body systems may occur. Side effects include the following conditions:
- apathy and abulia;
- increased muscle tone;
- causeless anxiety;
- vomiting and nausea;
- pallor of the skin or sharp "tides" of blood to the face;
- sensation of dry mouth or increased salivation;
- constipation or diarrhea;
- Parkinsonism;
- lacrimation;
- dizziness and arrhythmia;
- urinary retention;
- increased sweating;
- decreased potency in men and frigidity in women.
If the drug is used for a long time, dyskinesia may develop and a significant weight gain.
Opinion of Patients and Doctors: Pros and Cons of Medication
Expert opinion and feedback from patients who undergone or are undergoing treatment with Mazepril.
The main advantages of Mazeptil are the effectiveness and safety. It has a beneficial effect on the state of the nervous system and shows a high degree of effectiveness in the process of application for various mental disorders.
Side effects occur extremely rarely. In addition, almost any family can purchase Mazheptil, its price is quite democratic.
Psychoneurologist, 21 years of experience
My elder sister has schizophrenia, the doctor advised me to drink Tyopperazine. Improvements are evident now, although she takes the drug only a few weeks. The medicine is well tolerated, we did not notice any side effects, but the benefits are obvious.
Lisa, 29
Nowadays it is very expensive to get sick, the price of medicines is sometimes sky-high. But there are exceptions. I get Mazeptyl for my husband, the price is acceptable, even with our small pension, and the effect is good.
Nina Pavlovna, 59
And I would not venture to purchase a cheap drug for a loved one with such a huge list of contraindications and side effects. How can such pills help? One treat, the other cripple. And the fact that not all side effects occur, it's a matter of luck, but it's not worth the risk.
Semen Nikolaevich, 47
Purchase and similar effects
The drug is available in tablets, 10 pieces per blister. The cardboard package contains 20 tablets. The solution for injections is released in boxes containing 50 ampoules of 1 ml of substance in each.
To purchase the drug you need a doctor's prescription. The average price of a medicinal product is from 180 to 250 rubles.
You can store the medication for 4 years, in a dark place with moderate humidity, at an air temperature of 25 degrees.
The analogues of Mazeptil are the following drugs:
- Haloperidol;
- Droperidol;
- Triftazine and others.
