Hemomycin suspension for children. Instructions for use, analogues, reviews, price

In the treatment of various bacterial infections, Hemomycin is prescribed. This drug contains azithromycin and has a convenient form of release for children. The suspension affects a wide range of microbes and rarely causes side effects.

Forms of release and composition of the drug

Hemomycin is a product of the Serbian pharmaceutical company Hemofarm. The drug is marketed in the form of capsules, oral suspension and injection solution. Moreover, the vials contain not a ready-to-use syrup, but a powder for diluting the medicinal solution. The dry mix bottle is made of dark glass. The powder itself is white in color and has a pleasant fruity aroma.

In addition to the bottle, a translucent scooped spoon is placed in the Hemomycin package, designed for a maximum of 5 ml of the drug. Thanks to the dispenser, you can measure 2.5 ml of liquid syrup. Moreover, the Hemomycin suspension has different concentrations of the active substance, therefore it is produced in a dosage of 100 mg and 200 mg in every 5 ml of the finished syrup.

The main active ingredient of the drug is azithromycin. This antibacterial agent is used in the form of a powdered dihydrate.

In addition to azithromycin, the medicine contains auxiliary components:

• sorbitol;
• calcium carbonate;
• sodium phosphate;
• xanthan gum;
• silica;
• sodium saccharinate;
• fruit flavors.

Hemomycin is a suspension for children, which belongs to the group of azalides - macrolide antimicrobial substances of high activity. In addition to the syrup, the drug is sold in the form of capsules, each of which contains 250 mg or 500 mg of azithromycin. For injections, a lyophilisate is used in vials with a dosage of 500 mg. Taking capsules and injections is contraindicated in patients under 12 years of age.

Pharmacological properties

Just like other representatives of the macrolide subgroup, they have a bacteriostatic effect on a number of pathogenic agents. If you use azalides at an overestimated concentration for several days, azithromycin will completely destroy the causative agent of the infection, suppressing the synthesis of proteins and blocking the processes of their reproduction.

Pharmacological properties of Hemomycin are used in relation to anaerobic and aerobic microorganisms of the following groups:

• pneumococcal;
• staphylococcal;
• whooping cough sticks;
• streptococci, including pyogenic;
• bacteroids;
• hemophilic sticks;
• mycoplasmosis;
• pair of pertussis.

Azithromycin also exhibits a powerful bactericidal effect against Helicobacter pylori, clostridia, pathogens of gonococcal and chlamydial infections. Affected by the influence of azalides and gram-negative spirochetes, gardnerella and ureaplasma.

At the same time, gram-positive microorganisms with developed resistance to erythromycin are immune to azithromycin. In this case, cephalosporins and drugs of the penicillin series are used.

The active component of Hemomycin is able to accumulate inside cells, therefore, it demonstrates the maximum activity against intracellular pathogens.

Azithromycin is converted in the liver, after which the unclaimed residue of the antibacterial substance leaves the body the next day after ingestion. In the foci of infection, the main component is present for 5-7 days, due to which Hemomycin can be used for a short course.

Pharmacodynamics and pharmacokinetics

The principle of action of the drug is based on the mechanisms of suppression of vital biochemical reactions occurring in cell membranes. In particular, after the start of taking azithromycin, protein synthesis is inhibited by combining the substance with the 50S-subunit of the ribosome.

The result of this interaction is the blocking of peptide translocase, leading to a slowdown in the growth and reproduction of pathogenic flora.

Azithromycin in high concentrations is effective against all types of microbes, however, some microorganisms may initially have resistance to the antibacterial component of Hemomycin.

As for the pharmacokinetic properties of azithromycin, it is worth noting the rapid absorption of this substance from the gastrointestinal tract. The reaction rate is due to its hydrophobicity and resistance to acidic environments.

After the intake of a substance in an amount of 500 mg in the gastrointestinal tract, it reaches its maximum concentration after 3 hours. In the blood serum, the level of azithromycin is 0.4 mg / l with a bioavailability of at least 35%.

Chemomycin in the form of a suspension for children easily penetrates with the bloodstream into the respiratory system, into the kidneys and urinary tract, bladder, and pelvic organs. Moreover, in soft tissues, the concentration of azithromycin can be tens of times higher than its amount in plasma.

