Metformin or Glucophage: which is better, and what is the difference, comparison, compatibility

Overall comparison Medicine

And Glucophage and Metformin belongs to formulations containing metformin. Both hypoglycemic agent is made in the form of conventional oral tablets and prolonged the release rate of the active substance. Drugs need to drink at one time with a breakfast reception and / or dinner, while a 3-fold use of the way - and in the afternoon.

The main effect of drugs aimed at suppressing the formation of glucose in the liver cells (effect on gluconeogenesis from glycogenolysis). This allows you to control the blood sugar, preventing the increase of the level up to the critical exponents. It is important that the substance metformin does not stimulate the production of the pancreatic hormone insulin. Therefore reception glyukofazh and Metformin is a direct indication for the treatment / prophylaxis of insulin-independent diabetes mellitus (type 2 disease).

The overall impact on the body substance metformin:

• improves insulin-sensitivity tissue receptors to the hormone;
• It is not able to eliminate xerostomia hyperglycemia and other symptoms;
• accelerates the processing of glucose muscular fibers;
• retards or stops weight gain;
• It is causing a large number of obese patients with diabetes gradual weight loss;
• lowers cholesterol, fat, triglycerides, LDL lipoprotein species;
• It slows down the absorption of glucose in the digestive tract;
• suppresses the feeling of hunger.

Glucose-lowering effect metformine higher than that of other hypoglycemic agents. Therefore Glyukofazh, Metformin and their analogs have high absolute therapeutic efficacy equivalent degree. A significant difference in the results of their actions is only in the case of falsification.

varieties of Medicine

Both medicines are made by producers from different countriesSo they have small differences in the forms of output and value. At the beginning of November 2018 Metformin price ranges 9-608 rubles, and on Glyukofazh - 43-1500 rubles. The difference depends on the dosage and duration of drug action, place of production, the number of tablets in a single package.

Varieties hypoglycemic agents in the table:

comparison parameter	metformin	Glyukofazh
Dosing substance metformin in a single tablet with a conventional release rate	500 mg, 850 mg, 1000 mg	500 mg, 850 mg, 1000 mg
Dosing agent metformin in a single tablet prolonged action	500 mg, 750 mg, 850 mg, 1000 mg	500 mg, 750 mg, 1000 mg
Types of coating tablets	Metformin normal release rate release uncoated or film coated or enteric	Tablets Glucophage conventional action film-coated
Prolonged action tablets with a coating or film type manufactured without	Long Glyukofazh released without shell
The place of production of drugs	Russia: Izvarino Pharma, Biochemist, Kanonfarma Production, Vertex, Rafarma, Biosynthesis, Ozone, Medisorb	France: Merck Sante
Serbia: Hemofarm	Spain, Germany: Merck
Belarus Borisov Pharmaceutical Plant	Russia: Nanolek
Czech Republic, Slovakia: Zentiva
Israel: Teva
Hungary Gedeon Richter
Synonyms and Metformin Glucophage	Gliformin, Lanzherin, Diaformin, Metfogamma, Siofor, Metospanin, Sofamet, Novoformin, Formetin, different absolute analog (single-component medication with metformine)
The two-component formulations, which is composed of metformine	Galvus Met, Bagomet Plus, Glimekomb, Amaryl M, Avandamet, Yanumet
Nosological analogues (drugs with hypoglycemic agents)	Vildagliptin, glibenclamide, gliclazide, glimepiride, rosiglitazone, Sitagliptin

Attention! Prohibited action Metformin tablets simultaneously Glyukofazh supplement. Both tools are absolute analogs of each other, so there is an overdose agent metformin.

The use of medications

Glucophage, or metformin in the therapy or to reduce body weight is administered in the absence of the effect of diet and exercise therapy. Any of these drugs are used for the treatment / prevention of hyperglycemia, type 2 diabetes, prediabetes, insulin resistance increase. In the case of obesity, polycystic ovary syndrome, type 1 diabetes and other diseases is one of the tools comprise complex therapy.

Optimum reception circuit glyukofazh or Metformin:

• Tablets normal release rate - with a meal in the morning or in the evening, every 12 hours (breakfast and dinner), morning / in the afternoon / evening, during dinner.
• The tablets of the prolonged action - at a time with dinner 1 time / day.

There is no difference if you compare Glucophage and Metformin on the method of application. Tablets are taken together with food, 1-3 times / day, 150-200 mL of water is drunk. The therapeutically effective daily dose is 500-3000 mg. Do not exceed the amount of the substance 3 g metformine / 24 hours: to be overdosed, entailing life-threatening complications.

Side effects of medications

There is also no difference between the metformin and Glucophage in the manifestation of side effects, since both agents contain metformin.

Metformin substance causes:

• vomiting;
• nausea;
• flatulence (flatulence);
• pain in the stomach, intestines;
• loose stools or diarrhea;
• dysgeusia;
• erythema;
• metallic taste;
• anorexia (loss of appetite);
• lactic acidosis;
• megaloblastic anemia (due to absorption disorders vitamins B₉, B₁₂);
• dermatitis;
• urticaria.

In a small number of reviews have concluded that Glyukofazh causes fewer side effects as compared with metformin. This is a wrong interpretation of the data, since both drugs contain the same ingredient in identical dosage. The differences in the effects of the case on three occasions: Prolonged drugs are taken after the body has accustomed to the action of conventional tablets, the person can tolerate metformin or does not violate the rules of consumption medications.

Contraindications receiving Medicine

I never assigned Glyukofazh with metformin, as it is the absolute counterparts. Both products are prohibited for use in case of intolerance to the composition, and are contraindicated for children under 10 years. They are rarely used during pregnancy and lactation. If they assign a breastfeeding woman, a child is transferred to the power formula.

Other contraindications and limitations:

• diet in which the caloric content corresponds to the index ≤ 1000 kcal;
• dehydration;
• impaired renal function, liver;
• respiratory / cardiac insufficiency and other states which involve hypoxia;
• alcoholism or alcohol intoxication (metformin incompatible with ethanol);
• viral, bacterial and other infectious diseases;
• diabetic ketoacidosis, coma, predkoma;
• hypoglycemic crisis;
• or metabolic lactic acidosis;
• trauma, surgery on extensive areas of the body.

Time Limit for receiving glyukofazh is Metformin or surgical or diagnostic treatment using iodine-containing solutions for infusion. Tablets metformine stop drinking for a couple of days before the procedure.

overdose Medications

If we increase the daily dose of 3 g or greater at the same time with taking Glucophage metformin - overdose occurs. It manifests the development of lactic acidosis.

Symptoms of overdose of metformin or Glucophage:

• lethargy, loss of appetite;
• stenokardicheskie pain;
• muscle pain, cramps;
• disorientation;
• mucosal dryness;
• hepatitis symptoms (yellowing of the skin, sclera);
• respiratory failure;
• sleep disturbances;
• cardiovascular failure;
• vomiting;
• diarrhea;
• abdominal pain;
• areflexia;
• incomplete paralysis;
• metabolic acidosis.

Due to the lack of medical care comes giperlaktatsidemicheskaya coma and death. Overdose of Glucophage, or metformin eliminate hemodialysis with concomitant administration of symptomatic therapy drugs.

product review

Endocrinology noted that patients with diabetes easier to tolerate prolonged reception Metformin tablets or glyukofazh compared to the same drug release rate of a conventional material. Symptoms of dyspepsia appear at the beginning of the treatment, so the first two weeks, people should drink a minimum dose of the drug.

In people with normal levels of sugar and Glucophage and Metformin is allowed to use for correction of weight, treatment of polycystic ovary syndrome or other diseases. When following the instructions and recommendations of the doctor is not ill health on the background of hypoglycemia or development of lactic acidosis.

Since the two agents have the same properties, the choice of the best drug physician takes into account the release rate of the active ingredient. In complex therapy is recommended to take long-acting tablet. Most patients buy Metformin because it is cheaper Glucophage.

afterword

about preparations data collected from medical sources and annotations manufacturers, supplemented by assessment reviews of doctors, patients and people using the tool for weight loss. Information articles about Metformin, Glucophage, and their analogs is presented for the purpose of review. Optimal drug dose and duration of the course is to recommend an endocrinologist or other physician specialty.

On a note! The substance metformin scientists continue to investigate. Who proved its effectiveness in the prevention of cancer of all types, reversible infertility treatment, dermatological, cardiovascular disease, senile dementia.

sources:

Vidal: https://www.vidal.ru/drugs/metformin-5
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = ac45cb5c-4394-42ca-8479-a60a7a67e0b0 & t =

Found a bug? Select it and press Ctrl + Enter