Indications
Metformin is prescribed for people with insulin-dependent diabetes. By resorting to drug therapy when using moderate physical activity and diet do not get to take control of your blood sugar levels.
You can use it as a drug for monotherapy, but if necessary, appoint metformin in combination with other hypoglycemic agents or insulin. Due to the action of drugs is possible to normalize the sugar, but the patient should be on a diet.
To avoid complications, doctors also recommend completely give up alcohol. After Metformin incompatible with alcohol.
Pharmacological characteristics of Metformin
Hypoglycemic tablet made on the basis of metformin hydrochloride. This substance inhibits gluconeogenesis. Under the influence of Metformin receptor sensitivity to insulin increases, stimulated recycling process received dietary glucose by various tissues of the body.
Tablets do not affect the contents of insulin, they change the pharmacodynamics hormone. Decreases the ratio between bound and free insulin. Under the action of Metformin is stimulated glycogen production process. The transport capacity of membrane glucose transporters in the body increases. The process of absorption of sugars in the intestine is delayed.
Under the action of Metformin:
- reduces glucose absorption intensity of the products;
- improving blood circulation;
- It increases the feeling of satiety;
- It reduces the severity of the oxidative process.
In drug treatment, body weight did not change either gradually decline.
After receiving tablets are absorbed in the gastrointestinal tract, the maximum plasma concentration observed after 2.5 hours after drug use. Food intake and slows degrades the drug absorption process.
The list of contraindications
Patients who have problems with alcohol, you can not take metformin.This can significantly worsen the condition. Chronic alcoholism is a clear contraindication to receiving hypoglycemic agents. If poisoning alcohol diabetics need to temporarily abandon the treatment of hypoglycemic agents. Simultaneous treatment with metformin and alcohol is not allowed.
Not recommended to take the pills to people who:
- Hypersensitivity to metformin;
- a state of diabetic ketoacidosis, coma, or precoma;
- problems with kidney function, including those caused by infectious diseases;
- injury, surgical operation, after which the recommended insulin;
- infringement of the liver, including hepatic failure;
- Symptoms of chronic and acute diseases in which the possible tissue hypoxia (respiratory or cardiac insufficiency, myocardial infarction);
- lactic acidosis (including cases in history).
It is not allowed the treatment of metformin in pregnant women. Abandon his admission, patients must adhering diet in which less than 1000 kcal is consumed per day. So important for people to understand that alcohol is strictly forbidden to them. After all, when a low-calorie diet the body receives a limited amount of carbohydrates, such nutrition mix with intake of alcohol can trigger the development of hypoglycemia.
Refuse metformin for 48 hours recommended after any radiozotopnyh radiographic studies, in which the organism of iodine-containing contrast agent was injected.
Drinking alcohol in diabetes
Diabetics are advised to give up alcohol because of the fact that when it is used for many it becomes difficult to control the amount of food eaten. If a patient starts to focus on the products contained in the composition of a large number of carbohydrates, the hyperglycemic crisis can occur. Even if you take Metformin and drinking alcohol, to prevent the development of hyperglycemia fail.
But this is not the only reason that patients with carbohydrate metabolism disorders, doctors recommend to completely eliminate alcohol from the menu. Pure alcohol does not affect the level of sugar in the body directly. But it acts on the liver and stops the conversion of protein into glucose. Even 1 glass of spirits is enough to disrupt the process of gluconeogenesis.
The danger also lies in the fact that people under the influence of alcohol can not understand that he had hypoglycemia. After the critical reducing sugar having the same symptoms as if intoxicated:
- incoherence of speech;
- confusion of consciousness;
- lightheadedness.
If at this point not to check the concentration of sugar and put everything down to the effects of alcohol, it is possible to miss a critical moment. If glucose levels continue to decline, it is possible the development of hypoglycemic coma.
While small amounts of alcohol does not change the content of sugar. If the patient fails to control diabetes through diet, physical activity, then from a small number of "light" of alcohol problems should not be. But doctors do not recommend even to combine beer and Metformin. The composition of this drink includes a small amount of slow carbohydrates, thus such alcohol does not cause significant vibrations sugar.
From the dessert wines, liqueurs, cocktails should be completely abandoned. They contain large amounts of sugar.
Compatibility hypoglycemic drugs and alcohol
The instructions to metformin indicate that it is not recommended to take the tablets at the same time with alcohol. This is because the risk of lactic acidosis increases with alcohol intoxication. The greatest danger is to people who have liver failure.
Critical condition can develop in diabetics who stick to a low calorie diet. In order to assess the compatibility of alcohol and metformin, learn enough that manufacturers do not recommend the treatment, even taking the medicine, as part of which contains ethanol.
If the patient is taking metformin for maintaining the sugar concentration is normal, it is important to keep the process of gluconeogenesis (glucose production from liver cells of protein). This avoids a sharp drop in blood sugar level.
If you consume alcohol along with metformin, it is possible to face the fact that the glucose level is critically low. After Metformin inhibits gluconeogenesis, it increases the utilization of sugar by the cells. Get rid of hypoglycemia is easy enough - you need to hit the body glucose. You can eat a piece of candy, sucked up a piece of chocolate. But it provokes unwarranted jumps in blood sugar.
potential complications
Overestimate the seriousness of the consequences that may arise if at the same time with alcohol taking metformin, it is impossible. When combined pills with alcohol are at increased risk of lactic acidosis.
The condition can develop in the presence of these risk factors:
- Fasting for a long time;
- ketosis;
- decompensated diabetes;
- hepatic, renal insufficiency.
On the development of this condition is the appearance of diabetic breathing. Breath is similar to that which occurs in people after drinking. In parallel, there is a pain in the stomach, there is a decrease in body temperature. You may experience nonspecific symptoms, such as seizures or dyspepsia.
It is important to see a doctor immediately if you suspect on the development of lactic acidosis. Many refuse to timely medical care for fear that their doctors will refuse to learn about alcohol. If you do not pull the time, and went to doctors at the first signs of lactic acidosis, it is possible to avoid serious consequences.
Side effects
When you use Metformin, especially in combination with alcohol, may develop complications.
Most often, patients complain of such disruption of the body:
- diarrhea;
- vomiting;
- appetite loss;
- constant feeling of nausea;
- dysgeusia.
Prevent the emergence of diarrheal illness is possible, if the dosage of Metformin to increase slowly. Initially recommended to take it during the meal.
To assess the effect of Metformin on the body, it is necessary to consider other possible side effects of its use. In rare cases, may cause skin reactions, disorders of the liver work, the development of drug-induced hepatitis. After discontinuation of the drug normalized state.
If necessary, receiving hypoglycemic drugs, patients should immediately figure out how to interact with metformin alcohol. Simultaneous reception of drugs and alcohol is not allowed. This can lead to tragic consequences, including death. A particular danger is people who can not control the amount of alcohol consumed.
sources:
Vidal: https://www.vidal.ru/drugs/metformin-5
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = ac45cb5c-4394-42ca-8479-a60a7a67e0b0 & t =
Found a bug? Select it and press Ctrl + Enter
