Dipyridamole. Instructions for use, price, reviews, analogues

Dipyridamole refers to preparations that are assigned to the normalization of the cardiovascular system. The main effect of the drug is aimed at restoring blood flow (including cerebral and placental), preventing the formation of blood clots, and strengthen the immune system.

Rules for use of the drug, as well as existing contraindications and side effects, to be discussed with your doctor, as well as specified in the instructions.

Shape and composition of the drug release

Dipyridamole is produced in dosage forms 3:

• pills. The composition is coated with a film cover yellow. The tablets are packed in mesh plate 10 pieces. and 4 and 10 in the blister package;
• suspension. Agent is in the form of a yellow liquid, smooth consistency. It has a distinctive almond flavor. The package contained 1 bottle of 150 ml;
• solution (Intravenous and intramuscular injections). Produced as a clear yellow liquid. The composition is placed in ampoules of 2 ml, in a package of five vials.

Depending on the shape release composition changes only the auxiliary components, the active ingredient is the same for all the shapes, but has a different concentration.

Dipyridamole drug components	Description of the components
Pills
actuating element	Dipyridamole (25, 50, 75 mg)	Possesses antiviral effect, it prevents platelets to stick together, expands and protects the blood vessels.
Optional components	Corn starch	A connecting component (comprising substances contained tablets).
lactose monohydrate	Filler. It is used to impart the desired dosage form.
calcium stearate	Used as a thickener and combining the components.
Suspension
base material	Dipyridamole (50 mg in 5 mL)	—
additional elements	magnesium aluminum silicate	It is used to stabilize the formulation (suspenders).
polysorbate	Stabilizer.
ammonium glycyrrhizinate	Enhances the Antiviral properties of the slurry.
Citric acid monohydrate	Improves the absorption of the drug components.
sodium dibasic anhydrous	It is an emulsifier.
Emulsion 30% Simethicone	Normalizes digestion ingredient.
propylene glycol	It is a solvent. It is used to combine the components.
liquid maltitol	Sweetener.
Methyl parahydroxybenzoate	Preservative.
distilled water	To make soft consistency slurry.
Propyl	Preservative.
levomenthol	Enhances the antiseptic properties of the drug.
almond flavor	To impart a pleasant odor.
xanthan gum	Thickener and stabilizer.
Injection of 5%
The active ingredient	Dipyridamole (10 mg per ampoule)	—
Excipients	Purified water	—
Wine acid	Preservative.
propylene glycol	—

The desired form of release is determined by the treating specialist on the general condition of the patient.

pharmacological properties

Dipyridamole is used for normalization of vascular permeability and prevents thrombus formation, but also prevents the development of viral diseases.

Pharmacodynamics and Pharmacokinetics

Dipyridamole (instruction manual describes the effect of a part of the components on the body after use of the drug) is an active substance in all forms of drug release and provides the following steps:

• vasodilation, particularly in the myocardium (heart muscle layer medium);

  

• normalizes blood circulation in the vessels, including in the capillaries;
• restores venous outflow;
• It prevents blood stasis;
• It reduces the tone of blood vessels in the brain;
• prevents platelet adhesion;
• normalizes the concentration of oxygen in the blood;
• reduced permeability of the vessel walls;
• improves the vessels;
• lowers blood viscosity;
• It activates the placental circulation, resulting in preventing fetal hypoxia pregnant;
• It lowers the pressure indicator;
• regulates production of interferon, resulting in reduced risk of viral diseases;
• in excess dosage is relaxation of vascular activity (blood flow is slowed down).

Absorption of the drug in the stomach is performed (the main part) and in the small intestine. The therapeutic effect observed after 1-1.5 hours after oral application and after 10-20 minutes the introduction of a solution for injection. Excretion basic substance begins 30 min after use Dipyridamole and ends after 12 hours.

The active substance is metabolised in the liver and excreted in the stool (the majority) and urine (about 3%).

Indications

Dipyridamole is assigned in the following cases:

• poor circulation in the brain and in the prevention of the disease;
• prevention of blood clots in arteries and veins;
• deterioration and vascular permeability;
• reducing post-operative period of the heart valves;
• in violation of placental circulation;
• the deterioration of blood circulation;
• viral diseases and their prevention (in combined treatment);
• impairment of blood circulation to the retina and kidneys;
• reduction in blood flow in the muscle of the myocardium;
• the deterioration of the heart;
• increased blood clotting. Administered in combination with aspirin.

By restoring vascular condition and normalization of blood flow is recommended to use the drug in the treatment of hemorrhoids and its prevention.

Contraindications

Dipyridamole (user of the application prohibits the use of the drug in the presence of any contraindications) provides the effect on the blood density, blood flow to the heart and brain, so its use is possible only by appointment doctor.

