Will the metformin in polycystic ovaries, because in the summary says that the means used to treat type 2 diabetes? This question is often heard gynecologists. But, despite the fact that the instructions include indications Unknown polycystic doctors for several years successfully used the drug for the treatment of disease. Consider why there is polycystic and the help of metformin.
What is polycystic
Hollow tumor on a leg filled with liquid, is diagnosed on the ovaries in 3/4 of women of reproductive age. Cyst may grow, compressing the surrounding tissue and causing pain. But despite the pain and other discomfort, solitary cysts of the ovary does not violate a woman's work and almost never found abnormalities in the reproductive sphere.
But if the organ appears multiple cysts, the doctors diagnose PCOS or polycystic ovarian disease.
Multiple educational and disrupt organ function in patients says:
- decreased libido;
- failure of the menstrual cycle;
- rapid weight gain when eating habits;
- loss of hair on the head and other parts of the body;
- emotional lability (anger may give way to fits of apathy and depression);
- insomnia or trouble falling asleep.
One of the common causes is polycystic hormonal ratio of estrogen and progesterone caused by increased insulin synthesis. Pancreatic hormone responsible for glucose metabolism, inhibits the maturation of the follicle, causing the cycle failure and enhances the production of testosterone, which leads to the development of polycystic.
How to help Metformin
To understand how Metformin helps with polycystic ovary syndrome, you need to become familiar with the drug.
The active ingredient of the drug - metformin hydrochloride.
When receiving the drug, the following occurs:
- slowing gluconeogenesis;
- accelerating glucose utilization primary connections;
- reduced lipid levels and triglycerides;
- increased susceptibility to insulin;
- slows down glucose absorption in the intestine.
Metformin has no direct effect on the pancreas - insulin synthesis is reduced in the reduction of carbohydrate and fat metabolism. Reducing the amount of sugar in the bloodstream causes reflex reduction of the synthesis of the insulin hormone.
Metformin with polycystic ovarian provides the following:
- Restoration of ovarian function. The woman going on a full ovulation, accompanied by the release of the mature egg from the ovary. This physiological process prevents the appearance of cysts.
- Restoring the normal amount of blood lost during menstruation (when the disease is marked scanty menses).
- Getting Rid of PMS (abdominal pain, unmotivated mood swings);
- Normalization of the menstrual cycle (periods are regular).
- The opportunity to conceive. Women, after the treatment of polycystic metformin may become pregnant and bear a healthy child.
Further reduced weight, hair stopped falling out, and there is a sexual attraction. Improving the appearance and sexual desire appeared favorably affect the mood of women.
How to drink the medicine
When polycystic take Metformin tablets administered 1-2 times a day, depending on the degree of increase insulin index. Drinking medication should be during a meal or immediately after a glass of water.
The initial dose, with good tolerability and insufficient therapeutic effect may be increased to 3-4 tablets.
How when PCOS Metformin drink depends on the nature of any abnormalities. During the treatment the doctors several times a woman gives direction to the delivery of analyzes to determine the level hormones, insulin and glucose, conduct a pelvic examination to assess the condition of the reproductive system and make the US appendages. Usually treatment is about six months.
If necessary, patients after a short break to re-appoint taking Metformin.
In the treatment of polycystic ovary doctors can appoint only one Metformin or pick complex therapy with the additional reception of hormones or drugs capable of influencing hormone levels.
Indication of the full treatment is to normalize the hormone ratio in the blood test and the absence of signs of illness during the ultrasound of the ovaries.
Contraindications
Metformin drink from polycystic ovarian appoint not all.
Contraindication for administration of the drug are:
- idiosyncrasy medicinal components;
- diabetic ketoacidosis;
- functional disorders of the kidney;
- heart attack;
- heart failure;
- state after injury or surgery;
- liver failure;
- alcoholism;
- hypocaloric diet (for medical reasons);
- pregnancy;
- breast-feeding.
With care Metformin is recommended to use in the elderly and women engaged in hard work.
Adverse reactions
The drug is well tolerated by patients but side effects sometimes appear with polycystic ovarian Metformin:
- bloating;
- diarrhea;
- nausea;
- itching, redness or swelling;
- sleep disturbances;
- memory impairment;
- decreased performance;
- depression;
- abnormalities in the thyroid gland.
Metformin prevents the absorption of vitamin B12 and it can cause the development of iron deficiency anemia.
How dangerous overdose
Excess doses of the drug leads to the development of a life-threatening condition - lactic acidosis.
Symptoms of overdose:
- profuse vomiting;
- diarrhea;
- hypothermia;
- muscle pain;
- dizziness;
- dyspnea.
Gradually, the woman starts clouding of consciousness, and she falls into a coma. Without medical care of the condition results in death.
In a hospital to eliminate lactic acidosis hemodialysis, and then pick the symptomatic therapy to correct disorders evolved.
But with diabetes, the maximum daily dose - 6 tablets, and if the woman during treatment of polycystic mistakenly take the extra pill overdose is not there.
Cause lactic acidosis is the accumulation of the drug when applied at Metformin polycystic ovaries in women with renal disease. Slow elimination of metabolites leads to the fact that the metformin hydrochloride accumulate in the body, causing symptoms of an overdose.
Are there any analogues
Instead of Metformin in the treatment of polycystic woman doctors can appoint:
- Gliformin;
- Siofor;
- Glucophage;
- Metfogamma.
Assigning at polycystic Metformin, gynecologists and endocrinologists provide advice on their own do not replace prescription medications for analogs. This is due to the fact that despite the same active ingredient, similar means have a different composition from excipients and effect on the body can vary.
It always helps with polycystic Metformin
60-70% of women polycystic appearance associated with decreased insulin sensitivity. In this form of pathology metformin will have a good therapeutic effect.
But the use of the drug does not help, or bring a small relief if the cause of polycystic steel:
- inflammation of the reproductive organs;
- endocrine diseases that cause hormonal imbalance;
- intestinal diseases;
- chronic nerve strain;
- other hormonal disturbances (changes in insulin levels and change in the ratio of sex hormones appear as a secondary complication of a pathological process).
If the disease is caused by the reasons listed above, then treat polycystic metformin is ineffective. It is necessary to choose the drugs capable to eliminate the cause, provocative cyst formation.
Metformin Ineffectiveness may be due to the individual characteristics of the patient when the body is impervious to the drug. Often replacement metformin or Glucophage Siofor provides a positive trend in the treatment of polycystic.
Another factor reducing the effectiveness of metformin, becomes non-diet. On the treatment of polycystic woman recommended the power to monitor the synthesis of insulin. Failure to medical recommendations leads to the fact that the food body receives an excess amount of sugars. Accepted therapeutic dose of Metformin can not dispose of excess glucose, so it is necessary to improve the state of women reduce insulin occurs.
The effectiveness of the treatment of polycystic metformin affects the general condition of women: hormone levels, age, presence of chronic diseases. In young women with no serious diseases, the treatment of polycystic runs better than in the more mature ladies.
Reduce the effect of the treatment of polycystic available to women in the history of chronic heart disease and blood vessels, digestive problems, abnormalities in the thyroid gland.
If PCOS Metformin helps if pathology is caused by increased production of insulin. Acceptance of the drug allows gradually normalize glucose metabolism and increase the sensitivity of tissues to insulin. In other cases, the use of Metformin does not help - you need another treatment to eliminate the cause of the disease.
sources:
Vidal: https://www.vidal.ru/drugs/metformin-5
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = ac45cb5c-4394-42ca-8479-a60a7a67e0b0 & t =
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