NSAIDs. List of drugs: pills, injections, ointments, gels, suppositories. Classification, side effects, indications and contraindications. Prices and names of medicines

Preparations having both an analgesic, antipyretic and relieves inflammation effect, called NSAIDs. Pharmacological list includes tablets, injections and medicines for external use.

What are NSAIDs

Agents that have anti-inflammatory ability, reduced body temperature, reduce painful sensation, but not included in the group of corticosteroids are nonsteroidal anti-inflammatory drugs or NSAIDs.

These medications have properties similar in strength to hormonal anti-inflammatory drugs, but did not have such a list of side effects as steroids.

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Operating principle

NSAIDs group means showing blocking properties with respect to production of enzymes that are responsible for the pain in the body, allergic reactions, pyrexia.

Suppressing the activity of enzymes of the lipid, non-steroidal drugs inhibit the formation of inflammation in the body, as well as reduce pain perception.

Indications

NSAIDs (list of drugs in this group of drugs to date are very large) should normally be used at pathological conditions in the body, associated with inflammation, pain, as well as increasing temperature.

For example:

• autoimmune disease of the connective tissue with a lesion of the musculoskeletal system;
• long flowing pathology of cartilage and surrounding tissues;
• inflammatory disease of the vertebral joints;
• psoriasis lesions with bone joints;
• allergic condition affecting tissue, joints, Reiter's disease;
• changes in the joints due to accumulation of uric acid crystals;
• painful menstruation;
• neoplastic bone formation;
• spasmodic headache;
• post-operative state;
• pain during inflammation of the body;
• trauma;
• hyperthermia;
• hyperextension renal pelvis.

Classification

Nonsteroidal drugs in chemical structure and method of influence on the organism to be divided into two groups.

Compounds containing hydrogen;

• Salicylic acid. The mechanism of action lies in influencing the pituitary adrenal system and stimulation to develop adrenokortikosteroidov, which have anti-inflammatory and analgesic influence.
  
• pyrazolones - five-membered heterocyclic lactams, pyrazole derivatives having a keto group. Drugs in this group have an effect on the vascular wall, sealing them, thereby making them more durable and less brittle. Dull pain, exhibit antihistaminic effect, reduces the response of the organism to inflammatory stimulant, relieves spasms.
• Esters of glycolic acid. Have all the properties of NSAIDs - relieve fever and inflammation, pain relievers do not allow platelets to stick together. Medicines of this type have a negative effect on the lipid enzymes that trigger inflammation.
• Methylene group of phenylacetic acid. The drugs are based on anti-inflammatory, antipyretic and analgesic effect, due to reducing the effect of arachidonic acid enzyme that provokes pathological processes in body.
• oxicams - a new generation of drugs. It has a pronounced anti-inflammatory, hypothermic, analgesic effect. Less influence the production of substances involved in protecting the gastrointestinal tract and kidneys.
• Metiluksusnoy acid derivatives. The substance has a negative effect on the growth of bacteria, thereby exhibits anti-inflammatory activity.

Substances that do not contain acid:

• Alkanone derivatives. Drugs in this group have good anti-inflammatory activity, which is not an analgesic effect. Alkanones not have a binding effect on the lipid enzymes arachidonyl acid.
• Sulfa inhibitors. Medicines of this variety of NSAIDs do not associate the possible accumulation of neutrophils at the site of inflammation, making them inactive. It inhibits pathological effects. It does not affect the binding of platelets.

List of first-generation drugs

NSAIDs (list of drugs should be divided into several kinds) - drugs that have units for generations - the first and second (recent or contemporary).

The first generation includes:

• Acetylsalicylic acid;
  
• Anapran Es;
• Ibupreks Software;
• Dikloberl;
• Indomethacin.

A new generation of NSAIDs

To date, pharmacological industry is not standing still and there are several NSAIDs new generation or second.

For example:

• Melbek;
• Nimedar;
• Eksinef;
• Dilaksa.

What are the advantages of a new generation of NSAIDs

The second generation of non-hormonal agents reduces inflammation has a number of differences from the pioneers of NSAIDs.

