Nise gel. Instructions for use, price, reviews, analogues

Nise gel - a pharmacological agent, widely used in the treatment of disorders of the musculoskeletal system, accompanied by pain syndrome. The drug is used on doctor's orders and according to the instructions.

Shape and composition of the drug release

The preparation has a dosage form and is produced in the form of a gel for external application. Means for plastic packaged tubas, packed in cardboard containers. The nominal volume of each tube - 50 g The active substance acts nimesulide - 10 g per 1 g of the agent.

Additional composition:

• 50 mg of diethyl phthalate;
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• 50 mg diethylene glycol monoethyl ether;
• 50 g of hydrogenated oil poliaksilkastorovogo;
• 1 mg of sodium benzoate;
• 70 mg of propylene glycol;
• 2 mg trometamol;
• 12 mg of carbomer-980;
• 1 mg of disodium EDTA;
• 0.4 mg of butylated hydroxytoluene;
• filtered water.

Also, means is discharged in tubes nominal volume 20 g. This form is less common, however, is completely identical to the composition and reading.

pharmacological properties

Naiz gel, instructions for use which indicates the absence of hormonal components in drug belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDs). It belongs to a class sulfonanilides.

The medicament is intended to eliminate inflammatory reactions, exhibit a pronounced analgesic and antipyretic effect. Removes puffiness, swelling, redness at the site of the pathological process.

The active substance has a blocking effect against cyclooxygenase-2.

It is noted the following mechanisms:

• arresting processes promoting platelet activation;
• by inhibiting protein kinases and fosfodiesteray type 4 decreases generated substances - superoskid anion;
• reduction steps hypochlorous acid;
• reduction in risk of development giperlazii by suppressing the factors causing the development of neoplasms (tumors);
• suppression of proteases;
• and suppression of histamine release;
• arresting the chemical reactions associated with the formation of metalloproteinases.

Due to the action of menthol achieved Anesthetic, local irritating and distracting effect. At the same time there is a decrease of itching and inflammation. The substance has a sedative effect, exhibits antiseptic properties character.

Effect of menthol is due to the ability to influence the substance nerve fiber endings and cutaneous and mucosal receptors. In this case, there is stimulation and the development of substances endogenous nature - endorphins, peptides, kinins.

These substances are actively involved in the regulation of pain, degree of vascular permeability. Due to such actions there is a reduction of pain, there is a red and antipruritic effect.

Additional component exhibits antiseptic properties indiscriminate action. The resultant effect of stimulation reduces pain by providing vasoconstrictor effect. When this condition is accompanied by a sense of cold, slowly rolling in a burning sensation or a mild tingling.

Visceral functions cutaneous receptors contribute to improving tissue trophism, increases vascular tone and tugor located throughout the body system.

Capsaicin blocks production of Substance P, acting in neyrotransimittera. This material conducts at nerve endings and the fibers pulses responsible for the development of pain and itching from the central to the peripheral nervous system. Capsaicin suppresses the production and release of substances which reduces the painful sensations.

Methyl salicylate is a salicylic acid derivative. When applied externally exhibits a high absorption capacity, it has a high degree of penetration into the deep layers of the epidermis. It metabolized forming anions of salicylic acid.

It inhibits cyclooxygenase production, prevents the production of prostaglandins, which leads to a decrease in inflammatory reactions, puffiness removal, elimination of itching.

Component reduces capillary permeability, thus restoring the microcirculation, reduces pain in the joints, muscles and soft tissues. Thanks to the local irritating effect decreases the intensity and frequency of pain.

Pharmacodynamics and Pharmacokinetics

Naiz gel, according to the enclosed instructions for use, has certain pharmacokinetic properties.

When a single application at a dosage of 200 mg active ingredient concentration is observed after 24 hours. Component primarily metabolized in the liver to form the active metabolite - nimesulide-4-hydroxynimesulide. The components of the main metabolites found in the blood.

When using a means for 8 days, the concentration of the main component in the blood is less than 100 times as compared with a single dose.

The local application notes low degree of absorption, as a consequence, the data on the pharmacokinetic properties of the other components of the drug available.

Indications

The medicine is indicated for the development of acute disorders of the musculoskeletal system, degenerative diseases of the skeletal system, including the spine and joints.

Indications:

• microtraumas - bruises, sprains without soft tissue damage;
• fractures and sprains or muscle;
• relapsing sciatica appearance, accompanied by pain;
• development of neuritis and neuralgia of various forms;
• presence of rheumatoid arthritis accompanied by extensive lesions and pronounced pain syndrome;
• arthritis and polyarthritis of different nature of origin;
• violations in different parts of the spine - osteochondrosis;
• some form of bursitis, characterized by a lack of necessary surgical interventions;
• acute and chronic bursitis;
• inflammation in the tendons - tenosynovitis.

Means may also be used in gout mild to moderate severity. The gel helps to eliminate the heat and pain, eases nighttime symptoms of the disease.

Contraindications

Nise gel, instructions for use which indicates the development of undesirable manifestations, has some limitations for use. Means prohibited to use in the presence of high sensitivity to the components.

Contraindications:

• disorders in the gastrointestinal tract - erosions and ulcers, the risk of internal bleeding;
• gastritis flowing in acute exacerbations or having a development shape;
• stomach ulcer;
• Children under 3 years of age;
• liver dysfunction - violation body fermentation, hepatic failure;
• pregnancy and lactation;
• individual features of the body - hepatotoxicity when applying means on the basis of nimesulide;
• renal failure and other severe renal impairment;
• damage to the intended site of application means;
• or purulent inflammation of the affected areas, outbreaks.

Do not use the drug while applying means having a similar effect.

With high caution gel assigned under the following conditions and diseases:

• severe violations of cerebral vessels;
• diabetes and various forms of developmental stages;
• vascular insufficiency in the acute form;
• defeat the organism Escherichia coli, Helicobacter pylori;
• chronic form of heart failure;
• elderly age;
• Allergic reactions on the skin;
• peptic ulcer disease.

Extreme care agent indicated for concomitant use of hepatotoxic drugs, since such interaction can lead to toxic liver damage.

At what age can use the drug

The gel is allowed to use in children, ranging from 3 years old, because of side effects and the impact on the formation of the musculoskeletal system.

Instructions for use, the dosage of the drug

Nise gel, instructions for use which indicates one dosage form is applied only topically. Before the opening of the tube and the application of funds for the skin is necessary to conduct a thorough treatment of hands with soap and water.

It is also necessary to process the distribution of seats. Apply gently. Grabbing at the same small area around the painful area. Rub with light massage movements.

If you are using the medication are advised to avoid wearing tight clothes and ties. Standard application scheme strip composition (no more than 3 cm) are applied uniformly to the affected area 3-4 times a day, or as specialist indications.

Duration of treatment - no more than 7-15 days. Prescribed by a doctor, and only with the permission of courses may be repeated. The interval between treatments should be at least 3-5 days.

Do not use more than 1 package of the drug per day.

Side effects

Local use of pharmacologic agents is usually well tolerated by patients. In some cases, may develop adverse reactions.

Side effects:

• digestive organs: the formation of dyspepsia, nausea, vomiting, abnormal stools, the occurrence of pain in the stomach area, the development of ulcers.
• Central nervous system: dizziness, headache.
• Bodies and allocation system: the development of hematuria, fluid retention in the body.
• Skin and skin itching, rash, burning sensation at the site of the composition, desquamation, redness.

When laboratory diagnostics detected change (reduction) in the number of platelets, leukocytes. There has been the development of agranulocytosis, anemia, disorders of the liver enzyme formed.

If these symptoms develop or not marked in side effects instructions to cancel taking the drug and consult your healthcare specialist for consultation and appointment of symptomatic therapy.

Overdose

Cases of overdose of drugs have not been awarded. One application of 50 g of the composition may experience various side effects. There is no specific antidote. It requires specialist advice and appointment of symptomatic treatment.

special instructions

In the topical use of the drug is necessary to avoid any contact (contact) of the composition to the mucous membranes, the eyes, the open wound surface. Used only topically on the exposed areas. It is forbidden to use a medicament using occlusive dressings. Before applying the composition is recommended to thoroughly wash your hands with soap and water.

Extreme care should be prescribed to patients receiving nimesulide inside view of adverse reactions in the form of vertigo. Extreme care agent assigned to patients with high risk of adverse reactions associated with the use of salicylates.

Data on the use of medicines in children are absent. Research in this area is not performed. According to clinical research component of the drug does not exhibit mutagenic activity. For information on the effect of the main substance in the lymphocyte chromosomes are not provided.

It advised to exercise a high caution while taking the drug in the management of transport funds or conduct of work associated with high concentration of attention, due to the development of dizziness.

drug interactions

There are low risks of drug interactions with medications, playing the role of competition in relation to blood proteins binding. The main ingredient capable of potentiating the effect of drugs aimed at lowering blood clotting.

The drug reduces the efficiency of the simultaneous use of antihypertensive drugs and furosemide. The drug increases the risk of side effects of methotrexate. Using means may lead to increased concentration of lithium in the blood.

In the combined treatment, which includes the use of hydantoin and sulfa agents, it is necessary constant observation and passage specialist laboratory diagnostic methods for monitoring the status patient.

