Use for joints
Hyaluronic acid is a constituent of a lubricant articular cartilage knees, elbows, hips. Lack of lubricants dramatically reduces the amount of movement, provokes joint inflammation and severe pain.
Injections of hyaluronic acid into the knee joint can improve joint mobility and volume of its motion eliminate pain during stress and resting, reduce the severity of outbreaks inflammation.
Hyaluron detected in the epithelial layer of the synovial fluid, connective tissues. It prevents the friction elements of the joints, improves cushioning. If synovial fluid enough initially, or its volume reduced in the knee under the influence of abnormal or age-related factors, friction provoking desiccation and erasing cartilage, degenerative tissue damage joint.
pharmacological properties
The active substance of most drugs for the treatment of diseases of the knee joint by injection - sodium hyaluronate. This highly purified fraction with a certain predetermined chain length has biofermentativnoe origin.
Hyaluronic acid for such injections into the knee has visco-elastic characteristics similar to the synovial fluid. Due to the fact that its structure is not stabilized, hyaluronic acid penetrates quickly into the knee cartilage matrix, eliminating the deficit and restoring the elasticity of cartilage.
The molecular chain of hyaluronic acid has an optimal length for the activation of metabolic processes in the knee joint. In the reaction of hyaluronic acid with specific receptors - fibroblasts, chondrocytes - maximally stimulated endogenous hyaluronan synthesis. With this further hyaluronic acid produced in the knee in increased concentrations.
properties injection
Introduction Hyaluronic acid in the knee joint can achieve such therapeutic effects:
- improve trophism cartilage of the knee;
- increase the viscosity of synovial fluid;
- prevent the formation of inflammatory focus;
- accelerate regeneration of tissue damage;
- eliminate stitching cartilage of the knee;
- stimulate the production of hyaluronate predecessors;
- tie fluid into the cavity;
- perform a buffer function in high load.
The use of hyaluronates the tribe achieves these effects with regular administration.
testimony
Injections of hyaluronic acid in the knees are assigned in such pathologies and conditions:
- degenerative tissue damage joints - osteoarthritis;
- traumatic lesions of the joints;
- rehabilitation after artrotsenteza;
- osteoarthritis of the knee;
- Steynbrokera syndrome;
- pain and limitation of motion;
- arthritis knee joints of mild to moderate severity;
- arthrosis, gonarthrosis;
- periarthritis.
As an adjuvant, injections of hyaluronic acid used in orthopedic surgery. In the early stages of pathological process allows hyaluronic acid to prevent further development of the pathology and surgery.
List of drugs
Injections of hyaluronic acid in patients with knees held drug production in different countries, prices and methods of synthesis of the active ingredient.
Suplazin
A sterile solution according to 2 or 6 ml of each pre-filled syringe. It contains as active ingredient the hyaluronic acid sodium salt - 20 mg, and purified water injection. The package one syringe, sealed in a polymer blister. Produced in Ireland.
Used to improve the physiological function of not only the knees, but also the shoulders, fingers, hips. It allows you to simultaneously treat multiple joints.
adanta
Is released in a pre-filled syringes with the sodium salt of hyaluronic acid 25 mg per syringe. In one 2.5ml syringe, hyaluronate 10 mg per milliliter. Available Japanese pharmaceutical company Meiji Seika Pharma. It should be 1.5 times less Irish analog. In the case of the appointment in osteoarthritis of the wrist joint is effective not only in the early stages, but also in the complicated stage of the disease.
hyalgan
The drug, designed specifically to fill the knee joint. For other joints manufacturer information does not indicate. Released two milliliters in the ready-to-use syringes. The concentration of hyaluronate - 20 mg. Further comprises dihydrates, and sodium dihydrogenphosphate gidroforsfaty.
The knee joint injection of hyaluronic acid in the composition hyalgan exhibit effectiveness under moderate lesions. The medicine is produced by the Italian company Fidia Pharmaceuticals.
Singial
Sodium hyaluronate in the composition of this preparation was prepared by biotechnological, growing colonies hyaluronic acid bacteria Streptococcus Zooepidemicus. Immunobiological preparations for the knees. Also used for the treatment of the shoulder joint.
Available joint Ukrainian-Korean production Farmak with LG Life Sciences, Ltd. One syringe contained 2 milliliters of a solution containing 10 mg of active ingredient / ml.
Hialubriks
Medication with a higher concentration of hyaluronic acid. In 2 ml of it contains 30 mg. In a pack one sterile syringe. Used for the treatment of any of the joints affected by trauma or inflammatory diseases. Produced by the Italian company Fidia Pharmaceuticals.
Gialyuks
Released in the syringe 2 ml sodium hyaluronate with a concentration of 10 mg per 1 ml, as present in the composition of sodium chloride - 8.5 mg. It performs a synthetic prosthesis joint fluid. Used for the treatment of hip, shoulder, ankle, knee, differs prolonged action in compliance with the rules of administration.
injections
Assign an adult for use once a week. Duration of from 3 to 6 weeks. Introduced solely interarticular gap. Adjust the dosage the doctor, taking into account the severity of the disease and tolerability.
Hyaluronic acid is injected intraarticularly into the knee with the observance of these rules:
- procedure is carried out strictly under sterile conditions aseptically - the procedure must be performed by a qualified medical officer;
- if during the course is not marked improvement, therapy is stopped;
- be careful - the drug should not get into the bloodstream;
- to prevent ingress of hyaluronic acid on mucous membranes of eyes;
- recommended for use needles - 22-23 G, considering that the preparation viscous and elastic.
If the drug is pre-frozen, leave at room temperature for heating and comfort of administration. Use the syringe immediately after printing, the remains must be disposed of.
In cases where the disease is accompanied by severe inflammation, it is recommended to undergo a course anti-inflammatory treatment and reduce the focus of inflammation, as far as possible before introducing the drug the patient's knee.
During the 48 hours after the knee has been introduced into hyaluronic acid, does not load the knee exercise and weight loads.
Precautionary measures
Not to be administered hyaluronic acid to patients suffering from known reactions intolerance. Apply standard precautions and contraindications, as well as at any other intra-articular injections.
hyaluronic acid formulations can not be administered in the knee when it detects severe inflammation - that such patients often noted the development of side effects. Children, pregnant and lactating women is contraindicated, since hyaluronic acid safety profile for this group of patients was not investigated.
Avoid processing antiseptics containing ammonium salts, benzalkonium chloride, chlorhexidine. processing result may be the formation of undesirable precipitate.
Contraindications
Prohibited stabbing into the knee joint of hyaluronic acid in the presence of contraindications, as episodes hypersensitivity to the drug in medical history, pregnancy, lactation, childhood and adolescence age 18 years.
Contraindications severe pathology of the hepatobiliary system. Not administered at local or systemic infectious diseases. If the skin on his knee struck infectious, erosive disease, the introduction of an increased risk of blood poisoning.
Adverse reactions
Hyaluronic acid injections in the knee joints often accompanied by undesirable effects in the localization of the injection site:
- discomfort, pain;
- swelling, redness;
- rashes, irritated skin;
- pustules, haemorrhages;
- itching, synovitis.
Symptoms must disappear within 72 hours after injection into the knee. To the site of administration recommended to apply ice. Allergy is manifested anaphylactoid reactions, rash, dermatitis, anaphylactic shock without threatening the patient's life, headache. Detection of side effects in the form of allergies is the indication to the termination of injection into the knee.
Source:
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