Due to the long half-life, binding of azalide to blood proteins occurs rather slowly. This is also due to the penetrating properties of azithromycin: the antibiotic enters and accumulates inside eukaryotic cells only at low pH levels.

It is also worth noting the ability of azithromycin to concentrate in the structure of lysosomes, which is of particular importance for the complete elimination of infection.

The researchers were able to prove that the antibiotic is transported by phagocytes to the foci of accumulation of pathogenic agents, where the substance is subsequently released during phagocytosis. At the same time, a large amount of azithromycin in phagocytes does not affect their work.

The metabolic processes of the half-life of Hemomycin occur in the liver, and it takes at least 35 hours to remove its active components. In its original form, no more than 60% of azithromycin is excreted, and most of it leaves the body with feces, and the rest with urine.

Indications for use

The wide spectrum of action of Hemomycin explains the possibility of its use in a number of infectious diseases. Since azithromycin is active against almost all types of bacteria, it is used for diseases, provoked by such pathogens as:

• streptococcus;
• staphylococcus;
• mycoplasma;
• chlamydia;
• ureaplasma;
• pale treponema;
• gardnerella;
• Escherichia coli;
• borreliosis.

Hemomycin is a suspension for children, which is prescribed for pathologies provoked by one of these pathogens. To the list of diseases that serve as an indication for the use of drugs with azithromycin at an early age, include infectious and inflammatory lesions of the upper and lower respiratory tract:

• tonsillitis;
• laryngitis;
• sinusitis;
• otitis;
• scarlet fever;
• bronchitis;
• pneumonia, including SARS.

In addition to these diseases, indications for the use of Hemomycin syrup are urinary tract infections (urethritis, cystitis, cervicitis) and dermatoses that have arisen against the background of bacterial lesions. Azithromycin is effective even in the early stages of borreliosis (Lyme disease).

Contraindications

The antibacterial drug Hemomycin in suspension for children should not be used if there are contraindications. The first limitation for treatment with azithromycin is hypersensitivity to it. You should not undergo a course of antibiotic therapy with Hemomycin in case of an allergic reaction to erythromycin, other macrolides and ketolides.

With liver failure, this antibiotic is not prescribed to patients. Hemomycin is not suitable for treating bacterial infections in children under 6 months of age. Since the composition of the drug contains fructose, its use should be abandoned by patients with individual intolerance.

At what age can the drug be used?

In the first six months of life, Hemomycin is not prescribed. Starting from 6 months, the drug can be given to the child in the minimum dosage (100 mg / 5 ml). The suspension, 5 ml of which contains 200 mg of azithromycin, is used for children over 12 months of age. For newborns and infants under 6 months of age, Hemomycin is replaced with analogs with another active ingredient.

Instructions for use, dosage

In order to prepare a ready-to-use antibacterial syrup from a lyophilisate, it is necessary to strictly follow the algorithm:

1. It is necessary to prepare water for the suspension by boiling it and cooling it to room temperature.
2. Next, you need to fill the contents of the bottle to the level with the mark.
3. The resulting mixture must be shaken, having previously closed the bottle.
4. After shaking, make sure that the finished suspension reaches the bottle mark. If its volume is less, you need to add some water and shake the syrup again.

Before each subsequent use of the drug, the bottle must be shaken to evenly distribute the azithromycin settling to the bottom. You can take the medicine in its pure form and do not dilute it with water, juice or tea. After taking the medicine, it is advisable to drink it with a small amount of liquid so that the remains of the drug do not remain in the oral cavity.

Suspension Hemomycin for children is given 1 time per day throughout the course of treatment. Since food in the stomach can affect the absorption of azithromycin, the antibiotic should be given to the child about 1 hour before a meal. This can be done on an empty stomach or 2 hours after breakfast or lunch.

In case of missing the next medication intake, the suspension must be drunk as soon as possible, and not wait for the next day. It is advisable to observe the 24-hour interval between doses of azithromycin.

The scheme of antibiotic therapy with Hemomycin largely depends on the established diagnosis. For children under 3 years of age, the dosage is calculated by the doctor strictly according to body weight. Patients weighing more than 45 kg are prescribed the same daily dosage as adults - 500 mg.

So, for example, with bronchitis or other respiratory infections, a 3-day course of Hemomycin is prescribed at 10 mg per 1 kg of the child's weight per day. A similar dosage is used for dermatological infectious pathologies.

For the treatment of erythema migrans, a 5-day course of syrup is provided, where during the first day the maximum single dose is used - 20 mg / kg, and during the second to fifth days - 10 mg / kg.

Side effects

The frequency of adverse reactions and their types can be clearly seen in the summary table:

From which system side reactions are observed?	Often	Periodically	Rarely
Blood and lymphatic	a decrease in the level of leukocytes in the blood	thrombocytopenia, hemolytic anemia
Digestive	upset stool, nausea, epigastric pain	anorexia, gastroenteritis, flatulence, constipation, exacerbation of chronic gastritis, dysphagia, bloating, dry mucous membranes, belching, aphthous mouth ulcers	colitis, discoloration of the tongue
CNS	headache	dizziness, impaired taste, paresthesia, drowsiness, insomnia, nervousness	increased anxiety, irritability, light-headedness, convulsions, myasthenia gravis, delirium
Immune	angioedema, skin rashes	anaphylactic shock
Visual	decreased visual acuity
Respiratory	shortness of breath, nosebleeds
Cardiovascular	palpitations, tachycardia	lowering blood pressure
Skin	itching, urticaria, dermatitis, excessive sweating	exanthematous pustulosis
Hepatobiliary	hepatitis	liver dysfunction, cholestatic jaundice, liver failure

In addition to the above adverse reactions, while taking Hemomycin, there is also the likelihood of hearing disorders (tinnitus). One of the unpleasant consequences of antibacterial treatment is candidiasis - drugs based on azithromycin are no exception.

Hemomycin is a suspension for children that can also be used by adults, however, due to the low syrup dosage to achieve a therapeutic effect, patients would have to take the drug in large volumes.

Adverse reactions to azithromycin may not have external manifestations and are often confirmed by laboratory results:

• a decrease in the number of lymphocytes;
• an increase in the concentration of eosinophils;
• changes in plasma bicarbonate levels;
• an increase in the quantitative indicators of bilirubin, urea, creatinine.

While taking Hemomycin, patients may feel unwell, constant fatigue, and swelling of the extremities.

Overdose

The intake of an excessive amount of azithromycin into the body can lead to the appearance of symptoms characteristic of intoxication. An overdose of the drug is manifested by nausea, vomiting, diarrhea, dizziness. Hearing may be temporarily impaired in children. To eliminate the symptoms and consequences of an overdose, you need to wash the stomach and consult a doctor.

special instructions

As noted earlier, one of the possible side effects is the patient's hypersensitivity to azithromycin. When using macrolides, patients may experience complex allergic reactions in the form of angioedema. edema or anaphylaxis, as well as skin lesions, including generalized exanthematous pustulosis and necrolysis.

In some cases, the negative reactions that have arisen when using Hemomycin become chronic.

The initial stage of allergy to the drug is the basis for its withdrawal and the initiation of appropriate antihistamine therapy. After stopping the antibiotic, allergenic symptoms can disappear without medication.

Before starting the use of an antibacterial drug, the doctor should send the patient for a bacteriological examination in order to identify refractory pathogens and fungal infections. Azithromycin is ineffective against mycotic diseases.

When treating with drugs based on azithromycin, it should be borne in mind that the parallel administration of antacids assumes compliance with the recommended time interval (1 hour before or 2 hours after reception). It is undesirable to take an antibiotic based on this component for a longer period than indicated in the instructions from the manufacturer.

Otherwise, the risk of developing pseudomembranous colitis, provoked by Clostridium, increases. With such a complication, it is important to abandon the use of medications that inhibit intestinal peristalsis.

Patients suffering from hepatic impairment, Hemomycin should be taken with extreme caution in order to avoid the occurrence of hepatitis. Liver dysfunction may be indicated by asthenia, jaundice, discoloration of urine.

Special instructions for the use of Hemomycin also apply to patients with proarrhythmogenic factors. Against the background of therapy with antiarrhythmic and psychotropic drugs, it is possible to reduce the level of potassium and magnesium in the blood, change the water-electrolyte balance, and develop myasthenic syndrome.

Drug interactions

Hemomycin is a suspension for children, which, like any other potent antibacterial drugs, interacts differently with representatives of other pharmacological groups. Moreover, various combinations of medications do not always have a beneficial effect on the well-being of the child.

As noted earlier, antacids should not be used concomitantly with azithromycin. Otherwise, the absorption of the antibiotic will slow down, and the therapeutic effect will come much later. Similarly, Hemomycin is absorbed when using drugs containing ethanol.

It is impossible to use azithromycin together with cardiac glycosides (for example, digoxin), since the risk of an overdose of this drug and an increase in its concentration in the blood serum increases.

The antibiotic increases the rate of absorption and reduces the rate of excretion of anticoagulants from the body, glucocorticosteroids, phosphodiesterase inhibitors, dopamine receptor stimulants and oral hypoglycemic substances.

In no case should Hemomycin be taken with heparin drugs due to their pharmacological incompatibility. Despite the lack of confirmed information on the interaction of azithromycin with ergotamine and its derivatives, at the same time it is undesirable to use them in order to avoid the risk of developing ergotism - poisoning with alkaloids ergot.

Analogs

One of the most popular and well-proven analogs of Hemomycin is Sumamed. This antibiotic belongs to the same group of macrolides-azalides, contains the same active ingredient, and is produced in the form of a suspension with an identical dosage.

Sumamed also contains fruit flavors, so it is easily tolerated by children. Unlike ordinary Sumamed (100 mg / 5 ml), Sumamed Forte contains 2 times more azithromycin and is an absolute analogue of Hemomycin with a dosage of 200 mg / 5 ml.

In addition to these two antibiotics, other drugs are also produced with azithromycin in liquid oral form:

• AzitRus;
• Azithromycin;
• Azitrox;
• ZI factor.

In addition to antibacterial suspensions for children with azithromycin, any other macrolide can be used to replace Hemomycin.

The most effective and safest ones sold in syrup form are:

• Klacid;
• Wilprafen;
• Klabaks;
• Macropen.

If macrolide antibiotics are contraindicated for a child or an adult, he is prescribed drugs from the group of cephalosporins or penicillins.

All of them are available in syrup form, taken orally:

• Flemoxin Solutab - a representative of the penicillin group, in which the main active ingredient is amoxicillin. This component belongs to a broad spectrum of antibiotics. Unlike Hemomycin, Flemoxin Solutab has no age restrictions.
• Augmentin - belongs to the same group of drugs as the above Flemoxin Solutab. In addition to amoxicillin, Augmentin contains clavulanic acid, a component that expands the spectrum of antimicrobial action. The suspension can be given to children under 12 months of age.
• Suprax - antibiotic of the cephalosporin series in the form of a syrup. The active substance is cefexim. In the treatment of infectious diseases, Suprax can be given to children over 6 months of age.
• Zinnat - antibacterial suspension for children containing cefuroxime. Suitable for therapy in children over 3 months of age. It rarely causes allergic reactions.

Terms, conditions of sale and storage

Antibacterial drugs, regardless of the form of release, are sold in pharmacies only upon presentation of a prescription from a doctor. These measures were taken to avoid cases of uncontrolled and illiterate self-medication, which often leads to negative and sometimes irreversible complications.

Powder for diluting the syrup is packaged in dark glass bottles to protect the lyophilisate from exposure to sunlight. To prepare a suspension, only boiled or distilled water should be used.

Like most medicines, Hemomycin suspension is usable for 3 years from the date of manufacture. In this case, the diluted syrup must be used within 5 days. After opening, the bottle should be stored in the refrigerator.

Price

The average cost of a suspension for children Hemomycin at a dosage of 100 ml / 5 mg is 150 rubles. For a bottle with a higher concentration of azithromycin, you will have to pay about 250 rubles.

Video about the drug Hemomycin

Review of the doctor about the drug Hemomycin: