Dostinex. Instructions for use for the termination of lactation, how to take the tablets. Reviews

Dostinex tablets prescribed to suppress lactation in the postpartum period, but that the drug did not cause harm, before starting therapy you need to carefully read the instructions for use, which is applied to each pack.
release Form

The medicament is discharged in the form of white, flat oval tablets. On one side there are letters «P» and «U», which are separated by the notch on the other - the number "700" and two dashes, arranged above and below the figures.

As the active component of the medicament comprises karbergolin, 1 tablet in its 0.5 mg. Except it, a part of tablets are indifferent ingredients, lactose and 2-amino-4-methylpentanoic acid.

Operating principle

Cabergoline relates to ergoline derivatives and a dopamine receptor agonist.

Once in the body substance:

• d2-activates dopamine receptors lactotropic cells localized in the adenohypophysis;
• It has a strong and long-lasting effect prolaktinsnizhayuschy;
• It has central dopaminergic effect when drinking medicament dosages greater than that required to reduce lactogenic hormone in the body;
• selectively operates does not change the production of hydrocortisone and other pituitary hormones, except mammotropina;
• It lowers blood pressure (not curative effect, dose-dependent and it is most pronounced in the first 6 hours after drug administration).

Indications

Dostinex, instructions for use which contains information on the purpose of the drug, is used to:

• notify the beginning of the milk post-partum;
• finish breastfeeding;
• the treatment of disorders caused by elevated levels of prolactin hormone in the blood, including the absence of menstruation and ovulation, oligomenorrhea, production of milk from the breast with a lactation unbound;
  
• prolactinoma therapy, idiopathic hyperprolactinemia, syndrome of "empty sella" is accompanied by a high content of mammotropina in the body.

Contraindications

Dostinex, on the application to which the instruction reported cases in which the drug is prohibited to appoint, not recommended if there is:

• intolerance to the drug composition;
• proliferation of connective tissue with the appearance of scars, causing any heart disease and lung, including a history;
• intolerance to milk sugar, lack of lactase, malabsorption of sugars;
• age under 16 years;
• hypersensitivity to ergot alkaloids.

Long can not take the medication if before starting therapy with echocardiography was confirmed by dysfunction of the heart valves.

With care treatment should be carried out, if a woman has identified the following pathologies:

• bleeding from the gastrointestinal tract;
• peptic ulcer disease;
• pronounced disorders of the liver;
• serious cardiovascular pathology;
• Raynaud's disease;
• pronounced psychotic disorders, memory problems, decreased mental performance and other cognitive functions, including those in the past;
• arterial hypertension, which appeared during gestation or after birth.

Due to the probability of occurrence of orthostatic collapse, Dostinex with caution should you drink with medicines that lower blood pressure. Due to the absence of controlled scientific tests, prescribe for women in the state can be when the benefit to the mother prevails over the harm to the fetus.

Upon the occurrence of conception during treatment with prolactin-reducing agent should resolve the question of the expediency of its further use. If treatment continues, the woman should be under constant supervision of a doctor because of the risk of increasing the size of the pituitary gland.

According to statistics, the treatment of hyperprolactinemia medicament in dosage is not increased to 2 mg per week the number of spontaneous abortions, premature birth, multiple pregnancy, and abnormalities in newborns.

The negative effects on the body

Dostinex, on the application to which the instruction warns of adverse reactions, can trigger unwanted body's response:

• hypotension, palpitations;
• fatigue, cephalalgia, dental pain, dizziness, weakness, impaired sensitivity, weakening of concentration, trouble sleeping, nervousness, anxiety, dizziness, fainting, depression;
• nausea, vomiting, gastralgia, abdominal pain, difficulty with bowel movements, gastritis, dryness and irritation in the mouth, indigestion, bloating;
• acne, itching;
• cramps in the calf muscles, arthralgia;
• cramps fingers vessels, bleeding from the nose, rush of blood to the head;
• passing partial loss of vision;
• refusal to eat;
• swelling;
• mammalgia;
• abnormal hair loss;
• impaired liver function, an increase in liver enzymes;
• decrease or weight gain;
• nasal congestion, gribopodobnoe state;
• mania, aggression, mental disorder, sudden bouts of sleep or gambling;
• dyspnea, respiratory insufficiency;

  

• increase in sexual desire and activity;
• pericarditis.

Efficiency of tablet

After oral administration, the medicament is rapidly absorbed from the digestive tract, the highest concentration in the bloodstream is observed after 30-240 min.

Reducing lactogenic hormone level in the blood observed after 3 hours after administration, tablets and kept low for 1-3 weeks in women with hyperprolactinemia and 2-3 weeks postpartum period. Prolaktinsnizhayuschy effect is characterized by a dose-dependent with regard to the strength and duration of action.

Food intake does not change the speed of adsorption and distribution of the active ingredient in the body.

After you have chosen the optimal treatment regimen hyperprolactinemia, once a month to check the amount of prolactin hormone. Normalization mammotropina observed in most women within 14-28 days.

Taking the drug at a mastitis

At occurrence of mastitis Dostinex prescribed in combination with antimicrobial agents, especially if the disease is the appearance of pus. The drug is taken to halt the production of milk, because it can enhance the severity of the pathological process.

Prescribed drug in the tablet case 0.5 (0, 25 mg) twice a day, 2 day course of therapy. Breastfeeding during therapy is interrupted, as there is no information whether the active substance is released from the milk, but it is known that it is stored in the body for up to 2-3 weeks.

How to drink tablets

Dostinex is necessary to take during a meal in the dosages prescribed in the instructions:

testimony	The dosage regimen
In order to prevent the secretion of milk	1 time on the first day after delivery at a dosage of 1 mg, which corresponds to 2 tablets
To complete breastfeeding	The medicament is drunk for half tablets twice a day, the reception rate 2 days, course dose of 1 mg
In pathological processes caused by high levels of the hormone prolactin	Dosage: The initial dosage of 0.5 mg per week, which can be mistaken for one time or divided into 2 doses (taken at half the tablets at the start and middle of the week). You need to increase the dosage to 1 tablet per month. Generally, therapeutic dosage is 1 mg per week, although it may vary from ½ up to 4 tablets per week. Top weekly dosage for women with hyperprolactinemia - 4.5 mg. Depending on the drug tolerance, the weekly dose is permitted to take time for 1 or drink in several stages. Share weekly dosage should be if it is more than 1 mg. If a woman has hypersensitivity to dopaminergic agents, then, to reduce the risk of adverse reactions, it is recommended to start taking medication with 0, 25 mg per week, gradually increasing it to therapeutic. If during therapy with any adverse reactions, is to reduce their severity, the dose may be temporarily reduced and then slowly improve, for example, on poltabletki every 14 days

Do I need to express milk after taking Dostinex

Dostineks suppresses prolactin production and reduces the quantity of milk, so normally the woman to express milk is not required. After receiving Dostinex need to express milk from the breast, if your breasts are swollen and sore. This can be done manually or by using a breast pump.

Express milk until the end is not necessary, the procedure is only carried out in order to get rid of engorgement and pain in the chest.

When severe pain before decanting can drink an anesthetic and put the breast under the warm water, or to carry out all manipulations in the shower. After the procedure is required to put a cold compress on the chest, which will slow down the production of milk.

Also, you need to express milk if the woman decided to interrupt the feeding only at the time of, for example, due to illness or taking medication incompatible with breastfeeding.

lactation Recovery

To restore lactation after taking Dostinex, you need to follow some rules:

• often take the child in his arms;
• to give the baby the breast when he cries, put the baby to her for the night;
• fully fed (should be present in the diet of meat and fish, dairy products);
• increase lactation walnuts, but the maximum recommended them to eat 3 pieces per day, as they can cause allergies;
• drink tea with milk, dairy products, fresh carrot juice, broth hips;
• melissa increase lactation and oregano;
• can not be used parsley, basil, mint;
• constantly express milk;
• You can drink medicines and supplements that increase lactation (Apilak, Mlekoin, Agnus-plus LaktoMama, Laktafitol herbal tea);
  
• the child does not give a bottle, or after it, he can not take the breast, it is necessary to feed with a cup, spoon or syringe.

As with other drugs, including in the ergot, Dostinex is required to use with caution. Instructions for use warns that the drug belongs to prescription drugs, so they self unacceptable.

Author of the article: Huseynov Natalia

Registration of the article: Lozinski Oleg

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