The drug Ostererep prevents the destruction of bone tissue, promotes its resorption and is used to treat and prevent osteoporosis.
The product is available in white, oblong, biconvex tablets.
The active substance of the drug is alendronate sodium trihydrate.
Contents of the article
- The effect of the drug on the body
- Pharmacokinetic properties
- Indications and contraindications for use
- Purpose of the drug for specific categories of patients
- How to use
- Symptoms of overdose and first aid
- Possible "pobochki"
- Drug interaction
- Special instructions
- From the practical experience of using
- Thancan replace the drug
The effect of the drug on the body
Alendronate sodium refers to bisphosphonates, whichs are synthetic analogs of pyrophosphate. And it is necessary for the binding of hydroxyapatite, the main component of bone tissue.
Alendronate sodium is a non-hormonal specific inhibitor of osteoclast activity. It prevents the destruction of bones, activates bone formation, increases the bone mineral density, helps the formation of bone of normal composition and structure.
Pharmacokinetic properties of
After oral administration at a dosage of 70 mg 2 hours before tomorrow, the absorbability is 0.64%.If the interval between medication and food intake is reduced, then the percentage of adsorption of alendronate sodium decreases.
One-time taking of tablets with orange juice or coffee reduces the absorption of the drug by 60%.
In the body, alendronate sodium is not subjected to metabolic reactions.78% are associated with plasma proteins. Once in the body, the active substance is first distributed in the soft tissues, and then passes into the bones. The drug is excreted by the kidneys.
Indications and contraindications for use
The drug is prescribed for osteodystrophy, osteoporosis during postmenopause, for the prevention of vertebral fractures and bones.
Contraindications to the use of the drug are:
- pathology of the esophagus and other factors that make it difficult for the drug to pass through the gastrointestinal tract( including achalasia, stenosis);
- patient's inability to maintain a vertical position for at least 30 minutes;
- hypocalcemia;
- lack of vitamin D;
- severe disorders of mineral metabolism;
- individual intolerance;
- CRF( clearance less than 35ml / min);
- patients under the age of 18;
- child bearing;
- lactation.
The drug is taken with caution in pathologies of the gastrointestinal tract, such as:
- swallowing difficulties;
- inflammatory diseases of the gastric mucosa;
- inflammation of the 12-colon;
- stomach ulcer;
- bleeding from the digestive tract.
Prescribing the drug to specific categories of patients
Do not prescribe tablets to children, women in the position or breast-feeding, since there is no reliable data confirming the safety of the medication treatment of such patients.
Persons suffering from liver disease do not need to adjust the therapy regimen.
Do not prescribe medication to patients with clearance less than 35 mg / ml, as there is no clinical data on the safety of the drug for the treatment of such patients.
How to use
The drug is intended for oral use. The drug is drunk once a week for 2 hours( but not less than half an hour) before breakfast or liquid intake.
It needs to be swallowed whole, without chewing and not rassasyvaya. To reduce the likelihood of irritation of the mucous membrane of the oral cavity and esophagus, after waking up, drink at least 200 ml of plain water and take the medicine, then for 30 minutes it is necessary to stay in a vertical position.
If you miss a regular tablet, it should be taken the next morning. It is inadmissible to take 2 or more tablets per day.
In the treatment regimen, in addition to Osterepar, calcium and vitamin D. must be administered.
The duration of the doctor's appointment is selected individually based on the severity of the pathology, and may last for more than one year.
Symptoms of overdose and first aid
In the case of an accidental or intentional overdose, calcium and phosphorus in the blood may decrease, undesirable effects from the upper parts of the digestive tract, such as heartburn, esophagitis, inflammation of the gastric mucosa, ulcer.
There is no specific antidote. You need to take milk or antacids containing calcium. The victim should stand or sit, but do not lie.
Do not induce vomiting, as this will increase the chance of esophageal irritation.
Possible "pobochki"
On the background of treatment the following negative reactions of the body are possible:
- From the digestive organs : pain and swelling in the abdomen, swallowing disorder, indigestion, constipation, diarrhea, ulcer of the esophagus, heartburn, nausea, vomiting, gastritis, esophagitis, tarry stool, stenosis and perforation of the esophagus, bleeding.
- From the part of the musculoskeletal system : aches and pains in the joints and muscles.
- From the side of the CNS : headaches, irritability.
- From the skin : itching, rash, redness of the skin, photosensitization.
- Allergy : Urticaria, Quincke's edema, toxic epidermal necrolysis, malignant exudative erythema. From the metabolism of substances : hypocalcemia.
- From the side of the eye : uveitis, scleritis.
Drug interaction
Drug interactions:
- calcium, antacid and some oral preparations, food, drinks, including mineral waters , affect the absorption of alendronate sodium;
- Ranitidine increases the bioavailability of alendronate, but the clinical significance of this interaction is not yet known;
- NSAIDs increase the adverse effects of alendronate on the gastrointestinal tract.
Special instructions
The active ingredient may cause local irritation of the gastrointestinal mucosa. The pathology of the upper parts of the digestive tract may worsen against the background of drug therapy.
The likelihood of side effects appears more often in patients who do not follow the conditions of admission.
Therapy with the help of the drug Osterepar is allowed to begin only after correction of metabolic disturbances of vitamins and minerals( especially calcium and vitamin D).Taking medication leads to an increase in the level of mineral salts in the bones, which can flow without visible signs.
It is necessary to take calcium and vitamin D preparations with simultaneous treatment with alendronate and glucocorticosteroids.
Tablets do not affect the ability to drive and do not slow down the reaction when working with dangerous machinery.
With a long reception once a quarter, you need to do a detailed analysis of blood, urine, donate blood to biochemistry.
From the practical experience of using
Reviews of doctors, as well as patients using Osterepar for the treatment of osteoporosis.
I suffer from osteoporosis for a long time. The doctor prescribed Osterepar. Unlike analogs, it is quite affordable for the price of 4 tablets costing around 300 rubles. When the last time checked the condition of bone tissue, the doctor noted the positive dynamics.
Albina, Moscow
Osteoporosis is a disease in which bone tissue becomes very fragile and, as a result, the risk of fractures increases even with minimal stress. There is such a pathology in people over 50 years old. The Polish drug Osterepar warns of the development of fractures of the skeleton. But do not prescribe it yourself. Before the course of therapy, you need to pass a series of tests.
Check the level of minerals in the body, if necessary, bring them back to normal. And only then start taking the medicine. Duration of therapy should also be selected by a doctor and it is necessary to conduct bone densitometry and, if necessary, adjust the treatment.
Trauma Practitioner
Than you can replace the medicine
The pharmaceutical industry produces the following analogues of the drug Osterepar: 
- Ostalon;
- Fosamax;
- Forosa;
- Alendronate.
Before you change tablets to another remedy, consult your doctor.
The drug belongs to the prescription list. Store the medicine at a temperature of maximum 25 degrees, in a place protected from light and children.
Osterepar has a good therapeutic effect, but has a number of contraindications and side effects, so self-medication is unacceptable.
