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What better Metformin or Siofor? Drugs are structural analogs of each other. Effective component drug is metformin hydrochloride. Drugs have similar shapes. Both products are manufactured in a tablet form. Dosages tablets they have the same (500 mg, 850 mg, 1000 mg).
To compare Metformin and Siofor necessary to study their properties. Siofor and Metformin is prescribed for diabetic patients. Metformin hydrochloride, a part of the preparations well reduces gluconeogenesis in liver tissue. Active substance reduces fatty acid synthesis. The therapy drugs reduced the concentration of blood sugar glucose accelerated processing molecules increases the sensitivity of insulin receptors.
Metformin Siofor and help to reduce the absorption of glucose molecules across the intestinal wall. Medications help weight loss. body weight, some patients may not decrease, but remain at the same level, not rising throughout the treatment.
Siofor and Metformin in diabetics are allowed to use as a hypoglycemic drug. Medications can be used in patients older than 10 years of age. Children drugs are prescribed as monotherapy or in combination with insulin.
Restrictions on the use of medicines:
- coma and ketoacidosis with diabetes;
- bad work renal (creatinine clearance less than 60 mm per minute);
- the use of iodine-containing formulations during further studies;
- diseases associated with tissue hypoxia (respiratory and heart disease);
- liver dysfunction;
- lactic acidosis;
- gestation period;
- lactation;
- poisoning spirituous beverages, patients suffering from alcoholism;
- diet containing a very small amount of calories (less than 1000 kcal per day);
- children under 10 years of age;
- are allergic to metformin.
Carefully prescribed drugs in patients 10-12 years of age. The medicine should be cautious to use in elderly patients over 60 years of age, since this group of patients there is a high likelihood of developing lactic acidosis.
The difference between treatments
The difference between the metformin and Siofor in their value. Metformin has a value of 93-465 rubles. Siofor price equal to 212 - 477 rubles.
Analogue Siofor and Metformin is:
- Glucophage (popular drug);
- Formetin;
- Nova Met;
- Metformin-Teva.
All these analogs are composed of metformin hydrochloride. They can vary the price and the concentration of the substance in tablet form. Indications and limitations of counterparts are practically the same as that of the Siofor and Metformin.
In Siofor Metformin and there are restrictions on the combination with drugs from other pharmacological groups. Formulations of Metformin is forbidden to use in conjunction with drugs containing iodine are required as contrast agents. If applied together, in diabetic patients may develop lactic acidosis. Siofor and Metformin to cancel up to 2 days prior to the additional examinations using iodine-containing drugs. Taking hypoglycemic drugs can be just 2 days after the test. These conditions occur only at normal creatinine levels.
It is not recommended to use the hypoglycemic agents with drugs available in the composition of ethanol. Medications that hypoglycemia can not be used in patients with alcohol-containing beverages poisoning. Ethanol may cause lactic acidosis.
Siofor Metformin and gently combine with danazol, contraceptives, epinephrine, glucagon, thyroxine. These substances can cause a decrease in blood sugar levels.
Nifedipine and cimetidine with hypoglycemic agents need to be used cautiously, as they reduce the rate of excretion of metformin. Metformin may reduce the effectiveness of anticoagulants.
Simultaneous use of metformin with glucocorticosteroid drugs, diuretic drugs and β2-agonists can provoke a decrease of blood glucose molecules. If you want to use these combinations, the dosage Siofor (metformin) should be reduced by the entire course of the combination therapy and after its completion. Medicines pressure, insulin, salicylates able to reduce the amount of blood sugar. If the patient assigned to such a combination of drugs, the dosage of hypoglycemic agents to change.
Terms of Use hypoglycemic agents
Drugs are analogues to each other. Metformin may be used instead of Siofor, and vice versa. Dosages of drugs are practically identical. Siofor and Metformin is used only by doctor's orders. Dosages of drugs calculated for each patient individually.
Medication should be used only as intended dosage, to avoid overdose. High doses of drugs danger of lactic acidosis. Before using hypoglycemic agents it is necessary to eliminate all restrictions to the destination, so as not to harm the body of the patient.
The use of Metformin
Metformin should be taken during or after a meal. Metformin (monotherapy) at the initial stage of therapy shown to accept an adult to 500 mg. This dosage should be taken 1-3 times per day. If the initial dose is 850 mg, it drink 1-2 times per day. Over time, the dosage was increased to 2-3 g
A child of 10 years of age and older Metformin (as monotherapy) administered at the beginning of 500 mg (twice per day) or 850mg (once). The dosage can be increased to 2 g per day. Increasing the dose goes with breaks in 1 week (2-3 stages). During therapy, a correction may be the dosage based on the results of analyzes of blood glucose. Correction is carried out in 1.5-2 weeks.
If Metformin is used together with insulin, the dose for initial treatment is equal to 500-850 mg twice or three times per day. The dosage of insulin is selected based on the results of blood glucose. When hypoglycemia or lactic acidosis drug overturned.
Application Siofor
Siofor need to drink during or after a meal. The dosages selected according to the level of blood sugar. Adults formulation (monotherapy) at the beginning of therapy shown to take 500 mg 1-2 times per day or 850 mg once per day. 1.5-2 weeks dosage was increased to 2-3 g Maximum dosages per day is 3 g (divided into 3 use). If a patient is transferred from another hypoglycemic agent on Siofor, the previous medication overturned.
When using Siofor with insulin dosage in the beginning of treatment is 500 mg once daily (twice) per day or 850 mg once per day. insulin dose is selected based on the results of blood glucose analysis. Gradually increase the dosage Siofor. The maximum dose of the drug is 3 g (divided into 3 use).
If the patient has kidney malfunction, the dosage Siofor selected by the level of serum creatinine. During therapy, carried out monitoring of renal function.
When using Siofor (monotherapy) in patients 10-18 years of age treatment drug initially administered at 500 mg once (twice) per day or 850 mg 1 time per day. The dosage can be increased by 1.5-2 weeks to 2 g (divided into 3 use). If Siofor used together with insulin, the dosage of the drug will be the same. The amount of insulin is determined by the number of blood glucose.
Simultaneous use of funds
Metformin and Siofor are drugs which contain the same therapeutic agent. Metformin at the same time can not be taken Siofor. When used together, the drug in patients possible overdose. According to the instructions of medicines, metformin hydrochloride can cause severe consequences when used in high dosages.
Large doses of drugs provoke lactic acidosis or pronounced decrease in blood glucose levels. In case of overdose the most frequent manifestation is lactic acidosis. It has a very characteristic symptoms. In patients with marked lack of energy, impaired respiratory function, dyspepsia, abdominal pain, hypotension, slow heart rate, decrease in body temperature. It is also possible the emergence of muscle pain, impaired consciousness.
If a patient has appeared lactic acidosis clinic, it must be admitted to hospital. For relief of pathological symptoms the patient shows a hemodialysis and symptomatic therapy. After completion of treatment the patient to go home, adjust the dosage of Metformin or Siofor.
conclusion
Metformin Siofor and are structural analogs of each other. They are interchangeable. Simultaneous reception Siofor and Metformin is prohibited, as this may lead to lactic acidosis and severe decrease in blood glucose levels. Apply the medication you need separate courses. Independently use hypoglycemic agents can not, because the uncontrolled intake of these drugs can lead to complications, gain unwanted effects.
sources:
Vidal: https://www.vidal.ru/drugs/metformin-5
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = ac45cb5c-4394-42ca-8479-a60a7a67e0b0 & t =
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