Orvirem for children. Instructions for use, syrup, price, reviews

Orvirem - is an antiviral drug that is created for the prevention and treatment of children aged from 1 year to 7 years. The manual, which comes bundled with the product, compiled a detailed diagram of taking the medicine, taking into account the number of complete years of the child, as well as its weight.

Orviremom therapy takes place in several stages with a daily dosage correction. Such therapeutic approach enables to suppress the activity of pathogenic microorganisms virus as soon as possible and restore the normal functioning of the immune system.

Medicament Orvirem has the following pharmacological properties:

• terminates transcription of influenza virus genome strain A and A2, making it impossible to continue the reproduction of microorganisms and the destruction of the child's body cells;
• It reduces the strain of influenza virus in toxicity, which provides a more gentle course of the disease with minimal risk of complications;
• It accelerates the process of healing in children who become ill SARS, reduces the time of the acute phase disease, and it makes symptoms less intense that positively affects the well-being the child;
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• It stimulates the protective functions of the immune system to more active resistance to viral microorganisms;
• It acts as an effective and safe means for the prevention of morbidity of influenza virus, SARS and the common cold after prolonged hypothermia.

Orvirem is a drug for children, in which the instructions indicated that this tool was created to countering influenza virus and mitigate its symptoms in children who have already been infected with pathogenic strains A, A2 and B.

Timely receipt Orvirema, which was launched in the first 5-7 hours after the onset of the first signs of the viral invasion, Accelerates the healing process in a 2-fold, and the disease occurs in the subacute phase. The body of the child is not suffering from a vast intoxication caused by viral microorganisms.

Structure

In Orvirem the medicinal preparation contains one active substance which has an antiviral effect, as well as complex auxiliary elements improving the pharmacological properties this tool. The table below contains information on ingredients Orvirema.

Name of substance	Properties of the main and subsidiary components of
rimantadine hydrochloride	It is the main active component of the drug, which violates the further multiplication of influenza virus and its pathogenic activity within the cell infection media. It can act as basic active ingredients for the treatment of SARS, influenza and common cold, as well as part of the integrated circuit during treatment of complicated forms of the disease. It can be used as a means for the prevention of morbidity of influenza virus during the epidemic outbreaks of disease among children They are in closed collectives and daily contact with each other (kindergartens, educational institutions, sports schools, boarding schools, lyceums).
Sugar	It belongs to the category of auxiliary substances Orvirema. The total proportion of sugar in the composition of a medicinal drug is not less than 60%. High concentrations of this component allows the medicament pleasant sweet taste, aftertaste suppresses drug prevents reflex emetic. This is especially important when treating young children who often refuse the drugs because of their odor or taste.
sodium alginate	This salt of alginic acid, which is used in the pharmaceutical industry as an auxiliary component is included in the medicines. Acts as a conduit basic substance Orvirema - rimantadine hydrochloride. Sodium alginate reduces its toxic properties, acts as a stabilizer acidity drug. As part of the drug can be displayed by the acronym E401. Completely safe antacid, which does not cause intoxication, does not violate the digestive function and does not affect the work of other organs and systems of a child.
E122	Excipient Orvirem drug, which is also known as the chemical component azorubin (karmuazin). It refers to a category of azo dyes on synthetic basis. It belongs to a coal tar derivative. It is used to inject the drug dark pink hue. The main purpose of the additive E122 - a staining liquid in red, burgundy and pink colors. The dye does not lose its properties after the heat treatment, and also has good light fastness, no precipitating after longer stay under a stream of direct sunlight.
Purified water	Specially prepared auxiliary substance which is cleared of extraneous chemical impurities. It provides the drug in liquid form, prevents crystallization of sugar-based drugs.

In what form is available

Orvirem for children, the instruction which contains detailed information about the properties of the drug is released in the form of a syrup dark pink color with sweet-bitter aftertaste.

This thick and viscous liquid, which is produced in glass vials made of glass of dark color and volume 100 ml. The drug is dressed in packaging of cardboard. In each such box complete with drug goes measuring spoon capacity of 5 ml.

Each 5 ml syrup Orvirem contains at least 10 mg of active substance - rimantadine hydrochloride.

This is an important indicator that is accounted for in the calculations and in the process of formation of the final dosage of the drug, which is adjusted individually for each child. It takes into account the age of the baby, the weight of his body and the number of active substances to be safe for the patient the respective age category.

Farmodinamika

Orvirem for children, the instruction which contains information on the procedure for receiving a drug intended for internal use. Once in the gastrointestinal tract, the active drug components are rapidly absorbed and penetrate into the bloodstream.

Together with blood rimantadine hydrochloride extend to all tissues and the internal organs of the body of the child. The maximum concentration of active substance in plasma is reached after 2 hours after taking the drug. The minimum time interval between reception of the next dose should be at least 4 hours.

Complete degradation of the active substance syrup - rimantadine hydrochloride takes place within 8 hours. About 80% of the components of drugs excreted by the kidneys in the urine. Half-life of the rest of the chemicals medicament occurs in the liver, followed by excretion with feces.

A distinctive feature of the preparation is that the active and auxiliary substances do not accumulate in the internal organs, performing the filtration function (kidney, liver), and do not impair their functional activity.

Pharmacokinetics

Orvirem for children, which guide displays the biochemical properties of medicinal ingredients syrup differs rapid therapeutic effect and cupping pathogenic viral activity microorganisms.

Rimantadine hydrochloride, which is the main component of the syrup Orvirem in combination with an adjuvant sodium alginate, prolonged circulating in the body of the child without premature collapse into components elements.

Rimantadine Hydrochloride released gradually dosed entering the cells and tissues of internal organs. Due sodium alginate improves drug pharmacokinetics, reduced toxicity basic substance, minimizes the likelihood of side effects of allergic reaction.

After hitting rimantadine hydrochloride in a cage, inside which penetrated the influenza virus is its gradual destruction. If he is still outside the intracellular space, the pathogen loses its ability to merge its shell membrane of the endosome.

Thus there is a blocking transfer of the genetic material inside the cell cytoplasm. Furthermore, rimantadine hydrochloride prevents the microorganisms from viral intracellular space.

There is a gradual decline in the population size of the virus from further destruction. In the case of reception of a medicament as a prophylactic agent, pathogenic microorganisms can not penetrate into the body tissue and die even at the stage of the incubation period.

application

Orvirem for children, which includes instruction reception standards of drugs prescribed for each individual child in need of comprehensive antiviral therapy. During treatment of SARS, colds, resulting from prolonged hypothermia or influenza A, A2, B, syrup taken inside after a meal, drinking plenty of water.

In this respect the following rules dosage of medication:

• child age from 1 year to 3 years - a 1-day therapy should take 2 hours. l. drug 3 times a day, the next day and 3 day 2 hours. l. Syrup 2 times per day, at day 4 for 2 hours. l. 1 times a day;
• child age 3 to 7 years - 1 day therapy should drink about 3 hours. l. Syrup 3 times a day, the next day and 3 for 3 hours. l. drug but already 2 times per day, at day 4 of treatment - 3 hours. l. medicine 1 time a day.

In cases where children daily visit places with large crowds, travel by public transport, go to kindergarten and school, there is a real threat of infection with influenza or SARS, Orvirem syrup is indicated for use as a prophylactic facilities.

In this situation it is necessary to adhere to the following scheme Hour:

• child age from 1 year to 3 years old to take 2 hours. l. the drug is not more than 1 time per day;
• child age 3 to 7 years old should drink about 3 hours. l. the drug 1 time per day.

The average duration of treatment and prevention of disease by influenza virus using Orvirem syrup is 10 to 15 days.

The duration of treatment depends on how the reception syrup was initiated in a timely manner, as well as the spread of the outbreak of a viral infection. The total daily dose of the active substance - rimantadine hydrochloride should not exceed 5 mg per 1 kg body weight of the child. Otherwise not excluded drug overdose.

Contraindications

In most cases, the syrup Orvirem well tolerated in children ages claimed that pass rate of influenza prevention or treated after infection with pathogenic microorganism.

In spite of this drug is contraindicated for reception children who are suffering from the following diseases and pathological conditions:

• liver disease, being in the acute stage, which are characterized by rapid or gradual destruction of its cells - hepatocytes (cirrhosis, viral hepatitis or intoxication, oncology);
• chronic or acute renal failure;
• All children under the age of 1 year;
• inclination of the organism to an allergic reaction to at least one of the main and auxiliary components syrup;
• lactation baby mother's milk;
• thyrotoxicosis thyroid tissue.

The drug with extreme caution administered to children who are exposed to the history of the diagnosis - epilepsy. Patients with diabetes mellitus during the reception of a syrup must be carefully controlled blood glucose level, because the drug contains 60% sugar concentration.

Overdose

In case of non compliance with drug dosing rules, use of a large amount of syrup possible overdose rimantadine hydrochloride, which exhibits the following symptoms:

• nausea, vomiting reflex occurrence;
• physical weakness, fatigue, drowsiness;
• short bowel disorder that is manifested by diarrhea;
• abdominal pain;
• skin yellowness (negative reaction liver when using large amounts of medicament);
• headache, decreased blood pressure.

When you see the child first signs of an overdose of syrup Orvirem, perform the following steps, aimed at the provision of first aid and emergency:

• call an ambulance;
• to give the child to drink as much as possible the amount of water that is naturally excretion of the drug active substances from the body;
• to try to cause a gag reflex, if the medication has been accepted for the last 10-15 min .;
• drink preparations child sorbents in the form of activated carbon (4-7 tablets), powder slurry prepared on the basis Atoxil (1 sachet, dissolved in 200 ml water) Enterosgelya (1 tbsp. l.).

After doing all of the above actions of the child must be put in a horizontal position, keep at rest, fresh air and wait for the arrival of doctors.

Side effects

The occurrence of side effects is unlikely. Clinical trials of the drug showed that the syrup Orvirem virtually no side properties. Their appearance is due to specific features of the body of the child, the presence of concomitant diseases of internal organs, individual intolerance medicament active components facilities.

In such a case, may cause such side reactions:

• nausea and vomiting attacks, which can appear as on an empty or on a full stomach;
• increased bloating and flatulence;
• a sense of acute epigastric pain;
• a complete lack of appetite and rapid weight loss;
• headaches, a sharp drop in blood pressure, dizziness;
• insomnia, nightmares and restless sleep syndrome;
• poor concentration, confusion;
• the appearance of a red rash and itching spots on the skin surface of the abdomen, as well as other parts of the body that is typical of an allergic reaction to the active and auxiliary substances Orvirem syrup;
• depression, mood swings.

When the above side reactions occurring after taking the drug, it is necessary to stop further Orviremom therapy. Then you need to show the child's pediatrician, so that it appreciated his state of health and appointed another antiviral agent with the other components of the substance.

drug interactions

There is no definitive contraindications reception syrup Orvirema with concurrent therapy with other drugs.

At the same time it must be remembered about the interaction of the drug with the active substance by the following means:

• simultaneous reception sorbents preparations astringent effect on rimantadine hydrochloride, which reduces the effectiveness of antiviral syrup;
• Acetazolamide, sodium hydrogencarbonate, and other medications that increase the acidity of urine syrup enhance the therapeutic effect and slow excretion its main component;
• Acetylsalicylic Acid, Paracetamol and reduce the therapeutic efficacy of rimantadine by 11%;
• Orvirema and combined use of drugs with antiepileptic effect, reduce the action of the latter, which entails the risk of seizures;
• Cimetidine reduces the effect of the active substance of syrup at 18%.

In that case, if there is an urgent need for child care with simultaneous reception of drugs, affecting the syrup effect, it is recommended to use medications not at one and the same time, and with an interval of 2-3 h. Otherwise, you may not get the expected therapeutic effect.

Conditions and terms

Orvirem syrup should be stored in a dark and cool place without direct sunlight. ambient air temperature may not be higher than 25 degrees Celsius. Otherwise, you can change the biochemical properties of the drug and the loss of its therapeutic value.

Bottle of medication all the time should be in the reach of children. If all of the above rules of storage of the drug have been complied with, it does not lose its medicinal properties for 3 years.

Conditions of supply of pharmacies

To purchase Orvirem syrup does not require a prescription from a pediatrician. It is sufficient that the child had a specialist examination, was the direction of the change required list analyzes found infecting a child with influenza virus or SARS and designated receiving the drug. Orvirem syrup can be purchased at retail pharmacies of the city.

The average cost of the bottle of 100 ml capacity is 370 rubles.

Reviews

Most parents who treated their children's drug Orvirem to accelerate their recovery from the flu or a syrup used for the prevention, positive about its therapeutic properties.

The drug is generally safe, has no effect of intoxication and thus inhibits the development of virus microorganisms, which is particularly important for fast recovery and eliminate the risk of complications that often occur in children younger age group.

Positive feedback about the drug Orvirem more due to the fact that the form of pharmacological medication in the form of a sweet syrup, makes it more convenient to use. Especially if we are talking about the treatment of children under the age of 4 years.

Treatment of very young patients using rimantadine tablets is practically impossible due to their very bitter taste and failure of children from their reception. Sweet syrup child always uses with pleasure, not capricious, and sometimes even asks additives.

analogs

There are drugs syrup Orvirem counterparts, as part of which contains exactly the same active substance, but available in other pharmaceutical forms and other manufacturers, namely:

• Rimantadine in tablets of 50 mg - Take 1 tablet 2 times a day is allowed for children therapy, age older than 7 years (the average cost of the drug - 96 rub.);
• rimantadine Aktitab - tablet formulation of the drug, which is manufactured by the pharmaceutical company "Obolensky" Russia (Take 1 tablet 2 times a day, is contraindicated in children younger than 7 years, and the average price per pack of 20 Table. is 99 rubles).;
• rimantadine Kids - syrup for the treatment of children who are not under the age of 1 year, the procedure, duration and dosage of reception similar to a drug Orvirem, released in retail pharmacy chains without a prescription (the cost of the drug - 230 rub.).

Orvirem syrup for children - an affordable and effective means for the treatment and prevention of disease influenza and SARS. The drug is available in convenient glass vials of capacity 100 ml.

It has special scoop, and is equipped with manual, which contains detailed information on the application and shelf life of the medicament. The medicament contains the minimum number of contraindications, side effects and is safe for sensing the child's body.

Useful video of Orvirem preparation for children and its effectiveness

Instructions for use of the drug Orvirem:

Indications for use: