Cardiomagnil. Instructions for use. Price, reviews, analogues

With a significant risk of diseases of the cardiovascular system, and after consultation with the cardiologist often is an issue of the treatment drugs such purpose. After all, they have a lot of nuances due to the sharp nature of the impact on the body. One of them - Cardiomagnyl, with instructions for use which are encouraged to review in detail.

Description of the preparation

Cardiomagnyl - German quality preparation, which relates to antiagregatov group. Their functional characteristics is a decrease in adhesion (adhesion) to the elements of the blood vessel walls and as a consequence, the prevention of thrombus formation. The cost of medication varies depending on the country of origin and the dosage and averages from 110 to 360 rubles.

dosage form

To store the drug form used rigid packaging (glass) containing tablets covered with a thin, sparing the stomach, a film for oral administration.

There are 2 dosage:

• Heart-shaped tablets, the ratio of acetylsalicylic acid or magnesium in which 0.075 g and 0.015 g
  
• Elliptical shape of tablets with a bar in the middle containing 0.15 g of acetylsalicylic acid and 0.030 g magnesium hydroxide.

the drug

One tablet contains cardiomagnyl main components:

• Acetylsalicylic acid (ACK) in dozah75 or 150 mg - is a basic compound antiinflammatory agents. Nonsteroidal analgesic, has a strong analgesic properties. When certain symptoms removes heat. It inhibits the enzyme initiating the further process of forming a clot that causes antiplatelet properties.
• magnesium hydroxide (15.2 / 30.39 mg) - neutralizes gastric acid, thereby protecting the gastric mucosa against aggressive ASA. On the one hand, its value is more surfactants in the medication category. However, this does not diminish its practical purpose in medicine.

Additional components:

• ≈12 mg microcrystalline cellulose;
• potato and corn starch in content ≈ 12 mg;
• magnesium stearate ≈ 150 micrograms.

The components that make up the skin:

• glycol polymers;
• hydrating agents;
• talc.

In some cases, designate an adult

Overview of the drug and its functional features needed to study, as the direction of action of ASA - multi-vector, and the degree of influence on the body - is colossal.

For example:

• Prevention of pathologies in organs and vessels of the circulatory system in prone to these diseases in patients in whom the diagnosis of cholesterol level in excess of the norm, as well as obesity.
  
• Elevated blood pressure as a premise of heart and vascular diseases.
• In the event that at least one of the next of kin of 50 years suffered a myocardial infarction.
• Prevention of vascular occlusion due to the transferred operation on them.
• Prevention of blood clots after the secondary has a myocardial infarction and / or occurred on the background of unstable angina.
• During the recovery after a stroke, heart attack, vascular occlusion provoked.
• Violation of the blood supply to the myocardium, provoking the majority of known heart disease, artery disease (atherosclerosis).

Dosage and administration for adults

The following are indicative data, which must be agreed with the attending physician and compartmentalized specialists (cardiologists, cardiac and other).

They are as follows:

• used as the primary prevention of thrombosis, and cardiovascular disease (acute coronary syndrome amid myocardial infarction) patients with a risk factor for patients - recommended 75 mg / day (one tablet in the dosage).
  
• Prevention of thrombosis secondary - recommended 150mg / day (one tablet in the dosage) initially and then 75 mg / day.
• Ischemic disease in acute and chronic form - 150 mg / day initially and 75 mg / day maintenance dose. In acute myocardial infarction and the consequences of its complications are assigned higher daily doses cardiomagnyl - 150-450 mg. In such cases, you need to take the drug as soon as possible.
• Liver dysfunction - to achieve a positive effect by the application requires its dosage correction preparation. Constructive treatment in case of severe failure is impossible.
• Renal dysfunction - positive effect of treatment is achieved exclusively adjusted dosage formulation. In severe renal impairment the use of drugs not prescribed.

Tablets should be swallowed whole. If for any reason this is difficult, it is permissible grinding and dissolution in pure water.

Indications and dosage for children

Since the aggressive influence of salicylates can provoke the development of fatal diseases of the digestive tract and brain, then there are some indications.

They are:

• Cardiomagnil, instructions for use which are often suitable for people of advanced age, appointed only in extreme cases, when the alternative treatment is not possible, and the risk of life outweigh the risks to health.
• The dosage is established only after consultation with the pediatrician.
  
