Rimantadine. Instructions for use for children 3-5, 6-7, 9-10 years in tablets. How to accept, composition, price, analogs

For the prevention and treatment of viral diseases frequently prescribed pediatricians agent based rimantadine. According to the instructions for use, all of which are antiviral, having code for J05AC02 Anatomno-Therapeutic-Chemical Classification.

What is it needed for

The drug is indicated for the first signs of sickness:

• weakness;
• dizziness;
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• chills;
• sore throat;
• headache;
• temperature above 37,5 ° C;
• copious purulent discharge from the nose;
• redness of the skin;
• cough.

The main indications for receiving rimantadine are:

• early and late therapy of viral diseases caused by strains of microorganisms:
• A group, including the A2;
• group B;
• group H1N1;
• supportive therapy for colds;
• encephalitis prevention during tick activity;
• treatment of herpes, caused by Herpes simplex pathogen;
• prophylaxis of viral diseases and epidemics of influenza.

In what form is available Remantadin

Tool is available in several forms:

• tablets of 50 mg;
• capsules in 100 mg.

Rimantadine tablets and capsules are intended for use in children older than 7 years.

The cost of the drug may vary by region and price policy of the pharmacy:

Means	Rigla	Gorzdrav	Dialogue	Apteka.ru	ASNA
Tablets, 50 mg, 20 pcs (OLEYNFARM)	159,50	162,50	174,60	176,00	175,54
Capsules, 100 mg, 10 pcs (OLEYNFARM)	234,50	179,60	201,00	194,90	198,90

Cost tablets rimantadine Russian production ranges from 56 to 100 rubles.

Composition rimantadine

Depending on the form of the release of the drug, changing its composition:

Type of product	Structure
Pills	Major component: gidrohloristy rimantadine; additional connections: calcium stearate; starch; milk sugar; talc.
capsules	Major component: gidrohloristy rimantadine; additional connections: milk sugar; starch; tsetiluksusnaya acid; dye: for color capsules - E110; for white capsules - titanium oxide and gelatin.

pharmacodynamics

Rimantadine instruction manual describes as an antiviral agent. The active agent component is derived from an adamantane compound, which is known for its strong structure. He can successfully bind strains of influenza type A cells, Herpes simleks the first two types and arbovirus of the flavivirus infection carried by ticks.

Rimantadine has significant efficacy against swine flu and influenza type B, but in the initial period of the disease. rimantadine substance has antioxidant and anti-toxic action, reducing the concentration of peptide proteins, or cytokines.

These structures make it possible to control the immune response in the body and maintain it at the desired level, and provide anti-inflammatory effects. With the increase of cytokine concentration in blood intoxication occurs because begin to accumulate their decay products. Rimantadine allows you to control the level of immune proteins, binding and taking them out of the body.

The preparation also reduces antigenic voltage when excessive immune response. It regulates the production of lymphocytes and normalizes the interaction of the nervous, endocrine and immune systems. The active drug substance is also a catalyst for the production of interferons alpha, beta and gamma.

This feature enhances the body's defenses and reduce inflammation.

rimantadine action mechanism is based on its ability to block the virus from replicating. When ingested, it begins to penetrate healthy cells, giving them their genetic material. rimantadine weakly alkaline substance has properties and increases the pH level in the cell and membrane structures of the virus.

This allows for blocking:

• the process of merger of healthy cells with pathogens;
• malicious agents reproduction process;
• the process of releasing virus from the cells.

The drug has a long period of withdrawal - for about a day, allowing the active substance for a long time to circulate through the bloodstream and provide immune protection.

rimantadine substance has moderate toxicity to the organism, so toddlers using syrups that contain or carmellose sodium alginate which form special metering education. They provide a gradual release of rimantadine and decrease its toxic effects.

Pharmacokinetics

Rimantadine, instruction manual which warns of the possibility of intoxication, can accumulate in the body if the patient has renal failure. Therefore this group of children need periodic adjustment and dose regimen.

Absorption of the active ingredient takes place in the intestine by 90%, while the rate of absorption is slow. The maximum concentration of active ingredient is achieved after 3 hours after dosing. 40% of the drug circulating in the blood plasma in the form of protein structures, and 50% - in the mucous membranes.

Rimantadine Cleavage occurs in the liver, and then excreted by the kidneys in urine. Period excretion in children may be from 15 to 28 hours. The unchanged from the body is released only 12% of the formulation.

Application rimantadine

Calculation of the dosage of the drug carried a pediatrician, depending on the child's age. The maximum daily rimantadine concentration should not exceed 5 mg per 1 kg weight. The prevention of tick-borne encephalitis or herpes treatment dosage is determined only by a pediatrician.

Rimantadine should be given to children after 20-30 minutes. after eating a small amount of water. Are 2 rimantadine regimen: prophylactic and therapeutic.

For children 1-3 years old

For this age group it is necessary to use a tablet or capsule, rimantadine is prohibited. You must use the same drugs in the form of syrup.

For children 3-5 years

For this age group can be used only to liquid form preparations.

