Blood along with the Rh factor are genetic parameters generated during embryonic development. They are not subject to self-change. At the same time, there are guesses that my blood group in humans throughout life, during pregnancy or after the transfusion. Medical experts say that this is a wrong assumption. But people continue to prove the opposite. Generate theory isolated cases of false results of laboratory tests on the group affiliation.
Can change
Genetics, the question may change the Rh factor in their lifetime, answer in the negative. For other blood parameter is inherited, there are discussions. In rare cases, under the influence of aggressive factors may change blood and broken coincidence laboratory data when interpreting studies. This unusual phenomenon is due to mild red blood cells such as alpha and beta, responsible for defining group membership.
Get false results possible under atypical conditions: on the background of progressive diseases or pregnancy. In men, such cases are rare. Hormonal disruptions and pathological processes blur the picture of the research and the methods used may not reveal the true data. It is important to remember that genetic parameters in such cases are not subject to change, regardless of gender and age of the patient.
by transfusion
The change in blood flow of life even after transfusion is impossible, due to the location or absence on the surface of red blood cells A and B. The specific antigens For their formation are responsible genes are inherited. In healthy people, can not change the parameters of blood - Rh factor, group antigens and produced - due to the individual structure of DNA.
In the presence of pathological processes that affect the bone marrow and immune system, may change the Rhesus blood transfusion. This risk is also possible in 12% of cases of transplantation spleen, bone marrow and liver, are responsible for the formation and utilization of erythrocytes. Rh factor is changed due to a malfunction in the immune system. Organ transplant or bone marrow destruction of immune cells is updated and may no longer attack the antigens that carry information about the other Rh.
during pregnancy
In women, in rare cases, during pregnancy can change blood type. During gestation the fetus is increased bone marrow blood, red blood cell count increases. As a result, it decreases the level of agglutination that are needed for red blood cell connections.
Proteins that characterize the group identity, it becomes difficult to determine. Therefore, according to the results of laboratory tests change group II, III, IV type can for I. It is important to remember that, in practice, indicators have not changed, and the patient receives false data analysis due to the individual characteristics of the structure of red blood cells.
If the parents have different Rh factor, the Rhesus-conflict may arise during embryonic development between the organism of mother and child. Therefore, it is possible that the parameter of the fetus will change from positive to negative.
Why might change
Set group membership can by gluing erythrocytes. Poured on a sterile glass a small amount of serum containing antibodies or agglutinins - A and B, α and β. After this reagent was added a sample of blood, the volume of which should be 10 times less than the amount of serum. For erythrocyte agglutination reaction was observed within 5 minutes under the microscope. As a result, you can identify the blood type:
- lack of adhesion talks about Group I, in which antibodies to red blood cells are completely absent;
- in the presence of a positive reaction with agglutinins A and α + β is determined II group;
- a combination of B and α + β type III suggests;
- α + β absence and presence of antibodies A and B indicate the IV form.
Change of blood groups is possible only due to the weak form of bone marrow red cell production or absence of antigens. If the group membership changes, the phenomenon indicates the presence of pathological processes, including:
- cancer, leukemia, gematosarkoma;
- Cooley anemia and other diseases of hematopoiesis;
- infection affecting the bone marrow;
- pregnancy and pathological conditions characterized by an increased synthesis of red blood cells.
In such situations, laboratory methods can not determine the type of agglutination. Therefore, when interpreting the results of measure blood for a short time can be changed on the wrong. This does not mean a complete change of group membership.
For some infectious diseases, pathogens begin to synthesize bacterial enzymes, transforming agglutinin A structure similar to antigen B. As a result, change the volume of the proteins, which is defined and Rh blood group. This phenomenon leads to a false interpretation of the results.
In clinical practice, it recorded a single case in Australia, where both have exchanged genetic indicators. After liver transplantation, the patient changed the parameters of the immune system.
Error in determining performance
In 95-97% of cases a group or Rh blood varies due to errors made during laboratory testing. Among them are the following:
- violation of the principles of the fence and transporting the material;
- incorrect introduction serum sample;
- incorrect determination of blood group using enzymatic methods;
- Use overdue material or reagents;
- incorrect decryption analysis.
In other cases, except for the transplantation of immune organs, possibly causing false data due to weak concentration agglutinogens. The results can vary due to oncological pathologies, diseases of the hematopoietic and cardiovascular systems, pregnancy.
