Human immunoglobulin E: normal overall, the rate of pregnancy, children, adults. A blood test, which means an increased level, causes and treatment

In humans via IgE immune system performs a protective function of the mucous membranes, skin and other parts of the body in contact with external environmental factors environment.

What is immunoglobulin E

According to the composition and structure of the antibody molecule is a separate type glycoproteins whose synthesis is enhanced by ingestion of infection of pathogenic microorganisms and helminth. In a healthy organism, this globular protein found in blood plasma in a small volume, and is an indicator of allergic diseases in humans.

Immunoglobulin E is one of the types of antibodies produced by the immune system to identify human and blocking propagation of different viruses, infections, harmful microbes and bacteria in the body. This kind of globular protein is produced in the submucosal tissues of the structural protein of the smooth muscle of blood plasma lymphocytes of group B.

It accumulates in the upper layers of the mucous membranes:

• respiratory tract;
• lungs;
• bronchi;
• adenoids;
• tonsils;
• gastrointestinal tract;
• integument.

Then, the resulting antibody molecules are attached to the walls of basophils molecules and move along with them through the lymphatic system for foci of infection in the instantly bind complexes of allergens and prevent progression disease.

Immunoglobulin E podvlasny properties attracted to the site of infection globulins other groups (A, G, M, D) to suppress virus protein, or a foreign substance, which causes an increase in temperature at the site of localization of pathogenic microorganisms.

In the absence of necessary medical procedures fever spreads to the whole body, as a result of the body's immune system response to the destruction of the virus or infection.

The role of immunoglobulin E in the body

IgE function in the body of an adult and a child is to protect all of the mucous membranes of the substances that provoke sensitization and allergic reactions.

In cases of penetration into the organism of foreign germs cells, immunoglobulin molecules bind with an antigen or allergen molecules than inhibit the growth and division harmful pathogens cells and gradually destroying them through increased release of serotonin and histamine neutralize toxic emissions and their metabolic decay.

The result - an allergic reaction to these highly active amino acids that trigger inflammatory processes on the site of infection.

Globulin protein molecules are actively involved in the destruction occurred infection and prevent subsequent infection of the body. IgE synthesis begins another 11 week fetal development, but the placental layer can not penetrate because of the high structure.

The high rate of immunoglobulin E Index in the analysis of umbilical cord fluid is a harbinger of the presence of atopic disease in the unborn child. As immunoglobulin E has antiparasitic action in the first 2 months of seeding gastrointestinal eggs of worms before they enter the larval state.

In the subsequent period of action antibodies parasites apply only to the area of ​​the intestine. Raising or lowering the IgE in the blood indicates a failure of the immune system and the availability of allergic diseases.

Norms of performance in children, adults, pregnancy

Norms IgE level indicators for different age groups differ not only in Depending on the age of the patient, but also the time of year, previous diseases or having allergies diseases. Immediately after the birth of a child IgE presence indicators are absent due to the weak development of the immune system.

With increasing age of the newborn immunoglobulin index increases rapidly.

In the spring, this figure (both adults and children) are always much higher, sometimes above normal. This is due to the abundant flowering, causing allergies and a low content of vitamins in the body. In the fall of the index of this type of antibody mostly minimum for each age category.

For the average rate is considered to be such indicators:

1.	Children	From 0 to 50 kE / l
2.	Teenagers	15 to 200 CFU / l
3.	Adults	From 20 to 100 CFU / l
4.	Elderly people	From 20 to 80-100 CFU / l
5.	Pregnant women	From 20 to 60-70 kV / l.

In the elderly index level of immunoglobulin E gradually decreases due to the weakening of the immune system.

Why appoint analysis on IgE?

Assay for IgE level is assigned to determine the ability of the organism's immune system to produce the desired group antibodies to various external stimuli, infectious agents, parasites and microorganisms for people with allergic disease.

They are as follows:

• bronchial asthma;
• allergic rhinitis;
• hives;
• dermatitis.

Doctors prescribe patients to test for IgE:

1. Determine the possibility of allergy in children whose parents suffer from such diseases.
2. Diagnostic development, operation and general condition of the patient's immune system.
3. Screening for the presence of intestinal parasites.
4. Testing results and efficiency of drugs used to treat allergic diseases.
5. Surveillance and monitoring of patients with immunodeficiency.
6. Diagnosis and selection of medicines for all varieties of allergic reactions in the body with similar signs and symptoms.

Such analysis facilitates accurate diagnosis and selection of products for the rapid and effective treatment of a particular disease.

