Supraks. Instructions for use. Price, reviews, analogues

Supraks - cephalosporin antibiotics. The instructions for use is described as a tool that can resist infections caused by pathogenic bacteria.

Release form and composition of the drug

Dosage forms Supraksa:

• Pills. Supraks Soljutab tablet form dissolves in the oral cavity. Each contains 400 mg

active agent cefixime, has a shape elongated oval yellowish risk middle. On one side of the tablet the inscription «SUPRAX», on the other - «LUPINE».

• Capsules. The composition of capsules for oral administration is 400 mg of cefixime. On brushed shell with one siorony written "N808" is contained within the granular powder of yellowish color.
insta story viewer
• Soluble Granules, for recovery slurry. After recovery contain 100, 200 or 500 mg of cefixime. Within each vial contained 35 g of the granular material forming a concentrated slurry by dissolving 100 g of active substance per 10 5 or 20 ml. Medicine scented strawberry smell.
• Powder. The vial contains 500 gram cream powder and the vial containing 100-200 g, filled with a white powder. Both flavored strawberry smell.

Active substance, the basis of all four types of drugs - cefixime trihydrate. Trigidratnaya form of this substance allows it to go undefeated through the active gastric environment. He then enters the intestine and from there spreads the blood vessels throughout the body, getting in the affected organs bacteria.

Inactive ingredients in the tablets:

• Anhydrous dibasic calcium phosphate;
• Valium;
• magnesium stearate;
• cellulose;
• polyethylene glycol;
• pregelatinized starch;
• titanium oxide;
• triacetin;
• tartrazine.

The capsules:

• colloidal silica;
• enterosorbent crospovidone;
• nizkozameschonnaya hydroxypropyl cellulose;
• magnesium stearate;
• mannitol;
• shellac.

The powder slurry:

• colloidal silica;
• sodium benzoate;
• sucralose;
• xanthan gum;
• food flavoring.

pharmacological properties

Supraks belongs to the group of beta-lactam antibiotics and acts as an antibacterial, antiparasitic agent. Drugs in this group exhibit a greater antimicrobial activity against gram-positive and gram-negative microorganisms at an elevated level.

The preparations consist of natural organic substances, and a number of semi-synthetic compounds. Cephalosporin antibiotics exhibit biological activity to certain microorganisms and can stunt or kill bacteria.

Common signs of preparations:

• low toxicity;
• allergenic identity between penicillins and cephalosporins;
• a wide range of doses.

Protection from bacteria is performed by inhibiting the synthesis mukoleptidov in the cell wall of bacteria. Cefixime stops the growth of bacteria but does not destroy the healthy tissues at the same time.

Through drug circulation system is spread throughout the body, "it is" harmful bacteria and infects them. Supraks one of potent antibiotics, because he opposed the enzymes that produce the bacteria with antibiotics protection.

The bioavailability of the drug in the affected places is 45-55%, regardless of the meal. Food absorbed together with the drug and increases the absorption of 0.7 hours. G_max 200 mg Tablets - 3.7 ug / ml. In the slurry concentration higher than that of the tablets is 25-30%.

The capsule is 400 mg taken fasting bioequivalent to tablet 400 mg. Simultaneous reception with food reduces its absorption by 15%.

The peak concentration occurs between 2.5-6 hours after receiving 400 mg tablets or suspensions. Plasma protein binding is not dependent on drug accumulation and is 65%. After 24 hours, the active ingredient is released by 60% in the urine. serum half-life period is independent of dosage forms is 3.5-4.5 hours.

Bacteria are not treatable using Supraksa:

• Bacteroides fragilis;
• Clostridium spp .;
• Enterococcus (Streptococcus) group D;
• enterobacter spp .;
• Listeria monocytogenes.

Indications

Supraks cures uncomplicated bacterial infections arising in various organs.

It can be:

• ENT-organs (pharyngitis, tonsillitis, sinusitis).
• Urogenital system (cystitis, pyelonephritis, cholecystitis).
• Infections of the skin (cellulitis, abscesses, boils).
• Airways (bronchitis).
• Infectious inflammation affecting the skeletal system.
• Enterococcus serogroup D.
• urinary tract infection without structural changes.
• Uncomplicated urethral gonorrhea.

