Dexamethasone in bodybuilding and sports: how to apply, the statement

The pharmacological properties of Dexamethasone

The hormonal drug penetrates the cell nucleus, synthesis gives proteins which mediate the development of inflammatory, allergic, immune reactions. Inhibited the release of interleukins, interferons, inhibited secretion of thyroid-stimulating hormone, increases excitability of the nervous system. Effect on metabolism: enhanced protein breakdown, especially in the muscles, increased formation of atherogenic lipids, contribute to the development of atherosclerosis in vessel walls.

Inhibited all stages of the inflammatory response, including the step of regeneration and tissue repair. In the body, it increases the level of catecholamines, constricts blood vessels, all this leads to increased blood pressure.

Chronic administration of corticosteroids adrenal glands stop producing endogenous hormones during abrupt cancellation this may lead to failure or endocrine organ syndrome "cancel". Signs syndrome "cancel": temperature increase to very high numbers, abnormal discharge from the nasal cavity, flushing conjunctival membrane of the eye, headaches, dizziness, neuro-psychiatric disorders, myalgia, arthralgia, severe weakness, loss operability.

positive aspects

The use of dexamethasone in the sport attractive positive consequences:

• cheapness. Compared with anabolic steroids Dexamethasone is inexpensive, thus available without prescription and doctor's prescription in many pharmacies;
• The powerful anti-inflammatory effect. The main cause of pain in the muscles and joints of athletes - inflammation after injury. Dexamethasone penetrates cells alters protein synthesis at the ribosome, including proteins, which are responsible for the development of the inflammatory response. As a result, it blocked all phases of inflammation, including exudative - the main cause of negative symptoms: pain, swelling, redness, dysfunction;
• Delayed elimination of water and sodium from the body. With a small delay of water (2 liters) increases the amount of synovial fluid, which prevents further development of inflammation thereby reducing pain. When using Dexamethasone better lubricated joints, the articular surfaces are not worn;
• Improving appetite. Diet is very important for professional athletes. Of appetite and the amount of food eaten useful depends on the speed of the body's recovery between workouts and before the competition.

negative aspects

Application Dexamethasone in sport without having unacceptable indications for use, since it is a powerful hormonal agent that is administered in serious pathologies.

Corticosteroids cause a large number of mediated reactions and side effects:

• Immunosuppression. With prolonged use or receiving large doses of dexamethasone reduces the body's natural defenses against viruses, bacteria, cancer;
• Ulcerogenic action. This effect is connected with the violation of the synthesis of prostaglandins that protect mucous membrane of the stomach and the duodenum from the effects of hydrochloric acid. Chronic administration of ulcerative defects may appear corticosteroids;
• protein catabolism. Dexamethasone contributes to the destruction of proteins in muscle tissue, reduces blood globulins;
• Impact on carbohydrate metabolism. Increases in blood glucose concentration, promotes the development of steroid diabetes. In patients with pre-existing diabetes increases the need for hypoglycemic agents;
• Impact on lipid metabolism. Dexamethasone increases the level of cholesterol, low density lipoproteins and triglycerides in the blood, promotes the redistribution of body fat with preferential accumulation in the shoulder girdle, the person belly;
• Corticosteroids inhibit the synthesis of collagen, the connective tissue cells. Chronic administration of dexamethasone reduced the rate of tissue regeneration and scar formation;
• Effects on the endocrine system. Upon receiving Dexamethasone adrenal insufficiency may occur, their atrophy, decreased concentrations of catecholamines in blood, Cushing's syndrome, weight gain;
• Loss of calcium, potassium, muscle weakness, atrophy;
• Neuropsychiatric disorders up to depression, psychosis and convulsions;
• Pancreatitis, esophagitis, dyspepsia;
• Accession secondary infections;
• Increased blood pressure, allergic reactions;
• Thrombosis, embolism, decrease of lymphocytes, platelets, increased leukocytes, eosinophils;
• After a course of dexamethasone treatment must be withdrawn gradually. When the abrupt cancellation may develop symptoms of adrenal dysfunction, hypertension.

Get a detailed overview of contraindications and side effects, you can read the official instructions for use of dexamethasone.

Dexamethasone athletes take in small doses (1-2 mg per day), introducing the solution of the drug intramuscularly, waiting while reducing pain and enhancing the appetite. The same effects can be obtained by taking a safe non-hormonal drugs or special anabolic steroids. Thus, the positive effect of dexamethasone in the sport does not justify the risks of receiving medicament.

Dexamethasone powerlifting

In use pauerliftinge Dexamethasone also inadmissible. Some athletes use corticosteroids to reduce inflammation and improvement of the musculoskeletal system. In this case, the drug helps temporarily, after the abolition of pain, swelling and redness of the increase. In addition, the chronic administration of dexamethasone increases risk of developing gastric ulcers.

conclusion

Dexamethasone is often used in sports unfounded. For anti-inflammatory effect, reducing pain and enhancing the appetite can be used more sparing agents, physical therapy, special diets. For athletes, it is important to keep the immune system and metabolism at optimal levels, so most doctors forbid Dexamethasone as a drug to eliminate inflammation. The facility can be used only when there are clear indications prescribed in the official statement.

sources:

Vidal: https://www.vidal.ru/drugs/dexamethasone__36873
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 5db6dfe2-5236-4cd7-86de-d6f534373dd4 & t =

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