Loratadine. Instructions for use (tablets, syrup). Price, reviews, analogues

Loratadine - medical drug commonly prescribed for those who suffer from allergies. It is indispensable in the fight with a lot of exhibits symptoms that bring discomfort and discomfort.

Effective drug complex: gradually reduces the level of allergen in the body and thereby helps to eliminate itching and swelling. According to the instructions, the use of means of allowing people of all ages.

Shape and composition of the drug release

Loratadine can be produced in one of two forms - as a tablet or syrup. Both tools have the same function. They are based on the same components in approximately the same proportions as additional substances that make up the drug may vary.

release Form	Appearance and packaging	Structure
Loratadine tablets	The tablets have a weight of 10 mg. One package may be 7 or 10 units immediately. Packaging is contoured and is made up of cells. For its production are used polyvinyl chloride and a thin aluminum foil. Tablets may also be sold in a bank made from polymers. In one such vessel is kept to 30 pcs., Found cans 10 th, 14 th and 20 th tablets.	Active ingredient is loratadine. The role of additional components are: corn starch; magnesium stearate; talc; sodium carboxymethyl starch; aerosil; microcrystalline cellulose; milk sugar.
Loratadine syrup	A syrup may be superficially similar to plain water, introducing a liquid with a colorless or yellowish white. Unlike conventional water it has a bland smell of fruit. Bottle Loratadine syrup may be a volume of 50 or 100 ml.	The main component of the syrup is loratadine. Of the additional ingredients are present: sodium benzoate; ethanol; rectified; propylene glycol; citric acid; sorbitol food; ordinary water; a substance that imparts a pleasant taste and aroma.

pharmacological properties

Loratadine is a tricyclic blocker peripheral H1 histamine receptors. If taken without exceeding the recommended dosage, it is not expected to have any sedation. Even among those who took the drug for a long time, we did not change the most important functions.

Loratadine has no effect on the activity of H2 histamine receptors, does not prevent the capture of norepinephrine and has no adverse effects on the heart and blood vessels. After applying the base material and other components of the drug is easily absorbed, and then break up, developing mainly in the desloratadine.

The drug has a long therapeutic effect, showing their antizudnye properties and is a good tool antiexudativ. This is an effective assistant in the fight against allergies and, if necessary, removal of spasm and swelling.

Pharmacodynamics and Pharmacokinetics

Loratadine - antihistamine drug that selectively blocks peripheral H1-histamine receptors. He is able to permanently provide anti-allergic effects. The effect begins after half an hour after administration. Its maximum point antihistaminic effect reaches about 10 hours after the drug has started to operate.

This effect lasts longer than 24 hours. Components of the preparation is not able to cross the blood-brain barrier and does not affect the central nervous system. In addition, it does not cause drowsiness and does not affect the speed of the flow of psychomotor reactions. Upon receiving loratadine not lengthened QT interval on the electrocardiogram.

Suction

Absorption of the drug components occurs at high speed. In fact, to its concentration in the blood reached a maximum, it takes less than 1.5 hours, and the active metabolite of the drug, called desloratadine, reaches a maximum concentration of 2-fold slower.

Slow down this process promotes the food if it would be used for both the drug intake. In this case, to achieve the maximum concentration required for 1 hour longer.

Maximum concentration varies from person to person and depends on the age and the state of health: The older the person, the greater the concentration of loratadine in his blood, whereas younger patients the maximum concentration is noticeably smaller.

Increases the concentration of the substance and those who have any problems with the kidneys or liver. In particular, the maximum concentration of loratadine increased in those who suffer from chronic renal failure, as well as those whose liver struck alcohol.

Distribution

The substance binds to the proteins contained in the blood of more than 95%. Identical and loratadine metabolite concentrations in blood are obtained 5 days after administration.

The substance does not pass through the blood-brain barrier.

Metabolism

Once in the liver, a substance converted into desloratadine, aided by cytochrome P450 isoenzyme 3A4 and cytochrome P450 isozyme 2D6, but not in such a great extent.
breeding

The excretion of these substances from the body involving the kidneys and bile. It takes a few hours. The minimum clearance between loratadine - 3 h then the maximum can reach 20 hours. On average, on excretion of the drug required 8.5 hours.

Desloratadine is displayed longer. The minimum output time - 9 hours, and a maximum - 90 hours. The average period of excretion of desloratadine - almost 30 hours. In elderly people, these numbers will be different. They have an average period of elimination of loratadine is 18 hours and the mean clearance of desloratadine - 17.5 hours.

For the period of excretion is influenced by such health problems as liver damage alcohol. Thus in patients with chronic renal failure disintegration period remains unchanged. If we carry out dialysis, then it does not affect the pharmacokinetics of the drug and its metabolites.

Indications

Loratadine, instructions for use which needs to be studied beforehand prescribed to those patients who suffer from allergic rhinitis. Moreover, it does not matter embodiment manifestations of this disease - seasonal or year-round.