When combined with cyclosporine gel increases the likelihood of adverse effects on the kidneys. Glucocorticoids and antidepressants may lead to the development of internal gastric bleeding.

analogs

Nise gel, instructions for use which indicates the development of allergic reactions, intolerance to the components can be replaced by other drugs:

• Voltaren Emulgel. The active ingredient is diclofenac. Medication belongs to a class of non-steroidal anti-inflammatory drugs. Has bright pronounced analgesic effect, reduces edema, and inflammatory reaction. Assigned when various forms sciatica, arthrosis, rheumatism. It is effective in the treatment of injuries, contusions, tendon ruptures. Contraindications: Children under 12 years of age, pregnancy and breastfeeding, as well as intolerance to salicylates. The composition is applied to the affected area two times a day every 12 hours. It is forbidden to use their own means of more than 14 days. The cost of packaging (1%, 50 g) - 223-456 rub.
• Fastum gel. Means a member of the NSAIDs group. The main component - ketoprofen. The composition of the drug helps to eliminate pain, remove inflammatory reactions and manifestations of edema. It is not assigned to the children's age 1 to 5 years, in the period of childbearing and breastfeeding, with impaired renal function and liver, as well as in disorders of the part of the lymphatic system - thrombocytopenia, leukopenia. It is used 1-2 times a day. Apply a thin strip in the area of ​​inflammation. Duration of treatment - no more than 14 days. The course can be extended only after consultation with a specialist. Price - from 287 to 710 rubles. packing (50 g).
• Dikloran. Produced in gel form for topical application. The main ingredient - diclofenac. The drug exhibits a local analgesic and anti-inflammatory effect. Prescribed for violations of the musculoskeletal system with the inflammatory nature of origin and accompanied by pain. Effective in the treatment of sciatica, rheumatoid lesions, osteoarthritis, post-traumatic syndrome. Banned the use of children under 6 years old, in the period of gestation of the child, in case of intolerance of components and salicylates. Applied topically 3-4 times per day. Means rubbed massaged. The dosage in children aged 6 to 12 years is no more than 2 times a day. The course of treatment - no more than 10 days. The cost - 194-210 rubles.
• Ultrafastin. It is produced in the form of gel for external use. The main component - ketoprofen. Designed to eliminate pain, inflammation. It is used by small courses of 7-10 days. Contraindication is the presence of open wound surfaces, children up to 15 years, as well as the third trimester of pregnancy. Means applied 2-3 times a day her large strip - from 3 to 4 cm. If used improperly, can lead to various adverse reactions. Prior to use, it is imperative to consult a doctor. The cost of the tube (50 g) - 160-275 rub.
• Long. Produced product in the form of a cream or gel for topical use. Country of origin - Germany. Active ingredient - ibuprofen. Due to its composition has antipyretic, anti-inflammatory and analgesic effect. It belongs to the class of NSAIDs. The medicament is intended to eliminate inflammation, removal of edema and pain. Not applicable on surfaces having exudative processes, eczema and other field applying means injuries. In a cream formulation applied 3-4 times per day. Duration of treatment - from 2 to 3 weeks. In the form of a gel is being used 3-4 times a day - a strip of no more than 5-10 cm. therapy - not more than 21 days. The cost varies between 143-228 rubles. per pack.
• Hondroksid. The medicine of the domestic manufacturer, is made in the form of gel, ointment and capsules. The main active ingredient - chondroitin sulphate 5%. The drug is indicated for degenerative diseases of the musculoskeletal system. Effective it is in the treatment of osteoarthritis, rheumatoid pathologies, osteoporosis. Not used on the skin, with inflammatory or exudative processes. Apply to the affected area 2-3 times a day. Duration of the course depends on the nature of the pathological process and varies from 2 weeks to 3 months inclusive. The cost of the tube (30 g) - 332 rubles.

Self-medication to replace another drug is prohibited in order to avoid complications and side effects. The selection of the analogue should be engaged specialist, based on the characteristics of the disease.

Terms, conditions of sale and storage

Store in a dark place must be at a temperature no higher than 25 ⁰C. Shelf life - 2 years from date of manufacture. Do not use after the expiration date printed on the packaging.

Available without a prescription.

Price in drugstores of Moscow, St. Petersburg, regions

The cost of the drug varies depending on the region and sales. The price is also affected by trade pharmacy chain and the manufacturer directly.

Purchase pharmacological agent can be in any specialized medical institution or pharmacy:

Area, region	Nominal volume,	cost of
Moscow, Moscow region	20 g	45-423 rubles.
Moscow, Moscow region	50 g	230-615 rub.
St. Petersburg	20 g	170-305 rub.
St. Petersburg	100 g	456-752 rub.
St. Petersburg (suburbs)	20 g	150-305 rub.
Leningrad region	100 g	224-655 rub.
Novgorod region	50 g	297 rubles.

Nise gel before application is recommended to consult a doctor or pharmacist, as well as carefully consider how to use the drug.

Registration of the article: Mila Friedan

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