• The drug is strictly contraindicated in children under 15 years.

For pregnant women and during lactation

Prescribe medication based on the condition of the woman and / or fetus and the pregnancy:

• Minor dosage of the drug are relatively safe from 1 to 28 weeks of pregnancy.
• Contraindicated for women and fetus in the last trimester.
• Specific recommendations are prescribed during breast-feeding (see. Dosages below and applying conditions for pregnant and lactating).

Contraindications

The biological activity of the ACC is that its presence in the body triggers a chain of significant physiological processes that patients with pre-existing particularly hard to bear violations.

They are:

• Abrupt susceptibility to constitute the medicament, in particular to salicylates and other derivatives of salicylic acid;
• poor blood clotting, as a result, increased frequency of bleeding;
• violation of myocardial functions;
• hemorrhagic diathesis;
• aggravated form peptichnoy ulcers;
• allergic reactions (asthma), provoked by the action of NSAIDs, salicylates, or similar compounds, a history;
• acute liver dysfunction and / or kidney;
  
• dangerous combination with other drugs, e.g., methotrexate in a dosage above 15 mg / week with other drugs.

Precautionary measures

Pathological conditions listed below do not preclude the use cardiomagnyl.

However, a more careful and regular monitoring of deviations from the norm according to the main direction of the treatment in the following cases:

• The risk of hypersensitive responses of individual organs and systems (violation patency bronchi due to spasms or asthma attack) in patients with allergy to some patients drugs. This effect could provoke preparations of NSAIDs:
• analgesics;
• anti-inflammatory;
• antirheumatic drugs.
• The reason for the special control is the tendency to skin rashes (allergic dermatitis origin) and / or respiratory disease (nasal polyp, hay fever).
• Chronic gastrointestinal diseases. Ulcerative diseases along with a syndrome of gastrointestinal bleeding prolonged nature require thorough correction dosage formulation.
• Cardiovascular disease, including complications such as congestive heart failure, extensive surgery, and:
• sepsis;
• renal vascular pathology;
• hypovolemia;
• heavy bleeding.
• Hepatic and renal insufficiency. Salicylates can exacerbate vascular dysfunction kidney and liver.
• The deficit in the body, glucose-6-phosphate dehydrogenase reduces the duration of the existence of red blood cells and, as a consequence, the development of anemia.
• Tendency to gout. A minor dose of acetylsalicylic acid can reduce urea excretion from the body, leading to an aggravation of the disease.
  
• Routine is not recommended for surgical procedures of any complexity in the period taking the drug, since it is possible amplification (emergence) of bleeding resulting from inhibition of the aggregation of the ACK platelets.

Cardiomagnil (instructions for use for adults is written below) is associated with health risks only when pre-treatment is not a state / features of the body were taken into account.

An increase in temperature with SARS in children and adolescents is not a reason to use the drug without a medical examination.

In the case of administration of acetylsalicylic acid as an adjunct medicament in the treatment of bacterial diseases not there is a possibility of Reye's syndrome.

Doses and conditions of use for pregnant women and during lactation

Among other things angioprotectors action aimed at reducing the production of cyclooxygenase important biologically active substances. Among them - the prostaglandins, which play an important role throughout the entire period of gestation, and indirectly affect the susceptibility to pain signals.

Their depression will negatively affect in particular during pregnancy and fetal development. I-II trimester. Cardiomagnil, instructions for use which is studied in detail by the treating physician and the patient is assigned exclusively to a clinically justified cases.

For women in this period, the concentration of the drug must meet the minimum sufficient therapeutic effect, and reduced with respect to the rest of the treatment periods patients - include a short breaks.

III trimester, prostaglandin inhibition may affect the health of both mother and fetus:

• deterioration of blood supply to the heart of the fetus as a result of violations of myocardial contractility or dilatation of the right ventricle;
• the likelihood of developing renal dysfunction vessels;
• the likely increase in the duration of bleeding in women. Antiagregatny similar effect is possible even at low doses of the drug;
• inhibition of the contractile function of the uterus, which could negatively affect the labor.

acetylsalicylic acid decomposition products penetrate into breast milk already in trace amounts.

Studies have found no negative impact on cardiomagnyl infant health during the reception drug to the mother: to interrupt breast-feeding is not necessary. However, with potentially long-term treatment and high doses of the drug should stop breastfeeding in the early stages.

