Analogues of ceftriaxone injections
Application of antibacterial drugs in injectable form allows more rapid and pronounced therapeutic effect for various kinds of infectious diseases. The most common analogs of Ceftriaxone in the form of injections, are available in an assortment of almost every pharmacy:
cefazolin
It refers to the generation of cephalosporin antibiotics 1. It has a strong antibacterial effect. Appearance - powder for solution for injection. Binding to blood proteins - about 85%, half-life - 1.8 hours.
Indications are similar to the recommendations on the use of ceftriaxone. The drug is used to eliminate urinary tract infections and genital (syphilis, gonorrhea, prostate inflammation, infectious diseases of the kidneys and bladder). The main difference from Ceftriaxone - the need to reduce the dosage in the presence of renal or hepatic impairment in the patient.
Dose and mode of administration:
- average daily dose in adults - 1 g, for children - 20-40 mg / kg body weight;
- multiplicity of introduction - 2-4 times a day;
- for the prevention of infection after surgery is administered 1 gram for half an hour before it starts, 0.5-1 grams during the operation, and then every 6-8 hours during the day after its closure (maximum - 6 gram course).
cefotaxime
Rapidly absorbed after intramuscular injection and distributed uniformly in the body. Communication with blood proteins - about 40%. Approximately half of the dose is excreted in urine in the initial state, 20% - in the form of metabolites.
The peculiarity of the drug - suppression of vitamin K in the gut, which may result in an increased risk of bleeding when used in conjunction with drugs which reduce platelet aggregation (NSAIDs, aspirin, sulfinpyrazone).
As Ceftriaxone, the drug has extensive antimicrobial effects under the most severe conditions:
- sepsis;
- gonorrhea;
- meningitis;
- peritonitis;
- Lyme disease;
- abdominal and other infections.
mode of administration and dosage:
- adults and children from 50 kg - 2.1 grams of 2-6 times a day;
- children in the weight class up to 50 kg - 2-6 times a day in a dose of 50-180 mcg / kg body weight;
- the maximum daily dose in adults - 12 grams, children with a weight up to 50 kg - 180 mg / kg body weight.
Ceftriaxone therapy - the most inexpensive treatment option due to the need for single use per day. The average price of 1 bottle - 15-20 rubles. Cheap Ceftriaxone drug analogues produced in Russia and called the active substance in the composition of the drug.
If necessary Ceftriaxone is replaced with another drug directly in the treatment process with appropriate adjustments dose and frequency of administration of injections. One of the most expensive drugs-synonyms Ceftriaxone - Rocephin. Price per bottle on average 500 rubles.
Analogues of Ceftriaxone in tablets
The most common medications for internal use, similar to ceftriaxone, contain in their composition cefixime and cephalexin. For children discount Ceftriaxone substitutes in the form of powders for oral suspensions. There is no need to prepare sterile injection solutions and to conduct the children that greatly simplifies the treatment process. However, such forms of preparation are recommended for treating diseases of mild to moderate severity. In severe cases the treatment is preferably injectable forms of the drug.
Tablets and capsules
There are several options that can replace the drug ceftriaxone. Among them:
Supraks
The active substance - 400 mg of cefixime. Number of tablets per pack - 6, 7 or 10, depending on the manufacturer and the form of the drug release. Dispersible form facilitates the treatment process at the difficulties encountered in swallowing large capsules or tablets.
Bioavailability - 50%, regardless of the meal, with the largest concentration in serum is created faster by 50 minutes at the reception during the meal. Communication with plasma proteins - 65%, about half of the dose is excreted by the kidneys in its original form, half-life - 3-4 hours. The drug inhibits the synthesis of cell wall membrane of the pathogen, bactericidal effect.
Indications for use are similar to ceftriaxone:
- ear infections;
- bronchitis;
- sinusitis;
- pharyngitis;
- tonsillitis;
- uncomplicated gonorrhea;
- kidney and bladder infection.
Receive Mode - 400 mg once a day. Duration of therapy - 7-10 days. Infections caused by streptococcus, a course of treatment - not less than 10 days. In uncomplicated gonorrhea - 400 mg single dose of the drug.
cephalexin
Ceftriaxone effective substitute in tablets or capsules containing 500 mg of active ingredient, 10, 16 or 20 pieces in one package. The preparation also gives processes of forming the cell membranes of bacterial agents and prevents their propagation.
As Ceftriaxone, has a substantial spectrum antimicrobial activity, however applied at more indications:
- infections of the skin and tissue;
- renal and bladder disease;
- infections of the upper respiratory tract, respiratory system;
- infectious diseases of bones and joints.
Receive Mode:
- adults and children from 10 years old - 0.25-0.5 grams four times a day;
- the average duration of therapy - 7-14 days;
- treatment of diseases caused by streptococcal infection - not less than 10 days;
- drug requires adjusting the dose KK under reduced kidney;
- daily dose - 1-4 grams.
Analogs Ceftriaxone in tablets and capsules enhance the effect of anticoagulants and increase the toxicity of diuretics (furosemide) for kidney. At the same time taking caution should be exercised.
Analogs Ceftriaxone in suspension
The vast majority of antibiotics in tablets are also available in forms suitable for the treatment of children. The package comprises a strictly controlled amount of the active ingredient. Cooked according to instructions and suspension receiving the recommended volume for ease and efficiency of antibacterial therapy.
Main counterparts Ceftriaxone in the form of suspensions:
Supraks
Packaging formulation comprises granules in an amount of 30 grams for the preparation of 60 ml of solution. Dilution with a 2 stage should add 20 ml of cooled boiled water, each time carefully shaking the vial to dissolve the drug granules. Once formed foam settles, should ensure that the resulting level means comes to the mark printed on the side of the vial. If necessary, add water.
Store the prepared suspension is allowed at a temperature of from 15 to 25 ° C for up to 2 weeks. The product contains 100 mg of cefixime each 5 ml in reception mode is similar to the adult. Dosage is calculated on the weight of the baby's body, and is 8 mg / kg body weight. Duration of treatment - up to 14 days. At low efficiency it is recommended to replace a timely ceftriaxone oral form.
cephalexin
The vial formulation comprises 40 grams of powder with 5 gr. active substances for the preparation of 100 ml of suspension for the children in 5 ml of the diluted agent - 250 mg of cephalexin. Method of preparation similar.
reception and dosage regimen:
- the dose is calculated based on the weight of the child's body;
- dosage is 25-100 mg / kg, depending on the severity of the condition;
- multiplicity of reception - 4-6 times a day;
- course of treatment - 7-14 days.
Assimilation is not dependent on food intake, 95% of the drug is rapidly absorbed from the gastrointestinal tract. A therapeutic concentration in serum is saved 4-6 hours then repeated reception dose required to maintain therapeutic effect. The drug is approved for use in children 6 months.
Analogues of Ceftriaxone in tablets, capsules and suspensions allow for outpatient treatment without having to go to nursing services for the introduction of the next injection. However, forms for oral administration generally have less therapeutic effect, however, in some cases, a hospital and parenteral therapy.
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