Acne is a disease - a common problem faced by people of all ages, particularly skin inflammation often occur among adolescents. Isotretinoin is used to treat severe forms of acne when other methods do not already give results. During therapy, it is important to comply with the instructions for use, this will help avoid unintended consequences.
The content of the article:
- 1 Release form of the drug
- 2 Composition of tablets, ointments, gel, face
- 3 pharmachologic effect
- 4 Indications
- 5 Contraindications
- 6 Instructions for use Isotretinoin acne gel
- 7 How to use the ointment?
- 8 The dosage regimen and dosage tablets
- 9 Features of the application in pregnancy
- 10 Side effects
- 11 Interaction
- 12 special instructions
- 13 Overdose
- 14 Terms of sale and storage
- 15 Cheap and expensive counterparts
- 16 The price of the drug in drugstores of Moscow, St. Petersburg and the region
- 17 Reviews dermatologist about the effectiveness of agents
- 18 Video on Isotretinoin
Release form of the drug
Isotretinoin is available in several forms: the preparation for external application and the internal. For oral administration a tablet or capsule are provided with different dosages.
For topical product is manufactured in the form of:
- ointments;
- gel;
- solution.
Each form has a different dosage. In most cases, the tablets and capsules produced with a dosage of 10 or 20 mg of active substance. Except Aknekutan preparation, it quantity Isotretinoin may be either 8 mg or 16 mg.
This difference is caused by the fact that most Aknekutan soft and gentle preparation, it reduced the number of contraindications and possible side effects. An ointment is produced with a possible dosage 0, 1 or 0.05 of active ingredient. Ointment called retinoic. Topical retinoids are used in the 2-3 stage of acne.
A solution for external use is produced at a concentration of 0.25, a volume of 50 ml.
Gel for external use produced in a tube whose volume is 30 g. The gel contains additional active ingredients that increase the efficiency of the use of Isotretinoin.
Composition of tablets, ointments, gel, face
The active ingredient in each of the forms protrudes Isotretinoin. This component is active regardless of whether internal or external means. The gel for the face contains an additional component - Erythromycin. It increases the permeability of the components through the skin, improves efficiency and allows to achieve the desired results in a shorter time.
Additional substances differ in each of the forms described above issue, they are presented in the table:
| Pills | Ointment | Gel |
|
|
|
Virtually all tablets and capsules, the active substance which is Isotretinoin, have a similar composition. There are only minor differences. Texture ointment and gel significantly different from each other. Due to substances in the ointment, its texture is very dense and heavy.
It should be taken into account in long-term and frequent use for skin prone to inflammation. Incorrect application of face clogged pores that provoke the emergence of new inflammatory elements in the skin.
pharmachologic effect
Isotretinoin (user of the application provides a complete description of the pharmacological action of the drug) has a broad spectrum of action. Isotretinoin is considered a derivative of an element of Vitamin A. In their structure, there are some similarities, so during treatment Isotretinoin drugs prohibited supplementation of vitamin supplements containing vitamin A.
Due to the structural similarity of this can lead to an overdose.
Isotretinoin detailed mechanism of the effect on the skin and on the entire human body is not detected completely. It is believed that the positive effect achieved by suppressing the activity of the sebaceous glands and changes in the structure of sebum. Under the action of the substance the skin sebum changes its consistency, it becomes more liquid. That is why the skin pores are not clogged.
In addition, treatment with isotretinoin helps histological reduction in pore size. The excess of sebaceous secretion causes of inflammatory cells in the skin. Too dense sebum produced by the sebaceous glands in excess, leads to the formation of comedones.
Consequently, it appears on the skin acne various types, as well as closed comedones, called "black spots". Isotretinoin action aimed at the suppression of the process. Medicamentous preparations containing isotretinoin, contribute to the normalization of cell differentiation process. Consequently inhibited bacterial colonization of the sebaceous duct.
Isotretinoin for both internal and topical works in three ways:
- Means reduces the sebaceous glands in size. Excessive sebum increases the pore lumen is formed, wherein there is accumulation of sebum. Due to the normalization of the sebaceous glands is possible to get rid of not only inflammatory cells but also from enlarged pores.
- Komedonoliticheskoe action. The active substance is directed to the dissolution of substrate fat plug, which causes clogging of the pores. Due to this action possible to prevent the occurrence of new acne, as well as to eliminate the old ones.