For children 6-8 years

For children up to 7 years using liquid rimantadine. With 7 years of age are allowed to use tablet form. Tablets need to be swallowed without chewing, drinking water.

Preventive scheme:

1 tab. in a day. Duration of reception - 14 days.

The therapeutic scheme:

• 1 day: 1 tablet. 3 times a day;
• 2-3 days: 1 tablet. 2 times a day;
• 4-5 hours: 1 tab. 1 per day.

For children 9-13 years

Children this age Remantadin can be given an increased concentration up to 150 mg on the first day of treatment only once.

Preventive scheme:

100 mg per day. The maximum dose - 150 mg per day. Course duration - 14 days.

The therapeutic scheme:

• 1 day 100 mg three times a day;
• 2-3 day: 100 mg 2 times a day;
• 4-5 hours: 100 mg 1 time per day.

For children 14-18 years old

Instructions for use permits to take Rimantadine from 14 years in the form of capsules and tablets. The capsules must be swallowed whole with water.

Preventive scheme:

Rimantadine 150 mg 2 times a day. Duration of reception - 14 days.

The therapeutic scheme:

• 1 day 100 mg three times daily or 300 mg once daily;
• 2-3 day: 100 mg 2 times a day;
• 4-5 hours: 100 mg 1 time per day.

Contraindications rimantadine

The drug is contraindicated in:

• liver pathology in acute phase;
• renal failure;
• acute nephritis;
• hyperthyroidism;
• pregnancy and breastfeeding;
• hypersensitive to the components that make up the rimantadine.

Additional contraindications for the release form of the drug:

Type of funds	Contraindications
Pills	Age 7 years; high gag reflex.
capsules	Age up to 14 years.

Rimantadine should be taken with caution in:

• epilepsy;
• chronic renal failure, severe;
• diabetes;
• liver failure;
• frequent vomiting;
• pain in the abdomen of unknown etiology;
• diarrhea;
• elevated pressures.

Overdose

When high doses of rimantadine in children may appear:

• vomiting;
• metallic taste;
• nausea;
• weakness;
• anxiety;
• hallucinations;
• arrhythmia;
• jitters.

Upon detection of symptoms of overdose should:

• stop taking the drug;
• gastric lavage, or the child to drink plenty of water;
• give the sorbent;
• an enema;
• consult a doctor.

Pediatrician after inspection can assign multiple dialysis or infusion rates of physostigmine intravenously.

Side effects

When receiving rimantadine in children may occur:

• dry mouth;
• nausea;
• stomach ache;
• migraine;
• loss of appetite;
• allergic reactions;
• distracted attention;
• fatigue;
• irritability;
• sleep disturbance;
• bloating.

If you experience any adverse effects to stop taking the drug, give the child a sorbent. While maintaining the symptoms should seek help from a pediatrician.

Combination with other drugs rimantadine

Rimantadine, instructions for use which indicates its high reactivity, not recommended for use in conjunction with several means:

• sorbents and antacid drugs reduce the absorbability of the active ingredient in the intestine;
• paracetamol, acetylsalicylic acid can reduce the number of rimantadine in plasmas;
• means for reducing the acidity of urine increase the activity of the basic substance and reduce its ability to renal excretion;
• Rimantadine partially reduces effectiveness of anti-epilepsy and can trigger seizure;
• drug enhances the effect of stimulants of brain activity and increases the excitability;
• antiallergics based cimetidine reduce the degree of purification of blood plasma rimantadine.

If necessary, the parallel administration of other drugs with rimantadine necessary consultation pediatrician.

Conditions and terms of rimantadine

All preparations based rimantadine stored in a dark place, away from children and pets, at a temperature not higher than 25 ° C.

Shelf-life of the drug:

• Tablets: 5 years;
• Capsules: 2 years.

Means prohibited to use at the expiration of said expiration date.

Conditions of supply of pharmacies rimantadine

Rimantadine is not included in the list of drugs, prescription.

analogs rimantadine

In the drug has few peers in composition.

Rimantadine Aveksima and rimantadine-STI

It means produced in the form of tablets containing 50 mg of active substance. We packed it with 10 or 20 units of the drug. The tool is designed for oral administration.

The dosage depends on the patient's age:

scheme	The child's age, years
7-10	11-14	14-18
preventive	50 mg once a day for 14 days
therapeutic	50 mg to 2 times per day. Course - 5 days	50 mg to 3 times a day. Course - 5 days	1 day 100 mg three times daily or 300 mg once. 2-3 day: 100 mg 2 times a day. 4-5 hours: 100 mg 1 time per day.

Orvirem and Alguire

Formulations realized in the form of a syrup with a concentration of 2 mg active ingredient / ml. They are packaged in bottles of 100 ml. Liquid rimantadine is intended for use in children under 14 years. The maximum concentration of the basic substance of 5 mg per 1 kg weight.

The dosage used depends on the age of the child:

scheme	The child's age, years
1-3	3-7	7-14
preventive	10 ml, or 2 tsp once. Course - 14 days	15 ml, or 3 tsp once. Course - 14 days	20 ml, or 4 tsp once. Course - 14 days
therapeutic	1 day10 ml, or 2 tsp 3 times a day. 2-3 days: 10 ml, or 2 tsp.. 2 times a day. 4-5 hours: 10 ml. or 2 tsp once.	1 day: 15 ml, or 3 teaspoons, 3 times a day. 2-3 days: 15 ml, or 3 tsp.. 2 times a day. 4-5 hours: 15 ml. or 3 tsp once.	1 day: 20 ml, or 4 tsp 3 times a day. 2-3 days: 20 ml, or 4 tsp.. 2 times a day. 4-5 hours: 20 ml. or 4 tsp once.

Rimantadine has a number of unique, similar in action. Take they should be strictly according to instructions after consultation with the pediatrician.

Arbidol

The main component means a umifenovir. Arbidol available in capsule and tablet form. It is permitted for use in children from 3 years old.

Assign it at:

• acute respiratory viral infections;
• influenza type A and B;
• bronchitis;
• Epidemic viral diseases;
• secondary immunodeficiency;
• pneumonia;
• herpetic disease;
• reducing immunity;
• intestinal infections.

Arbidol Dosage depends on age:

scheme	The child's age, years
3-6	6-12	12-18
preventive	50 mg 2 times a week. Course - 21 days.	100 mg 2 times a week. Course - 21 days.	200 mg 2 times a week. Course - 21 days.
therapeutic	50 mg 4 times a day. Course - 5 days.	100 mg 4 times a day. Course - 5 days.	200 mg 4 times a day. Course - 5 days.

Tamiflu

The preparation includes oseltamivir phosphate. Tamiflu implemented in several forms: capsule, and powder. The tool is designed for use in children 6 months. Assign drug for the therapy and prevention of influenza and during epidemics of viral diseases. Tamiflu dosage depends on body weight.

Treatment:

• From 15 kg to 30 mg 2 times a day;
• 16-23 kg: 45 mg 2 times a day;
• 24-40 kg: 60 mg 2 times a day;
• 41 kg: 75 mg 2 times a day.

Children aged 6 months is recommended to give a dose calculated from the 3 mg of active ingredient per 1 kg of body weight. Children from 13 years should take 75 mg 2 times a day. Duration of treatment - 5 days.

Prevention:

• From 15 kg to 30 mg once daily;
• 16-23 kg: 45 mg once daily;
• 24-40 kg: 60 mg single dose;
• 41 kg: 75 mg once daily.

Duration of reception - 10 days.

When using the powder to prepare a slurry, it is necessary:

1. Measure 52 ml of water.
2. Add it to the vial.
3. Shake the container.

After dissolution of the powder, the concentration of active ingredient will be 12 mg / ml. For dosing need to dial the suspension is attached syringe, where there is a special mark of milligrams.

Kagocel

The composition of the drug as the basic compound used patented sodium Kagocel polymer. It comes in tablet form and is designed to accept children from 3 years old.

Kagocel prescribed for:

• influenza;
• acute respiratory viral diseases;
• colds.

Kagocel Dosage depends on age:

scheme	The child's age, years
3-6	6-18	12-18
preventive	1 tab. 1 times a day. Course - 2 days.
therapeutic	1-2 days: 1 tab. 2 times a day. 3-4 hours: 1 tab. once. Course - 4 days.	1-2 days: 1 tab. 3 times a day. 3-4 hours: 1 tab. 2 times a day. Course - 4 days.	1 tab. 2 times a day. Course - 6 days.

Relenza

As part of the drug is zanamivir. Relenza is produced in the form of inhalable powder and is used in pediatrics to 5 years for the therapy and prophylaxis of influenza types A and B. Included with the product is a special inhaler.

Regardless of age for the treatment of influenza should be carried out by 2 inhalations per day to 10 mg of drug, ie 2 doses at 1 time. Duration of treatment - 5 days. For prevention should be carried out 2 inhalations per day, 5 mg of zanamivir for 10 days.

The procedure for conducting the procedure:

1. Raise the cover of the inhaler and pierce the packaging of the drug.
2. Close the lid.
3. Exhale and insert the end of the mouthpiece in his mouth, holding his lips.
4. Make slow deep inhalation through a mouthpiece and pull it from the mouth.
5. Hold your breath and exhale slowly.
6. Pull the tray up to the end without touching clamps, and slide it back. This manipulation allows the disk to turn part of the same dose.
7. Repeat steps 3-5 three times.

One disk contains 4 cells, which constitute one dose, and contain only 5 mg of active substance. It is worth noting that to exhale into the inhaler is strictly prohibited.

Rimantadine antiviral agent is most effective in the treatment of incipient disease during the first 2 days. Note also indicates that the drug is able to relieve the symptoms of disease when applied at the later stages. Before using rimantadine it is recommended to consult a pediatrician.

Videos about rimantadine

Instructions for use, analogs and price:

Author: Anna Shalunova