Sooner or later, in the life of every person, there comes a time when something seems to be breaking inside him. There comes apathy, work capacity is almost zero. Not everyone knows that depression is not just a bad condition of a person, it's a disease.
Without treatment, depression does not go away. If you do not take care of your health - there may be various accompanying psychological disorders, and a bad mood turns into a way of life.
With depression, the patient not only changes mood, the disease affects overall health, behavior and thoughts. Since any medications that are designed to fight this disease affect the entire nervous system, only the attending physician can choose an effective and safe medicine that does not harm and at the same time has the maximum positive effect.
In the case of severe depression, psychologists and neurologists around the world are almost always prescribed a new generation of 
antidepressants in a complex of general therapy. In comparison with other types of antidepressants, they can be used for almost all patients( with special reservations even to children and pregnant women), there are practically no side effects of such medications.
In addition, antidepressants of the new generation have a double action, not only serotonin but also noradrenaline is inhibited. Thus, this type of drugs is suitable for all cases of depression. Including, and for a chronic type of disease.
Features of the
group Because antidepressants act on the nervous system, there are a number of important features. For example, any drug in this group should never be discontinued immediately.
The dose should be gradually reduced. This will avoid relapse of the disease. We can not forget about the seriousness of depression. When appointing patients with antidepressants, they should be constantly monitored during the first weeks of the drug - this is done to avoid attempts at suicide.
Practical studies of
These medications performed well in a clinical trial in the Netherlands. For the purpose of the most objective evaluation it is worth to exclude the placebo effect, especially for this type of antidepressants of a new generation, such as invitro. Placebo is a change in the state of the body with the help of autosuggestion, in which case this is not due to the effect of any biochemical drugs.
Very well shown by such a drug as Fluoxetine, it acts without any side effects, but its effectiveness is somewhat weaker than that of other modern antidepressants of the new generation.
If several antidepressants are used simultaneously, the most effective drugs will be Escitalopram and Mirtazapine, and also the same Fluoxetine. When only Sertraline was used, the effect was lower, compared with the combined course of treatment.
A new generation of antidepressant, such as the Effector, was also tested, or, in other words, venlafaxine. It blocks all receptors of serotonin, but it should not be forgotten that in the case of a dose increase, the reverse capture of a substance such as norepinephrine will be blocked.
There is another tool with a non-standard principle of action - Remeron, which stimulates the production of histamine. Also, this drug helps to overcome insomnia. However, do not forget that this drug has its side effects, like all other antidepressants.
The best antidepressants of the new generation
In the Netherlands, a study was conducted that was aimed at comparing the antidepressants of the new generation. For comparison, factors such as the effectiveness of treatment, side effects and the tolerability of drugs by patients were used. This study involved more than 25,000 people who suffered from depression.
Based on the data, feedback and analysis of open information, we compiled the following list, which included only the best modern antidepressants of the new generation, almost all of which without side effects:
- Sertralin .The drug has a very good degree of efficiency, low price. But do not forget about the side effects. And this is
drowsiness, pain in the head area, ataxia, aggressiveness, anxiety, dry mouth, decreased appetite and others. - Paxil .A fairly well-known antidepressant which is prescribed by a large number of doctors. Do not use it in combination with Thioridazine and MAO inhibitors.
- Escitalopram .The drug has a high level of efficacy and excellent tolerance in people over 18 years of age. Children should choose another medicine.
- Citalopram - an antidepressant has shown good tolerability, and also has quite a few contraindications, among which there is too much sensitivity to the substance or the administration in conjunction with MAO inhibitors.
- Bupropion has good tolerability, but for some, price plays a big role. The monetary value of the drug is quite high, and the efficiency is quite average. For this reason, it is better to pay attention to other medicines.
- Fluvoxamine .The drug has a fairly good level of efficacy and has good tolerability. Of the side effects is worth noting pain in the head, respiratory tract infection, lowering of the libido and others.
- Milnacipram .The drug occupies the middle of the list and is something average in all indicators. At pregnancy it is necessary to refrain from passage of treatment by means of this preparation.
- Fluoxetine has a low level of effectiveness, but side effects are practically absent. You can even use this medication even for pregnant women, but when you are undergoing treatment, you should stop breastfeeding.
- Mirtazapine .The drug also showed a very high level of efficacy, but more than 15% of the subjects interrupted treatment due to increased appetite, confusion, strange dreams, asthenia and other side effects.
- Insidon .Most often it is prescribed for outpatient treatment. Has an effect against vomiting and against seizures, and is also an anesthetic.
- Venlafaxine - an antidepressant showed excellent efficacy, but a large number of side effects were noted. Virtually every 5 people who took it - there were side effects. Among them, insomnia, increased drowsiness, asthenia, nausea and others.
- Paroxetine , like Fluoxetine, is not highly effective. Also, there may be side effects such as hives, myalgia, nausea and vomiting, sweating. The drug is poorly tolerated.
- Duloxetine .It has an average degree of effectiveness and side effects often manifest, so it's better to pay attention to other antidepressants.
- Agomelatin .Not so long ago appeared antidepressant, which showed itself perfectly. However, it is not recommended for use in children, as well as with lactose intolerance. When mania appears, stop using the drug.
- The closest in the list is the Reboxetine .Poor tolerance and low efficiency suggest that this is not the best cure for depression.
The voice of the people
Reviews of people who have been treated with antidepressants of a new generation.
I used Reboxetine a few weeks ago. I had panic attacks. I have no side effects. This was my first practice of taking antidepressants.
Karina, 34
I had an astheno-depressive syndrome. I tried to drink many antidepressants, but only Libera helped me. No side effects. The only drawback is the high price.
Maxim, 54
I had a disturbing depression. The attending physician appointed me Fevarin. Since before I had already taken antidepressants - I decided to stop using it myself. As a result, she threw too sharply. As a result, the condition was as in the first days of the disease, as well as vomiting and diarrhea.
The moral of my story, at the end of the course, go again to see a doctor, do not throw this antidepressant drug abruptly.
Alina Vyacheslavovna
Summing up
Do not forget that antidepressants, both new and previous generations, have application features and side effects, so you should carefully study the instructions to the medication and in no case should you use a medication if you haveContraindications.
In addition, before you buy an antidepressant - contact your healthcare professional. Each antidepressant is necessary for a certain type of depression, not all of them can have a positive effect on the body and the general state of the body.
For the course of treatment, consult with your doctor, it will help to calculate the dose correctly in order to avoid relapse of the disease. Also, do not take the initiative and try to stop taking the drug yourself.
