product characteristics
Nimesil relates to the pharmacological group of nonsteroidal anti-inflammatory drugs (NSAIDs). Sold in effervescent tablets or granules, which are accepted in the suspension. Each tablet or powder contained 100 mg of active substance - Nimesulide.
Nimesil effect on the body
The ingestion inhibits the production of the enzyme cyclooxygenase, thereby inhibiting the synthesis of prostaglandins and other biologically active compounds, causing the development of inflammation in tissues. Inflammation is accompanied by swelling, pain and local temperature increase. It is against these symptoms directed drug action.
Bonus nimesil in diseases of the musculoskeletal system - chondroprotective action. It protects the cartilage from the damaging effects of inflammatory mediators. Effect of the drug starts after 30 minutes and lasts for 6-12 hours. The maximum concentration of drug observed in the female genital organs, synovial (joint) fluid, muscle, and structural elements of the skeleton.
Indications
Nimesil used as anti-inflammatory and analgesic drug with:
- Menstrual pain syndrome (algodismenoree);
- Toothache;
- Injuries of muscles, ligaments and skeletal apparatus (torn ligaments, fractures, sprains, bruises, sprains);
- Pathologies of the musculoskeletal system, accompanied by painful sensations in the back and joints (myalgia, osteochondrosis, bursitis, arthritis, osteoarthritis, sciatica, lumbago, and so forth.);
- Pain of unknown etiology;
- Headache.
Prescribe the drug after dental procedures and surgical interventions.
Contraindications
Using nimesil prohibited in:
- Pathologies of the circulatory system (hemophilia, bleeding disorders, hemorrhages different localization);
- Exacerbation of chronic diseases of the gastrointestinal tract (colitis, enterocolitis, Crohn's disease, esophagitis, gastritis, gastric ulcer and duodenal ulcer and so forth.);
- Intolerance to NSAIDs;
- Application of medicaments that have toxic effects on the liver (e.g., other analgesic agents);
- Fever on the background of colds (flu, SARS and ARI);
- Severe liver disease, kidney;
- Drug and alcohol addiction.
Limited use of the drug after heart surgery, during pregnancy and lactation. Nimesil suspension is contraindicated in children under 12 years.
Application nimesil in pregnant and lactating
The opportunity to study in detail the impact of the drug on the health of the expectant mother and the child, for humanitarian reasons is absent. Information on whether Nimesil may be pregnant, includes formal instruction on the use of the drug. However, in a brief statement it said that its effects on the fetus are poorly understood, in this connection, lactating and pregnant women is not recommended to take Nimesil. But during pregnancy, a woman may experience a variety of pain, including non-interest position.
The FDA authoritative international organization, to conduct clinical trials on animals and their offspring, which revealed some patterns. Contraindicated Nimesil adversely affect the course of pregnancy and child development.
Use of the drug in the first trimester, when the embryo is formed all systems, organs and tissues increases the risk of birth defects (heart disease, vascular, kidney, liver, etc.). Disrupting kidney and liver in the mother pathologically affect on blood pressure (increasing or decreasing it).
Nimesulide accumulates in the female reproductive organs and increases the tone of the uterus, It increases the likelihood of spontaneous abortion and the occurrence of uterine bleeding. During pregnancy in 3 trimester take Nimesil dangerous because of the side effects on the kidney and circulatory system of a woman.
Disruption of the kidneys, high blood pressure and swelling can cause pre-eclampsia and eclampsia - severe pathology that carry a lethal threat of life. In this case, you may need an emergency delivery. All of these risks increase with prolonged use of drugs and excess doses.
Application of Nimes in the later stages may result in problems with the stomach and intestines. The growing uterus compresses the organs of peritoneal and stomach. There is frequent heartburn. The mucosa of the digestive system becomes vulnerable to the action of analgesic and other drugs with irritating properties.
Heartburn, epigastric pain, acid regurgitation, gastritis, gastric ulcer and duodenal ulcer. Here is a partial list of those ailments that may trigger nimesulide in pregnant women in the second and third trimester.
Note! Nimesil drink during pregnancy or lactation is possible only after consultation with your doctor.
During breastfeeding is allowed to take the medicine if feeding is suspended for the duration of therapy. After completion of treatment the child may again be applied to the chest.
How to take Nimesil
Nimesil allowed to drink during pregnancy in the absence of diseases of the stomach, the threat of miscarriage, bleeding; edema, liver disease, kidney disease. A single dose - 1 sachet or 1 effervescent tablet. Taken after meals in the form of a slurry. The solution is prepared immediately before use by dissolving the drug in a glass of water. Note! Ready solution can not be stored!
The maximum daily dose - Two tablets or two sachets taken in 2 hours. Therapeutic course varies from a single application (in rare cases, pain) to two weeks (for inflammation). The average duration - 5 days. If you feel unwell, immediately cancel the drug and seek the advice of a doctor who oversees pregnancy.
conclusion
Nimesil belongs to the group of drugs that are used for pregnant women is not recommended. The use of one or two doses needed to get rid of dental, joint or a headache, it is unlikely there will be something serious. But for long-term, it is better to choose something a little more secure, and the possible replacement is necessary to ask the doctor.
If you still receive nimesil during pregnancy can not be avoided, it is necessary to strictly observe the recommendations for application. And then with his mother, and with the baby everything will be all right!
sources:
Vidal: https://www.vidal.ru/drugs/nimesil
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = feea99ed-6bbf-4079-920f-ad79aeed5c36 & t =
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