These include:

• selective effect on the focus of inflammation and pain;
• less side effects of the digestive system;
• Rare cases of thrombocytopenia;
  
• the best activity in the pathological process in the organism;
• not adversely affect the cartilage.

List of common NSAIDs for the treatment of joints

For the treatment of articular pathologies must be applied systemically nonsteroidal second generation drugs - they have a selective effect and do not show significant side effects, like the first- generation.

1. Flogoksib-Health:

• Capsules includes coxibs anti-inflammatory agent;
• preparation of this group does not negatively affect on the shell in the gastrointestinal tract and the blood circulation in the urinary system;
• reduces inflammation in the affected bone joints without disturbing the cartilage, has a sufficiently strong blocking effect on pain receptors;
• the cost of the drug ranges from 180 rubles. to 200 rubles.

2. Algezikam:

• Tablets consist of no hormonal anti-inflammatory agent derived from the group oxicams;
• the drug acts on the lipid enzymes only in the field of inflammation without affecting the stomach and kidneys;
• drug has a pronounced anti-inflammatory effect in musculoskeletal pathologies;
• the price of pills in pharmacies from 280 rubles. to 330 rubles.

3. Nimedar pellets:

• the drug enters sulfanilamide inhibitor;
• active drug substance has a blocking action on lipid enzymes causing local swelling, inflammation and pain, and also inhibits platelet agglutination;
• pharmacological effect means the body is primarily antipyretic, reduce inflammation, and then the analgesic effect;
• the cost of drugs ranging from 280 rubles. to 310 rubles.

issuance

NSAID drugs have not only a large number of species.

Pharmaceutical industry manufactures a diverse list of dosage forms:

• for external use;
• tablet form;
• suppositories for rectal;
• gel-like substance for topical use;
• injection;
• syrups;
• eye drops;
• capsules;

  

• suspension.

Pills

One of the most popular forms of non-steroidal drugs - a tableted kind of drugs.

Asaf:

• medicine consists of salicylates;
• exhibits analgesic and antipyretic properties;
• the preparation is effective as the prevention of thrombus formation in the CNS, disturbances in blood circulation of the myocardium, as well as for the integrated treatment of ischemic heart disease. Assaf well established as a antipyretic;
• the cost of drugs ranging from 140 rubles. to 210 rubles.

Indomethacin retard:

• active ingredient - indoleacetic acid derivative;
• the drug exhibits analgesic and anti-inflammatory effect;
• It should be used for the treatment of pain symptoms in bones and muscles in pathological changes fractures and surgery, painful menstruation;
  
• the price of the pharmaceutical preparation in pharmacies: from 155 rubles. to 240 rubles.

Diclobru:

• in a preparation methylene group phenylacetic acid;
• This means the group has primarily antirheumatic effect, and also possesses antipyretic, anti-inflammatory and general analgesic activity;
• It exhibits a good effectiveness in the treatment of pathologies associated with joint problems in the body;
• the cost of the drug varies from 270 rubles. to 310 rubles.

ointments

Pathology of the musculoskeletal system in the treatment of NSAID should be treated for outdoor use.

Doloksen Fast:

• in an ointment includes methyl salicylate;
• preparation has a pronounced analgesic effect against pathologies of the musculoskeletal system of the body;
• You need to use externally with pain syndrome and inflammatory destructive changes in the affected bone joints and muscles;
• the price of the drug in the range from 195 rubles. to 240 rubles.

ketonal:

• basic ointments active substance - a propionic acid derivative;
• formulation exhibits good analgesic and antiinflammatory action;
• the drug should be used in injuries of bones, muscles and tendons;
  
• tool can be purchased at the price of 215 rubles. up to 250 rubles.

Phenylbutazone:

• formulation consists of pyrazole derivatives containing a keto group;
• Activity has at painful sensations in muscles and joints;
• It means well established in the treatment of burn disease - for small areas, in the therapy of pathologies of autoimmune etiology with painful musculoskeletal syndrome;
• the cost of the drug ranges from 260 rubles. to 290 rubles.

candles

NSAIDs (list of drugs includes as rectal means) - a group of anti-inflammatory drugs, which produces pharmaceutical industry in various forms and for the treatment of various pathologies.

One of the safest types of non-hormonal drugs in inflammatory pathologies - a candle. Application of this type of means has no direct effect on the liver (portal vein bypasses) and passes through the rectum vessels directly into the bloodstream.

Inflamin:

• main component of candles - a preparation from the group oxicams;
• medication belongs to a non-hormonal agents, reduces inflammation and rheumatic pains;
• rectal suppositories should be prescribed for the relief of pain associated with an autoimmune disease of the connective tissue with bone disease and muscle, as well as in gynecology;
  
• means the cost varies from 210 rubles. up to 250 rubles.

Dikloberl 50:

• suppositories consist of a methylene group phenylacetic acid;
• drug has sufficiently strong analgesic and antiinflammatory action;
• the drug is effective in many pathologies with pain and inflammatory symptoms in the body - from rheumatoid attacks to a toothache;
• price for rectal drug - 210 rubles. - 240 rubles.

Harofeh:

• drug substance comprises metiluksusnoy acid derivative;
• rectal means exhibits its activity against hyperthermia, pain associated with inflammation;
• the drug should be used in the heat, as well as the pain of moderate severity;
• the cost of the drug varies from 180 rubles. up to 250 rubles.

Gel

In the treatment of inflammatory pathologies with painful sensations nonsteroidal gels occupy one of the first places. They are easy to use, well-cropped pain, reduce inflammation, and do not leave a greasy film on the body.

Remisid:

• gel substance consists of a derivative of sulfanilamide series;
• formulation exhibits activity in painful sensation in the musculoskeletal system - morning syndrome stiffness, as well as reduces inflammation in the place of application, without affecting surrounding tissues;
• drug should be used in the combined treatment or as mono therapy for disorders of the joints with painful stiffness;
  
• medication costs in the range of 140 rubles. to 170 rubles.

Algozan:

• the main active ingredient of the drug - a methylene group of phenylacetic acid;
• a preparation for topical use in the composition has a horse chestnut and has a complex action on the body - with flushing removes damaged tissue injury or inflammation and joints. It has positive effects on venous insufficiency;
• gel to be used in different types of tissue damage, ligament and bone (not open), as well as degenerative pathologies of the musculoskeletal system;
• the price of the drug varies from 130 rubles. up to 160 rubles.

Valusal:

• the gel material includes a derivative of propionic acid;
• formulation exhibits sufficiently strong analgesic effect. Good reduces edema from the damaged tissue, which is triggered by an inflammatory process;
• agent must be used with at bruises sprains;
• the cost of drugs in the range - 245 rubles. - 260 rubles.

injections

NSAIDs (list of drugs includes injecting means) - hormonal medicines for relief of pain of different etiology, as well as inflammatory processes. Pharmaceutical industry produces nonsteroidal drugs in the form of injections.

Almiral:

• in the injectable solution includes a derivative of phenylacetic acid substance;
• medicine for potency can replace morphine means, showing very pronounced analgesic effect;
• injection should be administered under strong pain of various etiologies;
• the price of the drug from 400 rubles. to 500 rubles.

Ketalgin Long:

• Injecting drug substance consists of a derivative of acetic acid;
• drug has analgesic effect and reduces inflammation;
• means should be used for the relief of short-term time, postoperative pain, as well as rheumatic and gouty attacks;
  
• the cost of medicines for 250 rubles. to 280 rubles.

Dinastan:

• of the fine powder is included prodrug voldekoksib;
• the drug has a strong analgesic effect;
• injecting means to be used in the postoperative period in all pathologies and for the relief of cancer pain;
• the price of the drug varies from 2400 rubles. up to 2800 rubles.

Drops

The widespread use of non-steroidal agents found in ophthalmology.

Akuvayl:

• eye drops formulation consist of structurally related indomethacin;
• preparation has a pronounced anti-inflammatory and analgesic effect on the eye, especially in the postoperative period;
• the drug should be used after surgery to the eye for relief of unpleasant and painful sensations. And also in order not to give join secondary infection;
• means the cost to pharmacies from 790 rubles. to 850 rubles.

Diftal:

• the main active substance droplets - this preparation phenylacetic acid;
• the drug has a positive anti-inflammatory effects in the preoperative and postoperative period, and also has analgesic effects on the eyes in the post surgical period;
• drug should be used for the relief of pain in the organ of vision after cataract surgery, and as prevention of joining a secondary infection;
• the price of the medicine in the pharmacies from 158 rubles. to 215 rubles.

Indokollir:

• of the eye drops include indoleacetic acid derivative compound;
• the drug has a local anti-inflammatory and analgesic activity;
• apply the means necessary after surgical operations on the eye with the aim to stop the pain and prevent the penetration of infection;
• the cost of drugs ranging from 320 rubles. to 370 rubles.

application rules

Incorrect use non-hormonal anti-inflammatory drugs there is a high risk of side effects.

In order to avoid this, you must perform the following recommendations:

• NSAIDS drugs should be used only on prescription;
• before the use of any kind of medications should read the annotation to the drug;
• for systemic use of non-steroidal agents as protection should be applied preparations of proton pump to protect the stomach wall;
• always have to drink the medicine after meals and drink plenty of fluids;
• alcoholic drugs and NSAIDs are incompatible. At their joint use has been increasing adverse effects on the gastrointestinal tract and liver;
• tableted dosage form undesirably take a supine position;
  
• can not be used at the same time various types of non-steroidal anti-inflammatory drugs - this will increase the negative impact on the body.

What dosage to choose

As a rule, the amount of medication NSAIDs should be calculated from the initial weight of the patient. To 50 kg - 0.5 g. Generally a single dose of the drug should not be more than 0.1 g non-hormonal agents. Duration of therapy is always appoints doctor.

Use during pregnancy

NSAIDs group of drugs should not be used orally, rectally and injections during gestation pregnancy as well as lactation. For the relief of back pain, which often occur in women, there are many other means, is not able to provide adverse effects on fetal development.

From the research found that the use of non-hormonal anti-inflammatory drugs during gestation pregnancy adversely affects the fetus and can lead to the development of intrauterine pathologies.

Which drugs are best suited for children

In childhood, drugs NSAIDs can be used to reduce the high temperature, but not all. By permitted medications include drugs group-propionic acid derivatives.

Apply them to be in the form of suppositories, syrups, suspensions:

• Bofen suspension;
• Faspik granules;
• Harofeh candles;
• Ibufen syrup.

Prescribe nonsteroidal anti-inflammatory drugs can only pediatrician.

How to protect the stomach at a nonsteroidal drugs

Drugs NSAIDs group have varying degrees of negative impact on the digestive tract.

In order to protect the body from the negative effects of drugs need to fulfill certain conditions:

• drink tablets should only be after a meal;
• nesteroidy should use the shortest possible period of time;
• used only on a doctor's prescription;
• systemic use of anti-inflammatory drugs necessary in the treatment with the drugs proton pump.

Contraindications

Any medicine has pharmacological contraindications for use.

No exception, and non-steroidal agents:

• erosion and gastric ulcers;
• a history of allergic reactions;
• disruption of the duodenum;
• pathology gepatogilliarnoy system;
• severe renal insufficiency.

Side effects

The main side manifestations of NSAIDs include:

• urticaria;
  
• itching;
• anaphylaxis;
• indigestion;
• migraine;
• ulceration of the gastrointestinal tract.

consumer opinion

The instructions for using any variety of NSAIDs described many warnings. Despite this, according to the people (on the Internet), who take NSAIDs, drugs are paramount for relief of most of the negative processes in the body.

NSAIDs are serious drugs, which is very large list. But prescribers can only physician.

Registration of the article: Lozinski Oleg

Video of the NSAID drugs

3 rules for the safe use of NSAIDs: