Nasonex. Instructions for use for children, adults. Price, analogues, reviews

Spray Nasonex helps relieve symptoms of inflammation in the upper airways. A careful study of the instructions for use to help find the right dosage, to avoid possible adverse effects during therapy.

the drug

Nazoneks, instructions for use which describes in detail the preparation composition is a suspension for topical use. Mometasone furoate is a part of - is a synthetic glucocorticosteroid.

Among the additional components:

• specially prepared cellulose - emulsifier and stabilizer medium;
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• glycerol - to increase the viscosity;
• Sodium citrate - improves the sensitivity of receptors of the nasal cavity;
• polysorbate - to create an environment;
• phenylethyl alcohol - perfume;
• prepared water.

release Form

The drug release in the form of an off-white suspension in the vial-spray mass 10 and 18 g. Each tank is equipped with a valve for precise dosing of the drug - one press releases 50 micrograms of mometasone.

pharmacological properties

Nazoneks (instruction manual is available in each packet and official register drugs) affects all three phases of inflammation.

For example:

• preventing tissue damage;
• reduces selection-exudate fluid;
• prevents hyperplastic tissue overgrowth.

Momentazon reacted with lipocortin-proteins that block the action of phospholipase A2. This delays the output of arachidonic acid, which is involved in the synthesis of inflammatory mediators - prostaglandins and leukotrienes.

Pharmacokinetics

Bioavailability Nazoneks preparation of fractions of a percent, however when topically (intranasal) application of the active substance is not detected in the peripheral blood. Even if swallowed during inhalation those small amounts of money that goes into the digestive tract, practically not adsorbed and do not have a systemic effect.

pharmacodynamics

Nazoneks - synthetic hormonal drug that acts when applied topically.

In the area of ​​inflammation, he:

• slows the release of arachidonic kislty and prostaglandin synthesis;
• It prevents the formation of clusters of neutrophils, due to which produce less exudate;
• perameschenie blocks of tissue macrophages in the inflammatory focus by adjusting the amount of inflammatory infiltrate;
• It prevents excessive growth of new tissue, reducing the likelihood of the development of large granulation;
• It affects the immediate and delayed allergic reactions, stopping pathological inflammation.

To investigate the efficacy of the drug was conducted placebo-controlled trials in which it was found that Nazoneks indeed highly effective against various types allergic reactions.

The drug demonstrated a clinically significant decrease in the level of activity of eosinophils and fall production of inflammatory mediator histamine, reducing the number of corpuscles. Also, decrease in the concentration of proteins have been reported which are responsible for adhesion to the epithelium of the blood cells and the reduction in the number of neutrophils in the outbreak.

Indications

The suspension Nasonex discharged under the following nosology:

• manifestations of allergic rhinitis (permanent use or during periodic deterioration state);
• relief of sinusitis, sinusitis on the background of antibacterial therapy;

  

• prevention of rhinitis of an allergic nature of moderate and severe.

Instructions for use

Nazoneks, instructions for use which comprises a procedure for use of the drug applied intranasally. To use was more comfortable with the delivery of the drug in the inflammatory focus and strict observance of dosage vials are equipped with a special handy nozzle.

Compliance with the simple tips to avoid an overdose and make the treatment comfortable:

1. Before each use, the patient should be several times quite sharply shake the vial of the drug.
2. To adjust the supply of clear preparation before the first use of the vial must repeatedly press the dispenser. This eliminates the air bubbles and adjust the supply of spray equal doses.
3. If the patient is using irregular means, after the next inhalation has been more than 2 weeks, it is necessary to recalibrate the dispenser for uniform supply of spray.

Application of allergic rhinitis

Nasonex suspension is effective for the prevention and control of major symptoms of allergic rhinitis, significantly worsens the quality of life for patients. When the mucous membrane of the middle nasal inflammation, severe in all patients over 12 years: 1 drug once a day. For inhalation in each nostril is 2 injection.

The daily dosage of the slurry - 200 micrograms. For elderly patients receiving multiplicity of correction, reducing the daily amount of corticosteroid hormone is required.

Relieving the condition usually occurs within 10-12 hours after the first inhalation and appears to reduce the severity of, the disappearance of the allergic symptoms. If the background of an average therapeutic dosage to a patient does not become easier, it increased to 400 mcg per day. Multiplicity purpose funds does not change, increased single dose. As the relief should go to 200 mg / day.

Upon reaching the result (sick notes how the feeling of discomfort, burning, itching, swelling, nasal congestion with separating exudate) reduced dosage: Injection is performed 1 time per day in each nostril is performed at 50 micrograms per nostril.

If the patient has rhinitis seasonal current, the drug allowed for the prevention of 100-200 micrograms / day. Treatment is initiated in advance - for 2-4 weeks before the onset of allergies.

long-term studies have been conducted, which confirmed that even with the constant treatment with Nasonex at patients did not develop atrophy of the nasal mucosa, in assessing tissue preparations were reported clinical improvement picture. The duration of continuous treatment was 12 months.

During exacerbation of sinusitis

Nasonex is prescribed for the relief of symptoms of swelling and inflammation on the background of chronic sinusitis in the acute stage. It is approved for people from 12 years. The preparation is applied at an interval of 12 hours for primary treatment. Single application mometazola equal to 200 micrograms (2 injections into each nostril), a day the patient receives 400 micrograms.

When the patient stabilization of the drug given in a smaller amount. If the disease is severe course, permitted increase in the amount of hormone to 800 mg / day. Then the patient performs 4 inhalations per nostril in 1 reception, the multiplicity of purposes is left unchanged.

when adenoids

Some otolaryngologists prescribing Nasonex to counter hyperplasia nasopharyngeal tonsils, note positive effect of hormone spray on their size.

The drug is administered at a dosage preschoolers not more than 100 g / d., Once.

However, other ENT doctors are skeptical of such treatment and point to its ineffectiveness. The instructions to the adenoids as a medicament indication for missing.

Pregnancy and lactation

Nasonex, instruction manual which contains information about the extremely low bioavailability of the drug in the local use, should not have a negative impact on women's reproductive function and not to cause harm to the developing the fetus.

However, due to the ban of clinical studies involving children, pregnant and lactating women, the actual safety of the drug for these categories of patients have never been evaluated.

Therefore Nezoneks valid for use in these patients only if the anticipated benefits of the therapy will be much higher than the possible harm to the fetus or already born child.

Clinical pharmacologists, endocrinologists recommend to conduct a survey of adrenal function babies whose mothers were treated with the drug during pregnancy. Such attention to their health will help to identify possible depression glands on the background of a synthetic hormone drug woman.

children

Nasonex is approved for use in children aged two years, if they have allergic rhinitis has a severe course. Hormone administered 1 time per day for 1 inhalation in each nostril (100 g / d.).

Use of the human liver

Spray a small amount of biotransformation in the liver, but the instructions do not have any indication of dosage adjustment or cancellation of therapy because of comorbidities.

Contraindications

Hormonal spray Nazoneks banned for purpose of the following diseases / the special conditions of the organism:

• early childhood - up to 2 years;
• injury, the effects of surgical treatment of the nose - therapy to cancel restoring the integrity of tissues;
• nasopharyngeal site of infection involving the oral epithelium;
• hypersensitivity reaction of the means of components;
• severe systemic viral disease;
• tuberculosis regardless of the stage;
  
• clinical manifestations of herpes simplex virus types 1 and 2 involving the eyeball tissues.

Side effects

Undesirable effects in response to Nasonex at children and adults do not have basic differences.

In the treatment of allergic rhinitis spray hormone may cause:

• nasalbleedings different severity (the patient can notice the blood, mucus blood impurities);
• pharyngitis;
• pain in the nose;
• dryness and burning in the nose;
• sneezing immediately after inhalation.

In response to Nasonex in pediatric practice also recorded complaints of headaches. However, this symptom is rare, with the same frequency as on the background of a dummy drug.

During adjuvant therapy acute sinusitis, sinusitis patients such undesirable effects have been identified:

• nosebleeds;
• burning sensation in the nasal cavity;
• irritation of the nasal mucosa;
• pharyngitis.

By a very rare adverse effects include: perforation (disruption of) the nasal septum and the first discovered high intraocular pressure.

Overdose

It was registered episodes Nasonex overdose of the drug. Prolonged use of means for administration of general background corticosteroid preparations (tablets, injections) causes adrenal suppression operation due to long Incoming outside hormones. However, such an overdose occurs in connection with medicines that have an effect on the entire body.

Nasonex, instructions for which there is information about low bioavailability momentazona suspension does not cause symptoms of overdose when using. If a patient by accident or deliberately used drug in large quantities, the introduction of a specific antidote is not required. The patient must be monitored, followed by resumption of treatment in a designated dosage.

special instructions

Precautions when appointing Nasonex helps to avoid complications.

For specific guidelines during therapy include:

1. Periodic inspection consultation audiologist with the nose cavity during a long course to assess the state of the epithelium.
2. In the event of opportunistic infections in the nose and throat medicine cancel, appointed antifungals.
   
3. The simultaneous appointment of Nasonex and systemic corticosteroids - indication for evaluation of the adrenal glands over time. Cancel tablet formulations should be made gradually, against abrupt discontinuation of therapy may be signs of withdrawal.

Against the background of prolonged corticosteroid therapy may reduce local immunity. The patient must be treated carefully to his health and to contact the therapist if he suspects any secondary bacterial infections. They may indicate such symptoms in the eye swelling, redness, toothache, swelling of the face, fever.

drug interactions

Clinical studies to evaluate the interaction of Nasonex with other medicines have not been conducted. If necessary, a number of patients receiving treatment in combination with antiallergic loratadine (trade names -Klaritin, Lomilan, Erolin, Klarisens) with good tolerability.