The drug copes with purulent wounds, skin damage caused by fungal pathogens. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Supraksa, it should only be used in the treatment of diseases provoked by susceptible bacteria.

The transition from one form to another drug, such as tablets, the suspension shall take place only under the supervision of a physician. Do not take 2 doses at the same time the drug.

Contraindications

Supraks (instruction manual includes recommendations for people who should refrain from taking preparation, as well as consume it with the utmost care) is contraindicated in sensitivity to some components.

The reasons for the contraindication:

• Hypersensitivity reactions to cephalosporins, penicillins;
• disorders associated with impaired metabolism of amino acids (Chewable Tablets contain phenylalanine);
• age younger than 6 months;
• age over 60 years (taken with caution);
• infections caused by clostridia;
• chronic kidney disease: Step 3A, 3B with caution, 4 (severe), 5 (failure).

Supraksa for use and dosage instructions

Cefixime, active ingredient contained in Suprakse tolerated well by most people. The medicine is taken orally with or without food, no more than 1 times a day, as directed by the physician. Antibiotics work best when the amount of the active substance in the body is maintained at a constant level.

Therefore, it is necessary to take it in regular intervals, with certain intervals until the full prescribed amount is over, even if symptoms disappear after 2-3 days of reception. Too early discontinuation of the antibiotic causing bacterial growth that leads to recurrent infections.

The recommended dose of cefixime - 8 mg per kilogram but not more than 400 mg daily for adults and for children over 12 years, having a weight of 45 kg. Tablet is taken as a whole, if desired, it can be divided in half, taking every 12 hours by ½ part. In the presence of gonococcal infections registers 400 mg Supraksa disposable, or 20 ml of suspension.

Medication taken without regard to meals, dose course of treatment prescribed by the doctor. The optimal time of reception - 7 days. In cases of pyogenic streptococcal infection pills take 14 days.

Tablets desirable to drink non-carbonated bottled or boiled water, not less than ½ cup. You can not drink compote, tea or juice. The capsules must be swallowed whole, pour the contents is not recommended.

Doses for children in the pediatric ward is calculated taking into account body weight. When buying a product, in a package which is the dosing spoon, to calculate the amount of the drug is not necessary. For the treatment of otitis media tablets can not replace the suspension.

When recovering the slurry from granules water should be topped up in two stages, and then the solution must stand for 5 minutes. When restoring, you need to use a dosing spoon or a special syringe, contained in the package. Such measuring instruments as a teaspoon, not recommended to use a pipette.

Excess water above set point will break the slurry concentration. In this case, it will be unfit for consumption. The suspension is taken immediately, it can be washed down with water as needed. Take it at any time without regard to meals.

The dose of water required to restore the substance:

The amount of drug	Size ml vial	Amount of water ml
100 mg / 5 ml 200 mg / 5 ml	100	68
100 mg / 5 ml 200 mg / 5 ml	75	51
100 mg / 5 ml 200 mg / 5 ml	50	34
200 mg / 5 ml	26	17
500 mg / 5 ml	20	14
500 mg / 5 ml	10	8

Recycled medication if his plan to keep, tightly cover and leave in a cool darkened place. It can be stored up to 2 weeks. Before use, shake vigorously.

Children from 6 months to 6 years Supraks given in the form of a suspension. Older children are assigned tablets, provided that the parents will ensure that they chew them. Capsules are written to teenagers, since 12 years, and only in that case, if the weight exceeds 50 kg.

People with impaired renal function should not use the drug in capsules, but only a suspension or dispersible tablets. Dose (400 mg) is independent of which entity struck infection, it is always the same.

Duration Hour:

• infectious diseases of upper respiratory tract -7-14 days;
• tonzillofaringit - up to 10 days;
• gonorrhea - odnorazovo 1 tablet 400 mg;
• diseases of the female urinary tract without complications (urethritis) -3 -7 days;
• inflammation of women upper urinary tract infection (pyelonephritis, cystitis) -14 days;
• infectious diseases of male urinary tract without structural changes - from 1 to 2 weeks.

The basic rule of reception of antibiotics - the medicine must be taken in the next 2 days after disappearance of all signs of infection.

Side effects

Supraks instruction manual describes as means with a small amount side effects, can cause complications in the form of symptoms:

• frustration and pain in the stomach;
• diarrhea or constipation;
• nausea.

Apart from gastrointestinal disorders, registered and Other reactions to the drug:

• Hypersensitivity. The occurrence of skin rash, urticaria, angioedema and facial edema, serum sickness.
• Liver failure. When used Supraksa possible change in the level of alkaline phosphatase, the occurrence of hepatitis, jaundice, hepatomegaly.
• Deviations from the kidneys. A temporary increase in creatinine, acute renal failure. Signs of rejection: the end of urination, swelling of the legs, shortness of breath, convulsions, lethargy, paresthesia.
• Deterioration of the circulatoryand lymphatic systems. May occur temporary thrombocytopenia (increased bleeding), decrease of leukocytes, increasing the intracellular enzyme, affecting the contraction of the heart muscle. There is a tendency to hemorrhage, hemolytic anemia, hypoprothrombinemia, neutropenia, thrombocytopenia and bone marrow depression.
• Disturbances in the musculoskeletal system as arthralgia.
• Abnormality of the respiratory system in the form of shortness of breath.
• Abnormalities in laboratory tests. The drug can affect the increase of serum bilirubin, to decrease values Hb, platelets, white blood cells, cause false positive results in the assay of urine for diabetes.

Because the drug - is a cephalosporin antibiotic used to treat many types of infections caused by bacteria, some patients experience Rare but serious side effects:

• persistent nausea or vomiting;
• yellowing of the skin or eye sclera;
• urine dark color;

  

• light bruises on the skin, bleeding;
• change in amount of urine;
• genital itching;
• vaginitis;
• toxic epidermal necrolysis.

In 30% of patients who took the drug were associated gastrointestinal disorders: pain, flatulence, dyspepsia. The same symptoms are experienced and patients in the pediatric age.

Overdose

Special antidote by application of excess cefixime not exist. It is necessary to gastric lavage, take any absorbent, such as activated carbon. By hemodialysis or peritoneal dialysis cefixime not removed from the body.

special instructions

Supraks, instructions for use which requires special accuracy in dosage when people use functional renal impairment, caution should be taken in patients undergoing peritoneal and hemodialysis outpatient. These patients should be carried out constant monitoring.

Dose for patients with renal insufficiency:

Suspension	Pills
creatinine	100 mg / 5 ml Dose ml / day	200 mg / 5 ml Dose ml / day	600 mg / 5 ml Dose ml / day	400 mg Dose / day
60 and more	The normal dose	The normal dose	The normal dose	The normal dose
From 21 to 59 or kidney dialysis	13	6,5	2,6	not suitable
20 or less, or continuous peritoneal dialysis	8,6	4,4	1,8	0.5 tablet

Cephalosporins, including Supraks may be the cause of the fall of prothrombin activity.

refer the patient to the risk:

• with renal or hepatic insufficiency;
• poor nutrition;
• extending a long antimicrobial therapy;
• previously stabilized on anticoagulant therapy.

Supraks "washes out" of the body's vitamin K. It should be borne in mind so who use it to strengthen the skeletal system and better blood clotting. Research scientists found no evidence of damage to the fetus during pregnancy cefixime, but use it doctors suggest, in extreme cases, with caution.

Also has not been studied in the time of passage Supraksa mother's milk. Doctors recommend to refrain from its use during lactation. Supraksa safety of use in children younger than 6 months has not been established. People 65 years and older need to adjust drug dose due to the different pharmacokinetic parameters in young and elderly.

With extreme caution should be used drug for people with gastrointestinal diseases. Long reception violates microflora, which leads to the emergence of anaerobic bacteria of the genus Clostridium can cause severe diarrhea, colitis. Acceptance of the drug can cause tinnitus, dizziness, so to drive vehicles and operate moving mechanisms undesirable.