Survey Preparation

Before any analysis of immunoglobulin E index should:

• Abandon the physical activities and sports for 3 days.
• Do not use alcohol, fried, fatty, salty and spicy food.
• Do not carry out chest X-rays, ultrasound, x-ray, physiotherapy and massage treatments.
• Stop taking drugs (except antihistaminic drugs) for 2 weeks before the test.
• Eat no later than 7-8 hr., To give a blood sample.
• Drinking water without a required amount of gas, the amount of its use is not limited.

Children under 5 years of age is recommended for 30 minutes. before drawing blood to give to drink boiled water for more accurate readings.

How to take a blood test?

Analysis of immunoglobulin E is carried out in the laboratory by studies of blood serum.

Rent in the morning on an empty stomach from the ulnar vein in adults and umbilical veins in young children, in the amount of 1 ml.

Which shows total immunoglobulin E?

Total IgE is determined by enzyme immunoassay research and identifies the number of antibodies in the blood unit in her serum, able to withstand the alien antigens.

In the healthy organism this index is at a minimum level, but in the presence of chronic diseases of allergic origin such as asthma, eczema, dermatitis and atopic diseases congenital need to conduct a further study on specific immunoglobulin E.

Normal total immunoglobulin E index does not mean that the level of other, specific antibodies are not elevated.

Abnormal antibodies in the index in terms of higher or lower indicates the disorder of the immune system and the development of allergic disease.

Which means a reduced content

Reduced levels of globulin protein E is reduced immunity due to myeloma blood or immunodeficiency. The body is not protected from external influence and allergic infectious agents, and operation of the immune system is weakened and does not synthesize protective antibodies.

The reason for this can be:

• substantial depletion of the body after serious illness;
• poor nutrition;
• anemia;
  
• malignant neoplasms;
• damage to plasma cells;
• HIV infection.

The reasons for raising

Increasing index immunoglobulin E represents growth in the body of allergic reactions, which may cause occurrence serve as external, internal stimuli or congenital atopic disease that can develop into extensive inflammatory processes.

The factors that cause increased synthesis of antibodies, can be:

• vegetable allergens (pollen, flowers fluff and odor);
• animal dander, feathers and down of birds;
• the smells of household chemicals, cosmetics and synthetic air fresheners;
• certain types of medicines;
• some foods;
• bronchial asthma;
• diseases of the blood and the nervous system;
• infections and viruses;
• skin diseases;
• inflammation of any mucosal tissue in the body;
• autoimmune diseases, destructive own immune system;
• the presence of worms and other parasites;
  
• the presence of transplanted organs;
• genetic pathology - immunoglobulin E syndrome.

The first index increased globulin protein indicates the propensity of the adult and the child's body to allergies.

When interpreting the analysis must take into account the time of year, during the formation of the immune system of the child and his age, elderly patients.

To which the doctor ask for deviations indicators

In the event of an immunoglobulin E level readings in a big way should consult an allergist to determine the cause of the violation. If the problem is disease specific organ, circulatory or nervous system, the doctor after extensive survey to send a specialist for subsequent consultation or treatment.

In the case of a significant decrease in the antibody index is necessary to address to the immunologist, as in this case, broken or missing feature is the immune system.

reduced level of treatment

Low rates IgE level require advanced survey and find out the exact reason for the failure of the immune system. In this case eliminates the need for the cause of the pathology, then the level of the amount of antibodies aligned itself.

In some cases, the doctor prescribes the appropriate dose injection of medical preparations containing immunoglobulin E, depending on the type of disease.

How to lower high levels of immunoglobulin E?

High immunoglobulin E index lower antihistamines and folk remedies, previously eliminating allergy caused by the reaction.

People with hereditary allergy, especially in the period of flowering plants, experts recommend taking in a small amount in the form of infusions or injections are allergens, which shows a significant reaction. From the diet is necessary to eliminate foods and beverages that cause allergies and increase the range of products, strengthens the immune system.

Drug treatment

In cases where it is impossible to completely remove allergens, doctors prescribe medication drugs, depending from the analysis results, the degree of allergy and causes disease in the form of tablets, injections, ointments and creams. The dosage and duration of treatment is determined by a specialist on an individual basis for each patient.

For this purpose preparations:

1.	Antihistamine tablets (injection)	Suprastin, Tavegil, Diazolin, cetirizine, loratadine, Zodak, Clemastine.	Reduce susceptibility to antigen receptors.
2.	Ointments, creams and gels	Bipanten, Radevit, Diprosalik, Fenistil, Eplan, Imacort.	Eliminate outdoor allergy symptoms.
3.	immunostimulants	Arbidol Amiksin.	Activate the action of the immune system.
4.	anthelmintic	Piperazine, pyrantel, Levamisole.	Neutralize and destroy worms and parasites.

