Dexamethasone metipred and are very effective drugs related to glucocorticoid hormones. What better metipred or Dexamethasone? This question is difficult to answer unequivocally. Drugs have varying degrees of success, but are used in the same conditions.
Metipred well suited for first aid, as well as for routine treatment of diseases requiring the appointment of glucocorticosteroids (GCS). It is permissible to use the duration of the course. Dexamethasone is more widely used in emergency situations, as well as a short course of treatment.
Comparative characteristics of drugs
Dexamethasone can be compared with metipred. Metipred refers to klyukokortikosteroidam short exposure. Adverse effects are less pronounced. Less develop osteoporosis, Cushing's syndrome is less bright, less increases blood sugar, not much blood pressure rises. Dexamethasone is considered long-acting hormonal drugs. While taking medication may develop severe adverse events (diabetic coma, osteoporosis, hypertension, and others).
Characteristics |
metipred |
dexamethasone |
active component |
Methylprednisolone sodium succinate |
Dexamethasone sodium phosphate |
The form |
Tablet (4 mg tablets, 16 mg), injection (250 mg vials). |
Tablet (0.0005 g), injection (ampule 1 mL (4 mg), 2 ml ampoule (8 mg)). |
testimony |
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Restrictions on the use of medicines:
- ulcerative damages the alimentary tract;
- infectious diseases of various etiology;
- state after immunization (up to 8 weeks prior to vaccination, 14 days after), lymph nodes after BCG;
- postinfarkt, hypertension, hyperlipidemia, heart failure;
- HIV;
- diabetes mellitus, hypothyroidism, Cushing's disease, severe obesity;
- renal and hepatic dysfunction;
- glaucoma;
- polio;
- gestation period;
- are allergic to components of the medication.
Like a drug Methylprednisolone Prednisolone considered. It is less effective, but it is used frequently.
General principles of drug use
The difference between the drugs is that metipred used for longer courses, as it has a short duration of action. Dexamethasone is accepted if glucocorticosteroids short exposure and expectancy do not have the desired effect. Methylprednisolone has a less pronounced side effects of unlike dexamethasone.
For patients requiring continuous use of glucocorticosteroids (autoimmune diseases: autoimmune hepatitis, multiple sclerosis, etc.), often prescribed long courses Methylprednisolone. When pregnancy is taking Dexamethasone or metipred? In pregnancy, the doctors prefer methylprednisolone, since it is less toxic to the fetus and cause fewer adverse events. Pregnant patients during gestation shown drink formulation for relieving symptoms of acute exacerbation or chronic allergies and autoimmune conditions.
At the same time it is impossible to take Dexamethasone metipred. Dexamethasone is often used for the relief of an acute condition, then transferred gradually metipred or other hormonal drug. Dosage Methylprednisolone in the initial therapy is 4 to 48 mg, dexamethasone - from 4 to 20 or more depending on the type of disease and patient. Medications do not cancel abruptly as this can lead to adrenal insufficiency.
conclusion
Glucocorticosteroids are considered very powerful drugs for the treatment of allergy, rheumatology, autoimmune and other diseases. Yourself, do not use them. Before using the preparations necessary to address to the attending doctor for the selection of dosage and duration of therapy. After normalization of the doctor should appoint a dose to reduce the daily and discontinued medications. Self-medication can not undo.
sources:
Vidal: https://www.vidal.ru/drugs/dexamethasone__36873
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 5db6dfe2-5236-4cd7-86de-d6f534373dd4 & t =
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