Fungal infections of the oral cavity are found not so rare. Fluconazole in stomatitis is one of the most commonly prescribed agents, since this drug is not only safety, but also the effectiveness against many pathogens of fungal origin, not only against the most common - type of mushroom Candida.
Fungal stomatitis - the main manifestations and predisposing factors
This is a fairly common disease of the following symptoms:
- Pain, burning sensation in the mouth and throat;
- When viewed from the oral cavity defined by a white coating, including the language, a mucous coating hyperemic, and if the patient is attempting to remove plaque - the damaged area to begin bleed;
- Also frequent complaints about the deterioration of the perception of taste, unpleasant (sometimes metal) taste in the mouth.
Among the predisposing factors to the development of thrush can be identified:
- Insufficient (as well as excess) oral hygiene;
- Frequent mechanical or thermal damage to the mucous membrane;
- Substandard or improperly installed dentures;
- Immunodeficiencies of various genesis;
- Lack of vitamins;
- Fluctuations in hormonal levels.
Features of the pharmacological action of Fluconazole
The active ingredient of the drug inhibits the vital activity of pathogenic and conditionally pathogenic fungi by disrupting the synthesis of cell membrane components. In this case, similar enzymatic systems of the human body Fluconazole is almost overwhelming.
One of the characteristic features of the drug is its ability to penetrate biological fluids. Its concentration in the synovial fluid and saliva is the same as in the plasma, and the content in the cerebrospinal fluid is only slightly lower. Due to this feature the drug effectively including when caused by fungal pathogens of meningitis.
When stomatitis take Fluconazole is justified only in cases where there is an exact confidence in its fungal natureAgainst viral and bacterial pathogens ineffective drug.
Possible contraindications and limitations
Stomatitis treated with fluconazole can not in all cases.
This medicament may be contraindicated in:
- Confirmed by medical records or anamnestic giperchuvsitelnosti to the current, or auxiliary substance components;
- Nor can use this drug in the treatment of astemizole, terfenadine or other drugs that affect duration of electrical systole the ventricles;
- Fluconazole at a stomatitis in children can not be used under the age of 4 years.
Features dosage Fluconazole stomatitis
Dosage Fluconazole in stomatitis depends on a number of clinical features of the disease:
- Most patients with stomatitis Fluconazole administered at a dose of 150 mg once-daily, the duration of this treatment can be up to 2 weeks, and in cases of immunocompromised much longer;
- A special case - stomatitis in patients with AIDS. For the prevention of relapse after the main course Fluconazole 150mg of the drug is prescribed once a week;
- When candidal stomatitis caused by wearing dentures can also be administered in a dose of 50 mg Fluconazole. The duration of the treatment - 2 weeks, at the same time must be processed with fluconazole prosthesis antiseptics.
sources:
Vidal: https://www.vidal.ru/drugs/vero-fluconazole__10369
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = a35154cb-6bbe-4dc2-b8a1-c478d7407760 & t =
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