Instructions for use with Flexen in all forms of release

flexen tablets To reduce acute pain, Flenseen is often used. Many rheumatologists prescribe this medication to reduce pain in rheumatic diseases of the joints, spine and other injuries of the musculoskeletal system, including traumatic injuries.

Flelex refers to a group of non-steroidal and anti-inflammatory agents. It has an analgesic, anti-inflammatory, antipyretic effect. In addition, it affects the aggregation state of thrombocytes. This drug is often used in the complex treatment of various diseases of the OA and with injuries of the joints and spine.

Contents of the article

Form of formulation
Pharmacological profile
When the
is prescribed What indications are not recommended for use
How the drug is used and in what dosages
Symptoms of overdose and side effects
viewpoint Price issue

Form of formulation and composition of the agent

Flexan is produced in several forms:

In the form of capsules .They have an oblong shape. Structure is opaque, gelatinous, soft. The color of the capsules is pale yellow. Inside, they contain a suspension with a cream color, the structure is oily. Produced in plates of 6 pieces. In one carton pack contains 2 plates.
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In the form of rectal suppositories , in appearance they are candles with an oily structure. In color, they have a white or white-flint color. One candle contains 100 mg of ketoprofen. Suppositories are placed in a strip of 6 pieces. The carton contains 2 strips.
In the form of gel .The gel has a transparent, uniform consistency and colorless structure. The level of ketoprofen is 25 mg. Produced in tubes with a volume of 30 and 50 mg. The tube is placed in a cardboard box.
In the form of ampoules .The package contains 1 ampoule with a powder of lyophilized type( homogeneous mixture with a white tint) and 1 ampoule with a solvent, namely water for injection and benzyl alcohol. Produced in a cardboard package of 6 pieces.

Regardless of the form of production, Flexene contains the following components:

active substance - ketoprofen;
hydrated soybean oil;
vegetable oil;
beeswax;
vegetable-hydrogenated vegetable oil;
soybean lecithin;
gelatin;
titanium dioxide;
sorbitol;
glycerol;
sodium propyl parahydroxybenzoate;
sodium ethyl parahydroxybenzoate.

Experts of chemistry and English language will be interested - about the active substance Flexen:

Pharmacological profile

The active substance of the drug is ketoprofen. This component belongs to the NSAID.Due to the fact that it has an inhibitory effect, during its entry into the body, the activation of cyclooxygenase-1 enzymes occurs. As a result, the development of inflammation is prevented, and the occurrence of leukotrienes is suppressed.

During the period of drug use, there is a persistent decrease in the functioning of granulocytes of the neutrophil type, and the activity of the lysosome membranes is also stabilized. The active component of the agent falls into the depth of the synovial solution, as well as into the connective membranes.

With intramuscular administration of the drug, the highest level of distribution lasts from 15 minutes to half an hour. The level of communication with proteins is reached up to 99%, the level of bioavailability is 90% and higher. The average distribution in the blood occurs within a day. The period of therapeutic distribution in the synovial fluid is from 6 to 8 hours.

Metabolism predominantly occurs in the liver due to the approach to glucuronic acid. The half-life is between one and half to two hours.

When the

is assigned

The instructions for use indicate that Flexen should be used during medical therapy in acute pain syndrome accompanied by inflammatory processes with different etiologies:

during therapy of osteoarthrosis, psoriatic arthritis, ankylosing spondylitis, gouty and rheumatoid arthritis;
during algodismorrhoea;
for bursitis and tenosynovitis;
in the occurrence of dorsalgia, myalgia, neuralgia, sciatica, radiculitis;
during pain syndrome in post-traumatic form;
with otitis media, adnexitis;
during severe headaches;
for dental pain;
during the onset of severe pain during oncological pathologies;
during problems associated with the lumbosacral plexus;
with pain during phlebitis and thrombophlebitis;
with strong joint pain;
during renal colic;
for injuries, bruises, injuries.

It is desirable to relieve acute pain, use Flexen forms with a quick action - candles or injections.

At what indications are not recommended to use

Medication can not be used in the following cases:

during peptic ulcers of the stomach and duodenum, as well as at the stage of exacerbation;
in case of gastrointestinal bleeding;
various violations of the functioning of the liver in acute form;
presence of acute disorders in the functioning of the kidneys;
for disorders of the circulatory system, as well as for leukopenia, hemophilia, thrombocytopenia;
with severe heart failure;
in the presence of severe pain before and after cardiovascular surgery;
during pregnancy and lactation;
for children under 18 years;
in case of hypersensitivity and intolerance to drugs belonging to the NSAID group.

How the drug is used and in which dosages of

Depending on the form of release, the specific features of Flexen are different, the therapy is performed in several ways:

In case of severe pain, the use of with intramuscular injections of is recommended. The solution is administered 100 mg once every 24 hours. The maximum allowable dose for 24 hours should not be more than 300 mg. In order to prepare the solution, it is necessary to dilute the lyophilized powder in a special solvent. Parenteral therapeutic treatment Flexen is spent about 2 days. After the patient becomes better, further treatment is performed by suppositories or capsules.
Flexen in the form of capsules should be taken orally immediately after eating. Capsules should be swallowed in a general form, they are not chewed. To facilitate swallowing, the capsules are washed with water. At a time, 50-100 mg of the drug is taken, approximately 1-2 capsules, 2-3 times a day.
Apply a small, even layer of gel to the areas of the skin that are located next to the inflamed area. The gel should be rubbed with slow, massaging movements. Apply the product 2-3 times a day. The maximum period of application is 2 weeks.
A drug in the form of rectal suppository is used for 100 mg( 1 suppository) 1-2 times per day.

Overdose Symptoms and Adverse Events

If the recommended dosage is exceeded, overdose symptoms may occur:

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may cause bleeding;
feeling sleepy;
state of nausea;
problems in kidney and liver;
manifestation of epigastric pain.

In these cases, gastric lavage is done, absorbents are applied. Further therapeutic treatment is carried out.

If you believe the reviews of many patients, this Flexen almost does not cause side effects and is well tolerated, but the instruction indicates that the following side effects can sometimes occur:

the appearance of a headache;
dizziness;
state of asthenia;
on the part of the digestive system - nausea, vomiting, flatulence, diarrhea, state of gastralgia, decreased appetite, pain in the stomach, the appearance of gastrointestinal hemorrhages, ulcerative lesions of the stomach and duodenum may occur;
bronchospasm;
appearance of laryngeal edema;
dysponoe;
state of nosebleeds, rhinitis, shortness of breath, hemoptysis;
can sometimes cause allergic manifestations in the form of rash, itching, irritation and scabies.

Viewpoint

Real feedback from doctors and patients who have tried Flexen's action on themselves.

More than once I had to prescribe to my patients the use of Flexen for strong painful sensations due to rheumatic diseases, as well as traumatic injuries.

The drug is the most effective and fast acting as a solution for injection. This form should be used for acute pain.

And in the subsequent period, when the pains become less intense, you can switch to taking capsules or applying suppositories. The Flexan gel should be applied to affected and inflamed areas. It should be used as a preventive agent.

Physician therapist

Fleksen is an effective analgesic, anti-inflammatory, antipyretic drug that can reduce severe pain syndrome. According to the responses of my patients, this medicine is able to cope with acute pain, in which other drugs do not help.

In addition, this medication does not cause unpleasant side effects, is well tolerated and is suitable for almost everyone. The main thing during the application is to observe the dosage, otherwise serious consequences may arise.

For pain with high intensity, which are manifested due to joint diseases or traumatic injuries, it is advisable to do the injections within 2 days. In the following period, it will be possible to switch to other forms of medicine.

The doctor rheumatologist

During a hike in the mountains the back aches due to an exacerbation of an osteochondrosis strongly was ill. Apparently I then strongly tore it up. Immediately it became difficult to move, but at first did not submit to mind. In 3 days everything only worsened, and the pain became even stronger. The comrade noticed that something was wrong with me. After his questioning, I had to say that I had severe pain in my back, he gave me Flexen capsules, he also has the same trouble, and he is saved only by this remedy.

And indeed, after taking 2 capsules of pain subsided. After that, I thought about going home. After his arrival he immediately bought a medicine package, then went to the doctor for examination and further treatment.

Constantine, 48 years old

Due to the fact that I have a hard work, arthritis appeared in an acute form. Of course, immediately there were severe pains that did not allow to work normally. Because of this, I had to go to the hospital.

After the examination, the doctor prescribed treatment, and to reduce pain, recommended the use of Flexan. First I injected, and then switched to taking capsules. Yes, he removes pain instantly! This medicine greatly facilitated my condition and accelerated the process of recovery.

Maria, 52 years

Price issue

Packing Flexen in capsules 50 mg in the amount of 13 pieces costs from 140 to 180 rubles, the product in the form of suppositories with a dosage of 50 mg in the amount of 12 pieces costs from 180 to 220 rubles, the price of packing with ampoules of 100mg in an amount of 6 pieces from 200 to 260 rubles.

Ampoules of NSAIDs