- Reducing the thickness of the surface layer of the epidermis. This action only applies to external retinoids. The effect is caused by the fact that when applied topically Isotretinoin has a slight irritant effect. As a consequence, the stratum corneum begins to peel off gradually updated. Dead skin cells disappear, the pores open, so their therapeutic drug enters more effectively. When taken orally Ihotretinoina also observed desquamation of the skin, but this is caused by non-irritating action, and in that the epidermis becomes very dry.
Retinoic ointment on the basis of isotretinoin is indicated for the treatment of acne, eliminating skin aging. Since local Isotretinoin has a peeling effect, skin becomes clean, leveled her tone, the whole face looks healthy and uniform.
Isotretinoin also increases the fission rate of epidermal stem cells. This ensures that the skin begins to retain moisture better, it does not threaten dehydration. Gradually, existing wrinkles are filled from within, which significantly reduces the degree of severity.
Indications
Instructions for use involves the use Isotretinoin drug for the treatment of severe forms of acne, for the treatment of acne step 3-4.
Application at step 1-2 acne is not advisable, as the drug has many side effects for the whole body, for the treatment of mild forms of acne is better to give preference to an external means. Apply retinoids for topical application in mild stages of acne is not prohibited.
Additionally, isotretinoin is prescribed in the following cases:
- Seborrheic dermatitis type.
- Perioral dermatitis type.
- Rosacea.
- Subcutaneous mite (Demodex).
- The risk of nodulocystic scarring.
It is worth noting that Isotretinoin is for internal use may appoint a doctor.
Pre must ensure no contraindications to reception. This would require a blood test, as required diagnosis of hepatic parameters. Women before treatment must ensure that no pregnancy as Isotretinoin teratogenic.
Contraindications
Isotretinoin is an aggressive drug, so before starting treatment is very important to get acquainted with the instructions for use. This is particularly true of tablets and capsules for internal use.
Internal use Isotretinoin is contraindicated in the following cases:
- Individual intolerance and sensitivity to the composition of pharmaceutical remedies.
- The period of gestation and lactation.
- Planning for pregnancy.
- Severe kidney dysfunction, liver.
- The high concentration of vitamin A in the blood.
- The presence of malignant neoplasms.
- The high content of fat in the blood.
- The combination with antibiotics, tetracyclines.
Isotretinoin gently into use in the following conditions:
- Diabetes of any type.
- Frequent consumption of alcoholic beverages.
- Disturbances in lipid metabolism.
- Abnormally high body weight.
- Depressive and anxiety disorders.
Local retinoids are contraindicated during pregnancy and lactation, when taking tetracycline antibiotics, and should not be applied to places where compromised the integrity of the skin.
Instructions for use Isotretinoin acne gel
Isotretinoin in gel form dermatologists recommend the use of mild or moderate acne step.
The gel is applied in the following sequence of actions:
- Gently cleanse the skin of impurities and makeup. For purification should be used only sparing that do not contain corrosive components.
- Apply the drug on inflammatory elements in the skin, the gel layer must be thin. Remedy is applied locally on inflammation, as well as to the surrounding tissue. When light and medium stage there is no need to apply a remedy to the whole face entirely.
- The gel is applied 1-2 times a day. It is advisable to leave on all night.
- completely absorb you must give the gel into the skin. After tackiness disappear is allowed to apply cosmetics. Cosmetics have to be nekomedogennoy.
Duration of treatment dermatologist determines given pathological process step. The average duration is 2 months.
How to use the ointment?
Isotretinoin-based ointment is intended for topical application. Its use in mild to moderate stages of acne. In some cases, it may be assigned when severe acne as an adjunct.
Means applied to inflammatory elements, 2 times a day. Do not combine with decorative cosmetics, as an ointment has a peeling effect. Under the action of its thinner protective layer of the epidermis, which increases the likelihood of irritation and redness. In addition, the tonal foundations to increase the severity of flaking.
The average duration of treatment is 5-6 weeks. An ointment may be applied in single inflammations, must be applied locally. To eliminate wrinkles cream is recommended to apply 1 time a day every other day. In marked peeling to reduce the number of uses.
The dosage regimen and dosage tablets
Isotretinoin (instruction manual provides a detailed description of the treatment regimen) to be received in a strict dosage. But it is necessary to consider that the exact treatment regimen can be prescribed only dermatologist, having all the necessary diagnostic tests. The dosage depends on the age and weight of the patient, as well as the degree of acne.
The average dosage of 0.5 g per 1 kg of patient weight. In the absence of side effects of the dose is increased to 1 mg. Pills taken by mouth during eating. It is desirable to jointly take a small amount of oil, as Isotretinoin is a fat-soluble component.
The treatment regimen may be adjusted in the presence of side effects, as well as weaker expression of the therapeutic effect.
The result appears within 4-7 weeks of starting treatment. To achieve stable remission treatment was carried out for 4-6 months. The main objective when taking drugs based on Isotretinoin - dial cumulative dose for the entire period of treatment. On average, it is 120mg per 1 kg of body weight. Such calculations are not strictly recommended to yourself, as this should do the doctor.
When you start taking the capsules or tablets may increase the number of inflammatory cells, it does not require discontinuation of the drug and is considered absolutely normal. During exacerbation allowed to reduce the prescribed dosage.
Features of the application in pregnancy
Isotretinoin (instructions for use is strictly prohibited to take the drug internally or externally to use during pregnancy and lactation) It is used only when the pregnancy certainly can not be.
Since the drug is teratogenic, it is forbidden to women who want to become pregnant. Isotretinoin, in this case does not apply even in severe stage of acne. Internal use of drugs, the active ingredient of which is Isotretinoin, is a direct indication for abortion if the pregnancy occurred yet.
Side effects
The drug has many side effects that affect the entire body. All of them will be presented in the lower table in terms of frequency of occurrence.
| Often | Seldom |
|
|
At occurrence of any side effects should immediately consult with a specialist. When pronounced adverse drug reactions should be abolished completely. In all other cases, the side effects are almost always reversible.
Interaction
It is necessary to abandon receiving vitamin complexes containing vitamin A, since it will lead to the symptoms of an overdose. Prohibited taking means in conjunction with antibiotic tetracycline, as this entails increased intracranial pressure.
Do not take with hormonal therapy, in which a large dose of progesterone.
During treatment with Isotretinoin is necessary to abandon the consumption of alcoholic beverages, as they greatly increase the toxic effects on the body.
special instructions
Only physicians prescribe drugs for oral administration may be based on Isotretinoin who are familiar with the effect of systemic retinoids. To self-medicate it is strictly prohibited. During the course of the drug to the patient it is prohibited to donate blood.
During treatment it is necessary to closely monitor the condition of the body, regular blood tests to monitor liver performance. In order to reduce the peeling and skin irritation, it is recommended to additionally use with moisturizers nekomedogennym composition.
Overdose
In case of overdose observed symptoms of intoxication - nausea, vomiting, fever, headache and dizziness. It is also possible the emergence of symptoms of hypervitaminosis A. It may require gastric lavage, in severe cases, hospitalization is necessary.
Terms of sale and storage
Isotretinoin for internal use by prescription, external agents are commercially available. Keep recommended in dry and dark place that is not accessible to children. The temperature should not exceed 25 degrees. Open ointment should be stored in the refrigerator.
Cheap and expensive counterparts
Isotretinoin has many forms of release, the price at the same time strong enough range:
| drug Name | cost of |
| Roaccutane 10 mg Capsules | 2000 rubles. |
| Capsules 10mg erase | 1100 rub. |
| Capsules Aknekutan 8 mg | 1500 rubles. |
| retinoic ointment | 300 rubles. |
| Isotretinoin gel | 450 rubles. |
| The solution Isotretinoin | 320 rubles. |
| Isotretinoin 10 mg capsules | 1450 rubles. |
All analogues have a similar composition and an identical principle. The difference in their composition is not significant, it does not affect the outcome of treatment.
The price of the drug in drugstores of Moscow, St. Petersburg and the region
In addition, the cost depends on the sales region.
On the example of Roaccutane may notice a difference in the price:
| Moscow and Moscow Region | 2000 rubles. |
| St. Petersburg | 1800 rub. |
| Yaroslavskaya oblast | 1780 rubles. |
| Vologodskaya Oblast | 1900 rubles. |
| Krasnodar region | 2100 rubles. |
| Ryazan Oblast | 1650 rubles. |
Any form of drug may be purchased at the online pharmacy. Price depends on the dosage and form of medication.
Reviews dermatologist about the effectiveness of agents
Dermatologists point out that in order to achieve the best results it is important to choose the right treatment plan. This will help avoid unintended consequences.
Isotretinoin is the most effective treatment for acne, but it is very important to keep the instructions for use. It is effective even when other drugs do not bring the proper result.
Author of the article: Victoria Kolenova
Registration of the article: Lozinski Oleg
Video on Isotretinoin
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