Gol Dolobene - savior with bruises, sprains and other injuries

Soon winter and avoid falling and bruises simply will not succeed. To alleviate the pain, remove the bruise and reduce swelling of the tissues and joints will help Verified gel Dolobene.

The drug is a clear or slightly cloudy gel for external use. The color of the preparation is mostly colorless or slightly yellowish.

The main components of Doloben:

• sodium heparin;
• dexpanthenol;
• aqueous solution of dimethylsulfoxide.

The drug is available in tubes of 20, 50 and 100 grams.

Pharmacological effect

Dolobene cream ointment is a combined medicinal product that exhibits the following effects:

• anti-inflammatory is achieved due to the presence of dimexide, which affects inflammatory mediators;
• antiexudative - improves the permeability of capillaries, which contributes to the removal of excess fluid and reduce the swelling of tissues;
• analgesic - Dimexide affects the conductivity of nerve endings and reduces pain;
• antithrombotic -heparin has the properties of diluting blood and reducing hematomas;
• improves the regeneration of inflamed tissues - an active metabolite of dexpanthenol takes part in the regenerative processes that take place in inflammation sites.

Mechanism of action - it's all about the components

Dolobene is used only for outdoor applications. A wide range of gel action is provided by the presence of three main components in the composition:

1. Dimexide reduces inflammation, relieves edema and exhibits analgesic properties. Anti-inflammatory effect is achieved by reducing the activity of hydroxyl radicals, which are produced in large quantities in inflammation and have a destructive effect on tissues and organs. An analgesic effect is provided during a decrease in the speed passing through the peripheral neurons, pain impulses. Edema is removed by improving the subcutaneous metabolism reaction of inactivated hydroxyl radicals at the site of drug use. The antimicrobial properties of dimexide are associated with its hygroscopic properties. Due to this substance, which has the ability to penetrate through biological membranes in an amount of more than 50%, other components of the gel are delivered to the site of inflammation.
2. Heparin exhibits anti-inflammatory activity, helps accelerate the regenerative process in connective tissue. This is made possible by the inhibition of hyaluronidase activity. Also, heparin has an antithrombotic effect, which occurs due to inhibition of antithrombin activity 3. The possibility of heparin entering the focus of inflammation through healthy skin depends on the dose of the substance used and starts at 300 IU / g.
3. Dexpanthenol when applied to the skin initiates the transformation process and forms pantothenic acid( one of the B vitamins).This acid, being a component of coenzyme A, takes part in various tissue processes. It also helps the skin to restore its integrity faster by stimulating the processes of granulation and epithelialization.

Pharmacokinetics ointment

During the use of dimethylsulfoxide in a dose of 3 grams per day, divided into 3 doses, for 5 consecutive days, the average values ​​of its content on the skin are at the level of 3 mg / g, and in the blood plasma is 0.5 mcg / g.

When applied to the skin, heparin is absorbed minimally, but dexpanthenol is adsorbed much better, which is confirmed in the course of the experiments.

A quarter of the total dimethyl sulphoxide that is absorbed is excreted in a day, and from 37% to 48% is excreted by the kidneys during the week in the form of dimethyl sulfone( metabolite).

Also up to 6% of this component is metabolized to form dimethyl sulphide, which is removed by lung after 6-12 hours from the time the gel is applied to the skin.

Scope of application

Dolobene has a very wide range of indications for use, so when and from what the ointment helps:

• sports injuries , with the appearance of bruising, bruising, violation of the integrity of muscles and joints;
• tendonitis ( inflammation in the tendons);
• tenosynovitis ( inflammation that is localized in the tendon sheath);
• ligamentum ( inflammation in the ligaments);
• bursitis ( inflammation that occurs in the joint bag);
• aponeurosis ;
• fasciitis ( inflammation in the plantar fascia);
• acute neurological pain ;
• thrombophlebitis ( venous inflammation and obstruction);
• phlebitis ( pathological inflammatory process in the vein wall);
• periphlebitis ( inflammation of the tissues that surround the vein);
• varicose ( enlarged lumen of the veins, under which the walls protrude);
• trophism disorder with varices ( tissue nutrition).

