predisposing factors
Fungi of the genus Candida are present on almost all mucous membranes, as well as for almost the entire digestive tract. Normally, their excessive multiplication does not happen, because it is constrained not only the immune system strength body, but also the normal microflora, which prevents too rapid multiplication of opportunistic flora.
Factors that may contribute to a reduction of the immune response and the creation of favorable conditions for fungal growth and development of candidiasis include:
- Oncological processes and hematological malignancies, especially against the background of chemotherapy and treatment with ionizing radiation. Fluconazole in such cases are often assigned to prophylactic doses;
- Physiological immunodeficiencies. The immune response declines with age, pregnant women, against debilitating, frequent stressful situations. Still not fully formed organism children (including the immune system) and more susceptible to candidiasis lesions;
- Autoimmune pathology, as well as long-allergic processes. Especially pronounced inhibition of the immune system in patients receiving corticosteroids;
- Congenital and acquired immunodeficiency syndrome (acquired immunodeficiency, congenital De Giorgi syndrome);
- Prolonged treatment with antibacterial agents (particularly broad spectrum of action). In such cases it is also often appointed fluconazole for prophylaxis of candidiasis lesions.
Wherein drink fluconazole in the treatment of intestinal candidiasis may have in conjunction with several other drugsAs to a weakened immune system such pharmacological aid may not be enough.
Possible clinical manifestations of intestinal candidiasis
If you violate the natural protection arise candidiasis. Most often, this fungal infection manifests itself in the mucous genitals and mouth, but there are other options for localization. It should be borne in mind that this disease is to recognize their own, without further investigation, practically impossible, since the specific manifestations of almost none.
For lesions of the intestine characterized by the following symptoms:
- A frequent complaint is the first flatulence, which is particularly strongly disturbs patients after consuming large amounts of carbohydrates. Also, such patients may complain of abdominal pain, nausea, a feeling of early satiety, alternating constipation and diarrhea;
- Often start growing fungi of the genus Candida in the oral cavity, while in the absence of treatment and adequate immune response in the intestine and spreads. Therefore, when viewed on the mucous membranes of the mouth white coating is determined at which the detected ulcers;
- One of the most severe variants of candidiasis - diffuse. The condition of patients with this form of heavy, pronounced symptoms of intoxication. Worried as severe pain in the abdomen, blood in the stool can be impurity. Characters and candida lesions of internal organs. Treatment of candidiasis bowel fluconazole in this case - the need and the doses will be used at the same corresponding;
- It occurs and the so-called focal embodiment candidiasis. This secondary candidiasis, which joins the basic pathology such as peptic ulcer disease or ulcerative colitis, and significantly complicates treatment.
Pharmacological characteristics Fluconazole
To take the drug for intestinal candidiasis may have more than one. The most common options - Fluconazole, Nystatin, amphotericin-B. They are somewhat different mechanism of action, which increases efficiency while using.
Fluconazole Antifungal effect is achieved due to its ability to inhibit cytochrome P450 dependent enzymes of fungi, while having a minimal effect on these enzymes organism person. Inhibition of enzymes of the group violates the synthesis of membrane lipid mushrooms - ergosterol, resulting in increasing the permeability of cell membranes, disturb the process of their formation, which leads to death fungal cells.
For Fluconazole characterized by a high rate of bioavailability, it is well absorbed in the digestive tract, regardless of meal times. Active substance penetrates well into all bodily fluids, including cerebrospinal articular and that expands the range of possible use of fluconazole in different embodiments candidiasis.
main contraindications
When intestinal candidiasis Fluconazole can not drink in the following cases:
- When hypersensitive to the active agent (fluconazole) as well as in cases where the previously noted facts intolerance antifungal drugs with a similar chemical structure;
- Children under the age of 4 years also makes the treatment of candidiasis with fluconazole impossible;
- When candidiasis can not simultaneously receive Fluconazole and drugs that increase electrical ventricular systole duration (astemizole, terfenadine, and other drugs with a similar effect).
Possible side effects of the treatment of candidiasis fluconazole
Among the side effects of the treatment with fluconazole found:
- Abdominal pain, rastrojstva perception of taste, loss of appetite, diarrhea, are much less likely in patients receiving Fluconazole found liver function disorder from increased liver enzymes in plasma, to gepatonekroz;
- May be concerned about the headache, feeling dizzy, much less likely to occur cramps as a side effect;
- Possible while taking fluconazole, though rare, hematopoiesis disorders - reduction in the number of platelets, leucocytes;
- Frequent allergic reaction to Fluconazole is considered to be a skin rash, severe conditions such as Stevens-Johnson syndrome or toxic epidermal necrolysis are rare;
- It is also possible to increase the duration of electrical systole of the ventricles in patients receiving Fluconazole.
The dosage of fluconazole for intestinal candidiasis
How to receive at candidiasis Fluconazole bowel depends on the clinical features in each case of disease:
- For focal candidiasis, damaging existing ulcerative defects Fluconazole administered at a dose of 200mg per day. Duration of treatment 20 days;
- To diffuse intestinal candidiasis Fluconazole is considered second-line drugs. Fluconazole is assigned in a dose up to 400 mg per day and treatment duration a debilitating injury may exceed 30 days. First-line agents in such a situation is considered to amphotericin B;
- When gastric lesions primarily as Fluconazole dose is 200 mg per day.
sources:
Vidal: https://www.vidal.ru/drugs/vero-fluconazole__10369
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = a35154cb-6bbe-4dc2-b8a1-c478d7407760 & t =
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