Fungal skin lesions, mucous membranes, or nails, in the complex treatment must include antifungals. But among the variety of such funds is very difficult to choose. For example, it is better to Fluconazole or Terbinafine? This article will help determine the choice and conduct comparative characteristic of preparations. Before comparing the drugs, it is necessary to give a brief description of each of them.
terbinafine
terbinafine - an antifungal drug from a group of allylamines. It has preferably a fungicide (antifungal) effect on dermatophyte, as well as other species of fungi. It is destructive to the cell membrane of fungi, whereupon they were killed.
Terbinafine has a broad spectrum of action, but despite this, it advantageously administered for destroying pathogens dermatomycoses.
By the testimony of the drug include:
- Fungal infection of the scalp;
- Fungal diseases of the skin and nail plate;
- ringworm;
- Candidiasis of the mucous membranes and skin.
The drug is available in the form of a cream, ointment, spray and tablets. Terbinafine is contraindicated under the age of 2 years, during pregnancy and lactation period, when allergies to components of the drug, as well as in patients with chronic renal failure and diseases liver.
Now, to be compared with fluconazole, terbinafine, it is necessary to characterize and second drug.
fluconazole
fluconazole - antifungal azoles from the group. The preparation has predominantly fungistatic effect - inhibits the growth and reproduction of fungi. The drug prevents the growth of spores, acting on the membrane level. Flucanozole is an effective tool in the fight against pathogens of candidiasis.
Indications Fluconazole:
- cryptococcosis;
- Candidiasis of the mucous membranes, including the mouth, throat, esophagus, as well as non-invasive bronchopulmonary candidiasis;
- Genital candidiasis;
- Mycosis of the skin, including foot;
- Deep endemic mycoses.
In addition to the treatment Fluconazole is used to prevent fungal diseases with cytostatics after chemotherapy or radiation therapy in people with cancer.
The drug should not be taken for children under 4 years of age, during pregnancy and lactation (although in the case of heavy losses, reception can be assigned and pregnant women), and hypersensitivity to fluconazole components under severe lesions liver. Also antifungal agent does not accept, while the use of drugs such as terfenadine, cisapride, Astemizole.
Comparative characteristics
You can now conduct a comparative description Fluconazole and Terbinafine, as well as to find out whether it is possible to take medications at the same time.
By comparison,
- The active substance and the group in different preparations;
- Product form. Fluconazole is available only in the form of capsules for the reception inside when Terbinafine has many forms of release, not only for domestic but also local application;
- Age. Terbinafine in some forms of release can be used already from 2 years old when fluconazole is contraindicated in children up to 4 years;
- Indications. In Fluconazole them much more when Terbinafine is mainly prescribed for fungal infections of the skin and nail plate;
- Security. Fluconazole has a higher absorbability, so strongly affects the liver, rather than Terbinafine. It should also be considered when choosing a drug.
Which of these drugs effective depends on the type of disease, age of application and concomitant diseases. Thus for the treatment of onychomycosis, especially in children under 4 years is better to use Terbinafine, and to combat genital candidiasis and cryptococcosis Fluconazole is more effective. That is why with a choice of the best drug helps the doctor to decide.
In some cases, the treatment of, for example, onychomycosis, the doctor prescribes to take Terbinafine with fluconazole. Combining topical antifungal agent - Terbinafine Inland fluconazole, it allows to achieve a higher effect of reducing the treatment time.
sources:
Vidal: https://www.vidal.ru/drugs/vero-fluconazole__10369
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = a35154cb-6bbe-4dc2-b8a1-c478d7407760 & t =
Found a bug? Select it and press Ctrl + Enter