Prolonged use of the drug should be monitored for the hematopoietic system.

drug interactions

Supraks, instructions for use which contains not only a list of side effects, but also the nature interaction with various preparations should be taken with caution in conjunction with other medications.

• Anticoagulants. Simultaneous treatment with warfarin, Coumadin and Supraksa reduces prothrombin time and lead to clinical bleeding.
• Antacids. Formulations having in its composition of magnesium, aluminum hydroxide, inhibit Supraksa suction process. They are taken after Supraksa (1,5-2 hours) or before (for 4 hours).
• Diuretics. Delayed excretion of the active substance by the kidneys, which leads to increased toxicity in the body.
• Drugs used in the treatment of trigeminal neuralgia, antiepileptic from the group carboxamide derivatives. Simultaneous treatment with carbamazepine Supraksa, Karbatrolom, Epitolom, Tegretol antidepressants increases in plasma.
• Birth control pills. Precautions to take Supraks as some antibiotics decrease the effectiveness of birth control. During this period it is better to use barrier protection methods.
• Aminoglycosides. Increase the risk of nephrotoxicity.

Simultaneous reception Supraksa with herbal medicines increase the risk of bleeding.

These are the products of plant origin:

• anise;
• arnica;
• celery;
• chamomile;
• cloves;
• garlic;
• ginger;
• ginseng;
• horse chestnut;
• licorice;
• onion;
• Red clover;
• turmeric;
• willow;
• fenugreek.

analogs

Pharmaceutical companies produce 2 types of analogues - drugs that have different names, but the matching of the active substance. Are drugs-synonyms. And drugs that have a similar effect of treatment, but with a different active ingredient. This medication counterparts.

The first group includes drugs that have in their composition the active ingredient Cefixime:

• Tseforal Soljutab.
• Iksim lupine.
• Pantsef.
• Cefixime.

The second group of products belonging to the cephalosporin group, as does Supraks. They contain other active principles, but the therapeutic effect is the same as Supraks.

Analogs Supraksa:

• Azaran.
• Bakperazon.
• Biotrakson.
• Vitsef.
• Kefoteks.
• Klaforan.
• Lifakson.
• Medakson.
• Oritaks.
• Paktotsef.
• Sultsef.
• Triakson.
• Tsefatrin.
• Tsefosin.
• Cefotaxime.
• Ceftriaxone.
• Betasporin.
• Lendatsin.
• Movigil.
• Movoperiz.
• Operaz.
• Sultsefazon.
• Taltsef.
• Tseperon.
• Tsefabol.
• Tsebaneks.
• Fortum.
• Fortazim.
• Oframaks.

Terms, conditions of sale and storage

The instructions on the drug, it is indicated that Supraks can be stored at room temperature away from light and moisture in a refrigerator or up to 14 days. It is undesirable to keep it in the bathroom. Diluted suspension should be tightly closed and then shaken well before use.

All medicines should be kept out of reach of children and animals. Capsules, tablets, unused slurry stored at a temperature of + 20˚... + 25 ° C. The drug belongs to the list B is released from pharmacies on prescription form.

Price Supraks pharmacies in Moscow, St. Petersburg, regions

The price of medicines in the Moscow region:

• A preparation in capsules of 400 mg, 6 pcs. -598-749 rubles.
• Tablets in contour cell, 6 pcs. - 560-700 rub.
• Granules for restoring suspension 100 mg / 5 ml - 560-650 rub.

The price in the regions:

• Capsules 400 mg - 650-750 rub.
• Granules for restoring suspension 100 mg / 5 mL vial by 60 mL -560-620 rub.
• Tablets in a contour cell 400 mg, 6 pcs. - 600-740 rub.

The price of medication in St. Petersburg:

• Supraks 100 mg / 5 ml, 60 ml vial - 600-650 rub.
• Supraks 400 mg capsules - 600-700 rub.
• Supraks tablets 400 mg - 750-800 rub.

Supraks drug has a high efficiency, ease of use in disease of children, rare cases of allergic reactions. The instructions for use indicate that prior to use requires a mandatory consultation with a doctor.

Author: Belyaev Anna (bacheshca)

Registration of the article: Mila Friedan

Videos about Supraks

Indications for use Supraksa: