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Disulfiramopodobnyh reactions with the use of alcohol and drugs. What is it, analogues Disulfiram

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Reaction to alcohol can sometimes be unpredictable, especially if the person is also taking any medications. Alcohol can cause the body's so-called disulfiramopodobnyh effect, which in turn is able to cause serious damage to many systems of the body.

The content of the article:

  • 1 What is disulfiramopodobnyh reaction?
  • 2 How does the substance disulfiram?
  • 3 Drugs that cause disulfiramopodobnyh reactions
    • 3.1 sedatives
    • 3.2 antibiotics
    • 3.3 antihistamines
    • 3.4 antidepressants
    • 3.5 Analgesics and antipyretics
  • 4 Because of side effects
  • 5 Symptoms disulfiramopodobnyh reactions
  • 6 Consequences and complications
  • 7 First aid and treatment
  • 8 Antidote aggressive substances
  • 9 Table incongruous with alcohol preparations
  • 10 Encoding based on disulfiram
  • 11 How to choose the best medicine?
  • 12 Videos about alcohol compatibility with drugs

What is disulfiramopodobnyh reaction?

Disulfiramopodobnyh reactions received its name due to disulfiram - a drug that promotes the development of a pronounced intolerance to alcohol. Disulfiram - a specially synthesized remedy that has long been widely used for the treatment of alcohol dependence, coding it.

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The fact that disulfiram can be used as a radical treatment for addicts, it turned around in the middle of the XX century, when many factories for the production of Rubber has developed an unusual situation: the workers, especially those who loved to drink, become firmly give up your favorite alcoholic beverages, because of the extremely poor health after reception.

It soon became clear that the catalyst for the side effects of disulfiram has become, involved in the production.

How does the substance disulfiram?

Disulfiramopodobnyh reactions provoked by alcohol, occurs in the body fast enough, it passes in a few stages:

  1. After contact with alcohol, and then - ethyl alcohol in the body where there is disulfiram, blocked work disrupted liver and liver enzymes.
  2. Due to the fact that the work of the liver enzyme and its broken, ethyl alcohol decay process is strongly decelerated.
  3. The rapidly accumulating body ethyl alcohol and enzymes produced by the liver, causing strong intoxication.Disulfiramopodobnyh reactions with the use of alcohol and drugs. analogs Disulfiram

The collection of symptoms caused by intoxication of the organism, called disulfiramopodobnyh reaction.

Drugs that cause disulfiramopodobnyh reactions

Disulfiramopodobnyh reactions can cause a number of medical drugs, even if they include no disulfiram. In general, doctors do not recommend taking any drugs together with alcohol as even the most harmless and familiar tools can be a catalyst in the reaction with a strong side-effect to the body.

sedatives

Action sedation is aimed at the removal of anxiety and stress, decreased neural excitability. The mechanism of action of sedative drugs based on their ability to chemically inhibit neuronal excitability.

Compared with antidepressants, sedatives effect a softer, often in their role of herbal remedies act, for example, motherwort, mint, valerian. In order sedatives are also used small doses of hypnotic drugs such as barbiturates.

Take any sedatives with alcohol is not recommended because both alcohol and some sedative has an inhibitory effect on the nervous system.

Thus, their joint operation reception doubly inhibits human nervous system, because of which production is disturbed liver enzymes, and thus the process of disintegration of ethanol, which ultimately can lead to intoxication and disulfiramopodobnyh reaction.

antibiotics

The effect of antibiotics aimed at inhibiting the growth of living cells, in particular in the fight against bacteria. Beloveku, take antibiotics, it is extremely dangerous to drink alcoholSo as ethanol strongly modifies the properties of antibiotics and multiplies their toxic effect on the body.Disulfiramopodobnyh reactions with the use of alcohol and drugs. analogs Disulfiram

Disulfiramopodobnyh reaction in the case of antibiotics is also associated with inhibition of liver enzymes. Alcohol is especially dangerous for people taking tsefotsetan and metronidazole. In no case can not drink alcohol to those who appointed tinidazole, erythromycin, or linezolid.

antihistamines

Effect of antihistamines is aimed at suppressing the work of histamine, which starts at an allergic attack actively released and provoke different reactions, e.g., heart palpitations, stagnation of the blood, muscle spasm and others.

Antihistamine drugs of the first generation, e.g., clemastine, and have a sedative effect, and therefore, there is the same as when mixing alcohol and sedatives in their joint use.

Antihistamines of the second generation drugs do not possess a sedative action, but nevertheless also disrupts liver enzymes because of what the toxic effects of alcohol on the body increases.

antidepressants

Simultaneous use of alcohol and antidepressants is absolutely contraindicated for several reasons. Firstly, because antidepressants and alcohol are co-rotational action: first excite the nervous system, the second vice versa oppresses her.

Therefore, their simultaneous reception brain structures leads to confusion. Secondly, tyramine contained in certain alcoholic beverages, has a chemical effect, similar to adrenaline. As a result, the body seemed to have received a very large dose of adrenaline and blood pressure starts to rise sharply, which can cause a hypertensive crisis.

Finally, the third, and antidepressants can cause disulfiramopodobnyh reaction because both the alcohol and antidepressants "pass" through a "filter" - liver, and their combined use is fraught with intoxication body.

Analgesics and antipyretics

Virtually all analgesic and antipyretic drugs are toxic to the liver, which also acts toxic alcohol. Therefore, their combined use can lead to severe intoxication.

Disulfiramopodobnyh reactions with the use of alcohol and drugs. analogs Disulfiram
Disulfiramopodobnyh reaction when alcohol use with analgesics is very dangerous to life

The impact is further complicated by the fact that some analgesics increase the effect of ethanol. Even innocuous, seemingly, aspirin, used to fight a hangover-induced headache is not recommended, must be not less than 6 hours after the last drink.

Because of side effects

Disulfiram blocks the liver enzymes, and at the same time gives ethyl alcohol and decay process in the body. ethanol accumulation happens very quickly, if people do not drink a glass of alcohol, and a whole bottle. Accumulated in the body as a result causes the strongest ethanal intoxication.

Symptoms disulfiramopodobnyh reactions

Disulfiramopodobnyh reactions to their symptoms very similar to the symptoms of alcohol poisoning, these include:

  • chills;
  • severe nausea;
  • vomiting;
  • dizziness, loss of consciousness up to;
  • labored breathing;
  • reduction in heart rate;
  • lowering blood pressure;
  • loss of coordination;
  • excitation or vice versa breakdown.

Therefore disulfiramopodobnyh reactions sometimes confused with alcohol poisoning, believing that this day or evening on the for any reason simply it was not the best for the meal, and do not take any measures to facilitate state.

Consequences and complications

Disulfiramopodobnyh reactions, in addition to the painful symptoms and can cause some complications, which can also lead to death.Disulfiramopodobnyh reactions with the use of alcohol and drugs. analogs Disulfiram

For example, disulfiramopodobnyh effect provoked by sedatives, can complete coma and death. Disulfiramopodobnyh reactions can also cause swelling of the brain. It is also possible, and the collapse of the cardiovascular system and the following death.

Patient consent to the procedure of coding by disulfiram for alcohol dependence, always warned about the possibility of death in the case of drinking.

Only after receiving a written confirmation of the patient that he is familiar with all the possible consequences in death outcome, non-compliance with the rules, understand that the responsibility lies with him and agrees to accept it, the doctor begins to conduct procedure.

First aid and treatment

If disulfiramopodobnyh reaction the first step is to call the doctor as soon as he can properly block the action of disulfiram.

Before the arrival of the ambulance to help a patient, you can do the following:

  1. Rinse the stomach: drink plenty of warm water and induce vomiting;
  2. Take an adsorbent, such as activated charcoal, which can absorb toxins;
  3. Those who can, can also make an enema.

Leave a patient in any case it is impossible, you need to constantly monitor his condition.

Antidote aggressive substances

Special drug-antidote, which would be able to completely neutralize the effect of disulfiram and withdraw it from the body, does not currently exist.

However, there are contingent drugs - antidotes that can partially reduce the severity of adverse symptoms. These include ascorbic acid solution, one percent solution of methylene blue, as well as metabolites of the second generation antihistamines, e.g., Erius.Disulfiramopodobnyh reactions with the use of alcohol and drugs. analogs Disulfiram

These drugs can temporarily block the action of disulfiram that significantly mitigate the impact disulfiramopodobnyh effect, but the cause of it from the body does not remove. Ambulance doctors often put the patient dropper with a solution of ascorbic acid.

Table incongruous with alcohol preparations

You can make a list of medications that the reception of which can not be combined with alcohol.

A drug By-effect
oral contraceptives Alcohol lowers their action, at times reducing the protection to zero. In addition, significantly increases the risk of thrombosis.
antidepressants Liquor sometimes neutralizes the effect of the drug. Joint use can in a very short time, greatly increase the pressure up to a hypertensive crisis and cerebral hemorrhage.
analgesics Co-administration with alcohol greatly increases the risk of various side effects.
antipsychotics Alcohol consumption during reception antipsychotics may cause vaso-motor center and respiratory center until respiratory arrest.
antibiotics Alcohol increases the toxic properties of antibiotics.
antihistamines Antihistamines increase the effect of alcohol, strengthening and intoxication.
antipyretics Alcohol increases the side effects of drugs on the liver can cause an ulcer development.
Means, which influence on the cardiovascular system Joint use provokes a change in heart rate: bradycardia or tachycardia ..
hypnotics High risk of sleep apnea.
Antiplastic Can provoke internal bleeding, gastrointestinal, hemorrhoids, esophageal.

A more detailed list:Disulfiramopodobnyh reactions with the use of alcohol and drugs. analogs Disulfiram

Aspirin (acetylsalicylic acid) Irritate the digestive tract, causing heartburn, it promotes the formation of ulcers.
ketotifen Enhances alcohol intoxication, which is extremely negative impact on the functioning of internal organs.
Drotaverinum (No-spa) Provokes a weakening of activity of muscular system, as well as involuntary tremors and loss of sensation.
Ciprofloxacin and norfloxacin (and their analogues) It contributes to serious depression of the central nervous system, can cause a coma.
analgene Very toxic effect on bone marrow.
benzogeksony Lowers blood pressure to a critical state which may result in death.
Chloropyramine, Tofranil, and Nozepam Clemastine Severe intoxication, lethargy and loss of consciousness.
Diphenhydramine and Promethazine Even a small portion of alcohol will cause severe alcohol poisoning.
indomethacin Can provoke ulcers and acute inflammation of the gastrointestinal tract.
furazolidone The strongest poisoning, which can cause cardiac arrest.
clonidine Provoking a sharp drop in blood pressure, can lead to the confluence of the coma.
Chloramphenicol (chloramphenicol) Severe shortness of breath, chills, dyspnea.
Trichopolum (or metronidazole) Provokes severe intoxication, the consequences of which are heavy and unpredictable.
Paracetamol and all analogues (Tsitramon, Panadol, Coldrex, Fervex) Intoxication central nervous system, up to comatose state.
phenazepam respiratory failure, coma and possibly death.
amitriptyline Violation of all processes of the central uneven system until they stop, coma and death.
Disulfiramopodobnyh reactions with the use of alcohol and drugs. analogs Disulfiram

Co-administration of drugs and alcohol can often be fatal.

Encoding based on disulfiram

When encoding on the basis of disulfiram, a drug based on this matter in a special container, a catheter is sutured to the patient subcutaneous adipose tissue.

Usually the place for implantation becomes a blade area, abdominal, buttock or thigh.

Subsequently of sewn-container syringe drug dose will be gradually limited to blood flow and induce a specific reaction to alcohol.

The essence of the procedure is that the patient has developed a clear association of alcohol with an extremely serious condition after his admission as to encode the patient's body and feel so that it is perceived as an alcohol poison. In addition to the implant and an injection well used.

Acts disulfiramny implant approximately 5-6 months, repeat the course if necessary, but often, in order to develop a patient a negative attitude to alcohol, and enough one course. It is also possible disulfiram tablets, but it is less effective, because such treatment can be stopped independently and at any time.

How to choose the best medicine?

Today, there are two main methods of medical coding from alcoholism: Based on naltrexone and disulfiram-based and its analogues.

The first substance blocks the opioid receptors in the brain (the pleasure center), which is why alcohol is no longer cause the condition euphoria, that is expected from the liquor effect accepted it does not receive, which should contribute to indifference habits. Disulfiram is to "educate" the patient in fear of alcohol, more precisely in front of the side effects after administration.

For drugs of the first group are "Natreksol", "Vivitrol", "Antakson". Among disulfiramosoderazhih preparations can distinguish "Esperal", "Abstinol", "Teturam", "Binastim", "Antabuse," "Aktopleks" and others.

Reaction to encode drugs can be very severe, and caused them disulfiramopodobnyh effect have deadly consequences. Therefore, choose the best type of treatment, the drug, route of administration and the deadline may only professional narcologist, having before it all the necessary tests.

Registration of the article: Vladimir the Great

Videos about alcohol compatibility with drugs

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