Pharmacological properties, form, indications, limitations
Metronidazole is made in the form of tablets, suppositories (candles) solution (500 mg - 100 ml), gel. Tablets contain 500 or 250 mg of active ingredient, one spark - 500 mg of the drug. The active component of the drug is metronidazole.
Metronidazole refers to antiprotozoal and antimicrobial drugs. The drug restores 5-nitro bacterial pathogens. It contributes to deoxyribonucleic acid. As a result, this decreases the formation of nucleic acids, which leads to the death of the bacterial agent.
The drug helps fight Entamoeba, gardnerellami, giardia, obligate anaerobic, gram-positive organisms. On Metronidazole not react aerobic bacteria strains, as well as facultative anaerobic organisms. The drug is metabolized in the liver. Excreted in the biliary secretion and excretion.
Metronidazole analogues are:
- trihopol;
- Metronidazole-ICCO;
- Metronidazole-Nycomed.
Metronidazole has its indications and contraindications.
Indications for use of metronidazole |
Restrictions on the appointment of Metronidazole |
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Metronidazole has the following undesirable effects: dyspeptic symptoms, vestibular disorders, changes in consciousness, sleep disorders, convulsions, allergic reactions, impaired kidney function, changes on the ECG.
The concept ureoplazmoz, the general principles of diagnosis and treatment
ureoplazmoz - is a contagious disease that is sexually transmitted. By contact bacterium substantially not transmitted. Ureaplasmosis causes ureaplasma. This bacterial agent is small in size, having similar characteristics of viral and bacterial microorganisms. Ureaplasma has a thin wall and a small amount of genetic material. The bacterium can infect the genital tract after gonorrhea or any other sexual infections.
Ureaplasma appears, if the patient is very much reduced immunity. Often this bacterium infected people with HIV infection. A high percentage of infection ureaplasma in newborn children, especially girls. Newborns are able to obtain this agent during passage through the birth canal mothers.
Many people are carriers of ureaplasma. By reducing immunity during pregnancy, after surgery or during sexual contact bacterium begins to multiply rapidly. This contributes to the appearance of clinical manifestations.
Clinical manifestations of infection ureoprazmoy:
- urethritis in men and women;
- chronic pathologies of the uterus, ovaries, and fallopian tubes;
- the formation of kidney stones;
- higher risk of abortions and births in the early stages;
- itching, burning sensation in the urethra;
- discomfort in the genital tract and the pelvis when emptying the bladder, as well as during sexual intercourse;
- discharge from the urethra and the vagina;
- reduction drive;
- poor reproductive function.
When infection is suspected ureaplasma doctor making a smear from the genital tract and analysis of PCR-diagnostics for detecting bacterial agent. After receiving positive results the doctor prescribes treatment.
Ureaplasma treated with antibacterial drugs that will stop the proliferation of bacteria. The main antibiotics include macrolide, fluoroquinolone series tetracycline series of antibiotics. The treatment regimen includes ureaplasma antibiotics for 7-10 days.
The choice of antibacterial agent is carried out by analysis on bacteria sensitive to antibiotics. When drug therapy inefficiency antibacterials replaced. The therapy after the second day of symptoms brightness fades, patient's condition is getting better.
Ureaplasmas treatment is carried out immediately for both partners. During treatment, sexual intercourse is allowed, but it must be protected. For this purpose, the barrier method contraceptives (condom).
Besides the main antimicrobials shown at ureaplasmosis take Metronidazole. This drug is prescribed as an additional tool to enhance the effectiveness of therapy. Ureaplasma treated with metronidazole can be using candles or tablet form.
Terms of Use metronidazole, drug analogues
How to take metronidazole at a ureaplasma? The drug is prescribed candles, 1 suppository at night for 10 days. When using the tablet form of metronidazole at a ureaplasma reception rules are as follows: 1 tablet (500 mg) twice a day. In severe cases the patient to take the medicine prescribed to 3 tablets per day. Injectable form of the drug is used in severe disease or inability to oral medications. Gel shows men topically.
Pregnant patients with drug ureaplazmoy allowed to appoint, if the benefit to the mother outweighs the harm to the fetus. When this medication is not used in the first trimester. Metronidazole use only 2 or 3 trimester. Nursing mothers infected with ureaplasma, during therapy should be discontinued breastfeeding as Metronidazole is well into the milk and gives it a bitter taste.
In patients with liver disease and kidney medicine is prescribed only when indicated. Metronidazole is able to accumulate in liver tissue and degrade the function of the organ. During use, the drug load on the kidneys is also increased, so patients with renal insufficiency not prescribe medication.
Metronidazole should not be used on their own. The question is solved only therapy together with your doctor. Prior to use, confirm the diagnosis with a doctor to determine the sensitivity to antibiotics ureaplasma. Metronidazole as an independent means ureoplazmu when not in use. He was appointed to the main antibiotic therapy.
conclusion
Metronizazol shown as an additional antibacterial agent at a ureaplasma. This large variety of drug dosage forms. When treating ureoplazmy need to treat both partners. Otherwise there is a high risk of re-infection.
sources:
Vidal: https://www.vidal.ru/drugs/metronidazole__18699
GRLS: https://grls.rosminzdrav.ru/Grls_View_v2.aspx? routingGuid = 34a165f5-cd6a-4420-ac87-4d044867cd64 & t =
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