Dexamethasone: Improves blood sugar or not

Pharmacological properties, form, indications, limitations

Dexamethasone relates to glucocorticoid hormones therefore has high anti-inflammatory, immunosuppressive, anti-allergic effect, enhances sensitivity to β-adrenergic receptors catecholamines. Dexamethasone contributes to complexes that stimulate the synthesis of protein molecules. Under the influence of the drug stimulates the formation of blood plasma proteins, albumin in the liver and kidney tissues. Improves the formation of lipid molecular structures. Fat cells are preferably formed on the face, the shoulder girdle and abdomen. Increased cholesterol levels in the bloodstream.

The effect of dexamethasone on blood sugar as follows: increases the absorption of sugar molecules in the digestive tract, increases the concentration of glucose in the bloodstream, liver enzyme increases the formation, due to stimulation gluconeogenesis,

contributes to the development of hyperglycemia (high blood sugar).

Dexamethasone reduces the content of calcium in bone, reduces the excretion of sodium and fluids from the body. The drug reduces inflammation by reducing the production of inflammatory cytokines, leukotrienes, macrophages and other immune cells. It stabilizes the permeability of cell membranes and intracellular structures. Hampers the work of T and B cells of the immune system. It reduces the synthesis of specific antibodies. It promotes the release of mast cells synthesizing hyaluronic acid, histamine.

Reduces swelling of the mucous membranes of the bronchi, reduces the formation of mucus in the lumen of the bronchi and bronchioles, slightly liquefies phlegm. Inhibits the secretion of the hormone adrenoglyukokortikosteroidnogo. Metabolism of drugs takes place in the liver tissue. He went out through the urinary system. Dexamethasone is able to increase blood pressure.

It is manufactured in an injection and a tablet form. Ampoules with a solution of produce of 1 and 2 ml. 1 ampoule (2 ml) contains 8 mg Dexamethasone, the ampoule (1 ml) - 4 mg of the drug. 1 tablet contains 0.0005 g.

testimony

restrictions

systemic diseases (lupus erythematosus, rheumatic disease, dermatomyositis, scleroderma); children's and adult joint disease; allergic conditions; skin diseases; brain swelling (tumor, traumatic, surgical origin after radiation therapy); allergic eye disease, inflammatory etiology; the poor performance of the adrenal gland, adrenal hyperplasia; autoimmune renal disease (glomerulonephritis, nephritic syndrome); thyroiditis; hematopoietic system disease (anemia, leukemias); pulmonary diseases (bronchial asthma, sarcoidosis, fibrosis, alveolitis); Tuberculosis of the lungs, the brain; cancerous lung injury; pathologies of the digestive tract (Crohn's disease, enteritis, ulcerative colitis); multiple sclerosis; hepatitis (as autoimmune); increasing calcium bloodstream at onkopatologii; preventing the development of transplant rejection (together with other drugs); multiple myeloma; in carrying out the differential diagnosis of cancer samples adrenal; state of shock.

infectious diseases; strong bleeding medicament genesis; hypersensitivity to the drug; bone fractures; deforming arthritis; period after vaccination; post-infarction state; hyperlipidemia; diabetes; osteoporosis; kidney and liver dysfunction.

Dexamethasone has a large number of adverse events, which should be taken into account when treating patients.

Adverse drug effects:

• Cushing's syndrome;
• arrhythmia;
• dyspepsia;
• hypertension;
• delirium, euphoria;
• high pressure in the fundus;
• bone growth retardation in children;
• allergies and others.

How does Dexamethasone on carbohydrate metabolism

Is Dexamethasone increases blood sugar levels? The drug is able to enhance the absorption of sugars through the intestinal wall. When exposed to the drug activates the enzyme work glucose 6-phosphate. This enzyme contributes to the acceleration of penetration of liver sugar in blood. After that it increases the secretion of liver enzymes. These processes lead to the start of gluconeogenesis in hepatic tissue, which is the cause of high blood sugar.

During the use of dexamethasone in patients with diabetes mellitus blood sugar levels rise very quickly. High sugar can lead to hyperglycemic coma. It is very dangerous to life. In this case the patient needs medical assistance.

If a patient has a combination of diabetes and other diseases that require treatment with hormones glucocorticosteroid (GCS), the treatment prescribed in short courses. Therapy is always under supervision of a physician and under the supervision of a blood test for sugar. With a sharp increase in blood sugar therapy should be discontinued.

conclusion

Dexamethasone for patients with diabetes tend not to apply, as it greatly increases the sugar in the bloodstream. Constant use of corticosteroids can lead to steroid diabetes. It is allowed to use the drug for diabetes, but only when other therapy does not help. Dexamethasone is better to replace other effective means. The presence of diabetes (high blood sugar) greatly complicates the treatment of many diseases, in the complex therapy including dexamethasone. Therefore, doctors recommend that a healthy lifestyle to reduce the frequency of occurrence of diabetes today.

sources:

Vidal: https://www.vidal.ru/drugs/dexamethasone__36873
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 5db6dfe2-5236-4cd7-86de-d6f534373dd4 & t =

Found a bug? Select it and press Ctrl + Enter