Also, the drug is prescribed for:

• conjunctivitis;
• hay fever;
• urticaria (including chronic idiopathic);
• insect bites that cause any allergic reactions;
• pseudoallergic reactions that occur as a result of histamine release;
• itching dermatoses;
• angioedema.

Contraindications

Before you start taking the drug Loratadine should be familiar with its contraindications. Paramount concerns them increased sensitivity to the components of which it consists.

Should first study the composition of the drug, if it is found that it contains some a substance which the body can not tolerate and that causes allergic reactions, will have to abandon his application. Also, the drug should not be taken during lactation.

Loratadine can be given to children if their age is not less than 2 years, because among the members of the drug substance has alcohol. Pregnant women taking the drug is allowed, most importantly, take it gently. The same goes for those who suffer from liver failure.

for use Loratadine tablets and dosage instructions

Loratadine can often be present in the compiled lists doctors preparations intended for those patients who have allergic reactions are found. The drug acts on the body in complex: it reduces histamine levels in the plasma and attenuates expression of symptoms of allergic reactions.

Loratadine instructions for use requires patients to take the following rules:

1. Tablets coined by just before meals. When one tablet is compared with the same syrup preparation, it will correspond to 10 mg of liquid vehicle or 2nd hr. l.

2. The reception should be as follows:

• Adults and children who are over 12 liters and weight exceeding 30 kg, it is necessary to take 10 mg knock medicament (tablet 1). this treatment should last about 2 weeks, sometimes it is possible to finish after 10 days of systemic administration.
• If a child who prescribed treatment loratadine, not yet 12 years old and if its weight is less than 30 kg, the dose should be reduced by half: that is up to 5 mg per day. To do this, one tablet into two equal parts.

3. At the use of loratadine patient must give up the spirits. If you can not completely stop the use of alcoholic beverages, it should be reduced to a minimum. This will help avoid many of the side effects. Moreover, the effectiveness of treatment in this case will be the maximum.

In some cases, the doctor prescribes treatment with loratadine, taking into account individual circumstances. For example, the therapy can last for 1 day or take up to 1 month.

instructions for use and dosage Loratadine syrup Guide

Loratadine instruction on the application allows you to accept in the form of syrup according to the rules:

1. Apply the drug needed for 60 minutes before a meal. The dose depends on whether the human body has a mass: people who weigh more than 30 kg, it is necessary to take 10 mg syrup per day.
2. Patients with hepatic impairment should begin treatment with 5 mg. Should take a dose of 1 times a day, but then it can be gradually increased as required.
3. Children who are under 12 years of age, and whose body weight has not reached 30 kg, higher than the dose of 5 mg should not be. They enough 1 hour. l. syrup per day.

Side effects

After receiving loratadine has side effects, which in adults and children differ.

In adults, after taking the drug can be:

• anaphylaxis, including angiodema (something that has to do with immunity). This is the most serious side effect which may occur as a result of the drug;
• convulsions, dizziness, as a consequence of the negative impact on the central nervous system;
• tachycardia, palpitations - side effects associated with heart and blood vessels;
• nausea, dryness of the oral mucosa, sometimes gastritis - appear under the influence of the drug on the digestive system;
• rash andalopecia - the result of the negative impact of the drug on the skin.

The following displays are possible:

• headache;
• worsening liver;
• hypersomnia;
• excessive appetite.

Common disorders that may appear in the patient resulting from administration of the drug - a high fatigue. In children, side effects observed less. Often, after taking the drug the young patients complain that they have a headache. Perhaps a change in their behavior: the emergence of nervous irritability, or, conversely, sedation.

In conducting clinical trials in which children often attended all met the following side effects of this drug:

• Headache. This symptom is observed in more than 2.7% of young patients.
• Nervousness. This effect was less frequent, but not much. Its frequency - 2.3%.
• Fast fatiguability. This side symptoms are observed every hundredth child.

All of the above side effects occur only in rare cases. If you observe the correct dosage and in a timely manner to take the drug, they will be kept to a minimum.

Overdose

Overdose symptoms are related to the action antiholinegicheskomu this medicine. If a patient takes too many drugs, he first feels a headache. As an overdose patient becomes drowsy. Furthermore, excessive dosage adopted can cause tachycardia.

If it was accepted, and a large amount of the drug if the patient began to experience the above symptoms, you need to wash the stomach, take activated charcoal, as well as a symptomatic and supportive therapy. In this case, hemodialysis will have no positive effect. Just how effective is peritoneal dialysis, it is not known.

special instructions

Treatment based on pill or syrup Loratadine need to cancel, if you plan to carry out a skin test to allergens. It is desirable to do so no later than one week prior to the test.

All pregnant women the drug should be taken with caution. However, there is no established safe use of loratadine for women during this period, so its use the future mother is permissible only when it is clear that the use of the drug is greater than the potential risk to gestate child.

It is important to use caution when using the drug, and after the birth of a child, especially when feeding breast milk.