Where can I buy

Medication Nasonex available in online and offline pharmacies by prescription. packing cost depends on the amount of drug in the package. Price bottles of 10 grams - from 480 rubles to 18 grams -. 790 rub.

Storage conditions

The drug can be stored in the refrigerator or in the room. Nazoneks maintains its properties at a temperature of from 2 to 24 0 C, freeze forbidden.

Safe storage requires no children access packaged spray.

Nasonex shelf life when stored - up to 3 years

analogs

analogs table:

drug Name	Structure	Application Notes	Efficiency mark	The cost of 1 package
Dezrinit (spray)	Mometazol (homologous preparation)	The main recommendations are no different from those for Nasonex. Perhaps the use of inhalation therapy for asthma.	Patients evaluated the drug to be sufficiently safe and effective.	From 345 rubles. 18 g (about 2 times less Nasonex)
Kestin tablets	Ebastine, H1-receptor blocker	Kestin appointed to deal with seasonal or perennial allergic rhinitis. Tablets administered orally. It is forbidden to treat: Children up to 12 years; women during lactation, pregnancy.	The drug is prescribed 1 time at night. It is effective within 24-48 hours from the start of reception. At constant doses for 3-4 days, the patient may begin to skip pills because Kestin continues to operate. It helps to get rid of nasal congestion, sneezing, and excessive separation of exudate.	About 500 rubles. 20 days of therapy
Sinoflurin spray	Fluticasone propionate (a synthetic glucocorticoid)	When the appointment of a local bioavailability is negligible, it is only effective in the inflammation. It is recommended for the treatment of allergic rhinitis and sinusitis, symptomatic therapy. Allowed to 4 years old, it is forbidden for women during pregnancy and lactation.	The effect occurs within 1 day after the first injection. The drug was well tolerated. Some patients reported a lower efficiency relative Nasonex	It costs about 310 rubles. 1 package
Sinupret - tablets and oral drops	Vegetable preparation consisting of 5 herbal components.	The drug is recommended for acute and chronic sinusitis. It improves the separation of secretion, reduces swelling and the formation of inflammatory exudate, helps prevent infection. The drug is banned for use in early childhood form of alcohol is not recommended for patients with chronic alcoholism. Sinkpret take courses no more than 2 weeks, the dosage is calculated according to patient age. Children under 6 years are Sinupret drops.	It has good portability. Decreases sinus pain, facilitates nasal breathing during the first 2 days at sinusitis. Sinupret against allergic rhinitis is not applicable.	The cost of the package 1 by means of 450 rubles.

What better Nasonex or Avamys?

Avamys - intranasal formulation, a basic substance in a spray - fluticasone. Qualitatively, it is no different from Fliksonaze, but in a single dose suspension contained 27.5 g of the corticosteroid hormone that allows convenient dosing his children 2 years of age. Suitability: Recommended for treatment of adenoids in preschoolers.

Feedback from children's ENT physicians is an effective and safe drug. Feature spray Avamys is in his annotations no information on the possible use for prevention. The cost of the package of 120 doses is about 650 rubles.

Nasonex or Fliksonaze ​​- which is better?

Fliksonaze ​​- hormonal spray for nasal application. The active substance - fluticasone. The spray is recommended for the fight against allergic rhinitis in young patients four years of age and adults. The advantages include rapid action - the effect of the application has been developing for over 2 hours, providing relief of symptoms of respiratory allergies at night.

Patients evaluated Flikosnaze as a more powerful and effective medicine, noting he consults in cases in which Nasonex may not solve the problem.

Specific shortcomings include Flikosnaze sweet taste and unpleasant synthetic smell, but patients say that it quickly disappears.

Bioavailability and concentration of active ingredient in both preparations is virtually the same, a systemic effect when administered in a therapeutic dosage impossible.

Nasonex advantages: the possibility of appointing the age of two, and no unpleasant taste and smell when inhaled makes this drug is preferred for use in children. Both drugs are in the same price category.

What better Nasonex or Nazarel?

Nazarel - a drug composition which has no basic differences from the slurry Fliksonaze. The difference between these drugs is that they are produced by different companies. Fliksonaze ​​produces GSK, Nazarel - Teva. These annotations to both funds are almost identical. Nazarela cost for the same amount of the drug to just below the 70-100 rubles per pack.

Some patients describe Nazarel as less effective in relation to the Nasonex, complaining of weak action, the lack of sense of smell in patients receiving. Others point out that the drug is strong enough, easy to carry, relief occurs within the first 2 days of treatment. The advantages include low cost means 1 bottle can be purchased for 300 rubles.

The drug Nasonex helps to cope with the symptoms of allergic rhinitis, relieves swelling and a feeling of fullness during exacerbation of sinusitis. According to the instructions, application is permitted, even in pediatric practice - at the age of 2 years. Spray does not have a systemic effect on the body and does not require dose adjustment in elderly patients.

Registration of the article: Lozinski Oleg

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