Antimicrobial Drugs For Systemic Use

Amosin. Instructions for use, price, reviews, analogues

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Amosin - medical device, widely used in antibacterial therapy. According to the instruction, it refers to the group of penicillins. The drug is administered at various infectious and inflammatory processes caused by pathogenic microflora.

The content of the article:

  • 1 Indications
  • 2 Structure
  • 3 In what form is available
  • 4 Farmodinamika
  • 5 Pharmacokinetics
  • 6 application
    • 6.1 For children up to 18 years
    • 6.2 adult
    • 6.3 For pregnant
    • 6.4 for elderly
  • 7 Contraindications
  • 8 Overdose
  • 9 Side effects
  • 10 Combination with other drugs
  • 11 Conditions and terms
  • 12 Conditions of supply of pharmacies
  • 13 analogs
  • 14 Videos about the antibiotics penicillin group

Indications

The means employed under the following conditions and pathologies:

  • defeat infection upper respiratory system, including the presence of pneumonia and bronchitis;
  • pathological processes in otolaryngology;
  • disorders of the genitourinary system caused by infectious agents, - cystitis, urethritis, gonococcus defeat;
  • female genitourinary disease;
  • shock syndrome - the development of cholecystitis, peritonitis, typhoid fever;
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  • infection of the skin and soft tissues;
  • development borreliosis;
  • dysentery infection;
  • defeat salmonellosis;
  • meningococcal infection;
  • Listeria defeated;
  • putrid rotting - sepsis.Amosin. Instructions for use, price, analogs, reviews

The preparation can also be administered as prophylaxis in the development endokradita - cardiac inflammation inner shell.

Structure

The main active substance is amoxicillin - an antibiotic that helps in various diseases caused by dangerous infectious microorganisms. The composition is different, based on the formulation of a medicament.

Pills:

  • magnesium stearate;
  • calcium stearate;
  • potato starch;
  • talc;
  • povidone.

capsules:

  • titanium dioxide;
  • acetic acid;
  • potato starch;
  • methyl- and propilgidroksebenzoat;
  • gelatin.

Powder Composition:

  • povidone;
  • sodium hydrogen phosphate;
  • glucose;
  • Trilon B;
  • sodium alpha-glutamate monohydrate;
  • a flavor;
  • vanillin;
  • sucrose.

Additional ingredients in combination with the main component allows purposefully work on pathogens.

In what form is available

Amosin, instructions for use which indicates several forms of pharmaceutical remedies may issued as depot tablets, capsules and the powder mass to prepare solution.Amosin. Instructions for use, price, analogs, reviews

Capsules made of gelatin, as a flat cylinder. Inside, each capsule granules are white in color. Cost - from 31 to 63 rubles. per pack.

The powder is white or white with a yellowish tinge. Consistency is unusual smell, packaged for disposable bags of 6 g Bags are packed in a cardboard container. The cost of packaging (250 mg) varies in the range of 20-30 rubles. Price agent 0.5 g varies within 43-76 rub.

The tablets are white or almost white. Packed in blisters contour. Each blister contains 10 units. Packaged in cardboard containers. The cost depends on the nominal volume and dosage: 0.125 g - 30-46 rub, 0.25 g - 27-64 rub 0.5 g - 28-76 rub...

Farmodinamika

The drug is an antibiotic belonging to the category of semisynthetic penicillins having a wide range of effects. It has a pronounced antimicrobial action, overwhelming transpeptidase, which in turn leads to disruption of peptidoglycan synthesis.

Process causes suppression of pathogenic microorganisms. Highly resistant to an acidic medium.Amosin. Instructions for use, price, analogs, reviews

It is used in bacterial lesions caused by aerobic bacteria both gram-positive and gram-negative:

  1. Staphylococcus spp., Excluding the strains capable of producing the enzymes that cause the destruction of penicillin.
  2. Streptococcus spp.
  3. Meningococcal wand.
  4. Coli, promoting the development of gonorrhea.
  5. Bacillus anthrax.
  6. Listeria.
  7. Klebsiella.
  8. Helicobacter pylori.

Pathogenic bacteria that cause the production of penicillinase are resistant to the action of an antibiotic (amoxicillin).

The effect of the agent components comes after 20-30 minutes. after treatment. The duration of effect is observed within the next 8 hours.

Pharmacokinetics

Amosin, according to the instructions, after the application is almost fully and rapidly absorbed from the gastrointestinal tract. The absorbent capacity in this case is more than 93%. Eating food has no effect on the level of absorption of active metabolites. Amoxicillin is not destroyed by gastric secretory fluids.

The maximum content of the main substance in the plasma is attained after 1-2 hours after consumption means. The accepted dosage leads to 0.125 g active ingredient concentration of 1.5-3 mg / ml at a dosage of 0.250 g - 3.5-5 .mu.g / ml.

The active component of the medicament is produced in large quantities in the plasma, bronchial secretory secretions, pleural and peritoneal secretion.

Substances pharmaceutical remedies are also observed in the urine, papules, lung cells, the walls of the stomach, the female reproductive organs, skeletal system, adipose tissue, tissues formed fetus. The contents of metabolites in the body at double dosage also increases by 2 times. In this case, it means the level of bile more than in the blood several times.

The umbilical cord amniotic waters and drug levels as high as 30% compared with the patient during the childbearing. If meningococcal infection level acting metabolites in cerebrospinal secretion is 20%.

Amosin. Instructions for use, price, analogs, reviews
Amosin excreted by the kidneys unchanged

A small level means metabolites formed in human breast milk.

The level of binding proteins with a main component does not exceed 17%.

When ingested, the active component is partially metabolized, thus disintegrating on inactive components. Time means half-life - 60-90 minutes. The active components of the preparation is output in most urine in unchanged form (50-70%), bile - 20%.

Children born prematurely, infants and babies up to six months half-life of components vary in 3-4 hours. Patients suffering from a variety of kidney functions, this period may be increased up to 8.5 hours. Antibiotic completely removed from the body by hemodialysis.

application

Use the tool is only necessary for a doctor's prescription. Use before or after a meal. The dosage is set based on the patient's age and the nature of the disease.

For children up to 18 years

Amosin, instructions for use which permits the use of a means of childhood, children up to 5 years should be consumed in the form of powder mass to prepare a solution.

Terms of use:

  1. One packet with the means necessary to dilute in a cooled boiled water.
  2. Then stir until a uniform mass (slurry).
  3. Use it according to the instructions.

When breeding powder must take into account the nominal amount of water. When the dosage necessary to use 0.125 g of 2,5 ml of water, at 0.25 g - 5 ml, with 0.5 g -. 10 ml of pure water.Amosin. Instructions for use, price, analogs, reviews

Age Dosage daily rate duration of therapy
Ages 2 years 20 mg / kg portion divided into 3 equal reception from 5 to 12 days
From 2 to 5 years 0,125 g 3 times a day 5-12 days
From 5 to 10 years 0.25 g 3 times per day from 5 to 12 days
Children older than 10 years (weighing less than 40 kg) 0.5 g (in severe cases assigned from 0.75 to 1 g) 3 times a day duration depending on the disease
Preventive measures during surgery (endocarditis) 1.5-2 g 1 time once, for 1 hour before the operation

if necessary, the course is extended by the attending physician if tolerated drugs and only under his supervision.

adult

The dosage in adults is defined, based on the form of the disease:

  • When uncomplicated gonococcal infections - once 3 years
  • With the development of acute infectious-inflammatory processes in the gastrointestinal tract and biliary passages - 1.5 grams 3 times per day. In some situations it is appointed for 1-1.5 g 4 times a day.
  • When leptospirialnom lesion - at 0.5-0.7 g 4 times a day. Duration of treatment varies from six to 12 days.
  • Salmonellosis - 1,5-2 g 3 times a day. The course of treatment is determined individually, and is usually from 2 to 4 weeks.Amosin. Instructions for use, price, analogs, reviews
  • With the passage of preventive measures related to the operational activities for endocarditis - 3-4 g once for 1 hour before the operation. If necessary, repeat therapy is appointed through 8-9 hours after the surgical operations.
  • Patients suffering from kidney function disorders recommended interval between doses of medication for at least 12 hours. In chronic forms of renal dysfunction daily dosage of medicament decreases by 15-60% or maintained break of at least 24 hours.
  • With the development of anuria dosage is no more than 2 g 1 time per day.

For pregnant

The drug is given during pregnancy if the potential risks justify the use of funds. At the use of the drug is necessary to stop breastfeeding.

Dosage is calculated only by the attending physician based on evidence and research. The duration of treatment depends on the stage of pregnancy and the form of the disease.

for elderly

The facility can be used in elderly patients. However for a medicament it should be noted that the half-life of the active components significantly increased in comparison with the other groups.

Dosage adjustment is not required. In some cases, the treatment duration may be prolonged or shortened.

Treatment Regimen - standard, for patients in adulthood.

Contraindications

Pharmaceutical remedies has some limitations due to the use of high activity of the antibiotic.

Contraindications:

  • presence of bronchial asthma;Amosin. Instructions for use, price, analogs, reviews
  • the development of allergic diathesis;
  • defeat infectious mononucleosis form;
  • renal failure;
  • lymphocytic leukemia;
  • diseases of the gastrointestinal tract in history, including colitis caused by antibiotic therapy;
  • lactation;
  • means the presence of hypersensitivity to the components;
  • the presence of hypersensitivity to penicillins, cephalosporins.

The drug is in the form of capsules and tablets may not be used in children younger than 3 years. With high caution and only under the strict supervision of a physician is allowed to take the medication during pregnancy. When you use during breast-feeding should stop feeding until the end of therapy.

Overdose

unpleasant symptoms may develop in excess of the indicated dose.

Overdose:

  • nausea;
  • development of dizziness;
  • urge to vomit;Amosin. Instructions for use, price, analogs, reviews
  • diarrhea;
  • disruption of water and electrolyte balance.

With the development of these features should immediately contact a physician for the purpose of symptomatic therapy in the form of lavage and destination adsorbents (activated carbon, smectite). In some cases, drugs may be administered to restore the water and electrolyte balance, and hemodialysis.

Side effects

Amosin, instructions for use which indicates a high principal active substances may lead to adverse reactions associated with the individual characteristics of the organism.

Side effects:

  1. allergic reactions: Rash, itching, development, erythema (including exudative), urticaria. Often the use of the drug leads to angioneurotic edema, development of rhinitis, conjunctivitis. Occasionally the condition may be complicated by the development of fever, pain, eosinophilia, Stevens-Johnson syndrome. In extremely rare cases, the drug can lead to anaphylactic shock.
  2. Digestive system: Dyspepsia (nausea, bloating, vomiting), changes in taste perception, disorders of intestinal microflora, inhibition of liver function, stomatitis, glossitis. Extremely rare medicine may cause the development of pseudomembranous enterocolitis.
  3. Central and peripheral nervous system: Irritability, anger, anxiety syndrome, depression, impaired sleep-wake rhythms. The drug can cause confusion, behavioral changes, neuropathy, migraine, seizures.
  4. Urogenital: shape interstitial nephritis, candidiasis.
  5. hematopoietic system: leukopenia, anemia, thrombocytopenia purpura.
  6. Other reactions: abnormal heart rate (tachycardia).Amosin. Instructions for use, price, analogs, reviews

In patients suffering from chronic diseases, education superinfection occasionally observed.

With the development of adverse reactions from the use of the drug should stop taking and consult a doctor for the appointment of symptomatic therapy.

