How does the drug
The main active ingredient of the drug is Ambroxol (derivative bromhexine). This substance shows secretomotoric, sekretoliticheskim and expectorant properties.
After oral administration Ambrobene, alleviating the patient's condition occurs in half an hour, and the therapeutic effect lasts about six - twelve hours, depending on the dose.
Stimulating mucous gland serous cells of the bronchial passages, Ambrobene increases the activity of the ciliary epithelium, which causes dilution of the bronchial secretion and improves its excretion.
Clinical trials have shown that the drug has an antioxidant effect. When conducting complex therapy with antibacterials Ambrobene greatly enhances their levels in the bronchial secretion.
Indications for use
The drug is indicated for the treatment of inflammatory processes accompanied by cough with viscous sputum, and difficult to be separated in the following diseases:
- bronchitis (acute and chronic type);
- with pneumonia;
- chronic obstructive pulmonary diseases character;
- bronchiectasis with pathologies of the lower divisions of the respiratory system;
- in asthmatic bronchial disease;
- for symptoms of distress in infants.
Inhalations with saline Ambrobene and only after the doctor determines an accurate diagnosis and provide the appropriate appointment. For the procedure, you can use any equipment that is suitable for inhalation (except steam device).
What is saline
Saline (saline) - isotonic fluid that has an osmotic pressure similar to the pressure inside human cells. Saline - simplest of these solutions. It is composed of: sodium chloride at a concentration of 0.9% and water. This facility is mostly used for dissolving drugs for injection, and inhalation, and for washing the damaged surfaces.
In what situations is prohibited reception Ambrobene
Ambrobene child to drink are not permitted in the following cases:
- in the presence of hypersensitivity to the drug;
- intolerance preparations which include fructose;
- at deficiency sucrose-isomaltose;
- when glucose / galactose malabsorption;
- during the first three months of pregnancy.
Application Ambrobene for inhaled saline procedures performed with extreme care:
- with dysmotility-contained breathing apparatus;
- in case of increased formation of bronchial secretions;
- with erosive and ulcerative lesions of the digestive tract;
- during pregnancy (the last two trimesters);
- with severe renal and hepatic pathologies, in this case, may reduce the dose used.
Inhalation children with Ambrobene and saline should be done under the strict supervision of an adult. With the development of any uncomfortable conditions or occurrence of side effects is necessary to stop the procedure and seek the advice of a pediatrician.
As inhalations with saline and Ambrobene
For the procedure is allowed to use any inhalation devices (except steam). The drug is mixed with saline in the ratio 1: 1. Formulation be heated to 36-37 degrees Celsius (body temperature). During inhalation should not take deep breaths, the entire procedure is carried out during normal respiratory mode, otherwise increases the risk of attacks of coughing.
Patients with a history of asthmatic disease, is recommended prior to inhalation and saline Ambrobene take bronchodilators. This is necessary to prevent irritation of the respiratory system and the development of bronchospasm.
1 ml of product for inhalation - 7.5 mg of active substance (Ambroxol).
Recommended dosage for inhalation:
- for children two years of age - 1 ml Ambrobene diluted with saline (1-2 times a day);
- children from 2 to 6 years - 2 ml (1-2 times daily);
- for children over 6 years of age and adults - from 2 to 3 ml of the drug (1 -2 times during the day).
Inhaled drug treatments Ambrobene in young children should be carried out under the supervision of parents or health workers.
During the course of therapy should be observed abundant drinking regime.
The duration of treatment should not exceed 4 - 5 days.
Solution for inhalation and oral use can be used inside. In this case, there is no need to breed Ambrobene saline inhalation.
The drug is dissolved in the juice, tea or other drinks and used after the end of the meal, the following dosage:
- for young patients under the age of two years shall be appointed 1 ml of the drug twice a day;
- children from two and up to six years should take 1 ml solution Ambrobene three times a day;
- child from six to twelve years and for receiving use 2 mL of 2 to 3 times daily;
- patients older than twelve years prescribed in the first few days of therapy Ambrobene (2-3 days) 4 ml of the drug three times a day and the remaining period - 4 ml twice daily.
Intravenous Ambrobene carried out with a special solution, mixed with a solvent, in particular saline. In this case, the dosage is calculated based on the amount 1.2 - 1.6 mg per kilogram weight of the patient. In severe character pathology dose may be increased by the attending physician.
Ambrobene assigned dose may be increased in severe disease.
therapy Features
Inhalation of saline Ambrobene not use steam inhalers.
Before you start to apply the means necessary to carry out inspection of the attending physician, who will establish an accurate diagnosis and prescribe the appropriate treatment regimen.
Admission Ambrobene, including inhalation with saline, must be combined with the use of increased amounts of fluid. This is due to the fact that the mucolytic properties of the drug begin to appear with abundant water consumption.
Inhalation Ambrobene saline and any other use of the drug, including intravenous injection It can not be carried out in conjunction with antitussive drugs and tools that make it difficult removal of bronchial secret.
Side effects
During therapy, the drug Ambrobene, including during inhalation with saline following negative manifestations of side effects may occur:
- redness and discoloration of the skin;
- duster reaction;
- itching;
- anaphylaxis reactions, including the possible development angioedema;
- feeling of nausea;
- pain in the abdominal area;
- disorders of the digestive activity (diarrhea or constipation);
- sense throat mucous membrane dryness, mouth and larynx.
In the rare event reception Ambrobene and saline inhalation can trigger the development of severe allergic reactions, in particular Stevens-Johnson syndrome and Lyell syndrome. Therefore, in the event of any discomforts or symptoms of side effects is necessary to interrupt treatment and consult a doctor.
Breeding Ambrobene inhalation child should be strictly following the instructions, and using saline dilution (9% aqueous sodium chloride solution), it will help avoid the development of side effects and the possibility to give the baby will recover.
Interactions with other drugs
Not recommended Ambrobene, as well as inhalation of the drug with saline at the same time reception antitussive agents, as this may worsen the removal of bronchial secretions and cause complications disease.
The drug is often administered in combination with antibacterial agents, in particular amoxicillin, cefuroxime, erythromycin and doxycycline. The combined use of a long time and successfully used for therapeutic purposes, as Ambrobene increases the level of antibiotics in tissues and secretions of the respiratory system. And this applies to any method of using the drug, including inhalations with saline.
Injecting drug application is not permitted to solvents having a pH value greater than 6.3.
conclusion
Ambrobene drug has long been successfully used to treat a cough that is accompanied by a viscous and heavy sputum. For inhalations and intravenous injection of funds is necessary to dilute it with saline.
The therapeutic effect of saline inhalation Ambrobene felt already half an hour after administration and last from six to twelve hours. However, it is important to remember that a child can only be a means to breathe under the supervision of an adult, and before the start of therapy is necessary to make sure there are no contraindications.
It is very important to observe the inhalation proportion Ambrobene and saline solution to help achieve optimal humidification.
sources:
Vidal: https://www.vidal.ru/drugs/ambrobene__1523
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 4ce4b6f1-696e-44b0-a7ea-805c6d6df9b5 & t =
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