Dipyridamole any drug release form may not be used when:

• myocardial infarction in the acute form;
• the formation of lipid plaques in the arterial vessels of the heart;
• pathological changes in the state of the vessels;
• damage to the heart muscle;
• reduced pressure;
• failures in rhythmic contractions of the heart;
• poor blood clotting;
• ulcer formations in the digestive tract (using tablets or suspensions);
• the kidneys and the liver in the acute form;
• intolerance to the product components or allergic reaction to them;
• lactation;
• pulmonary system diseases.

Dipyridamole helps to normalize the placental circulation, but in the first trimester of pregnancy, the drug is used under medical supervision. In old age, the use of the drug is often accompanied by the development of side effects, so the course of treatment and dosage are selected strictly by the attending specialist.

At what age can use the drug

A preparation in the form of tablets and suspensions are not assigned until 12 years (action Dipyridamole components at a given age is not known), and a solution for injection of 18.

Instructions for use, the dosage of the drug

Dipyridamole is used only on a doctor's prescription with individual selection of dosage and course of treatment. In the absence of adjustments to the reception (from the attending professional) use of the drug is produced according to the instructions.

Pills

The purpose of the reception	age setting	Single and daily dose	course duration
Cerebrovascular accident	12-18 years	Take 5 mg (calculated on the active element) per kg body weight, 2 times a day.	The minimum acceptance of 20 days. Further, the duration of therapy is established by the dynamics of treatment.
18-60	Assigned tablets of 75 mg 3-6 times a day.	Course duration of 30-60 days.
after 60	Required to take 50 mg 2 times a day.	The duration of treatment is chosen individually.
during pregnancy	Taking tablets of 25-50 mg 2-3 times a day.	The course of treatment is 20-40 days. It requires constant monitoring by a specialist.
Prevention of thrombosis	12-18	Is assigned to 10 mg per 1 kg body weight 3 times per day.	The duration of the tablets amounts to 20-30 days.
18-60	Taking tablets containing 75 mg of active substance 6 times per day.	The course duration is 30-45 days.
after 60	Requires use tablets of 50 mg three times a day.	The duration of treatment is 20-30 days.
Pregnancy	Assigned tablets of 50 mg 2-3 times a day.	The course of treatment is chosen individually by the dynamics of therapy.
Violation status and vascular permeability	12-18	Take 5 mg per kg body weight two times a day.	Duration of 30-45 days.
18-60	Assigned tablets containing 25 or 50 mg three times a day.	The duration of treatment 30-60 days.
after 60	Requires receive tablets of 25 mg 2 times a day.	The course of 20-40 days.
Pregnancy	Taking tablets of 25 mg 1-2 times a day.	The duration of treatment is 20-30 days.
heart disease	12-18	Assigned 5-10 mg per kg body weight 3 times per day.	It requires individual selection of treatment on disease severity.
18-60	Taking tablets of 75 mg three times a day.
after 60	You want to use a tablet of 50 mg 2-3 times a day.
Pregnancy	Assigned tablets of 25 mg 2-3 times a day.
After heart surgery	12-18	The dosage is adjusted individually to the weight and condition of the child.	Pills required to make a week before the date of operation and continue for 7-10 days after the conference.
18-60	Requires take tablets with a content of the main substance 50 mg 4 times a day. After 5-7 days, single dose increased by 2 times.
after 60	Assigned tablets of 25-50 mg 2-3 times a day.
Restoration of blood microcirculation	12-18	It requires taking 5 mg per 1 kg of body weight, 2 times a day.	The duration of treatment 20-40 days.
18-60	Assigned pills with an active element 75 mg 3 times a day.	Course duration of 30-60 days.
after 60	Taking tablets of 50 mg 2 times a day.	The course of 20-30 days.
Pregnancy	Is required to use tablets of 25 mg 2 times a day.	The duration of the prescribed individually by the dynamics of treatment.
when SARS	12-18	Assigned to 5 mg per 1 kg of weight once a day.	Take Dipyridamole from the first days of the disease and continue to receive within 7-10 days after recovery.
18-60	It requires use of 2 tablets of 50 mg 2 times a day.
after 60	Taking tablets of 25 mg 2 times a day.
Pregnancy	1 tablet per day to 25 mg.
Violation of placental blood flow	Pregnancy	Take one tablet containing 25 mg of active ingredient 3 times daily. Dosage can be increased to 75 mg three times a day.	Duration of treatment 4-6 weeks.
Increased blood viscosity	12-18	It requires use of 5 mg per kg of body weight 1-2 times a day.	The course of treatment is chosen individually by the dynamics of treatment.
18-60	Assigned tablets of 75 mg 2-3 times a day.
after 60	Take 25 mg 2 times a day
Pregnancy	Is required to take the pills 25 mg 2-3 times a day.
Disease prevention and to strengthen the immune system	12-18	Assigned to 5 mg per 1 kg body weight once every 7 days.	Duration of treatment for 3 weeks.
18-60	Assigned tablets of 50 mg every 1 to 7 days.	Course duration 4-5 weeks.
after 60	Take 25 pills of 1 mg once every 7-10 days.	The course of 3 weeks.
Pregnancy	Assigned tablets of 25 mg of 1 times within 7 days.	The duration of 3-4 weeks.

Features of the application of tablets:

• tablet be swallowed whole and requires drink water;
• taking for 60 minutes before a meal;
• in the presence of disease in the digestive organs tablets require 150-200 ml milk drink.

If you have difficulty swallowing pills, are replaced on a tablet form slurry.

Suspension

The purpose of the reception	age setting	Single and daily dose	course duration
Cerebrovascular accident	12-18 years	Single and daily dosages are chosen by the patient's age.	Course duration of 20-40 days.
18-60	Take 5 mL of the preparation two times a day.	The course of 3-5 weeks.
after 60	Assigned to 5 ml of medicament 1-2 times per day.	Duration of the set by the attending physician.
during pregnancy	It requires use of 5 ml of the preparation 1 time per day.
Prevention of thrombosis	12-18	The dosage of the drug is determined individually.	The duration of treatment 20-40 days.
18-60	Is assigned to 10 ml of the suspension 3 times a day. If necessary, unit dosage may be increased to 30 ml.	The course of 30-60 days.
after 60	Take 5 mL of the preparation two times a day.	Take for 20-30 days.
Pregnancy	Assigned to 5 ml 2-3 times a day.	The duration of treatment 20-40 days.
Violation status and vascular permeability	12-18	The course of treatment and dosage can be set individually.
18-60	Take 10 ml, 2 times a day.	The course of 30-45 days.
after 60	Required to use 5 ml 2 times a day.	The duration of treatment is 20-30 days.
Pregnancy	Suspension Dosage and duration of treatment are selected individually.
heart disease	12-18	Single and daily dose are chosen by weight, and condition of the child.	The course is established by a doctor of the severity of the pathology and treatment of dynamics.
18-60	Assigned means 10-15 ml 3 times per day.
after 60	Take 5 mL of 2 times a day.
Pregnancy	required to use 5 ml 1-2 times a day.
After heart surgery	12-18	The dosage is calculated individually.	The suspension is prescribed for 7 days before surgery and during 7 days after the conference.
18-60	Is assigned to 10 ml, 2 times a day.
after 60	Take 5 ml 1-2 times a day.
Restoration of blood microcirculation	12-18	The course of treatment and dosage can be set individually by weight.
18-60	Is assigned to 10 ml 2-3 times a day.	The duration of treatment 30-45 days.
after 60	Take 5 mL of 2 times a day.	The duration of treatment is 20-30 days.
Pregnancy	required to use 5 ml 1-2 times a day.	The course of 20-40 days.
when SARS	12-18	The course of treatment and dosage of the treating physician.	To take the drug in the first days of the disease and continue for another week after recovery.
18-60	Is assigned to 10 ml of a suspension of 2 times a day, 1 time per week.
after 60	Take 1 ml of 5 times per 7 days.
Pregnancy
Violation of placental blood flow	Pregnancy	Assigned to 5 ml 2-3 times a day.	The course of treatment depends on the dynamics of therapy.
Increased blood viscosity	12-18	The dosage and rate appointed by the attending specialist.
18-60	Take 10 ml 2-3 times a day.	Duration of treatment 3-5 weeks.
after 60	Required to use 5 ml 2 times a day.	The course of 20-40 days.
Pregnancy	Assigned 5 ml 1-2 times a day.
Disease prevention and to strengthen the immune system	12-18	Dosage and duration of reception of the slurry is determined by a pediatrician.
18-60	Required to take 5 ml once a week.	Course duration is 3-5 weeks.
after 60	Assigned by 5 ml of 1 every 7-10 days	The duration of intake for 3 weeks.
Pregnancy	It is used in rare cases. The dosage and course are selected individually.

Nuances application of suspension:

• suspension is required to take 40-60 minutes before meals. You can drink water in a small amount;
• before using a bottle requires Shake to evenly distribute the components of the drug in the composition;
• dosage produce using specialized measuring spoon or syringe.

If you want a faster therapeutic effect, it is recommended to use Dipyridamole in the form of a solution for injection.

Injection

Dipyridamole in the form of an injectable solution used for 1-2 ml per day. Dosage (depending on age, general condition of the patient and the type of pathology) and the duration of application chosen strictly individually.

The rules of the injection:

• procedures, especially intravenous administration, made in a hospital under the supervision of the attending physician;
• Use of the drug is independent of food intake;
• when applying a medicament intravenously administered composition requires very slowly.

Importantly, i.v. necessary to exclude the possibility of allergic reaction to the drug use, since the composition penetrates directly into the bloodstream.

Allowed long-term use of the drug, subject to single and daily dosage.

Side effects

With the passage of the therapeutic course may experience negative reactions:

• nausea (possibly vomiting), diarrhea, abdominal pain;
• acceleration amount heartbeats;
• lowering the pressure indicator;
• headaches, tinnitus;
• allergy symptoms (itching, rash, swelling).

Also, the drug may increase bleeding, which is especially important to consider when administered during surgery.

Overdose

Dipyridamole (instruction manual prohibits independently adjust the dosage and duration of administration of the drug) overdose can cause the development of the following reactions of the body:

• a sharp decrease in pressure indicator;
• if there is bleeding ulcers may develop;
• increasing the number of heart beats;
• disruption of the liver and kidneys.

With an overdose of the drug required treatment in the hospital. Pre (orally) must be flushed and the stomach take activated charcoal.

special instructions

When the treating specialist Dipyridamole drug nuances of the drug required to comply with:

• the period of the course excludes the use of coffee and strong tea. Or adjustment is necessary and a single daily dosage of funds;
• in the presence of abnormalities of the coronary arteries, the preparation may enhance pain in the heart;
• when blood pressure surges or a recent heart attack medication is used strictly under medical supervision;
• use solution for injection in extreme cases. Dipyridamole for oral use has a softer therapeutic effect;
• if necessary, replacement of the preparation oral administration to intravenous / intramuscular required withstand time interval is not less than 24 hours.

In pregnancy, require regular monitoring of the fetal condition. Upon detection of deviations of the course of treatment will be stopped immediately. For the period of treatment is necessary to give up driving vehicles and work performance with increased accuracy.

drug interactions

Dipyridamole (instruction manual contains a list of medications with which the complex reception requires an adjustment of the course of treatment) It recommended with caution taking the following medicines:

• drugs to reduce acidity in the stomach degrade drug uptake (after oral administration);
• Simultaneous use of medicines and blood thinners Dipyridamole can cause bleeding development;
• drugs that affect the functioning of the cells of the nervous system and Dipyridamole may impair attention and memory;
• not recommended concomitant use of medications to normalize the functioning of the heart and Dipyridamole;
• drugs with reduced absorption of caffeine Dipyridamole;
• absolutely can not take both Dipyridamole and medicines to lower pressure (the lethal outcome is possible).

Precautions should take the medication with antibiotics, since they enhance the therapeutic effect of Dipyridamole.

analogs

When hypersensitive to the components included in the Dipyridamole or occurrence of side effects are replaced by the following medicines:

• Persantin. Solution for intravenous administration;
• Egitromb. It is produced in the form of tablets;
• Acetylsalicylic acid. Pills.
• Koplaviks. Pills;
• Chimes. Pills.

Replacing Dipyridamole made only by the attending physician, taking into account existing contraindications.

Terms, conditions of sale and storage

Dipyridamole in any form required stored at a temperature of from 4 to 25 degrees in a dark place. When these conditions are met, tablets and suspension are stored for 2 years, 3 years solution. Opened bottle with the suspension retains the therapeutic effect of up to 6 months. Sold upon presentation of a prescription in Latin with an indication of dosage rates and dosage form.

Price in drugstores of Moscow, St. Petersburg, regions

Cost (rub.) For Dipyridamole depends on the form of release, sales of the region and a network of pharmacies.

City	Tablets 40 pcs. (25 mg active substance)	Tablets 100 pcs. (25 mg active substance)	Suspension	Injection.
Moscow	370	420	360	220
Saint Petersburg	385	430	380	230
Yekaterinburg	360	410	340	200
Permian	350	400	330	200
Volgograd	330	390	310	190
Sochi	370	420	350	210
Khabarovsk	380	430	370	230

Dipyridamole helps to normalize cerebral blood flow, inhibits adhesion of blood clots and normalize the placental circulation in pregnant women.

The drug need be used with extreme caution in children and the elderly, as well as in complex treatment. It is important Dipyridamole dosage appointed doctor, in the absence of individual indications can be applied according to instructions.

Author: Svetlana Kotlyachkova

Registration of the article: Mila Friedan

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