In the modern world, it is rather difficult to remain completely healthy, as we are surrounded by various factors that in one way or another can shake this very health.
Perhaps the most unpleasant moment in the life of every person is a sudden pain that is interfering normally will continue the day. Also unfortunately, many do not help painkillers tablets. It is in such situations and comes to help plaster Durogezik Matrix.
Contents of the article
- Ingredients
- First introduction
- Pharmacological action and pharmacokinetics
- When is a patch necessary and when is it contraindicated?
- How to apply Durogesic: detailed instructions
- Important - cases of overdose and "pobochki"!
- Special instructions for use
- Administration of the drug for impaired renal and hepatic function
- Interaction with other drugs
- Pregnancy and lactation reception
- Admission of children
- Overview of the doctor
- Patient opinion
- Advice on receiving patients
- Advantages and disadvantages of
- Buying and storing
Composition of
The plaster contains only two components:
- Fentanyl;
- Menthol.
A drug is produced in the form of a patch, which consists of two polymer layers, between which is a gel from the main active substance - fentanyl.
It is important to know: there are no other forms of release by the manufacturer and this should be taken into account, since it is easy to confuse Durogesic with another analgesic.
Molecular formula of Fentanyl
The first acquaintance of
The Durogezik plaster is an anesthetic preparation made in the form of a usual transparent patch, which when applied to the problem zone has the strongest analgesic effect( several times stronger than usual analgesics).
A similar effect was achieved through the use of a substance such as fentanyl. This drug belongs to the group of potent analgesics( opioids and its analogs).It is used if the patient has intolerable pain caused by trauma, exacerbation of a chronic illness and the like.
Pharmacological action and pharmacokinetics
As mentioned above, the main active substance of the patch is fentanyl, which refers to narcotic analgesics of a synthetic nature. This substance is also capable of exerting psychotropic effects. Its action is manifested in interaction with opioid receptors.
The pharmacokinetics of the drug presented( in simpler words - the absorption of an anesthetic substance) does not cause difficulties. In less than a day, the drug is completely absorbed by the body.
The basis of the action of Durogesic is due to two main mechanisms of action: an analgesic as well as a sedative effect.
The effect of the plaster is aimed at increasing the pain threshold by preventing the transmission of impulse along the painful pathways to the main structures of the brain.
When is a patch necessary and when is it contraindicated?
Indication for the use of a plaster:
- pain in arthrosis, arthritis, osteochondrosis and other diseases of the musculoskeletal system;
- exacerbation of chronic pain syndrome;
- pain caused by advanced stage of cancer;
- benign tumors;
- period of exacerbation of diabetes mellitus;
- multiple sclerosis;
- is a phantom pain that is caused by the loss or amputation of the limbs.
You can not apply a patch when:
- hypersensitivity to the active substance;
- acute, fast-moving pain that is treated in a fairly short period;
- pregnancy and active lactation;
- skin irritation or rashes( a part of the drug substance can only exacerbate the situation);
- lung disease or difficulty during their functioning;
- renal or hepatic insufficiency, since fentanyl severely damages these vital organs;
- caesarean section or with the recent conduct of any other obstetrical operations.
How to apply Durogesik: detailed instructions
First of all it is necessary to prepare a place for gluing a patch. This place needs to be thoroughly washed and shaved off( to cut off) the hair.
Next, a patch is removed from the sealed package, the protective layers are removed and the preparation is immediately glued to the problem zone from both sides. For example, if a knee injury was received, then a patch should be pasted on both sides of the joint.
During the day the active substances completely absorbed into the place of pain concentration and after removal of the patch it will recede.
The maximum allowed dosage of the drug is 25 milligrams, depending on the concomitant disease and neglect of the disease.
25 milligrams is the initial dosage, which, as the disease progresses, needs to be increased to 100 milligrams.
Important - cases of overdose and "pobochki"!
Due to the fact that Durogesic is a potent analgesic, an overdose can be obtained simply by increasing the recommended volume.
If an overdose is necessary, bring it to the patient's senses as soon as possible, remove the patch from the body and call for medical attention.
Side effects are manifested by impairments:
- Nervous system : hallucinations, drowsiness, anxious and depressive condition, anorexia, headache, tremor, confusion.
- Functions of the respiratory system : shortness of breath, respiratory depression, bronchospasm.
- Digestive tract : the appearance of nausea( up to vomiting), a violation of intestinal activity, dry mouth, biliary colic.
- Cardiovascular and cardiovascular activity of : a decrease or increase in blood pressure, a violation of the heart rhythm.
- Sometimes it is noted itching and rashes on the skin, urinary retention, the onset of sexual dysfunction and "withdrawal syndrome".
A gradual decrease in the use of the drug reduces the severity of adverse events.
Specific guidance on the use of
Patients who report an adverse reaction to Durogesic application should be under close medical supervision within 24 hours after removal of the drug - the concentration of the active substance decreases after 18-20 hours.
During the period of drug use, it is recommended to cancel the exercises that require increased physical activity.
Administration of the drug in violation of the kidney and liver
Durogesic is able to influence the muscle tone of the digestive and bile ducts. That is why it is used with caution in patients who have a history of attacks of hepatic colic.
Due to the fact that such analgesics are excreted by the kidneys in an unchanged state, patients with impaired renal activity need special control when applying the patch. If there are side effects, the dose of the drug should be reduced.
Interaction with other
preparationsSimultaneous use of opioids, sedatives, antihistamines and hypnotics, tranquilizers, phenothiazines and spirits increases the risk of lowering blood pressure, hypo-ventilation of the lungs.
The application of Durogesic requires strict patient control! When taking insulin, hormonal and antihypertensive drugs will require a decrease in the dose of fentanyl.
Pregnancy and lactation reception
The drug is not recommended for use in the period of gestation, except for cases of acute need. Do not use it to nursing mothers - when lactating, fentanyl penetrates into the newborn's body and causes respiratory depression.
Admission of children
Strictly forbidden application of a plaster in childhood! The drug should be stored in places inaccessible to children.
Review of the doctor
Review of the plaster from the oncologist Nikolai Vaysman.
Oncology - this is quite a terrible disease, which literally in one moment destroys a person's entire life. In addition, the constant struggle with oncology my patients have to contend with a lot of pain, which was caused by chemotherapy procedures. As a rule, usual painkillers do not bring any result, but synthetic opioids help. Most often, patients are appointed precisely Durogesic, since it is inexpensive and has the most powerful analgesic effect.
Nikolay Vaisman
Patients' Opinion
Having studied the reviews of cancer patients and patients with other problems, it is possible to draw definite conclusions about the Durogesic patch.
My mother discovered breast cancer. At the moment she undergoes a course of chemotherapy after which the next morning she is overtaken by terrible pains in the spine and the only thing that helps is Durogesic, which she uses 2 times a day.
Julia Morozova
I got diabetes mellitus in my 40s in addition to diabetic polyneuropathitis, which can not be tolerated during an exacerbation without painkillers, and given the pains are very strong, I use a band-aid and 6 hours later I feel much better.
Nikita Mirnov
After the fracture of the hip joint, it was impossible to endure the pain. I was not helped even with painkillers and after my complaint to the doctor, he prescribed an anesthetic plaster Durogezik, which, according to him, has the strongest analgesic effect.
In the evening of the same day, I was helped to paste a band-aid and the pain was much quieter the next morning!
Julia Taranuha
Tips for receiving from patients
Durogesic is a very specific product that affects the entire body during use.
The most frequent recommendation that can be met from patients is a warning that you should take the drug only a few hours before a meal, as the patch can cause a brief breakdown in the digestive system.
Pros and Cons of Practice
Pros: 
- Relieve pain for the minimum amount of time;
- after the application of pain does not bother the patient for a long time.
Cons:
- use of a patch causes a breakdown in the food system;
- to the drug should not only get used, but also wean;
- at the beginning of the use of the patient feels terrible discomfort, and after the end of the course of treatment - the pain for some time exacerbated several times.
Purchase and storage of
The exact price of Durogesic is difficult to describe, as it is prescription-dispensed in specialized pharmacies.
Storage temperature from 10 to 15 degrees Celsius. It is released on the prescription of a doctor in specialized pharmacies.
In fact, there are not many analogues of this drug. Of these, we should highlight the Chinese plaster Bang De Li and the drug of domestic origin - Promedol.
But, the first of them, very few people know and there are no reviews of how it works, and the Russian analogue is somewhat more expensive than Durogesic.