Overdose

Cardiomagnyl (user is required to study the application) causes toxicity in non-compliance with the rules of the application. The symptoms of intoxication may occur already at a dose exceeding 150 mg / kg body weight, for each individual indicators. Dangerous dose is 300 mg / kg for adults, in which sharply raises the question of saving the patient's life.

With the systematic poisoning of the body dose exceeding limits, the state becomes chronic:

• Moderate chronic intoxication. It occurs after repeated administration to a moderately high doses, for the most part with nonspecific symptoms. Diagnose them as possible during the careful observation of the dynamics of the patient's treatment.
• Chronic intoxication of average weight. As a result of the systematic use of the dosage exceeded cardiomagnyl disease becomes obvious character:
• headache, dizziness;
• sensorineural hearing loss;
• weakness;
• vomiting spasms;
• violation of thermoregulation of the body;
• shortness of breath;

  

• disturbance of acid-base balance.
• Acute intoxication. It is the result of a single application of unduly high doses of the drug. The hallmark signs of poisoning is a clear change of pH in the body. This is particularly pronounced in cases of poisoning in children. However, the severity can be set only when the test results are not only blood, as may slow absorption of the drug still in the stomach (due to accumulation of stones or not dissolving the shell pills).

Associated symptoms:

• hypotension;
• convulsions;
• irregular heartbeat;
• decrease in glucose concentration in the sketch;
• bleeding disorder;
• pulmonary edema;
• brain edema;
• encephalopathy;
• coma.

The most dangerous is the chronic poisoning as a result of the systematic accumulation of toxic substances in the body. This is especially true for children and the elderly.

Treatment:

1. Immediate gastric lavage, reception ehnterosorbentov inside (activated carbon, white carbon, polysorb, etc.).
   
2. After first aid requiring hospitalization for the purpose of controlling the level of salicylates in the body and the condition of the blood pH.
3. In acute intoxication effective elimination of weak acids by using an alkali diuresis. A cleansing the body of toxic metabolic products is carried out by dialysis. This procedure helps to restore the water-salt metabolism and boost the excretion of salicylates.

Side effects

Fairly lengthy list of side effects from taking cardiomagnyl due to its main active ingredient - ASA and has been based on studies of many common medicines, the effect of which is based on the properties ASK.

For example:

• Effects on the digestive system: sensation of pain during digestion and other symptoms of dyspepsia, gastralgia, pain above the navel (epigastric).
• inflammation of the digestive system;
• ulceration of the mucous membrane of the stomach with the potential threat of erosion development;
  
• gemoragii and perforation, which are the consequences of the initial inflammatory processes in the digestive tract.

Cardiomagnyl (user of the application for adults contains the above), unlike earlier products, it operates on the basis of the consolidated doublet ASA + Mg (OH) 2. However, despite the barrier function of the magnesium hydroxide in the formulation, its molarity when joining the chemical reaction with an acid (hydrochloric acid and salicylic) sometimes not sufficient to neutralize the medium stomach.

Consequently, there is a negative effect on the mucous membranes and inhibition of prostaglandin synthesis.

Negative factors may serve as the individual characteristics of the patient gastrointestinal tract (see. item Precautions when taking cardiomagnyl).

There is also the likelihood of (minor) violations of hepatic function:

• On the part of the circulatory system: It affects the action of ASA on platelet aggregation properties whose values ​​can fall to critical limits. In such cases, can be observed:
• perioperative gemmoragii;
• bruising;
  
• bleeding of the organs of the urogenital system;
• intensifies bleeding gums and mucosa of the nasal cavity;
• cerebral hemorrhage;
• gemmorragii - can be particularly dangerous because they subsequently develop anemia. Its main symptoms - pale skin, chronic fatigue syndrome, hypoperfusion.

The above effects are caused by the primary pharmacological effect of ASA - inhibition of prostanoid production, one function of which is to participate in blood coagulation.

Side effects:

• On the part of the excretory system: it leads to functional disability of the kidneys and the further development of severe renal insufficiency.
• Effects on the respiratory system: rhinitis, bronchospasm.
• Allergic reactions.
• CNS effects: tinnitus, vertigo.

How to take

Often times a day is not important for the drug, since it has a cumulative effect in the body, and the concentration of ASA varies only in the beginning, middle and end of treatment.

There is also an assumption that the rational for some patients taking the drug in the evening. Probably due to the fact that the risk of cardiovascular disease and exacerbation of symptoms increased in the second half of the day.

Features	Terms of admission
When violations liver	Considered individually on the basis of the relevant medical tests.
When violations kidney	Unambiguous contraindication to the patients with clearance rates less than 10ml / min. With milder forms - individually, after consultation with the doctor.

How long to take the drug, efficiency

The duration of administration of the drug depends on the patient's age, and delivered him to the diagnosis.

But there are a few recommendations:

• Cardiomagnyl as indicated in the instructions for use, excludes the simultaneous use of a number of drugs, therefore it is not necessary to use other means to increase its efficiency.
• For serious pathologies cardiovascular system drug administered in most cases for life. This is taking into account that the main contingent of the consumer make the elderly (older than 45 years) and there is a high probability of renewal / exacerbation of the disease state in further.
• When it comes to any preventive or restorative measures, the treatment is limited to courses for 10-30 days, with brief interruptions.
• In the appointment of long-term therapy should be periodically Kardiomagnilom donate blood on coagulation.

In a survey of real patients taking Cardiomagnyl from 2 years or more, it was found that the vector efficacy difficult to determine unambiguously. Some are skeptical, others it make life easier, while the third has provoked new health problems.

Interaction with other drugs

Combined reception cardiomagnyl with other medications can affect the body as neutral, and may provoke adverse reactions.

They are:

• methotrexate. Parallel with the reception of the ACK increases its hematological toxicity. Methotrexate intensity decreases excretion by the kidneys due antiinflammatory agents occurring in blood plasma (provided methotrexate at a dose of 15 mg / week).
  
• ACE inhibitors. Used in heart and kidney failure. In combination with ASA reduces their hypotensive effect on factors of high blood pressure, as well as the intensity of the filtering decreases in renal glomeruli.
• acetazolamide. At elevated levels provoke the diffusion in the tissue salicylates. Because of this adverse effect is set acetazolamide (lethargy, drowsiness, blurred reason) and ASA (vomiting, tachycardia).
• Probenecid, sulfinpyrazone. Simultaneous treatment with ASA promotes mutual decrease metabolism.
• Other drugs antiagregatnye (Clopidogrel, ticlopidine), along with ACK lead to mutual reinforcement antithrombotic effect.
• Admission anticoagulants in parallel with the drug requires close medical supervision as they can provoke bleeding.
• Application cardiomagnyl during the use of ibuprofen would be ineffective due to a reduction of inhibitory properties of ASA

Compatible with alcohol

The combination of ethanol and the ACC has a strong irritating effect on the gastric mucosa, which is magnified in their joint impact. This leads to the development of gastritis and peptic ulcer disease. In patients already suffering from diseases of the gastrointestinal tract parallel to taking the drug and alcohol is fraught with the development of ulcers and prolongation of bleeding in the case of deterioration.

Storage conditions

Maximum permissible storage temperature: + 25 ° C (at a place inaccessible to children). Shelf life - 3 years.

What can replace Cardiomagnyl analogues

Analogs of this drug is quite a lot. Some of them are different from cardiomagnyl cost, other active ingredients, others - producer.

Most popular analogues cardiomagnyl:

• aspirin cardio - dosage of 100 and 300 mg. Manufacturer Bayer Germany.
  
• Aspikor - dosage of 50 and 100 mg. Russia Vertex.
• thrombotic ACC - dosage of 100 mg per tablet. Antiseptic and antipyretic. Producer - Austria.
• Magnikor - Dosage similar Kardiomagnilu. Producer - Ukraine, Kyiv Vitamin Factory.
• Cardi ASA - dosage of 50 and 100 mg. Manufacturer - Russian Kanonfarma.
• Atsekardin - dosage of 100 mg. Producer - Ukraine Phytopharm.
• Atsekardol - 50 and 100 mg. Manufacturer - Russian synthesis.

A wide range of analogues allows you to continue treatment even if for some drug to the patient is not suitable reasons.

Application cardiomagnyl on the testimony may not only older, but also younger patients, pregnant women, and in very rare cases - children. Only taking into account the instructions for use is calculated the potential benefits of the drug at the time of consultation with a physician.

Registration of the article: Lozinski Oleg

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