Modern life is a huge flow of information, a chaotic movement in the maximum possible rhythm. Stressful situations often lead to violations of mental balance. Depressive and anxiety disorders develop.
In some cases, the use of special drugs - psychotropic drugs, called antidepressants. One such drug is Tianeptine, manufactured under the trademarks Stablon and Coaxil.
Contents
- General information on the active substance
- Preparations based on Tianeptine
- Pharmacological profile
- Scope
- Contraindications to the prescription
- Instructions for use
- What is the risk of overdose?
- Adverse Reactions
- What do professionals and patients say?
- Summing up
General information about the active substance
Chemical formula Tianeptine
Tianeptinum belongs to tricyclic antidepressants. They got their name due to the triple carbon ring at the base of the element. Tianeptine is used as a sodium salt. He is referred to as atypical representatives of tricyclic compounds.
Preparations based on this substance in the trading network are called Coaxil and Stablon.
Information exchange in the cells of the brain is carried out with the help of a large number of nerve cells-neurons.
Mediators in this process are neurotransmitters, and such representatives of this family as dopamine, serotonin and norepinephrine are responsible for the development of the depressive state.
Simply put, with a decrease in the number of named mediators, a pathological condition, called depression, develops. Antidepressants are designed to normalize the biochemical processes of the brain and increase the number of necessary neurotransmitters.
Tricyclic antidepressants affect the increase in serotonin and norepinephrine by reducing the need for these substances during metabolism.
The chemical formula of Tianeptine is as follows: C21H25ClN2O4S.
As a drug, a tablet form is used, based on the active substance Tianeptine and standard auxiliary derivatives. Tablets are available in a dosage of 12.5 mg.
Drugs based on Tianeptine
Pharmaceutical companies offer drugs in which the active substance is Tianeptine, in Russia the drug is manufactured under the name Coaxil, and its analogue abroad is called Stablon.
The mechanism for the therapeutic effects of these drugs is not fully understood, but the distinguishing feature of Tianeptine-based drugs is 
facilitating reverse neuronal seizure of serotonin. There is no fundamental difference between Stablo and Coaxil because they have the same active substance.
Characteristic differences of Tianeptine-based drugs from other antidepressants in the absence of such side effects as drowsiness, decreased libido and weight effects( Coaxil and Stablon do not enhance appetite).
These drugs are used in the therapy of a wide range of mental disorders. Their reception is able to normalize behavioral reactions in patients with alcoholism during the period of abstinence.
Pharmacological profile
The pharmacological action of an antidepressant is to stimulate the re-uptake of serotonin, increase activity and restore the functionality of pyramidal cells responsible for the formation of emotions and memory consolidation.
The entire group of medicines refers to means of energizing action. With the beginning of the application, there is an improvement in mood, increased tonus and motor activity, decreased anxiety, normalization of sleep, and absence of somatic pathologies.
Coaxil and Stablon have a pronounced anxiolytic effect, which is aimed at reducing the symptoms of various phobias.
The agent is rapidly adsorbed from the gastrointestinal tract in full. It is characterized by stable bioavailability.
Active component Metabolised in the liver and excreted by the kidneys unchanged after 2.5-3.5 hours. In patients older than 70 years and in patients with impaired renal function, the withdrawal period is increased by one hour.
Preparations based on Tianeptine substance have a unique property: unlike known inhibitors, they are a selective serotonin reuptake enhancer( SSRE).In other words, SSRE antidepressants work hard to increase the absorption of serotonin.
The mechanism of their action on the neurotransmitter level is associated with dopaminergic activity. They have a variety of effects on the hormonal and enzyme balance.
Scope
The use of Tianeptine is justified in such diseases and symptoms:
- Depression of from a minor to severe stage of mental disorder, including in patients with alcoholism during the
abstinence period. An abstinence syndrome is a manifestation of discomfort( breakage) during a period of lowering the dose or completely giving up alcohol. The drug is prescribed for the treatment of depressive conditions in old age, in a complex of therapeutic measures aimed at combating premature aging of the organism and syndromes characteristic of old age. - Anxiety-depressive disorder .Coaxil and Stablon are successfully used in the therapy of somatic diseases, accompanied by a sense of anxiety. The arisen anxiety is a normal reaction of the body to the impact of stressful loads and unfavorable factors. Sometimes such a feeling arises for no apparent reason, and has no basis for it. In this case, subjective experiences and phobias lead to somatic disorders.
- Symptoms of depression and anxiety disorders of an organic nature .Clinical signs of impairment are similar to depressive and anxiety disorders of psychological etiology, but patients do not associate their condition with specific mental causes. This condition may indicate the presence of organic problems in the brain, which can be identified when conducting a thorough examination.
- Acute stress response to .Mental disorder of medium and severe degree in response to a powerful shock, severe stress( can develop with natural disasters, criminal actions towards the patient, injuries and accidents).
- Post-traumatic mental disorder .Depressive disorders and atypical behavioral reactions that have arisen in response to severe personal injury, physical suffering, psychological trauma.
