Exelon( Rivastigmine) is an inhibitor of acetylcholinesterase and affects the CNS and brain condition, promotes favorable emotional and behavioral changes, is used in the complex treatment of Alzheimer's and Parkinson's.
The drug is a vital drug, indispensable in the treatment of Alzheimer's dementia.
Contents
- Composition and Formulation
- Pharmacological profile
- Indications and contraindications for prescription
- Instruction for use
- Overdose and possible side reactions
- Additional recommendations
- Interaction with other medicines
- Practical experience with
- Neurologist's review
- The people's voice
- Purchase of the drug and analogs
Composition and form of release
Medicinal product Exselon is available in the form of capsules containing inside white or pale yellowth powder, solution and plaster. It's about pills.
The main active ingredient is rivastigmine. And also the preparation contains a number of additional components:
- silica;
- magnesium stearate;
- cellulose;
- hypromellose.
The composition of the shell includes gelatinous mass, iron oxide and titanium dioxide. Capsules are available in a cardboard package, in blister packs of 14 pcs.
Pharmacological profile
The main active substance of the drug is rivastigmine. This component helps normalize the vital processes of
The rivastigmine
formula in the brain and prevents the development of amyloid plaques.
High absorption rate of the substance and its low bioavailability, less than 40% are noted. The medication does not accumulate in the body, within a day 90% is excreted mainly by the kidneys, and less than 1% comes out with calves.
No information is available on whether rivastigmine enters breast milk.
Indications and contraindications for prescribing
The drug is used in the mild or moderate form of such diseases:
- Alzheimer's disease;
- Parkinson's disease.
It is forbidden to prescribe a medicinal product in the following cases:
- under the age of 18;
- with a special susceptibility to the components of the remedy;
- in case of a skin allergic reaction, which was noted as a result of the use of the Excelon patch.
Instruction for use
Drug is recommended to drink 2 times a day, in the morning and in the evening, before eating. At the initial stage of treatment the dosage should not exceed 1.5 mg 
at one time.
Patients with probable sensitivity to the components of the drug are taken at 1 mg.
If the patient tolerates the drug well, its amount is gradually increased, not earlier than 14 days after the start of treatment, to 3 mg, then to 4.5 mg, and then to 6 mg. After each dosage change, at least 2 weeks must elapse before the volume of the drug is increased again. The maximum daily dose should not exceed 6 mg per day.
When a medication is used as a supporting agent, its dosage can be 1.5-6 mg per day, divided into 2 divided doses.
After a break, the drug intake starts at the lowest dose.
Overdose and possible adverse reactions
As a rule, with a slight overdose, the patient does not feel any particular changes in his state of health. But in the case of a serious excess of the daily volume of the drug taken, the following manifestations are noted:
- nausea;
- vomiting;
- bradycardia;
- blood pressure jumps;
- fainting and hallucinations.
If overdose should stop taking the drug for a day. If the condition is associated with nausea and vomiting, Atropine sulfate is used.
The drug can cause side effects in various body systems. The most frequent adverse reactions include:
- headache;
- nausea;
- vomiting;
- diarrhea;
- dizziness;
- abdominal pain;
- is nervousness or depression;
- problems with urination;
- anorexia;
- syncope;
- skin rashes.
In rare situations, bradycardia, ulcerative lesions of the stomach and disturbed cerebral circulation.
Additional recommendations of
When taking Exelon medicinal product in the following cases, careful medical supervision and certain precautions are required:
- Pregnancy and lactation period .At the moment, it is not revealed how rivastigmine affects the body of the pregnant woman and fetus, and it is also unknown whether it is excreted in breast milk. For this reason, the drug should be prescribed only in cases where the potential benefit is higher than the potential risks. If the medicine is used during breastfeeding, it is better to transfer the child to artificial mixtures.
- Dysfunction in the liver and kidneys .In these cases, dosage adjustment is not necessary, but it is necessary to monitor the patient's condition.
- Driving your vehicle .To date, there have been no cases of impaired motor function and the rate of response in patients taking this drug. But since it is capable of causing dizziness, it is better to give up driving in the process of treatment.
There are also limitations during the course of drug therapy: 
- Drinking alcoholic beverages .In combination with alcoholic beverages rivastigmine can provoke uncontrolled processes in the body, the consequences of which are unpredictable.
- Childhood age .The effect of the medication on the child's organism has not been studied, for this reason it is not recommended to appoint it to persons under the age of 18 years.
In addition, individuals with Parkinson's disease may experience motor disorders and tremor in the extremities, so they need careful medical supervision during treatment with medication.
Interaction with other drugs
Exelon active ingredients are able to change the activity level of drugs of the cholinomimetic and anticholinergic group.
The drug can enhance the effects of muscle relaxants during anesthesia. With the interaction of rivastigmine with medications of other groups, no risks and negative manifestations were found.
Practical experience of using
Review of a neurologist, reviews of patients, as well as their relatives who know about Exelon firsthand.
Overview of the neurologist
The drug Exelon is considered one of the most effective in the treatment of neurological disorders such as Alzheimer's and Parkinson's.
How does it work? The main active substance of the drug is rivastigmine, it acts as an inhibitor of brain acetylcholinesterase and is involved in the destruction of acetylcholine.
This also helps to deter destructive processes. Despite the impressive list of possible side effects, in most cases the drug is well tolerated, only sometimes there are such conditions as depression, nausea, headaches and skin rashes.
The main drawback of the drug is its cost, not every family is able to afford it. Although the result is worth it.
Neurologist, 15 years experience
The voice of the people
When my husband was diagnosed with Alzheimer's disease, my children and I took it as a death sentence, only with a delay - everyone knows that this is not being treated. The doctor prescribed this medication, and we, of course, have purchased this non-expensive medicine, especially not hoping for anything. But the result pleases, the disease, although it develops, but not so rapidly as it is commonly believed. In any case, we do not notice any special changes in behavior.
Ekaterina Leonidovna, 58
The medicine helps, it's true. But I was not lucky - after increasing the dose, as the doctor advised, after a while the pressure began to gallop, and I had to lower it again. And with such a minimum amount of great relief, there is no need to wait.
Sergey Semenovich, 67
Unfortunately, I can not say anything about the improvements. Our case is heavy, but what does not get worse is good.
Nina, 41
Purchase of the preparation and analogues
Release forms, cost in rubles and analogues
The drug is available in capsules, in a cardboard package, which can contain 1,2,4 or 8 blisters with 14 capsules each.
The most common packaging, containing 2 blisters( 28 pieces).The price of the medicine with a dosage of 1.5 mg is 2 150-2 250 rubles, Exelon in tablets with a dose of 3 mg costs from 2,210 to 2,280 rubles per package.
The analogues of the remedy are Exselon solution and patch, as well as Alzenorm in the form of a solution or tablets.
Shelf life of the drug is 2 years. Keep the packaging away from sunlight in places with moderate humidity. The air temperature should not exceed 25 degrees.
Medication is dispensed in pharmacies only on prescription.
