The formation of blood clots in blood vessels disrupts the internal organs, and can cause complications. To resolve this problem prescribers blood thinning. One such tool is pentoxifylline, indications and recommendations for the use of which is described in the article.
The content of the article:
- 1 Release form and composition
- 2 Drug action
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3 Indications
- 3.1 osteochondrosis
- 3.2 varicosity
- 3.3 Prostatitis
- 3.4 Stroke
- 3.5 Atherosclerosis
- 3.6 Diabetes
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4 Instructions for use
- 4.1 Instructions for use of the solution
- 5 Features of the application of the drug Pentoxifylline
- 6 Use during pregnancy
- 7 Interaction with other drugs
- 8 Possible side reactions
- 9 consequences of an overdose
- 10 Contraindications
- 11 analogs
- 12 The cost of the tablets and ampoules
- 13 Video of pentoxifylline
Release form and composition
Pentoxifylline prescribed to patients in various forms of release, depending on the complexity of the disease and the doctor's prescriptions.
| release Form | Structure |
| Tablets (white, small size, the shell dissolves rapidly in the stomach under the influence of gastric juice). |
The drug substance comprises the following active ingredients:
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| Pentoxifylline liquid for injection (manufactured in the form of glass ampoules 5 ml). | The following components are included in the composition of the injection:
|
Pentoxifylline, indications of which are directed at eliminating the disease by improvement of blood microcirculation, released in pharmacies by prescription only provision of primary care doctor.
Drug action
Pentoxifylline has the following effects on the human body:
- improving and restoring properties, ductility erythrocytes, which allows to improve the microcirculation of the blood vessels in soft tissue;
- increase platelet sensitivity;
- drug substance has the property to dilate blood vessels;
- positive inotropic effect on the properties of the blood vessels;
- increasing the amount of oxygen in the tissues and accelerate its spread throughout the body.
Pentoxifylline refers to antiplatelet agents
Pentokfitsillin means does not accumulate in plasma and tissues, is displayed via the kidneys during the day. Prolonged treatment may be derived naturally unchanged.
Indications
Pentoxifylline indications for use, which are assigned in the following cases:
- chronic blood vessel disease in which there is the deposition of cholesterol on the walls of reducing the speed of blood circulation;
- nephropathy;
- vasoconstriction in soft tissue damage;
- ocular vascular disease;
- reduced blood flow in patients suffering diabetes mellitus;
- asthma;
- gangrene;
- cerebrovascular accident;
- ischemic stroke;
- malfunction of the hearing;
- cholecystitis;
- muscle degeneration.
Also, the drug may be included in the combined therapy for the treatment of many different diseases.
osteochondrosis
Pentoxifylline drug in the treatment of osteoarthritis allows to relax the muscle tissue in the region of inflammation and saturate the cells with oxygen. the oxygen supply improves the regeneration of damaged cells and prevents inflammation.
The drug reduces the swelling of the skin and normalizes the movement of blood flow. To achieve a visible result in the treatment of substance is used as an injection, after which to store the result of therapy is necessary to use tablets.
varicosity
When the disease veins medicaments may be used which contain a substance composed of pentoxifylline. Effects of the drug can reduce the plasma viscosity.
Pentoxifylline improves drug penetration nutrients in blood vessels to improve their elasticity. Active substance blocks the formation of clots and inflammation. It is also a means used to remove harmful cholesterol deposits on the walls of blood vessels.
Prostatitis
The active component is pentoxifylline has little effect on widening coronary vessels, thereby reducing inflammation in the prostate area. Drug substance eliminates congestion and improves the penetration of therapeutic substances in complex therapy. Duration of treatment and dosage appointed doctor individually, depending on the degree of development of the disease.
Stroke
Use of the drug in stroke reduces cortical ischemic damage of the brain. With the drug improves blood circulation and reduces disease progression.
Due to expansion of blood vessels is eliminated the risk of blood clots, and oxygen in the required amount to the brain, which prevents cell death. Before starting treatment with the drug need to be screened to reduce the risk of adverse symptoms and complications.
Atherosclerosis
Pentoxifylline improves penetration of the medicinal ingredients in the vessel lumen, expanding them and dilutes the blood. Thereby reducing the deposition of cholesterol in blood vessels, as well as recovery of protein and lipid in the plasma exchange.
In the formation of blood clots increases the permeability of blood vessels to prevent the appearance of plaques, and because - thrombi. It reduces inflammation and oxygenates the cells to the natural process of regeneration of damaged sites.
Diabetes
At elevated blood sugar levels occurs the probability of formation of complex diseases, including blood vessel damage. Sugar violates the permeability of the blood and increases its density. Application Pentoxifylline dilates blood vessels and improves the heart muscle and prevents limb periphery.
Preparation improves blood clotting, prevents gangrene and dying cells of soft tissues. Pentoxifylline is applied for the treatment of angiopathy and hyperglycemia reduces the risk of diabetic complications such as retinopathy and nephropathy.
Instructions for use
Pentoxifylline is used 30 minutes after ingestion. The tablet is swallowed and washed down with plenty of water. The preparation used 3 times daily, 2 tablets (200 mg of active substance).
Duration of therapy is indicated for each person individually and depends on the type of disease. In complex cases, it can be administered 2 tablets (200 mg) to 4 times per day. In such cases, the patient should be under medical supervision throughout the treatment.
For patients with marked disruption of the functioning of liver and kidney organs, the dosage is reduced to 2 tablets per day.
Instructions for use of the solution
The agent can be administered intra or as a drip into a vein. The patient should be in a supine position. Drug substance for medicine droppers mixed with sodium chloride and slowly administered intravenously, the maximum daily dosage of the substance - less than 200 mg. Administration duration - 90 minutes.
For intraarterial administration is necessary to add 0.1 g in 20 ml of sodium chloride. Duration of treatment - no more than 10 procedures. If necessary, the doctor prescribes a gradual increase in dosage. The duration of administration of the substance is 10 minutes.
Features of the application of the drug Pentoxifylline
Pentoxifylline, indications suggest the use of medications for treatment of blood diseases vessels used with caution under reduced blood pressure, and when malfunction of organs heart.
The drug is given under the constant supervision of doctors to patients who suffer from reduced kidney function and in the treatment of insulin. During treatment, the drug the patient has to quit tobacco smoking, as this habit can reduce the therapeutic effect of the drug.
In the period of treatment is necessary to conduct regular blood tests in order to avoid the risk of aplastic anemia.
The dosage for each patient individually appointed, but the treatment is started with the lowest dose and gradually increased to the desired level. Not applicable drug substance in pediatrics.
When using the drug in the vial is necessary to shake the vial qualitatively, hand squeeze, turn the valve and enter the syringe needle. The vial positioned upright and recruit the necessary amount of drug.
Use during pregnancy
Pentoxifylline, indications of which are discussed in the article, during pregnancy are appointed individually for every woman. When using the agent occurs slight vasodilation, whereby the placenta is saturated with oxygen, which positively affects fetal development.
However, in a lot of the drug can provoke bleeding that leads to premature labor. Pentoxifylline may be administered in the absence of other treatments, the drug is applied in the form of tablets.
For women who suffer from pressure drops, the drug is not administered. In the first trimester the drug contraindicated.
Interaction with other drugs
The drug substance may be administered for complex treatment of patients, but it is necessary to consider some features of the interaction with other types of drugs:
- used with caution trambolitikami and together with other substances that increase the clotting process;
- when used in patients using insulin, may increase the action of the latter;
- Cimetidine increases side reactions by use Pentoxifylline;
- Ketorolac use with drugs can provoke the formation of bleeding and reduce blood pressure;
- Caution is recommended with heparin, as a last resort tends to increase the effect of Pentoxifylline;
- is not used in conjunction with drugs to lower blood pressure;
- not recommended to be used in conjunction with drugs that contain caffeine - may unduly impact on the nervous system.
Combined therapy with the drug substance selected and adjusted depending on the patient's condition. Self-consumption of medicines with pentoxifylline may lead to side effects and long-term treatment of their consequences.
Possible side reactions
Depending on the individual, various adverse symptoms may occur when the drug reception:
- dizziness, insomnia, headache;
- nausea, urge to vomiting, upset stomach;
- heart palpitations, heart pain, low blood pressure;
- allergic reaction;
- labored breathing;
- chest pain;
- lack of appetite;
- bleeding;
- impaired vision.
Pentoxifylline can cause adverse symptoms with non-compliance indication for use. Adverse symptoms disappear on their own after a few days, if the symptoms are increased, you must stop the treatment and consult a doctor.
consequences of an overdose
Pentoxifylline, which indications for use are described in detail in the instructions rarely causes overdose (in compliance with proper treatment).
Improper dosage substance or its independent assignment may promote the formation of the following symptoms:
- weakness;
- dizziness;
- nausea;
- loss of consciousness;
- bouts of shivering and sweating;
- Bleeding in the digestive tract;
- carved reduced pressure.
To eliminate the unpleasant symptoms of overdose should wash out the stomach and stop the treatment. Then contact a medical institution for prescribing that normalizes blood pressure and withdrawn from the toxic components of the organism.
Contraindications
The drug is not used in the following situations:
- individual sensitivity of the organism to the constituents of the formulation;
- low blood pressure;
- disruption of the heart organs;
- hemorrhage;
- the presence of disease in the digestive organs;
- pregnancy and breastfeeding;
- poor blood clotting;
- liver disease and kidney.
The drug substance is not used for patients under 18 for older people use Pentoxifylline allowed in a reduced dosage.
analogs
When the manifestation of adverse symptoms after the application must use Pentoxifylline analogs which have similar effects on the human body.
By analogues include:
- flowerpots - a drug composition contains an active component is pentoxifylline. The drug substance is produced in tablet form. The drug oxygenates the cells and accelerates regeneration of damaged areas.
- Latro - a drug, which is produced in the form of a solution for intravenous use. Tool allows the blood vessels to expand and accelerate blood circulation.
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Polfilin retard increases the flexibility of erythrocytes, thereby increasing the elasticity of blood vessels. It prevents the accumulation of blood clots and increases the level of penetration of useful components and oxygen in the soft tissue.
- trental It has a similar composition and applied with pentoxifylline at various diseases of the blood vessels. The drug causes few side reactions and is used for complex treatment of various diseases. It may be produced in tablet or liquid for injection.
- Pentilin - a drug, which is assigned to raise the blood microcirculation in the blood vessels, as well as for tissue oxygen saturation. It can be used in tablets and liquids for injection.
- agapurin - analogue pentoxifylline, has similar indications and precautions for use. The substance improves the circulation of blood flow and prevents clots.
Each type of drug may have individual adverse signs depending on the characteristics of the patient. Therefore, before starting medical therapy recommended to carefully study the instructions for use.
The cost of the tablets and ampoules
Pentoxifylline Cost of funds:
- in the form of tablets - 50 rubles;
- Injection - 40 rubles.
preparation cost depends on the manufacturer and place of location of the pharmacy.
Pentoxifylline, indications and recommendations for the use of which is considered in the article is used for a comprehensive approach in the treatment of various diseases. The dosage and duration of treatment is prescribed individually for each patient, self-consumption can lead to negative consequences.
Author: Rostriga Victoria
Registration of the article: Vladimir the Great
Video of pentoxifylline
About pentoxifylline and its effects:
