Activated carbon
Substances produced from charcoal, coke, coconut flakes are collectively called activated charcoal. Analog Activated charcoal has the same properties.
These substances are effective, safe drugs to detoxify the body. Modern facilities are presented with activated carbon and its various analogues. They are representatives of other chemical groups, but have similar therapeutic properties - to collect on itself and eliminate toxins. Analogues are used for the same indications, they can be replaced, depending on the situation. Products of a similar pharmacological action called enterosorbents because it used to work in the intestines.
The principle of operation enterosorbents
Drug analogues Activated carbon have a similar operating principle, which is based on the presence of fine particles of high surface area material to accumulate on itself and other toxins substances. This property is called adsorption. It is provided a porous structure grains preparation. The strength of adsorption of the free surface zavitsit value, based on the one gram of drug.
Enterosorbent is inert, is not connected to the sorbed substance. The blood chemistry is no change.
Physiological filtering and similar processes it fluid reabsorption in the gut lumen via its villi are the principle action.
The strength enterosorbents
Sorbed and filters not only received food products, as well as those that are isolated from the blood. They captured enterosorbent, fixed on its surface, and then excreted in the feces out.
To determine the force purification using sorbents should know that intestinal villi passed molecules below albumin mass weight. Therefore toxic complexes with a greater mass without departing from the blood, and therefore can not be captured by sorbents. As high toxic substances received with food does not penetrate the blood going well analogues for elimination from the body.
mechanisms of action
The basic mechanism of action represented by the following effects:
- binding of toxic substances that are taken by mouth, once in the cavity of the gastrointestinal tract (GIT);
- binding toxins which are isolated from the blood into the intestine through the reverse filtering;
- absorption of toxins and waste falling into the lumen of the digestive glands - liver, pancreatic and gastric exocrine glands;
- binding toxins rot - metabolites formed at stagnation protein foods in the intestines (indole, skatole);
- sorption of nutrients when changing the diet components due to the absorption of proteins, fatty acids;
- aid in digestion - the transfer of food components;
- increase in the volume of the bolus according to the type of application of dietary fiber;
- enhancing effect on the enzymatic reaction.
To complement the effects of sorbents it is worth noting their impact on the capture of viruses and bacteria, as well as the inhibition of reproduction of pathological microflora. Umerennorazdrazhayuschee action enterosorbents intestinal wall enhances peristalsis, facilitate bowel cleansing. As sorbents have an enveloping, a cytoprotective effect on the intestinal villi.
analogs
Activated carbon has an analog which differs by brand, composition, value. Preparations having similar effects can be divided into two groups.
The first is the same drug composition but produced by other companies. They may differ only in name of the company, some of the formative components. The names of these drugs are synonymous. Good tolerability one manufacturer does not mean the same efficiency and sensitivity to peers.
Are similar preparations having excellent chemical formula, but similar mechanism of action effects.
dosage forms
Drugs with different chemical composition, similar to the action of the activated carbon is:
- polisorb;
- Atoxil;
- Smecta;
- Enterosgel.
Each analogue has manuals for use. Therefore it is impossible to replace the activated carbon without conversion dosages.
1. polisorb
Polysorb and Atoxil consist of silicon dioxide. It is produced in the powder to prepare a slurry. They may be represented by different bottles or sachets roominess in one portion.
2. Smecta
Smectite manufactured in powders for dilution consisting of specific substances - dioctahedral smectite.
3. enterosgel
Enterosgel postoobraznaya looks like a mass of gel, in which the composition has a unique substance polimetilksilosan. This preparation is ready for consumption is accepted tablespoons.
All drugs have different costs, analogs can be produced by different factories, with the same name. For long term drug treatment is more profitable to acquire a large package for the reception of a random - in bags. Domestic products are of excellent quality and lower price.
Dosing doses
The technique depends on the destination state, which requires treatment analogue Activated charcoal. When dyspepsia and flatulence are used low-dose selected according to the instruction. The course of treatment in this case - up to two weeks. Analog taken for 1 - 1.5 hours before eating or 2 hours after later.
When poisoning treatment is initiated as soon as possible immediately after the detection of a dangerous condition. Select the maximum allowable dose, appointed by short courses of three to five days to improve. Replacement Activated charcoal is made without consultation with a physician. This is possible due to low toxicity, safety of treatment with activated carbon.
testimony
Similar drugs are used for Activated carbon adsorption in the intestines of toxins, toxins and nutrients that it is important for weight loss.
In case of acute poisoning take the medication in larger doses, short course, as a sorbent for purification and weight loss - more durable, but in smaller doses.
The indications for use are:
- dyspepsia;
- flatulence;
- poisoning (domestic, chemical);
- food allergies;
- oral medication overdose.
When poisoning and overdoses analogues are used as soon as possible. The residence time of the toxin in the gut should be reduced to a minimum. After 24 hours, after exposure of toxic substances into the analogs of activated carbon - are not effective, as the drug or toxin already sucked into the blood and is not in the intestinal lumen.
Contraindications
Analogs Activated charcoal is not recommended for the same bowel disease, conditions of impaired absorbability. The use of drugs can lead to further damage to the walls of the gastrointestinal tract and exacerbate conditions.
Contraindications to the use of analogs Activated charcoal are:
- ulcer of the stomach, intestines;
- Crohn's disease;
- nonspecific ulcerative colitis.
Activated carbon with its counterparts not be used in patients who are in the stage of rehabilitation after severe diseases, because they interfere with the absorption of nutrients needed for recovery body. Activated charcoal analogues are safe for the baby, but are used to three years.
Drug interactions
Analogs of activated carbon interact with any medications that the patient is taking at the same time with the treatment of coal. The mechanism of interaction is caused enterosorbents sorption on the surface of any substances in the intestine. Then there is their inactivation and elimination from the body with feces.
Therefore, the efficiency of treatment by any oral medication is significantly reduced while the application of analogues of activated carbon. If necessary, drug therapy in the form of tablets disperse them with the time of reception of sorbents as far as possible from each other - at least 3 hours.
sources:
Vidal: https://www.vidal.ru/drugs/activated_charcoal__23846
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 7e933480-3f46-4b66-bce5-240a95414f91 & t =
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