Dexamethasone belongs to the glucocorticoid hormone drugs. It is used to treat allergic, rheumatic, acute conditions (shock, cerebral edema). Dexamethasone for joints prescribed more often by injection. Dexamethasone injections perfectly removes inflammation, swelling, pain.
Pharmacological properties, forms, indications and limitations
Dexamethasone produced in the form of tablets, as well as a solution for injectable administration. The active component of the drug is dexamethasone sodium phosphate. The tablet form is contained 0.0005 g of the substance, 1 ampoule of 1 ml of a 4 mg formulation 1 ampoule (2 ml) - 8 mg of drug.
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Dexamethasone has a good anti-inflammatory effect by reducing the synthesis of leukotrienes, macrophages, interleukins in the lesion. The drug also has anti-allergic action. The medicine reduces the amount of protein molecules in the blood plasma. Means increases the formation of fatty acids and tiglitseridov, increases the concentration of cholesterol in the bloodstream.
Dexamethasone increases the absorption of glucose in the digestive tract, stimulates the enzyme glucose-6-phosphate. Glucose begins to flow from the liver into the blood, resulting in hyperglycemia. Increased synthesis of hepatic enzymes, gluconeogenesis starts. The drug enhances the release of calcium from the bone tissue, it increases the excretion of urinary system.
Indications for use drugs:
- system disease;
- children's and adult joint disease;
- allergic diseases;
- skin diseases (psoriasis, scleroderma);
- brain edema;
- eye disease;
- poor adrenal function;
- autoimmune renal, hepatic disease;
- hematopoietic system disease (anemia, leukemias);
- pulmonary disease, pulmonary tuberculosis, the brain;
- cancerous lung disease;
- diseases of the digestive tract;
- differential diagnosis of adrenal cancer;
- shock states;
- arthritis of various etiologies, osteoarthritis, bursitis, osteochondrosis, tenosynovitis, epicondylitis, synovitis, frozen shoulder.
For joints take Dexamethasone should be in the form of injections. This helps to rapidly reduce inflammation and pain. The drug in solution may be used in the form of droplets in allergic conditions (dripping onto the conjunctiva).
Dexamethasone is not used in patients with diabetes, allergies to components of the drug, bone fractures, joint deformities, post-vaccination, osteoporosis, after a heart attack.
Terms of Use of the drug in diseases of the joints
Dexamethasone with osteoarthritis of the joints, if not more effective than standard therapy, the doctor may prescribe medication tablet form course for a few days followed by gradual withdrawal. Dosage selected individually depending on the clinical manifestations. Without prescription drug should not be used, since it has its indications and limitations. Incorrectly selected dosage and the wrong combination with other drugs can lead to serious complications. Dexamethasone treat joints often start using injecting the drug into the joint cavity.
Rules of administration
When joint pain stabbing Dexamethasone need in the cavity of the joint capsule. According to the instructions, the drug is administered volume of 0.2-6 mg. The dose of the drug is dependent on the size of the joint. For smaller joints and scapulohumeral periarthritis enough 0.2 mg of material. When the knee arthrosis need to 0.6 mg of drug. Prick make 1 time for 3 days for 3 weeks. When side effects: high blood pressure, hyperglycemia, osteoporosis, and other manifestations of the drug should be discontinued. After a course of treatment should take a break for 3-4 months to prevent suppuration, osteoporosis, osteonecrosis in the joint.
conclusion
Dexamethasone is considered a very strong drug, therefore its use in short courses. The medicine has a lot of positive feedback on the effectiveness of patients. It is prescribed locally in the joints up to 3 weeks with a break in order to prevent complications. You should not put yourself injections, as this may damage the structure of articular joints. Proper use of the drug will help prevent early development of destructive changes.
sources:
Vidal: https://www.vidal.ru/drugs/dexamethasone__36873
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 5db6dfe2-5236-4cd7-86de-d6f534373dd4 & t =
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