Combination with other drugs

When assigning funds should be borne in mind that ascorbic acid speeds up the process of absorption of amoxicillin. The funds relating to antacid group, aminoglycosides, and laxatives and food slow down the process of assimilation and absorption of the active ingredient.

They complement each other and enhance the bactericidal antibiotics from the group. The opposite effect is achieved by simultaneous application Amosina and bacteriostatic pharmaceutical remedies - tetracyclines, macrolides, hlormafenikola, lincosamides, sulfonamides.

Amoxicillin increases the effects of anticoagulants. Thus there is a suppression of the intestinal microflora, it decreases the efficiency of the use of vitamin K action decreases prothrombin.

With simultaneous application of drugs on the basis of the observed actions of estrogen second slide. There are risks of menstrual bleeding.

Increasing the concentration of the active ingredient and reduced calcium secretion occurs while the use of diuretics, phenylbutazone, oxyphenbutazone, allopurinol, as well as non-hormonal anti-inflammatory medicines.

Allopurinol in combination with amoxicillin can trigger the development of allergic skin reactions - rash. A combination drug with methotrexate can lead to increased toxicity.

Digoxin absorbent properties are significantly increased, while the use Amosina.

Conditions and terms

Store in a dry dark room at a temperature of from 15 to 25 0C.Amosin. Instructions for use, price, analogs, reviews

Shelf life - 2 years from date of manufacture. Do not use after the expiration date printed on the package.

Conditions of supply of pharmacies

Available on medical prescription.

analogs

Amosin, instructions for use which indicates that the tool has analogs intolerance to one or more components may be replaced by other drugs.

  • Amoxicillin. It is produced in the form of tablets. It belongs to the class of antibacterial drugs with a wide spectrum of action. It is used in the treatment of bacterial and infectious lesions. It is effective against most Gram-positive and Gram-negative pathogens. Can be administered in children aged 6 years. Dosing and dose determined by the attending physician based on the age, weight and disease of the patient. The duration of treatment is determined based on the nature and occurrence of the disease. Cost - from 30 up to 1320 rubles. per pack.Amosin. Instructions for use, price, analogs, reviews
  • Flemoksin. It is produced in the form of capsules. It refers to a group of bactericidal antibiotics and semisynthetic penicillin antibiotics. Used in the treatment of infectious and inflammatory diseases. It inhibits the activity of gram-positive and gram-negative microorganisms. With high caution can be used during pregnancy and children from 3 years. The dosage and duration of the course depends on the age, weight and disease progression. Price - from 208 to 428 rubles. for the agent.
  • Ekobol. It is produced in the form of tablets. The main ingredient - amoxicillin. It refers to a class of broad-spectrum penicillins. It has a pronounced antibacterial and anti-inflammatory action. Applied before or after eating. The dosage is made by the attending physician taking into account age, weight, and type of disease. The maximum rate of therapy should not exceed 1 month. Cost of equipment - from 132 rubles.
  • Ospamoks. It is produced in the form of tablets, capsules or granules for suspension. The main component - amoxicillin. It refers to a group of semi-synthetic penicillins, with a broad spectrum of action. Effective therapy of infectious diseases. Contraindicated in severe infections of the gastrointestinal tract. It can be used in children and during pregnancy under strict medical supervision. Dosage is calculated by the attending specialist based on weight, age, and type of disease. Cost is from 120 to 320 rub.
  • Ampicillin. It is produced in the form of tablets for oral use. It has a pronounced bactericidal effect. It belongs to the category of broad-spectrum antibiotics. The drug is not appointed during pregnancy and in children younger than 1 month. It is contraindicated in patients with renal insufficiency, bronchial asthma, presence of bleeding, hay fever. Dosage and duration is established physician, based on the severity of the disease and shape, as well as the patient's age. Cost - from 28 to 35 rubles.

Before using Amosina or its analogues should consult with their physician or pharmacist and read carefully the instructions for use.

Registration of the article: Mila Friedan

Videos about the antibiotics penicillin group

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