Contraindications to prescription

To prohibit the use of Dolobene gel there are such diseases and conditions:

• disorders in the functioning of the liver and kidneys;
• angina in severe form;
• presence of stroke or myocardial infarction;
• atherosclerosis;
• bronchial asthma;
• allergic reactions to the active ingredients of the drug.

Instruction for use

The gel Dolobene must be squeezed out of the tube onto the affected area by a column of at least 3 cm and evenly distributed on the joint or skin area. To rub the preparation you need soft, not pressing movements from 2 to 4 times a day.

When using Dolobene ointment under the bandage, follow the following instructions:

• apply the gel on the skin;
• , wait a few minutes to evaporate the alcohol that is contained in the composition and absorb the bulk of the gel;
• cover the sore spot with breathable dressings( bandage or gauze);
• , fix the bandage with an elastic bandage.

Important features of safe therapy

Our recommendations for practical application Dolobene:

1. From the skin before the application of the gel, it is necessary to remove the remnants of other drugs and possible contaminants.
2. Do not use ointment on the skin where there are wounds and scars. It is also necessary to refrain from using the drug on the mucous membranes, in the presence of dermatitis, dermatosis or other skin diseases.
3. During the use of the gel it is forbidden to sunbathe in tanning beds and in the sun. During this period, the reaction of the photosensitivity of the skin can develop.
4. It is not allowed to combine the ointment with other medicines in the form of gels and ointments due to the high absorption properties of dimethylsulfoxide.

The gel is also used for such procedures:

1. Ionophoresis is a method in which a drug enters the body under the influence of a constant electric current of low frequencies. Dolobene is applied to the cathode( +), because heparin, which is part of the gel, has the properties of anion( -).
2. Phonophoresis is an ultrasound method of transdermal drug delivery. The drug is applied to the skin, and a special apparatus carries the gel into the focus of inflammation. With the help of a medicinal product, the action of ultrasonic waves is enhanced.

Application in pregnancy and lactation

Clinical studies on the influence of Doloben on the fetus during pregnancy have not been conducted.

Therefore, due to the lack of sufficient data on the safety of the facility, it is forbidden to use it at this time.

Dimethyl sulfoxide falls into breast milk, so you can prescribe gel during lactation only after the baby has completely stopped feeding.

Application for the treatment of children

It is not recommended to use Dolobene gel for children under 5 years due to the lack of sufficient data on its safety in pediatric practice.

Possible adverse reactions

Since Dolobene is intended for external use, no cases of overdose have been reported to date.

In most cases, the use of the drug does not bring unpleasant sensations, but the development of such manifestations is possible:

• of transient erythema;
• itching and burning at the site of ointment application;
• odor from the mouth, which resembles garlic( caused by the presence of dimexide in the formulation);
• partial taste change;
• Quincke edema;
• difficulty breathing.

If the last two symptoms occur, you should immediately seek help from a medical institution.

Experienced that. ..

Gel Dolobene enjoys trust among doctors and increased demand among the population, which is confirmed by numerous reviews.

Pair of commercials on the topic:

Conclusions from the practical experience of using

Benefits of ointment:

• pleasant odor;
• leaves no residue on clothes;
• is rapidly absorbed;
• a wide range of applications;
• speed of action;
• efficiency;
• three different in volume tube allow all patients, regardless of their wealth, to purchase and undergo treatment with this drug.

Minus one ointment - Dolobene does not include anesthetic components in the form of NSAIDs, which causes the patient to use additional tablets in case of severe pain syndrome.

Price issue

Price of gel Dolobene depending on the volume of the tube:

• 20.0 grams 135- 150 rubles;
• 50.0 grams 280-360 rubles;
• 100.0 grams 404- 470 rubles per packing.

Shelf life 3 years from the date of release when stored at a temperature of no higher than 25o C in a dark place and out of reach of children.

The gel is on the list of OTC medicines, so the doctor's prescription for the drug is not needed.