We recommend the use of antiallergic ophthalmic and nasal drops, nasal sprays, and hormonal. Upon completion of the prescribed course of treatment is mandatory re-submission of analysis for monitoring the effectiveness of the drugs.

Folk remedies

For the treatment of allergies caused by the rise in the index of E antigen used recipes of traditional medicine, if the reactions are repeated periodically for obvious reasons. By popular recipes should be treated with care and begin treatment with small portions, so as not to worsen the condition. If the recipe is suitable for one person, it does not mean that it will help everyone.

The most common folk recipes:

1.	Eggshell + lemon juice.	Purified from the film shells 4 boiled eggs, 4-5 drops of lemon juice.	Eggshells dry in the oven, remove the foil, grind to a state of flour and mix with lemon juice.	Take 1 h. l. 3 r. per day for at least 1 month.
2.	Dandelion + mug.	1 tbsp. l. minced burdock root, 1 tbsp. l. chopped dandelion root.	The mixture roots pour 0.6 liters of water, brew 10-12 hr., Boiled for 10-12 min., For 15-20 minutes, and drain the cool.	Take 100 ml of 5 p. daily 2-3 months.
3.	Gathering herbs.	60 g Hypericum (sheet), 75 g of centaury (grass), 15 g of corn stigmas, 30 g of horsetail, 45 g of camomile (color), 60 g of rose hips (the fruits), 45 g of dandelion (root).	15 g of the ground mixture steamed 250 ml. boiling water for 5-6 hr., boil in a water bath, infuse 4-5h., drain the.	Drink a decoction for 3 hours during the day before eating. Take 4-5 months.

Strengthening immunity most acceptable way reduces the allergic reactions to external stimuli, reduces the rate and level of IgE antibodies to receptors cluster cells.

Immunoglobulin E is not amenable to such correcting means in the case of congenital or hereditary genetic deviations. In such situations need medical attention.

prevention

Prevention in the upward or downward deviations of antibodies is as much as possible and strengthen immunity of children and adults. Eating fruits and vegetables rich in vitamin C, a complete protein foods and natural juices and promotes the proper formation of the immune system in children.

Recommended tempering, exercise and physical work feasible.

Adults are recommended for the prevention of a healthy lifestyle, good nutrition, cleanliness, hygiene and personal baby. Exercise and proper rest have a positive effect on the stocks of forces in any organism.

If a hereditary predisposition to allergic diseases of the child, should be made aware of this your pediatrician and periodically do child analysis on IgE levels for the prevention and the prevention of disease, as well as at the slightest sign of allergic manifestations.

Advice of doctors to normalize rates

Doctors recommend to always check the level of globulin E under all forms of allergic reactions in the form of:

• skin rash, itching and redness;

• frequent rhinitis, bronchitis and tonsillitis;
• eczema and dermatitis;
• lacrimation;
• asphyxiation.

Experts consider the most effective treatment for complex methods of synthesis and tackle antibody concentration. Doctors do not recommend lowering the level of immunoglobulin E alone, and do extensive analysis to a specific globulin E.

This will reveal the strongest allergen causing irritation specific receptor, which causes increased antibody production and provide the ability to assign a preparation containing the necessary antibodies to neutralize excited receptor. The first step is to identify and neutralize the antigen itself, causing an allergic reaction.

Especially the diagnostic process is problematic for young children, in whom the immune system is still underdeveloped and emerging.

Allergy tests they are made with great caution and under a doctor's supervision. In children who are predisposed to allergies, it is necessary to constantly monitor the level of the group E antibodies and any violations of the indicators immediately contact a doctor.

A sufficient level of globulin protein provides the body with proper functioning of all organs and neglect the control of its presence within normal limits, both in children and adults is not necessary in order to avoid negative consequences for the health. Undiagnosed violation normalize always easier than to treat neglected diseases.

For protection against environmental influences immunoglobulin E in the body is important. Mucous membranes and human skin is constantly in contact with a large number of pathogenic viruses and microorganisms, to neutralize that only antibodies can generated this component of the immune system.

To maintain the necessary level of globulin in the blood can only be a healthy immune system, and this you must constantly monitor its condition and eliminate any irregularities and malfunctions of immunity.

Registration of the article: Lozinski Oleg

Video of immunoglobulin E

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