Description of the preparation
Akriderm - topical glucocorticoid that is drug used topically as an ointment. Is a synthetic analogue of glucocorticosteroids (adrenal hormone), but due to the peculiarities application (directly on the hearth disease) realizes a maximum of useful effects with minimal systemic complications.
Release form and composition
Akriderm discharged in the form of an ointment, which contains 0.05% or 0.064% active substance. To turn the ointment into tubes weighing 15 or 30 grams.
The main active ingredient - betamethasone, used as fillers petrolatum, paraffin wax, emulsifying wax and some other components.
When added to a preparation of a second active substance combination means obtained: Akriderm Gent - optional contains antibiotic Akriderm GC - added antibiotic and antimycotic agent, Akriderm SC - contains salicylic acid.
Patients often the question arises, what is better Akriderm psoriasis. In the treatment of this pathology are used all dosage forms - particular purpose determined by the nature of psoriasis flow.
Pharmacodynamics - acts as a Akriderm
After applying the cream to the lesions of psoriasis drug active substance inhibits inflammatory processes in the skin due to inhibition of pro-inflammatory cytokines (substances responsible for inflammation). Due to this, there is a delay penetration of leukocytes in the pathological focus. Another important effect - a reduction in vascular permeability that is accompanied by a decrease in edema.
When expressed psoriatic plaques prone to keratinization, more effectively treat psoriasis Akridermom SC. Its constituent salicylic acid promotes softening keratinized areas of the skin, accompanied by improvement in her condition and appearance.
Pharmacokinetics
A preparation for topical application, but sometimes there is an excessive absorption into the bloodstream, which is accompanied by undesirable pharmacokinetic effects (see. item "side effects").
testimony
Take Akriderm psoriasis should only be prescribed by a doctor - treatment of uncontrolled hormonal ointments can lead to negative consequences.
Common indications for use of said formulation are as follows:
- contact dermatitis and Professional;
- allergic rashes on the skin;
- chronic zoster;
- intolerable itching;
- ringworm;
- various types of cutaneous (pityriasis, pink, etc.).
Akriderm prescribed as in the simple psoriasis, and in complicated forms: accession of bacterial or fungal nature of secondary infection. Combination therapy involves the use of the system and preparations in complicated psoriasis is more effective.
How effective Akriderm in psoriasis
According to the results of the set of reliable research on the background of the treatment of psoriasis was observed Akridermom distinct positive changes: reduction in psoriasis lesions decrease in the activity of the local inflammatory process, to assess the therapeutic effect can already at 5-7 days application of the cream.
In the course treatment duration of 10 to 14 days, positive effects were observed in 35% of patients, but with a duration of more than 20 days - 50%. In this case, the negative results often have been associated with impaired use of regularity.
Contraindications
Absolute contraindications:
- rash secondary syphilis;
- herpetic eruptions;
- rash of chickenpox;
- cutaneous tuberculosis;
- children under the age of 12 months.
Akriderm HA psoriasis not be used in patients with uncomplicated disease.
How to apply for psoriasis - dosage
Any kind Akriderm cream applied in a thin even layer to the affected skin and rub it is not required - the cream absorbed himself. application mode: twice daily in psoriasis mild to moderate in adults; 1 time per day on psoriasis in children.
In severe forms of the disease dosing regimen can be modified to the individual - up to 6 times per day. In children, even in severe psoriasis Akriderm can not apply more than 2 times a day - dramatically increases the likelihood of systemic complications.
Akriderm begin to apply the cream for psoriasis on the hands, feet and body should be a simple form: A so-called "step" approach. Its essence lies in the fact that at first use a simple form of the drug, then, with accompanying identifying flora Akriderm changed to Akriderm HA or Akriderm Gent. Replacement of the drug is carried out on the recommendation of the attending physician.
Increase the effectiveness of the drug is possible by a simple steps: prior to the application of cream to the skin, it must be pre-moisten wet swab.
Akriderma therapeutic effects in psoriasis is much better if local treatment is complemented by preventive interventions: abstinence from stress and consumption of allergenic foods.
Use of hormonal ointments psoriasis does not exclude the use of other medications: combined use of drugs from different groups leads to synergy - mutual reinforcement of therapeutic action.
Duration of psoriasis Akriderm cream - by 2 to 4 weeks, it depends on the degree of effectiveness of the therapy. In the absence of a positive effect should be to clarify the diagnosis.
Side effect
Sustained or massive use of hormonal ointments leads to unpleasant events in the form:
- hypertrichosis (increased hairiness) treated skin areas;
- hypopigmentation;
- skin atrophy;
- folliculitis;
- perioral dermatitis;
- joining a secondary infection (for very prolonged use);
- acne-like rash.
In some patients noted idiosyncrasy that can develop
Symptoms of overdose
Systemic side effects due to introduction of large amounts of the hormone in the bloodstream, manifested in the form of hyperglycemia (high blood glucose), glycosuria (glucose in the urine), Cushing's syndrome. Way to deal with these phenomena, only one - the refusal of further use Akriderma and its replacement by a weaker counterparts.
special instructions
With long-term treatment of hormonal ointments can not abruptly stop their use - cancel them gradually to prevent withdrawal symptoms. With prolonged use of the drug may reduce its effectiveness due to habituation patient.
Do not use multiple hormonal ointments - it increases the toxic action of hormones, also in this case it is impossible to determine which one is more effective.
sources:
Vidal: https://www.vidal.ru/drugs/akriderm__13790
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = b8e9d5d7-17a6-47e8-aa72-65de7c7deeb9 & t =
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