Bonviva is a blocker of bone resorption and belongs to the group of bisphosphonates. Produced in tablets of 2.5 and 150 mg for oral administration, and in a 3 ml syringe tube for intravenous injection.
Active pharmaceutical substance - ibandronic acid.
Tablets of 2.5 mg are oval, slightly biconcave, film-coated, white or almost white, on one side of the tablet - engraving "I T", on the other - "L 3".On tablets 150 mg, on the one hand, you can see the numbers "150", on the other - "BNVA".
The injection solution is a clear, colorless liquid.
Article Contents
- pharmacodynamic properties
- Pharmacokinetics
- means indications and contraindications for
- use in the zone of interest - pregnant women and children
- Undesirable effects
- Pharmaceutical interaction
- treatment regimen and dosing
- oral dosage forms
- injectable form
- overdose cases
- Specific guidance
- Opinion simplepeople
- From the practice of a doctor
- Analogues of the drug
Pharmacodynamic properties
Ibandednew acid prevents bone destruction caused by fading gonadal function, malignancies retinoids.
Its selective action is explained by its affinity for hydroxyapatite, the main substance of bones. At the same time, it does not disturb the mineralization of bone tissue, increases bone mass, and reduces the incidence of fractures.
After discontinuation of therapy, there is an increase in bone loss rate, which is characteristic of postmenopausal osteoporosis.
Pharmacokinetics
After ingestion, the active substance is rapidly absorbed from the upper part of the digestive system. Adsorption of the drug is violated 
at one-time reception with food or drinks.
The interval between eating food, liquid( except clean water) and other medicines should be 1 hour.
Once in the body, a part of ibandronic acid quickly enters bone tissue and binds to it, the same part( 40-50%) that does not migrate to the bone is excreted unchanged by the kidneys. Also part of the active substance is excreted through the intestine.
The elimination half-life for tablets 2.5 mg ranges from 10 to 60 hours, for tablets with a dosage of 150 mg and an injection solution is 10 to 72 hours.
The level of active substance in the blood drops rapidly. Just 8 hours after taking the drug inside, it is only 10% of the dose( for intravenous injections - 3 hours).
Indications and contraindications for use
Bonviva tablets and injections are prescribed for the prevention of fractures in postmenopausal and age-related osteoporosis.
Absolute contraindication to the appointment of all dosage forms are:
- individual intolerance;
- child and adolescence;
- period of pregnancy and lactation;
- severe renal failure;
- calcium deficiency( before the drug is necessary to bring its level back to normal).
In addition, contraindication to taking tablets are the following diseases:
- inability for 1 hour is in an upright position;
- stenosis and achalasia of the esophagus;
- intolerance to carbohydrates( glucose, lactose, galactose);
- diseases of the digestive system in the acute stage( including gastritis, gastric ulcer).
In the zone of interest - pregnant women and children
It is not necessary to take the drug to pregnant women, since there is no data on the effect of the components of the drug on the fetus. In the experiments on animals, 
was observed to increase the duration of pregnancy, as well as the birth of offspring with anomalies of internal organs.
It is not known whether the active substance is excreted through the mammary glands, so during the treatment it is necessary to refuse breastfeeding.
There is no data on the effect of the drug on the growing body, so do not prescribe it to patients under the age of 18.
Patients with liver pathologies do not need dosage adjustment.
Persons with severe kidney disease, with creatine clearance less than 30 ml / min, should not prescribe medication.
Adverse effects of
The following side effects are observed when prescribing tablets and injections:
- from the digestive side : loose stools, gastritis, meteorisms, dysphagia;
- from musculoskeletal side : pain in muscles and joints, osteonecrosis;
- from the CNS : headaches, dizziness, insomnia;
- from the skin : rash;
- allergy : urticaria, angioedema.
At the beginning of treatment, symptoms resembling influenza are possible.
Additionally, when taking tablets, it is possible:
- from the laboratory indicators : decreased activity of alkaline phosphatase;
- from the digestive tract : ulcers and stenosis of the esophagus, duodenitis.
For IV injections, a decrease in the serum calcium concentration may be observed for a short time.
In addition, the following are possible:
- local reactions : edema, hyperemia, hematoma at the injection site;
- from the side of the heart and blood vessels : arterial hypertension, increased cholesterol, phlebitis, thrombophlebitis;
- from the view of I: scleritis, uveitis;
- common infections of : bronchitis, cystitis, nasopharyngitis.
Pharmaceutical interaction
Simultaneous administration with preparations containing calcium and other divalent cations slows the absorption of Bonviva tablets. This also applies to food and beverages. That's why the difference between their reception should be 1 hour.
When combined with NSAIDs, the risk of adverse reactions from the digestive system increases.
Ranitidine increases the bioavailability of ibandronic acid, but it has no clinical significance.
Do not mix Bonviva with other medications in one syringe.
Treatment and dosage regimen
Instructions for use for injections and Bonviva tablets.
Oral dosage forms
Tablets are taken orally for 1 hour before breakfast, without chewing, with a glass of plain water, then you can not take horizontal position within an hour.
Tablets of 2.5 mg taken daily, and 150 mg - 1 time per month.
If another tablet is missed with a dosage of 150 mg, and before the next dose remains more than a week, you need to take a pill in the morning on an empty stomach and then drink it once a month.
When there is less than a week left before the next appointment, it is necessary to wait for the day of reception and then to take it according to the established scheme.
Injectable form
Injection can be administered only intravenously, avoiding the entry of active substance into the artery and adjacent tissue. Do an injection can 
only specialist. Enter the drug bolus once a quarter.
Before injection, the solution should be visually assessed, its turbidity or discoloration is unacceptable.
If you miss a regular injection, you need to do it as soon as possible, and the next injection is allowed only after 3 months.
In parallel, you need to take calcium and vitamin D.
Cases of overdose
In case of an overdose of tablets, heartburn, esophageal perforation, decreased calcium and phosphorus can be observed.
It is recommended to take milk or antacid preparations to reduce absorption of ibandronic acid. Do not induce vomiting of because of the risk of gastrointestinal irritation, which is why you need to stand or sit after taking the tablets.
In case of an overdose of the injection form, a deficiency of minerals is observed. To increase the level of calcium, magnesium and phosphorus, they are administered intravenously. Dialysis is effective if it is appointed no later than 2 hours.
Special instructions
Since taking a tablet quite often there is a violation of the act of swallowing and defeat of the esophagus, then after taking the drug inside you can not lie down for an hour.
The patient should be informed about signs of calcium deficiency in the body, as well as symptoms of gastrointestinal tract damage and, if they arise, go to the doctor immediately.
Because of possible adverse reactions from the CNS, you need to be especially careful when driving.
Before the next injection, it is necessary to determine serum creatinine.
It is not necessary to conduct surgical dental procedures against the background of treatment with the drug because of the risk of developing osteonecrosis of the jaw.
The opinion of ordinary people
From the feedback of consumers found on the network.
Six months ago, I began to drink Bonviva, 1 tablet once a month. I feel bad. I can not raise my right hand. I can hardly turn around, because my whole body hurts.
I do not know how much the drug helps, but even if it is effective, then such pains endure, there is no more strength. I regret very much that I started treatment.
Maria, St. Petersburg
I have been treated for more than a year with Bonviva. First she injected every 3 months, now she switched to 150 mg tablets. In parallel, I take Calcemin.
Checked the condition of bone tissue, noticeable improvements. Of the side effects of a constant sensation of "sand in the eyes," but you can survive it, because you do not want to become disabled.
Anastasia, Kazan
From the practice of a doctor
The doctor's reference to the drug Bonviva will help to clarify some of the nuances.
The drug has proven itself at the initial stages of treatment of osteoporosis. Unfortunately, if the disease has already appeared, then it is no longer getting rid of. This disease is dangerous because the bones become brittle and there is a high probability of fractures. Here, to shorten their appearance and designate Bonviva.
Many patients with a severe degree of osteoporosis hope for a miracle. It should be understood that ibandronic acid does not eliminate osteoporosis, but reduces the risk of fractures that can lead to disability.
Before starting therapy, it is necessary to pass a urinalysis on DPID and only in case of an overestimated result start treatment.
Against the backdrop of treatment you need to take biochemistry of blood, a common blood and urine test every 3 months.
Alexander Vasilievich, rheumatologist
Analogues of the preparation
To date, pharmaceutical companies produce the following complete analogues of Bonviva:
- Bondronate;
- Ossica;
- Bandron Health.
In addition, on the market there are medicines belonging to the class of bisphosphonates:
- Zometa;
- Bonefos;
- Forosa.
Only an attending physician should select an analogue.
The drug is dispensed by prescription. Store it at a temperature of no higher than 25 degrees, away from children and protected from light.