- Neurasthenia .Irritability, fatigue and other symptoms indicative of depletion of the nervous system.
Contraindications to the prescription of
Drugs with active ingredient Tianeptine should not be used in such cases and by such patient categories:
- In case of intolerance to the components of the drug .Allergic reactions noted earlier in the patient are a valid reason for refusing to use drugs with this active ingredient.
- Children under 15 years of age, pregnant and lactating women due to ingestion of the active ingredient in breast milk. Clinical trials of drugs during pregnancy are absent.
- Assignment in conjunction with MAO inhibitors .In the case of switching from one group of antidepressants to others, it is recommended to make an interval of at least two weeks. And when switching from this drug to MAO inhibitors, a break of 24 hours is sufficient.
A narrow range of contraindications makes it possible to widely use the drug in the treatment of psychiatric disorders, including in the elderly.
Instructions for use
Coaxil( Stablon) is available in the form of biconvex tablets in a coating containing 12.5 mg of active substance. Assign the medication 3 times a day for 1 tablet( 12.5 mg), with plenty of water.
For elderly patients or patients with impaired renal function, the daily dose is reduced to 2 tablets( 25 mg per day).The drug is intended for oral administration.
As a rule, the medication already from the first days of use improves mood, normalizes sleep, reduces feelings of anxiety.
To increase the dose for patients with alcoholism is prohibited, should monitor the admission in this group of patients.
At the end of the course, the dosage should be gradually decreased within 7-14 days.
In the treatment of the postabstinal state in heroin-dependent patients, the dose is increased to 8 tablets per day and a short-term course of therapy is prescribed for 3-5 days.
What is dangerous overdose?
The use of tianeptine in doses exceeding the recommended levels causes symptoms similar to opioid effects. Increasing the dosage leads to addiction and dependence. 
Drug addicts make a slurry of crushed tablets for intravenous administration. Dependence on these drugs manifests itself clinically as a dependence on morphine.
In case of an overdose, it is necessary to cancel the drug, carry out gastric lavage and diagnose vital body systems. It is necessary to monitor the cardiovascular system. Symptomatic remedies are used to relieve symptoms.
The use of tablets should be monitored to avoid overdose and due to the propensity of patients with depressive disorders to suicidal attempts.
If the patient is to use anesthesia for surgery, an anesthesiologist should be warned about taking the remedy, and also cancel it 24-48 hours before the surgery.
The consequences of the ill-advised use of Coaxil as a drug are simply horrible, a further selection of videos is not for the faint of heart:
Adverse reactions
Co-axial and similar medications may be accompanied by numerous adverse reactions, which can cause serious health consequences: 
- from the sideCNS : dizziness, insomnia and nightmares, migraines and decreased concentration of attention;
- cardiovascular system may cause rhythm disturbances, angina pectoris;
- nausea, vomiting, flatulence, dry mouth and refusal to eat - typical of disorders in the of the digestive tract ;
- breathing apparatus : difficulty breathing, lump in the throat, spasm of the larynx;
- other adverse reactions of may occur in hot flashes, hot flashes and low back pain.
When taking Tianeptine, sodium is not recommended for drinking alcohol.
What do professionals and patients say?
Reviews of professionals and patients who know what Coaxil and similar medicines are, firsthand, can be read below.
Drugs with active ingredient Tianeptine are safe at the correct dosage chosen. With proper therapy, they give a positive effect.
The only negative is the duration of the course of treatment. As for addiction and dependence, at present this phenomenon is frequent with uncontrolled reception of psychotropic drugs.
Svetlana Viktorovna, Ekaterinburg, psychotherapist
Coaxil and similar preparations give a good effect from the first days of therapy. It is important to understand that it is necessary to monitor elderly people with alcoholism and other categories of patients under the supervision of a doctor. With proper treatment, addiction to the drug does not arise.
Sergey Yuryevich, Lipetsk, general practitioner
Coaxil brought me back to life. After the terrible stress, I could not sleep at night, scared of every rustle. My relatives approached the doctors at the time when I had an obsessive idea of a suicidal nature.
Since the first days of taking pills, sleep has become calm and stable. And after the course, I returned to my usual life. Misc. In life happens.
Olga, Murmansk
Treated with a Stabil from alcohol dependence. It was very difficult, at first I wanted to escape and hide. It was especially difficult to overcome the craving for alcohol. I'm glad that the treatment helped. After 2 months I began to feel like a full-fledged person.
Roman, Kazan
Summing up
Advantages of the drug: a positive persistent effect and good tolerability.
Cons: prolonged use in high doses leads to addiction, Coaxil can easily be turned from medicine into a drug when thoughtlessly applied.
The cost of drugs, depending on the manufacturer's company, varies from 400 rubles per package from 30 tablets to 12.5 mg. Storage times are indicated on the packaging. Store any drug in a cool dark place, unattainable for children.
Buy all medicines can be in the pharmacy only according to the doctor's prescription, which meets the requirements for the release of funds of group A.