The basic substance, a part of the drug is released along with the mother's milk, so the woman before the start taking the drug should stop breastfeeding. If the termination is not possible, you have to give up taking the medicine.

During treatment with loratadine to be careful drivers of vehicles and those required to do work which requires high concentration of attention and speed of psychomotor reactions.

After all, one of the side effects of this drug is increased sleepiness, which is very dangerous when car driving and other activities that require attention and constant concentration.

In the future, the degree of restrictions on the use of loratadine is set individually for each person. About the impact that this drug can have on fertility is not known yet.

drug interactions

Loratadine if used together with other drugs, it will cause some effect. For example, drugs such as ketoconazole, erythromycin and cimetidine when receiving loratadine, together with increased levels of the latter in the blood. It does not appear to be any clinical manifestations, including ECG.

Loratadine has no effect on the impact of ethanol on the central nervous system.

analogs

Loratadine has an equivalent in composition and application instructions are similar.

The most common ones are:

• Alerik. Means the active substance, loratadine and additional components - starch pregelatinized, lactose, magnesium stearate, microcrystalline cellulose, silicon colloidal silica. Available in the form of tablets of 7 pcs. in a blister pack in a cardboard box.
• Klaristin. In its composition contains loratadine, and as optional components protrude magnesium stearate, corn starch. Available means in the form of convex on both sides of the white pills. It may also be in the form of a liquid syrup.
• Claritin. This drug, which may be tablets, or be in the form of a liquid syrup. As additional substances act sodium benzoate, propylene glycol, glycerine, water, sucrose, as well as a component giving a specific flavor.
• Lorizan. This medication can be produced in the form of tablets or gel. Its main active component is loratadine. Apart from it, are present in the drug carbomer, glycerin, 15% ammonia solution, 96% ethanol, water and formaldehyde.
• Lorizan syrup. Active ingredient of the drug - loratadine, of the extra present - glycerol, formaldehyde solution, 96% ethanol, purified water, 15% ammonia solution. It is produced in the form of a gel, is used orally and nasally (for the treatment of rhinitis).

Terms, conditions of sale and storage

Loratadine (instruction manual allows its self-administration) is available without prescription. Keep it may be for 2 years, but only in strict compliance with the conditions of storage.

It is important to observe three basic rules:

• Place, which houses the drug must be protected from light.
• The ambient temperature should not be below + 2 ° C and not exceed + 30 ° C.
• Keep the drug is necessary in places where children can not reach.

The drug, which will lie for more than 2 years to apply strictly forbidden.

Price of loratadine in different dosage forms in pharmacies of Moscow, St. Petersburg, regions

The average price of the drug loratadine drug in Russia at the present time does not exceed 300 rubles. However, in the study of prices in different regions of the country and even in different pharmacies of the same locality, slight variations can be noticed.

For example, in Moscow pharmacies situation is as follows:

• pharmacies "Aloe" package 10-mg tablets №30 can be purchased for 299 rubles .;
• the same packaging and the same price sold in the capital's pharmacies "Impulse";
• for 297 rubles. this package can be purchased at the pharmacy, "Heart of the City";
• in "Hope" pharmacy of these pills have a price 291 rubles .;
• in Pharmacy "MELISSA" drug can cost 289 rubles.

The price of the packaging in which only 10 tablets, usually does not exceed 200 rubles.

And in less than 150 rubles. you can buy the packaging in which 7 tablets:

• Internet pharmacy "Dialogue", workers who can deliver the goods to the buyers of the Moscow region, a 100 ml bottle of syrup Loratadine-Akrikhin can be bought for about 150 rubles .;
• the pharmacy "Trick" the same product the same price;
• the pharmacy "Samson-Pharma" is sold for 175 rubles.

A similar situation exists in the Northern capital with the prices.

Here in many pharmacies Loratadine syrup-Akrikhin can be purchased at a price that starts from 150 rubles, for example:

• Internet pharmacy "MEDTORG" 100-ml bottle of this tool is worth more than 175 rubles .;
• in «Wer» pharmacy is sold for 168 rubles .;
• in St. Petersburg "Nevis" pharmacy the price - almost 180 rub .;
• in «Apteka.ru» it costs 161 rubles .;
• in "Ozerki" pharmacy the price 166 rbl.

The cost of the drug loratadine, is available in the form of tablets in pharmacies of the northern capital, it varies from 10 to 300 rubles. The average for the region - 92 rubles. It all depends on the number of pieces in the package and from most pharmacies, where the drug is sold.

For example:

• packaging, in which only 10 pcs., can cost anywhere from 10 to 60 rub .;
• packing with 30 tablets Loratadine-Akrikhin costs about 150 rubles .;
• packaging Loratadine-Teva 30 pills sells for about 230 rubles.

In other regions of Russia the prices for tablets and loratadine syrup are about the same as in the two capitals. Everywhere the drug in the free market, more importantly, before using read the instruction on its application.

Registration of the article: Mila Friedan

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