Plaquenil: instruction with explanations, patients 'and doctors' opinions

Plaquenyl is a drug intended for the treatment of many joint diseases. It is also used to prevent diseases such as malaria, lupus and other disorders that lead to a weakening of immunity.

The medication acts on the cellular level and directly affects the causative agent of the disease.

The preparation contains:

• an active substance of hydroxychlorine sulfate;
• of excipients is worth noting lactose and cornstarch, these substances create a shell for the capsule.

General information about the preparation

Structural formula of hydroxychlorinated sulfate

Plakvenil is a modern broad-spectrum drug, its main active component isis Busy gidroksihlorin sulfate.

The substance has a unique anti-inflammatory and immunosuppressive effect that inhibits the dangerous activity of immune antibodies and relieves the human body from a hypersensitive reaction to its own cells.

Plakvenil also effectively affects single-celled parasites of Plasmodium, which cause a serious infectious disease - malaria. That is why the drug is used for:

• treatment of autoimmune pathologies - rheumatoid and juvenile arthritis, systemic and discoid lupus erythematosus;
• prevention and treatment of malaria.

Pharmacological profile

The drug has the following series of effects on the human body:

1. Anti-inflammatory - the drug has a calming and anti-inflammatory effect, which removes the symptoms of arthritis and arthritis of various genesis.
2. Antiprotozoal - the drug is able to suppress, at the cellular level, and then completely destroy the causative agent of the infectious disease. It should be noted that in the first place this action refers to the causative agent of malaria. It is for this reason that the main spectrum of the drug is antimalarial.
3. Immunosuppressive - malaria and lupus severely undermine the immune system due to which even a slight draft can lead to colds and other infectious diseases. In turn, Plakvenil has immunostimulating effect and allows to strengthen immunity during the fight against the disease.

The medication has the ability:

• to suppress the action of toxic free radicals formed during metabolism( antioxidant action);
• suppress the action of enzymes that cause the disintegration of cartilaginous tissue;
• suppress the synthesis of prostaglandins - biologically active substances taking part in inflammatory processes;
• concentrate in leukocytes and strengthen the lysosome membranes - cell structures containing enzymes that can break down incoming food substances into the cell. Lysosomes also participate in the digestion of bacteria trapped by leukocytes;
• inhibit the activity of lymphocytes involved in immune reactions;
• inhibit the formation of rheumatoid factor - immunoglobulins( antibodies), perceiving the body's own tissues as foreign structures( antigens) and destroying them.

It should be noted that immediately after taking the drug, it is immediately absorbed by the body and enters the blood of the patient, then accumulates in the organs and tissues and starts acting at a certain moment( the maximum amount of medication in the blood is reached approximately 100 minutes after administration).The drug begins to decompose in the liver into active and inactive substances.

Active remain in the body, and inactive - are derived in a natural way through urine and feces. Also, the feature of the drug is that in women it can be excreted through the mammary glands, and not through urine or feces.

It should also be remembered that the medication is withdrawn slowly enough( not earlier than 1 month after entering the blood).

Plaquenil acts as follows:

• after taking and getting into the blood, it begins to actively decompose and is deposited in various organs;
• after a certain amount of time, the medicine is taken out by natural means;
• after a certain period the drug begins to act, since it has a cumulative, not immediate effect.

Indications for use

It should be remembered that Plakvenil is aimed at suppressing serious immune diseases and therefore it is recommended for use in the following cases:

• rheumatoid arthritis;
• malaria;
• vasculitis;
• lupus.

Also, the drug is actively used to suppress malaria of varying degrees( 3-day and 4-day, oval and tropical malaria).

It should be remembered that Plakvenil is one of the few drugs that can completely cure tropical malaria.

Rheumatoid arthritis is not a verdict:

Contraindications to the use of

Due to the fact that Plaquenil is intended for serious immune and articular diseases, it is not recommended for taking:

• an allergy to one of the elements of the drug;
• sugar intolerance, which is transmitted by hereditary path;
• changes in the structure of the retina( a disease called retinopathy);
• pregnancy and during active lactation;
• is also contraindicated in children under 6 years of age.

There is also a list of circumstances in which taking the drug is allowed only under the supervision of the treating doctor:

• infectious and hereditary blood diseases;
• vision disorder( due to the fact that the drug may have a detrimental effect on the organs of vision);
• if the patient has suffered or has psychoses and neuralgic diseases of various forms of expression;
• diseases of the digestive system can lead to poor drug tolerance;
• impaired functionality of the liver and kidneys, can lead to difficulty in taking medication, as it significantly harms these organs;

Instruction for use

Take Plaquenil during meals, drinking it with a glass of water or milk.

In the treatment of arthritis, the effect of taking the drug manifests itself only after a few weeks or even after 1 month, because the medicine has a cumulative effect.

But, it should be taken into account that all side effects can manifest themselves much earlier.

The dosage of the drug is selected individually by the attending physician, but if you drink more than 400 milligrams of the drug by oral route, it will lead to an immediate overdose, - the patient has nausea, malaise, dizziness.

Special instructions and cautions

As practice shows, side effects from taking medication are very rarely expressed, but if they are present, is expressed as a weakening of immunity.

Plaquenyl is not recommended for use with alcohol. If the kidneys and liver are impaired, this medicine should not be taken. The drug intake can be combined exclusively with the intake of glucocorticosteroid drugs.

Plaquenyl is not recommended for use in pregnancy and lactation. Children under 6 years are not allowed to take this medication.

Doctor's review

There is an opinion of

What patients think about the drug.

Advantages and disadvantages from the experience of patients

Analyzing the patients' opinions and the opinion of the doctor, the following plesques of Plaquenyla can be distinguished:

• high efficiency;
• is a rare manifestation of side effects;
• compatibility with many drugs of a similar action.

And cons:

• the presence of side effects;
• after the course of taking the drug in patients, weakening of immunity is observed.

Purchase and storage of

The preparation is issued in the form of capsules, the price per packing of Plakvenila is 1500 rubles on average.

Store the drug in a place where the temperature does not exceed 25 degrees Celsius for 3 years.

To the analogues of Plakvenil, such foreign preparations as Delagil and Plasmocide should be included.

There are no analogues of Russian production.