Chemical composition
Ambroxol is the active ingredient, and a part of many drugs expectorants, e.g., a drug Mucosolvan.
Ascoril - a complex preparation, which included can be found bromhexine, salbutamol and guaifenesin.
The compositions of drugs are different, though similar pharmacological effect.
What forms of drugs can be found
Ambroxol produced in the form:
- syrup;
- oral tablets;
- Slow Release Capsule substance with prolonged action;
- spray can;
- pastilles.
Ascoril occurs in the form of:
- syrup;
- tablets for oral administration.
The syrup is often assigned to children and tablets for adults.
Pharmacological action Ambroxol
Ambroxol promotes separation of secretion from bronchial excretion secretion and respiratory tract. The drug exhibits secretomotoric effect aimed at sputum especially when wet cough. Activity of the protective layer increases respiratory ciliated epithelium activated and improved peristaltic bronchi. Ambroxol promotes the formation of surface plenochki - surfactant - a special substance, whereby the secret can easily pass-slide in the airways.
Pharmacological action ASKOR
Ascoril helps eliminate muscle contractions in the bronchi, thins bronchial secretions and removes it, and separates it from the walls of the bronchi. Due salbutamol Ascoril blocks spasm in the bronchi. Manifested expectorant and mucolytic action.
Ambroxol with Askorilom are m mucolytic expectorant drugs.
When the drugs are taken
Ambroxol is indicated for diseases of the respiratory tract and bronchi when sputum alone can not be separated and displayed. Acute or chronic forms of bronchitis, catarrhal disease with accumulation of viscous mucus, bronchial asthma and others. Ambroxol is taken when manifested cough.
Ascoril indicated for:
- bronchial obstructive disease manifestations;
- bronchial asthma;
- pneumonia;
- inflammatory processes affecting both the trachea and bronchi;
- emphysema;
- Pulmonary disease, which develops after a long inhalation of dust (pneumoconiosis);
- infectious disease of the respiratory tract with a strong cough bouts;
- pulmonary tuberculosis;
Admission ASKOR and Ambroxol held in monotherapy or in combination with other anti-infective agents or mucolytic.
dosing regimens
Ambroxol - a medication that can be administered to children from birth under the guidance of a doctor. Children up to 24 months the dosage is assigned based on the ratio of 7.5 mg / reception of 2 times a day. With 24 months to 5 years, the dosage of 7.5 mg / administration, 2.5 ml of the syrup, 3 times a day. 12 years 15 mg ambroxol 3 times a day to 45 mg per day. Older than 12 years to 30 mg / reception to 90 mg per day, divided into 3 doses. Last the medication should not be later than 18:00, as the night will also be a process of expectoration, and the body can not relax.
Ambroxol capsules prolonged action taken once daily 75 mg.
In severe cases, or to quickly display ambroksol effect can be administered intravenously.
Ascoril syrup is appointed for 24 months before the children. Medication should be prescribed by a doctor only after a full examination, and all analyzes.
- from 2 to 6 years should take 5 ml of the drug in 3 divided doses;
- 5-11 years 5-10 ml ASKOR in 3 divided doses;
- 12 and older 10-12 ml 3 times per day.
Tablets are taken with 6 years. A child under 6 years old should not drink them.
- with 6-12 0,5 tablet in 3 divided doses;
- 13 years and over: 1 tablet 3 admission. The tablet must be swallowed whole, it is better with a glass of plain fresh water.
It is not recommended to drink at the same time ambroksol Ascoril, since these drugs one action, and can interfere with each other. But if the doctor considers it necessary, he can treat the patient at the same time the two drugs.
Which drug acts faster in the body
Ambroxol getting into the stomach, rapidly dissolves and is absorbed into the bloodstream. After 3 hours, the maximum concentration observed. Is displayed for a long time and slowly for 12-22 hours. Ambroxol derived mainly kidneys as metabolites.
Ascoril in view of the fact that this combination drug is absorbed and distributed unequally. Basically, all the components ASKOR absorbed well and quickly, but their ability to penetrate into tissues and organs is different. For example, bromhexine bioavailability is not high, because the first passage of the drug through the liver, a large part of the substance is metabolized.
Availability salbutamol better tissues is 50%. Guaifenesin begins to act after 30-40 min after administration, and penetrates into those tissues which contain mucopolysaccharides.
Thus, the difference between the ambroxol and Askorilom is as follows: Ambroxol slowly absorbed and long retains the therapeutic effect. Ascoril quickly absorbed, but the duration of therapeutic effect is less. Hence the appointment of Ambroxol 2 times a day, and ASKOR 3 times a day.
special instructions
Compare Ascoril and Ambroxol can be more for special instructions about taking ART. Both drugs should not be taken when in appointments discharged codeine, because it contributes to the difficulty of removing phlegm. Codeine has opposite therapeutic effect - antitussive.
Ascoril contraindicated to take with kidney and liver failure. As well as during pregnancy and lactation, as the drug enters the milk.
Ambroxol can not accept pregnant women who are in the first trimester, the rest during pregnancy should only be taken after medical examination. If necessary, reception Ambroxol during breastfeeding, it is necessary to temporarily stop feeding.
With inadequate renal and hepatic function Ambroxol should be taken with caution.
Different formulations of drugs does not guarantee that you can take another drug in a particular state.
Thus, Ambroxol Ascoril and similar drugs for the pharmacological and therapeutic action, It is contraindicated in cases of identical, but Ascoril has a complex action and affects operation bronchi. But Ambroksol solution can be used in children younger than 2 years. Ambroxol longer valid, and receive drugs should be carried out only 2 times a day.
analogues of drugs
Before replacement of a drug, you must first consult with your doctor, because the drug may have other contraindications.
Ambroxol can replace its analogues. They are today a huge amount on the pharmacy market. They differ by the manufacturer. Often, different preparations of the same drug component can be more or less effective. The effectiveness can affect the purity of the parent drug, or additional components that are included in the preparation. Ambroxol analogue differs in price. Best known analogues is Ambrobene, Lasolvan, Haliksol, Sekrol, Flavamed and others.
The analogue may be a drug ASKOR Kashnol and Kofasma. The compositions of these products are almost identical, but the dosages are part of the components are different from ASKOR.
sources:
Vidal: https://www.vidal.ru/drugs/ascoril_expectorant__1295
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = b9a86cb3-a4d7-45c6-91b4-b8a127cd2a2b & t =
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