Brief Description of Medicine
Hypoglycemic drug Metformin contains metformin - synthetic substance which belongs to the biguanide. In direct indications specified drug therapy / prophylaxis of type II diabetes. In practice, the means used in all conditions involving hyperglycemia and complications that may be associated with a metabolic disorder and / or an increase in glucose above normal. The drug include combined regimen polycystic ovarian reversible infertility, obesity, acne, diabetes type I.
Metformin is available in two types:
- Tablets normal speed metformin release agent;
- sustained-release tablets (metformine slowing of release).
Dyspepsia, or other adverse effects occur in the first 1-2 weeks of treatment. To prevent their manifestation medication with metformin be taken with food. Primary glucose-lowering correction correctly to start with the lowest dose of 500-850 mg / day. Then, the amount of the drug weekly increase. It is forbidden to use a day for more than 3 g of metformin substances.
What time of day to take Metformin - it depends on the type of medication. As standard, sustained release formulations drink in the evening, and the tablets with the usual speed of release - during the day. But each person's body reacts differently to metformin, so the endocrinologist in the course of treatment may offer different application schemes.
Receiving tablets with ordinary release rate
Metformin normal speed action release tablets without a coating or film, or enteric-coated. People with diabetes can be a means to assign to drink 1-3 times / day, always at the same time with a meal. Dosage depends on the level of sugar fasting and after food intake, whether the patient receives other hypoglycemic drugs.
Circuit Conventional Metformin monotherapy with conventional release rate:
- 500 mg or 850 mg of metformine / 1 times in the morning (with fasting hyperglycemia, prediabetes);
- 500-850 mg 1 time / meal (in case of a regular increase of glucose in the middle of the day);
- 500-850 mg for breakfast and dinner (at steady slight increase sugar);
- . 850-1000 mg of 2 r / day (morning / evening at moderately elevated glucose);
- 850 mg 3 times / day (high hyperglycemia with the initial stage of obesity);
- . 1000 mg 3 / day (diabetic obese);
- 500-850 mg / 1 time at any time (in states not associated with diabetes);
- 500-1000 mg of metformine 1-3 p. / Day (reception to lose weight, if no diabetes).
If a person is appointed several hypoglycemic drugs or insulin, metformin is optimally in the morning or at night with a minimum dosage. Metformine daily amount usually does not exceed 850 mg.
The long-acting pills
The drug substance with slow release rate release tablets without a coating or with a film coating. Displaying drink daily extended-release metformin overnight. Medication use at the same time with dinner or after its completion. If such a scheme, the level of glucose can not be corrected, the doctor recommends a 2-fold reception per day.
Recommendations Long metformin monotherapy according to the instructions:
- A single dose for the first 2 weeks of treatment equal to 500-850 mg 1 time / evening.
- In the third week from the start of intake, the amount should be increased to 850-1700 mg (on indications and in the absence of side effects).
- At week 4 of treatment drug it was necessary to take the recommended dose of an endocrinologist.
At least one month in the absence of a correct monitoring of the patient can be transferred to the sugar 2-time reception of prolonged medication. In this case shows the morning and evening to drink Metformin: 1/2 parts of a therapeutically effective daily dose with breakfast and dinner. After 1.5-2 weeks the endocrinologist evaluates the quality of glucose control. If the sugar level is unstable, the patient returned to treatment with conventional tablets release rate.
On a note
When combined treatment with metformin tablets instead of several possible hypoglycemic agents combined preparation appointment. In such medications metformin substance combined with vildagliptin, glibenclamide, gliclazide, glimepiride, rosiglitazone or sitagliptin. Two-component tools also use the scheme: morning / evening, breakfast / lunch / dinner, 1 time / day (on an empty stomach, in the afternoon or at night). More welcome is described in the instructions.
sources:
Vidal: https://www.vidal.ru/drugs/metformin-5
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = ac45cb5c-4394-42ca-8479-a60a7a67e0b0 & t =
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